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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2cgf P2N ATP-dependent molecular chaperone HSP82

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
2cgf P2NATP-dependent molecular chaperone HSP82 / 0.970
2iwx M1SATP-dependent molecular chaperone HSP82 / 0.911
2iws NP4ATP-dependent molecular chaperone HSP82 / 0.844
2xd6 XD6ATP-dependent molecular chaperone HSP82 / 0.837
2fxs RDAATP-dependent molecular chaperone HSP82 / 0.783
2wer RDCATP-dependent molecular chaperone HSP82 / 0.783
1qy8 RDIEndoplasmin / 0.770
2xx2 13CATP-dependent molecular chaperone HSP82 / 0.762
4ce1 7FKATP-dependent molecular chaperone HSP82 / 0.761
1u0z RDCEndoplasmin / 0.759
1bgq RDCATP-dependent molecular chaperone HSP82 / 0.757
2bre KJ2ATP-dependent molecular chaperone HSP82 / 0.751
2gfd RDAEndoplasmin / 0.745
1n35 CH1RNA-directed RNA polymerase lambda-3 2.7.7.48 0.744
1nmd ATPMajor actin / 0.744
1wet GUNHTH-type transcriptional repressor PurR / 0.744
1xxj UNCUricase 1.7.3.3 0.744
2d09 FLVBiflaviolin synthase CYP158A2 / 0.744
2fzk CTPAspartate carbamoyltransferase regulatory chain / 0.744
2jey HLOAcetylcholinesterase 3.1.1.7 0.744
2oap ANPType II secretion system protein (GspE-2) / 0.744
2z7q ACPRibosomal protein S6 kinase alpha-1 2.7.11.1 0.744
2zs9 ADPPantothenate kinase 2.7.1.33 0.744
3cwq ADPParA family chromosome partitioning protein / 0.744
3f8r NAPNADH oxidase/thioredoxin reductase / 0.744
3fzf ATPHeat shock cognate 71 kDa protein / 0.744
3u9d ATPActin, alpha skeletal muscle / 0.744
3ypi PGHTriosephosphate isomerase 5.3.1.1 0.744
3zzn ADPL-lactate dehydrogenase / 0.744
5bnt NAPAspartate-semialdehyde dehydrogenase 1.2.1.11 0.744
4egk RDCHeat shock protein HSP 90-alpha / 0.737
2yi5 YI5Heat shock protein HSP 90-alpha / 0.730
2iwu NP5ATP-dependent molecular chaperone HSP82 / 0.724
4ce2 BO5ATP-dependent molecular chaperone HSP82 / 0.724
4b7p 9UNHeat shock protein HSP 90-alpha / 0.714
3eko PYUHeat shock protein HSP 90-alpha / 0.709
4bqj XKLHeat shock protein HSP 90-alpha / 0.705
2fyp RDEEndoplasmin / 0.704
2ye4 2FYHeat shock protein HSP 90-alpha / 0.704
2ccu 2D9Heat shock protein HSP 90-alpha / 0.688
2yk2 YJWHeat shock protein HSP 90-alpha / 0.686
3k99 PFTHeat shock protein HSP 90-alpha / 0.680
3ekr PY9Heat shock protein HSP 90-alpha / 0.678
2bz5 AB4Heat shock protein HSP 90-alpha / 0.671
1yc4 43PHeat shock protein HSP 90-alpha / 0.670
2hkj RDCType 2 DNA topoisomerase 6 subunit B / 0.670
2xjx XJXHeat shock protein HSP 90-alpha / 0.664
2yjw YJWHeat shock protein HSP 90-alpha / 0.664
4egh 0OYHeat shock protein HSP 90-alpha / 0.662
1fp6 ADPNitrogenase iron protein 1 1.18.6.1 0.660
1h48 C5P2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 4.6.1.12 0.660
1yra GDPGPN-loop GTPase PAB0955 / 0.660
2bsm BSMHeat shock protein HSP 90-alpha / 0.660
2hs4 ACPPhosphoribosylformylglycinamidine synthase subunit PurL / 0.660
2xtn GTPGTPase IMAP family member 2 / 0.660
3fwy ADPLight-independent protochlorophyllide reductase iron-sulfur ATP-binding protein / 0.660
3kjg ADPCO dehydrogenase/acetyl-CoA synthase complex, accessory protein CooC / 0.660
4nxv GDPMitochondrial dynamics protein MID51 / 0.660
4nxx GDPMitochondrial dynamics protein MID51 / 0.660
4o3m ADPBloom syndrome protein 3.6.4.12 0.660
4afj SJJGlycogen synthase kinase-3 beta 2.7.11.26 0.658
3poz 03PEpidermal growth factor receptor 2.7.10.1 0.654
2xx4 13IATP-dependent molecular chaperone HSP82 / 0.650