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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1o9j NAD Aldehyde dehydrogenase, cytosolic 1 1.2.1.3

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 1.207
4pz2 NADAldehyde dehydrogenase 2-6 / 1.047
3b4w NADAldehyde dehydrogenase family protein / 1.013
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.989
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.987
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.977
4i8p NADAminoaldehyde dehydrogenase 1 / 0.976
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.974
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.962
4i8q NADPutative betaine aldehyde dehyrogenase / 0.947
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.944
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.943
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.939
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.935
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.932
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.931
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.930
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.929
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.925
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.912
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 0.906
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.905
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.902
2jg7 NADAntiquitin / 0.902
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.899
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.894
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.884
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.870
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.866
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.866
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.863
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.857
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.829
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.826
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.812
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.801
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.795
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.783
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.779
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.776
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.772
3ju8 NADN-succinylglutamate 5-semialdehyde dehydrogenase 1.2.1.71 0.770
3iwj NADAminoaldehyde dehydrogenase / 0.769
4pt0 NADAldehyde dehydrogenase / 0.766
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.760
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.759
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.758
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.758
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.756
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.755
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.753
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.749
1bi9 NADRetinal dehydrogenase 2 / 0.748
3haz NADBifunctional protein PutA / 0.747
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.746
4pxl NADAldehyde dehydrogenase3 / 0.746
2bja NAD1-pyrroline-5-carboxylate dehydrogenase / 0.740
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.740
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.740
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.739
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.735
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.732
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.731
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.730
4nmj NAPAldehyde dehydrogenase / 0.728
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.723
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.723
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.722
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.721
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.720
4h73 NDPAldehyde dehydrogenase / 0.720
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.716
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.713
3rhd NAPLactaldehyde dehydrogenase 1.2.1.22 0.708
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.707
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.705
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.704
1ez0 NAPNADP-dependent fatty aldehyde dehydrogenase 1.2.1.4 0.703
4i3v NADAldehyde dehydrogenase (NAD+) / 0.701
4zz7 NADMethylmalonate-semialdehyde dehydrogenase / 0.699
4i9b NADPutative betaine aldehyde dehyrogenase / 0.693
4nmk NAPAldehyde dehydrogenase / 0.690
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.689
4f3x NADPutative aldehyde dehydrogenase / 0.688
4i3w NADAldehyde dehydrogenase (NAD+) / 0.685
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.677
4zvy NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.677
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.672
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.671
2w8r ADPSuccinate-semialdehyde dehydrogenase, mitochondrial 1.2.1.24 0.669
4c3s NADAldehyde Dehydrogenase / 0.662
1oaa NAPSepiapterin reductase 1.1.1.153 0.658
1mg5 NAIAlcohol dehydrogenase 1.1.1.1 0.656
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.654
1kqo DNDNicotinamide/nicotinic acid mononucleotide adenylyltransferase 1 2.7.7.1 0.653
4is3 NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2 1.17.98.1 0.652
4j7u NAPSepiapterin reductase 1.1.1.153 0.652
2voj NADAlanine dehydrogenase 1.4.1.1 0.650