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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1o6k ANP RAC-beta serine/threonine-protein kinase 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 1.210
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.084
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.083
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.081
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.081
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.081
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.078
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.066
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.065
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.054
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.048
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.984
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.948
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.922
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.911
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.909
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.902
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.889
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.889
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.888
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.883
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.882
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.881
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.871
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.868
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.868
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.865
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.865
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.863
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.858
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.855
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.848
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.847
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.846
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.844
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.844
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.840
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.839
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.825
4dee ADPAurora kinase A 2.7.11.1 0.817
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.805
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.803
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.803
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.802
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.801
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.800
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.798
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.798
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.795
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.792
1m0w ANPGlutathione synthetase 6.3.2.3 0.791
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.790
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.789
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.788
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.787
5iqh GNPBifunctional AAC/APH 2.3.1 0.787
1mq4 ADPAurora kinase A 2.7.11.1 0.786
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.785
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.784
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.783
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.780
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.776
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.776
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.776
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.776
1cm8 ANPMitogen-activated protein kinase 12 / 0.774
4ysj ADPCalmodulin-like domain protein kinase / 0.773
5dn3 ATPAurora kinase A 2.7.11.1 0.773
1day GNPCasein kinase II subunit alpha 2.7.11.1 0.772
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.771
3ori AGSSerine/threonine protein kinase / 0.770
4ceg ADPAurora kinase A 2.7.11.1 0.770
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.769
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.768
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.767
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.767
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.766
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.765
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.762
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.761
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.760
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.760
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.760
5dr2 ATPAurora kinase A 2.7.11.1 0.760
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.759
2pyw ADPMethylthioribose kinase 2.7.1.100 0.758
4qny ANPMitogen activated protein kinase, putative / 0.758
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.757
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.757
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.753
5dt3 ATPAurora kinase A 2.7.11.1 0.753
4utd ACPAurora kinase A 2.7.11.1 0.751
4bn1 ADPAurora kinase A 2.7.11.1 0.750
5byl GCPBifunctional AAC/APH 2.3.1 0.749
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.747
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.746
1l8t ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.745
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.745
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.745
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.744
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.743
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.741
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.738
2io7 ANPBifunctional glutathionylspermidine synthetase/amidase / 0.737
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.737
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.736
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.734
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.734
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.732
3qc9 ADPRhodopsin kinase / 0.731
5ce3 ADPProtein kinase YopO / 0.730
5dos ATPAurora kinase A 2.7.11.1 0.730
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.729
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.729
2xan ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.729
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.728
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.728
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.726
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.726
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.726
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.726
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.725
5drd ATPAurora kinase A 2.7.11.1 0.725
2pml ANPUncharacterized protein / 0.724
2pup ADPMethylthioribose kinase 2.7.1.100 0.724
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.724
3t8o ATPRhodopsin kinase / 0.724
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.722
3rv4 ADPBiotin carboxylase 6.3.4.14 0.722
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.722
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.721
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.719
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.719
4o4d ATPKinase / 0.719
5iqb GNPBifunctional AAC/APH 2.3.1 0.719
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.718
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.717
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.713
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.713
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.711
4uxx ACPDiacylglycerol kinase 2.7.1.107 0.710
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.707
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.707
3orm AGSSerine/threonine protein kinase / 0.707
4ffr ATPUncharacterized protein / 0.707
2pul ACPMethylthioribose kinase 2.7.1.100 0.706
3wnz ADPAlanine--anticapsin ligase / 0.706
5iqe GNPBifunctional AAC/APH 2.3.1 0.706
2dwb ANPAurora kinase A 2.7.11.1 0.704
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.704
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.702
2pui ADPMethylthioribose kinase 2.7.1.100 0.701
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.701
1a9x ADPCarbamoyl-phosphate synthase large chain / 0.700
3t54 ATPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.700
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.698
4wh2 ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.698
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.697
2io8 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.696
2r5t ANPSerine/threonine-protein kinase Sgk1 2.7.11.1 0.696
2vqd AP2Biotin carboxylase 6.3.4.14 0.696
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.696
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.695
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.694
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.692
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.692
4fmq ANPMitogen-activated protein kinase 1 2.7.11.24 0.692
4ork GDPBifunctional AAC/APH 2.3.1 0.692
1ol6 ATPAurora kinase A 2.7.11.1 0.690
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.690
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.687
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.686
4xlv ACPInsulin receptor 2.7.10.1 0.686
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.685
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.685
4fu0 ADPD-alanine--D-alanine ligase / 0.685
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.685
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.684
2zdg ADPD-alanine--D-alanine ligase / 0.683
4mkf AP5Adenylate kinase / 0.683
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.682
2pz5 ACPFibroblast growth factor receptor 2 / 0.682
2eb3 ANPEpidermal growth factor receptor 2.7.10.1 0.681
2py3 ACPFibroblast growth factor receptor 2 / 0.681
3cly ACPFibroblast growth factor receptor 2 / 0.681
2osb AP5Adenylate kinase / 0.678
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.677
4tyq AP5Adenylate kinase / 0.677
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.676
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.676
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.676
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.675
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.675
3wo0 ADPAlanine--anticapsin ligase / 0.675
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.674
1dv2 ATPBiotin carboxylase 6.3.4.14 0.673
3c50 ADPRhodopsin kinase / 0.673
3vpc ADPGlutamate--LysW ligase ArgX 6.3.2 0.673
4zgn ATPCell division cycle protein 123 / 0.673
3bu5 ATPInsulin receptor 2.7.10.1 0.672
3c4z ADPRhodopsin kinase / 0.672
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.671
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.670
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.670
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.670
5dnr ATPAurora kinase A 2.7.11.1 0.670
2jiz ANPATP synthase subunit beta, mitochondrial 3.6.3.14 0.669
3dl0 AP5Adenylate kinase / 0.669
4yhj AN2G protein-coupled receptor kinase 4 2.7.11.16 0.669
1os1 ATPPhosphoenolpyruvate carboxykinase (ATP) / 0.668
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.668
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.668
2oap ANPType II secretion system protein (GspE-2) / 0.667
2yaa ATPDeath-associated protein kinase 2 / 0.667
3llt ANPProtein serine/threonine kinase-1 / 0.667
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.667
3c4w ATPRhodopsin kinase / 0.666
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.665
2oo7 AP5Adenylate kinase / 0.663
2pvr ANPCasein kinase II subunit alpha 2.7.11.1 0.663
2qaj AP5Adenylate kinase / 0.663
3oij SAHRibosomal RNA small subunit methyltransferase NEP1 / 0.663
4mv8 ACPBiotin carboxylase 6.3.4.14 0.663
5iqg GDPBifunctional AAC/APH 2.3.1 0.663
2vnw M01cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.662
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.662
4ffl ADPUncharacterized protein / 0.662
3igo ANPCalmodulin-domain protein kinase 1, putative / 0.661
5c93 ACPTwo-component system histidine protein kinase / 0.661
2eu8 AP5Adenylate kinase / 0.660
4gyi ADPUncharacterized protein / 0.660
1u54 ACPActivated CDC42 kinase 1 / 0.659
2wtk ANPSTE20-related kinase adapter protein alpha / 0.659
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.659
1fq1 ATPCyclin-dependent kinase 2 2.7.11.22 0.658
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.658
2pzp ACPFibroblast growth factor receptor 2 / 0.658
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.658
4o0u ADNAurora kinase A 2.7.11.1 0.658
4rqk ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.658
2qoq ANPEphrin type-A receptor 3 2.7.10.1 0.657
2x0q ATPAlcaligin biosynthesis protein / 0.656
3mfs ANPPeripheral plasma membrane protein CASK 2.7.11.1 0.656
3oro AGSSerine/threonine protein kinase / 0.656
3cqw CQWRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.655
1p3j AP5Adenylate kinase / 0.654
1zw5 ZOLFarnesyl pyrophosphate synthase 2.5.1.10 0.654
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.654
4c3p ACPAurora kinase A 2.7.11.1 0.653
4eom ATPCyclin-dependent kinase 2 2.7.11.22 0.652
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.651
4mkg AP5Adenylate kinase / 0.651
5l6w AGSLIM domain kinase 1 2.7.11.1 0.651
1ss9 UPFLgtC / 0.650
1zao ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.650
2xs0 ANPMitogen-activated protein kinase 8 2.7.11.24 0.650
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.650
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.650
5dmz ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.650