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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1nvm NAD Acetaldehyde dehydrogenase 1.2.1.10

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1nvm NADAcetaldehyde dehydrogenase 1.2.1.10 1.138
5ein NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 0.790
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.766
1zh8 NAPUncharacterized protein / 0.760
3b1j NADGlyceraldehyde-3-phosphate dehydrogenase / 0.760
3qv1 NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic 1.2.1.13 0.758
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.749
2cvz NDP3-hydroxyisobutyrate dehydrogenase / 0.748
3f3s NADLambda-crystallin homolog / 0.748
5a03 NDPGlucose-fructose oxidoreductase / 0.745
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.743
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.742
2g82 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.742
5a04 NDPGlucose-fructose oxidoreductase / 0.741
3ikt NADRedox-sensing transcriptional repressor Rex / 0.737
1h6c NDPGlucose--fructose oxidoreductase 1.1.99.28 0.736
5a06 NDPGlucose-fructose oxidoreductase / 0.736
1wp4 NDP3-hydroxyisobutyrate dehydrogenase / 0.735
2rcy NAPPyrroline-5-carboxylate reductase / 0.735
2q3e NAIUDP-glucose 6-dehydrogenase 1.1.1.22 0.731
3hwr NDP2-dehydropantoate 2-reductase / 0.731
5a05 NDPGlucose-fructose oxidoreductase / 0.729
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.723
5eio NAP[LysW]-L-2-aminoadipate 6-phosphate reductase / 0.722
3w6u NAP6-phosphogluconate dehydrogenase, NAD-binding protein / 0.721
1nqo NADGlyceraldehyde-3-phosphate dehydrogenase / 0.718
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.718
4dpl NAPMalonyl-CoA reductase 1.2.1.75 0.718
3cmc NADGlyceraldehyde-3-phosphate dehydrogenase / 0.717
4dbv NDPGlyceraldehyde-3-phosphate dehydrogenase / 0.717
1rm3 NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic 1.2.1.13 0.716
4p8r NADGlyceraldehyde-3-phosphate dehydrogenase / 0.716
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.715
1nq5 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.715
3zdf NADGlyceraldehyde-3-phosphate dehydrogenase / 0.713
3cps NADGlyceraldehyde-3-phosphate dehydrogenase / 0.711
1dss NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.710
1gd1 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.710
3tri NAPPyrroline-5-carboxylate reductase / 0.710
2ixb NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.709
5a02 NAPGlucose-fructose oxidoreductase / 0.709
1jn0 NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic 1.2.1.13 0.708
1h6d NDPGlucose--fructose oxidoreductase 1.1.99.28 0.707
1vsv NADGlyceraldehyde-3-phosphate dehydrogenase / 0.706
3ids NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.706
5bsg NAPPyrroline-5-carboxylate reductase / 0.706
1dbv NADGlyceraldehyde-3-phosphate dehydrogenase / 0.705
1q0q NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267 0.704
4o59 NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.704
3pvz NADUDP-N-acetylglucosamine 4,6-dehydratase / 0.703
2i3g NAPN-acetyl-gamma-glutamyl-phosphate reductase 1.2.1.38 0.702
3ing NDPHomoserine dehydrogenase related protein / 0.702
4lsm NADGlyceraldehyde-3-phosphate dehydrogenase / 0.702
3dmt NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.701
3nt2 NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.701
1evj NADGlucose--fructose oxidoreductase 1.1.99.28 0.700
1rm4 NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic 1.2.1.13 0.700
3cif NADGlyceraldehyde-3-phosphate dehydrogenase / 0.700
4gae NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic 1.1.1.267 0.699
1o6z NADMalate dehydrogenase / 0.697
1nqa NADGlyceraldehyde-3-phosphate dehydrogenase / 0.696
2ep7 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.695
3x2f NAIAdenosylhomocysteinase / 0.695
3keo NADRedox-sensing transcriptional repressor Rex / 0.694
1ofg NDPGlucose--fructose oxidoreductase 1.1.99.28 0.692
4boy NADGlyceraldehyde-3-phosphate dehydrogenase / 0.692
1cer NADGlyceraldehyde-3-phosphate dehydrogenase / 0.691
3b20 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.690
1h6a NDPGlucose--fructose oxidoreductase 1.1.99.28 0.689
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.688
5bsf NADPyrroline-5-carboxylate reductase / 0.688
5c7o NADGlyceraldehyde-3-phosphate dehydrogenase, testis-specific 1.2.1.12 0.688
3had NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.687
1vc2 NADGlyceraldehyde-3-phosphate dehydrogenase / 0.686
1u8f NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.685
4o63 NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.685
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.684
1h6b NDPGlucose--fructose oxidoreductase 1.1.99.28 0.683
3lvf NADGlyceraldehyde-3-phosphate dehydrogenase 1 / 0.683
2dbv NDPGlyceraldehyde-3-phosphate dehydrogenase / 0.682
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.682
2g5c NADPrephenate dehydrogenase / 0.681
2ahr NAPPyrroline-5-carboxylate reductase / 0.680
4k9d NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.680
1gl3 NDPAspartate-semialdehyde dehydrogenase / 0.678
1dc6 NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.677
1hdg NADGlyceraldehyde-3-phosphate dehydrogenase / 0.677
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.677
1qxs NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.676
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.675
1ryd NDPGlucose--fructose oxidoreductase 1.1.99.28 0.674
1n7h NDPGDP-mannose 4,6 dehydratase 2 4.2.1.47 0.671
1a7k NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.670
1vi2 NADQuinate/shikimate dehydrogenase / 0.669
3doc NADGlyceraldehyde-3-phosphate dehydrogenase / 0.669
3zcx NADGlyceraldehyde-3-phosphate dehydrogenase / 0.669
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.668
3ec7 NADInositol 2-dehydrogenase / 0.667
3o9z NADLipopolysaccaride biosynthesis protein wbpB / 0.667
3v1y NADGlyceraldehyde-3-phosphate dehydrogenase 1, cytosolic 1.2.1.12 0.667
1npt NADGlyceraldehyde-3-phosphate dehydrogenase / 0.666
2d2i NAPGlyceraldehyde-3-phosphate dehydrogenase / 0.666
3q2k NAIProbable oxidoreductase / 0.666
1rm5 NDPGlyceraldehyde-3-phosphate dehydrogenase A, chloroplastic 1.2.1.13 0.665
2x6t NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.665
3t4e NADQuinate/shikimate dehydrogenase / 0.665
3w8e NAD3-hydroxybutyrate dehydrogenase / 0.665
5lc1 NADL-threonine 3-dehydrogenase / 0.665
2hdh NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.664
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.664
4om8 NAD3-hydroxybutyryl-coA dehydrogenase / 0.663
3k2b NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic 1.2.1.13 0.662
1dap NDPMeso-diaminopimelate D-dehydrogenase 1.4.1.16 0.660
1szj NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.660
3ulk NDPKetol-acid reductoisomerase (NADP(+)) / 0.659
4weq NAPNAD-dependent dehydrogenase / 0.659
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.659
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.658
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.658
3jv7 NADSecondary alcohol dehydrogenase / 0.658
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.657
1ml3 NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.657
3oa2 NADUDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase / 0.655
3q3c NADNAD-dependent L-serine dehydrogenase / 0.655
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.654
3ntq NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.654
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.653
3ruf NADUDP-N-acetylglucosamine 4-epimerase / 0.653
1o0s NAINAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.652
3pym NADGlyceraldehyde-3-phosphate dehydrogenase 3 1.2.1.12 0.652
4z0h NADGlyceraldehyde-3-phosphate dehydrogenase GAPC1, cytosolic 1.2.1.12 0.652
1bws NDPGDP-L-fucose synthase / 0.651
1i36 NAPConserved protein / 0.651
2ag5 NAD3-hydroxybutyrate dehydrogenase type 2 / 0.651
3ket NADRedox-sensing transcriptional repressor Rex / 0.651
3ksd NADGlyceraldehyde-3-phosphate dehydrogenase 1 / 0.651
3wsw NADL-lactate dehydrogenase / 0.651
4xqc NADHomospermidine synthase 2.5.1.44 0.651
2f1k NAPPrephenate dehydrogenase / 0.650
2vyn NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.650
3uko NADAlcohol dehydrogenase class-3 / 0.650