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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1n7h NDP GDP-mannose 4,6 dehydratase 2 4.2.1.47

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1n7h NDPGDP-mannose 4,6 dehydratase 2 4.2.1.47 1.321
1n7g NDPGDP-mannose 4,6 dehydratase 2 4.2.1.47 1.245
1t2a NDPGDP-mannose 4,6 dehydratase 4.2.1.47 1.184
1rpn NDPGDP-mannose 4,6-dehydratase / 1.006
2z1m NDPGDP-mannose 4,6-dehydratase / 0.938
2ggs NDPdTDP-4-dehydrorhamnose reductase / 0.829
1rkx NADCDP-D-glucose-4,6-dehydratase / 0.806
4u7w NDPMxaA / 0.806
3uce NDPDehydrogenase / 0.804
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.798
3rua NADUDP-N-acetylglucosamine 4-epimerase / 0.791
4hp8 NAP2-deoxy-D-gluconate 3-dehydrogenase / 0.791
2gn8 NAPUDP-N-acetylglucosamine 4,6-dehydratase (inverting) 4.2.1.115 0.789
4hxy NDPPlm1 / 0.786
2q1u NADPutative nucleotide sugar epimerase/ dehydratase / 0.783
2jl1 NAPTriphenylmethane reductase / 0.779
2p5y NADUDP-glucose 4-epimerase / 0.772
2hrb NAPCarbonyl reductase [NADPH] 3 1.1.1.184 0.770
2pk3 A2RGDP-6-deoxy-D-mannose reductase / 0.770
2q1t NADPutative nucleotide sugar epimerase/ dehydratase / 0.766
4idg NADPutative UDP-glucose 4-epimerase / 0.764
3icp NADNAD-dependent epimerase/dehydratase / 0.762
3ru9 NADUDP-N-acetylglucosamine 4-epimerase / 0.760
3rud NADUDP-N-acetylglucosamine 4-epimerase / 0.758
3gy0 NAPNAD(P)-dependent oxidoreductase / 0.755
3mje NDPAmphB / 0.754
3sxp NADADP-L-glycero-D-mannoheptose-6-epimerase / 0.754
5d2e NAPMlnE / 0.754
2q1s NAIPutative nucleotide sugar epimerase/ dehydratase / 0.749
2z95 NDPGDP-mannose 4,6-dehydratase / 0.748
4z3d NDPCarbonyl reductase [NADPH] 1 1.1.1.184 0.748
4j7x NAPSepiapterin reductase 1.1.1.153 0.747
2c59 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.746
3bhi NAPCarbonyl reductase [NADPH] 1 1.1.1.184 0.744
3rue NADUDP-N-acetylglucosamine 4-epimerase / 0.743
4fc7 NAPPeroxisomal 2,4-dienoyl-CoA reductase 1.3.1.34 0.741
4gll NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.739
1eq2 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.738
3ehe NADUDP-glucose 4-epimerase (GalE-1) / 0.737
1w8d NAP2,4-dienoyl-CoA reductase, mitochondrial 1.3.1.34 0.736
1wvg APRCDP-glucose 4,6-dehydratase 4.2.1.45 0.736
2c54 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.734
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.733
3ruf NADUDP-N-acetylglucosamine 4-epimerase / 0.731
4id9 NADPutative UDP-glucose 4-epimerase / 0.731
2q1w NADPutative nucleotide sugar epimerase/ dehydratase / 0.730
3iah NAPPutative oxoacyl-(Acyl carrier protein) reductase / 0.730
3p19 NDPPutative blue fluorescent protein / 0.727
3lu1 NADUDP-N-acetylglucosamine 4-epimerase / 0.726
4clo NAPPteridine reductase / 0.726
5idw NAPShort-chain dehydrogenase/reductase SDR / 0.726
3h4v NAPPteridine reductase 1 1.5.1.33 0.725
1bxk NADdTDP-glucose 4,6-dehydratase 2 / 0.724
2b69 NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.723
1u7t TDT3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.722
1wp4 NDP3-hydroxyisobutyrate dehydrogenase / 0.722
4nbu NAI3-oxoacyl-(Acyl-carrier-protein) reductase / 0.722
3wmx NADNAD dependent epimerase/dehydratase / 0.721
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.718
2vrb NAPTriphenylmethane reductase / 0.717
2yut NAPPutative short-chain oxidoreductase / 0.717
3o26 NDPSalutaridine reductase / 0.717
1w73 NAP2,4-dienoyl-CoA reductase, mitochondrial 1.3.1.34 0.713
4m55 NADUDP-glucuronic acid decarboxylase 1 4.1.1.35 0.712
3ru7 NADUDP-N-acetylglucosamine 4-epimerase / 0.711
4e5y NDPGDP-L-fucose synthase 1.1.1.271 0.711
2dte NAIGlucose 1-dehydrogenase related protein / 0.710
5jyd NADShort chain dehydrogenase / 0.710
2bfo NDPPteridine reductase 1 1.5.1.33 0.707
3a4v NADNDP-sugar epimerase / 0.707
3sj7 NDP3-oxoacyl-(Acyl-carrier-protein) reductase, putative / 0.707
4b8z NAPGDP-L-fucose synthase 1.1.1.271 0.705
1g6k NADGlucose 1-dehydrogenase 1.1.1.47 0.703
2wsb NADGalactitol dehydrogenase / 0.703
3a28 NADL-2,3-butanediol dehydrogenase 1.1.1.76 0.703
3rj9 NADAlcohol dehydrogenase 1.1.1.1 0.703
3ruc NADUDP-N-acetylglucosamine 4-epimerase / 0.703
2pzj NADPutative nucleotide sugar epimerase/ dehydratase / 0.702
3d3w NAPL-xylulose reductase 1.1.1.10 0.701
1sny NAPLD36273p / 0.700
3ko8 NADNAD-dependent epimerase/dehydratase / 0.700
1n5d NDPCarbonyl reductase [NADPH] 1 / 0.699
3wds NADNADH-dependent quinuclidinone reductase / 0.699
1orr NADCDP-paratose 2-epimerase / 0.698
1g1a NADdTDP-glucose 4,6-dehydratase / 0.697
2zat NAPDehydrogenase/reductase SDR family member 4 1.1.1.184 0.697
3rj5 NADAlcohol dehydrogenase 1.1.1.1 0.696
1gco NADGlucose 1-dehydrogenase 1.1.1.47 0.694
3zhb NAPPutative dehydrogenase / 0.694
2x86 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.693
1sby NADAlcohol dehydrogenase 1.1.1.1 0.691
2x6t NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.690
4b4o NDPEpimerase family protein SDR39U1 / 0.690
4egb NADdTDP-glucose 4,6-dehydratase / 0.690
1zem NADXylitol dehydrogenase / 0.689
1mg5 NAIAlcohol dehydrogenase 1.1.1.1 0.688
3aw9 NADNAD-dependent epimerase/dehydratase / 0.687
2jcx NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.686
4b8w NAPGDP-L-fucose synthase 1.1.1.271 0.686
4imp NDPPolyketide synthase extender modules 3-4 / 0.685
1fdu NAPEstradiol 17-beta-dehydrogenase 1 1.1.1.62 0.682
2cvz NDP3-hydroxyisobutyrate dehydrogenase / 0.680
3ak4 NADNADH-dependent quinuclidinone reductase / 0.680
2ekp NAD2-deoxy-D-gluconate 3-dehydrogenase / 0.679
4tqg NDPPutative dTDP-d-glucose 4 6-dehydratase / 0.679
3i6q NDPPutative leucoanthocyanidin reductase 1 / 0.678
1vl8 NAPOxidoreductase, short chain dehydrogenase/reductase family / 0.677
2d1y NADOxidoreductase, short-chain dehydrogenase/reductase family / 0.677
2hun NAD336aa long hypothetical dTDP-glucose 4,6-dehydratase / 0.677
3r3s NADPutative oxidoreductase / 0.677
1xg5 NAPDehydrogenase/reductase SDR family member 11 / 0.676
1gee NADGlucose 1-dehydrogenase 1.1.1.47 0.674
1hdo NAPFlavin reductase (NADPH) / 0.674
1rwb NADGlucose 1-dehydrogenase 1.1.1.47 0.674
4hwk NAPSepiapterin reductase 1.1.1.153 0.674
2c29 NAPDihydroflavonol 4-reductase / 0.673
2yy7 NADL-threonine dehydrogenase / 0.673
3e8x NAPBH1520 protein / 0.673
4ej0 NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.673
2ztm NADD(-)-3-hydroxybutyrate dehydrogenase / 0.672
4aic NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase / 0.672
1nvm NADAcetaldehyde dehydrogenase 1.2.1.10 0.671
4dc0 NDPPutative ketoacyl reductase 1.3.1 0.671
4lis NADUDP-glucose 4-epimerase (Eurofung) / 0.671
1b15 NAEAlcohol dehydrogenase 1.1.1.1 0.670
1n2s NAIdTDP-4-dehydrorhamnose reductase 1.1.1.133 0.670
2rbe NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.668
3nug NADPyridoxal 4-dehydrogenase 1.1.1.107 0.668
4dmm NAP3-oxoacyl-[acyl-carrier-protein] reductase / 0.668
2zcv NDPQuinone oxidoreductase 2 1.6.5.2 0.667
4oqy NDP(S)-imine reductase / 0.667
2ydx NAPMethionine adenosyltransferase 2 subunit beta / 0.666
3ing NDPHomoserine dehydrogenase related protein / 0.666
3tox NAPPutative oxidoreductase / 0.666
2p5u NADUDP-glucose 4-epimerase / 0.665
2bd0 NAPSepiapterin reductase / 0.664
3u4c NDPNADPH-dependent reductase BacG / 0.664
3ijr NADOxidoreductase, short chain dehydrogenase/reductase family / 0.662
3rku NAPNADP-dependent 3-hydroxy acid dehydrogenase / 0.662
4fj2 NAP17beta-hydroxysteroid dehydrogenase / 0.662
3aut NAIGlucose 1-dehydrogenase 4 1.1.1.47 0.661
1kc1 NDPdTDP-4-dehydrorhamnose reductase 1.1.1.133 0.660
4j7u NAPSepiapterin reductase 1.1.1.153 0.660
5lc1 NADL-threonine 3-dehydrogenase / 0.660
3bmo NAPPteridine reductase / 0.659
2iyp A2P6-phosphogluconate dehydrogenase, decarboxylating 1.1.1.44 0.658
3pvz NADUDP-N-acetylglucosamine 4,6-dehydratase / 0.658
4bkq NAIEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.658
1ybm NAPUncharacterized protein At5g02240 / 0.657
3ndr NADPyridoxal 4-dehydrogenase 1.1.1.107 0.657
4b79 NADProbable short-chain dehydrogenase / 0.657
4pvd NDPNADPH-dependent methylglyoxal reductase GRE2 / 0.657
3tn7 NJPShort-chain alcohol dehydrogenase / 0.656
4i5e NAPAlclohol dehydrogenase/short-chain dehydrogenase / 0.656
4wec NADShort chain dehydrogenase / 0.656
1b14 NADAlcohol dehydrogenase 1.1.1.1 0.655
2ztv NADD(-)-3-hydroxybutyrate dehydrogenase / 0.655
1b16 NAQAlcohol dehydrogenase 1.1.1.1 0.654
4hbg NDP3-oxoacyl-[acyl-carrier-protein] reductase 1.1.1.100 0.654
1nah NADUDP-glucose 4-epimerase 5.1.3.2 0.653
4bms NAPAlclohol dehydrogenase/short-chain dehydrogenase / 0.653
1bdb NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase / 0.652
4yai NAIC alpha-dehydrogenase / 0.652
1p44 NADEnoyl-[acyl-carrier-protein] reductase [NADH] 1.3.1.9 0.651
3a9w NADNDP-sugar epimerase / 0.651
3qrw NDPPutative ketoacyl reductase 1.3.1 0.651
3uxy NADShort-chain dehydrogenase/reductase SDR / 0.651
4fj0 NAP17beta-hydroxysteroid dehydrogenase / 0.651
5aq1 NDPGlucose-6-phosphate 1-dehydrogenase / 0.651
1nff NAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase 1.1.1.53 0.650
2o23 NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.650
3f1k NAPUncharacterized oxidoreductase YciK 1 0.650
4qec NAPElxO / 0.650
4z0p NDPNAD-dependent dehydrogenase / 0.650
5ig2 NADShort-chain dehydrogenase/reductase SDR / 0.650