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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1jkk ANP Death-associated protein kinase 1 2.7.11.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 1.024
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.938
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.917
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.902
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.892
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.869
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.867
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.860
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.810
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.806
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.804
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.803
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.799
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.794
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.793
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.791
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.791
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.789
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.783
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.782
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.781
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.781
3dfc ANPDeath-associated protein kinase 1 2.7.11.1 0.780
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.780
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.780
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.779
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.779
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.779
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.779
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.776
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.776
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.775
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.775
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.774
5dr2 ATPAurora kinase A 2.7.11.1 0.774
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.771
5dt3 ATPAurora kinase A 2.7.11.1 0.771
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.770
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.770
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.770
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.769
4qny ANPMitogen activated protein kinase, putative / 0.767
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.767
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.762
4xlv ACPInsulin receptor 2.7.10.1 0.762
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.761
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.759
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.758
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.756
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.755
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.754
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.753
4dee ADPAurora kinase A 2.7.11.1 0.753
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.753
1zar ADPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.752
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.751
3c4z ADPRhodopsin kinase / 0.750
4bn1 ADPAurora kinase A 2.7.11.1 0.748
5drd ATPAurora kinase A 2.7.11.1 0.746
5dos ATPAurora kinase A 2.7.11.1 0.744
4ysj ADPCalmodulin-like domain protein kinase / 0.743
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.742
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.742
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.742
1j7l ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.741
1mq4 ADPAurora kinase A 2.7.11.1 0.741
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.741
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.736
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.736
3gu8 3GUDeath-associated protein kinase 1 2.7.11.1 0.735
4ceg ADPAurora kinase A 2.7.11.1 0.734
3t8o ATPRhodopsin kinase / 0.733
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.733
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.731
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.731
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.731
2olc ADPMethylthioribose kinase 2.7.1.100 0.730
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.729
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.729
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.729
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.729
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.729
3qc9 ADPRhodopsin kinase / 0.728
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.727
5dn3 ATPAurora kinase A 2.7.11.1 0.727
4utd ACPAurora kinase A 2.7.11.1 0.726
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.724
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.723
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.723
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.721
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.720
4nif ANPMitogen-activated protein kinase 1 2.7.11.24 0.718
5dt4 ATPAurora kinase A 2.7.11.1 0.718
5iqh GNPBifunctional AAC/APH 2.3.1 0.717
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.716
3c50 ADPRhodopsin kinase / 0.716
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.716
2yaa ATPDeath-associated protein kinase 2 / 0.715
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.715
1ol5 ADPAurora kinase A 2.7.11.1 0.713
3c4w ATPRhodopsin kinase / 0.713
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.713
4pds ANPSerine/threonine-protein kinase RAD53 2.7.12.1 0.713
5iqf GDPBifunctional AAC/APH 2.3.1 0.713
3cly ACPFibroblast growth factor receptor 2 / 0.712
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.710
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.710
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.710
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.709
4o4e ATPKinase / 0.709
3q1k ADPD-alanine--D-alanine ligase A 6.3.2.4 0.708
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.708
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.708
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.708
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.706
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.706
5eg3 ACPFibroblast growth factor receptor 2 / 0.706
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.704
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.704
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.704
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.703
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.703
1tqp ATPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.702
3oro AGSSerine/threonine protein kinase / 0.702
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.702
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.701
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.701
3bu5 ATPInsulin receptor 2.7.10.1 0.701
5iqa GNPBifunctional AAC/APH 2.3.1 0.701
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.700
1m0w ANPGlutathione synthetase 6.3.2.3 0.699
3rv4 ADPBiotin carboxylase 6.3.4.14 0.699
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.699
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.699
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.699
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.697
4y0x ADPSerine/threonine-protein kinase PknG 2.7.11.1 0.697
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.696
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.696
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.696
5byl GCPBifunctional AAC/APH 2.3.1 0.696
5dnr ATPAurora kinase A 2.7.11.1 0.696
5iqb GNPBifunctional AAC/APH 2.3.1 0.696
2py3 ACPFibroblast growth factor receptor 2 / 0.695
3orm AGSSerine/threonine protein kinase / 0.695
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.695
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.694
3wnz ADPAlanine--anticapsin ligase / 0.694
4ic7 ANPMitogen-activated protein kinase 7 2.7.11.24 0.693
1ol6 ATPAurora kinase A 2.7.11.1 0.692
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.692
5ce3 ADPProtein kinase YopO / 0.692
3hko ANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands / 0.691
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.691
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.691
3eth ATPN5-carboxyaminoimidazole ribonucleotide synthase / 0.690
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.690
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.690
4y12 AGSSerine/threonine-protein kinase PknG 2.7.11.1 0.690
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.689
3q5i ANPProtein kinase, putative / 0.689
1z2n ADPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.687
2dwb ANPAurora kinase A 2.7.11.1 0.687
4k33 ACPFibroblast growth factor receptor 3 2.7.10.1 0.687
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.687
4o4f ATPKinase / 0.687
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.686
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.685
4zgn ATPCell division cycle protein 123 / 0.685
5iqe GNPBifunctional AAC/APH 2.3.1 0.685
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.684
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.684
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.683
5iqg GDPBifunctional AAC/APH 2.3.1 0.683
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.682
1ol7 ADPAurora kinase A 2.7.11.1 0.681
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.681
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.680
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.679
2pup ADPMethylthioribose kinase 2.7.1.100 0.679
4ork GDPBifunctional AAC/APH 2.3.1 0.679
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.678
4axf ANPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.678
5iqi GNPBifunctional AAC/APH 2.3.1 0.678
2cci ATPCyclin-dependent kinase 2 2.7.11.22 0.677
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.676
2pun ACPMethylthioribose kinase 2.7.1.100 0.676
4ffr ATPUncharacterized protein / 0.676
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.675
3tdw GDPGentamicin resistance protein / 0.675
3wo1 ADPAlanine--anticapsin ligase / 0.675
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.673
2bkk ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.673
2pui ADPMethylthioribose kinase 2.7.1.100 0.673
4cki ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.673
4ffl ADPUncharacterized protein / 0.673
3a7j ADPSerine/threonine-protein kinase 24 2.7.11.1 0.672
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.672
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.672
4uxx ACPDiacylglycerol kinase 2.7.1.107 0.672
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.671
3c4x ATPRhodopsin kinase / 0.671
4ckj ADNProto-oncogene tyrosine-protein kinase receptor Ret 2.7.10.1 0.671
2pz5 ACPFibroblast growth factor receptor 2 / 0.670
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.670
3wo0 ADPAlanine--anticapsin ligase / 0.670
2itv ANPEpidermal growth factor receptor 2.7.10.1 0.669
1px2 ATPSynapsin-1 / 0.668
4c3r ACPAurora kinase A 2.7.11.1 0.668
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.667
5iqd GNPBifunctional AAC/APH 2.3.1 0.667
3tpt ADPSerine/threonine-protein kinase toxin HipA / 0.666
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.666
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.666
1u54 ACPActivated CDC42 kinase 1 / 0.665
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.665
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.663
1j7u ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.662
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.662
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.662
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.661
2pyw ADPMethylthioribose kinase 2.7.1.100 0.661
4gyi ADPUncharacterized protein / 0.661
2io7 ANPBifunctional glutathionylspermidine synthetase/amidase / 0.660
1ir3 ANPInsulin receptor 2.7.10.1 0.659
2pzp ACPFibroblast growth factor receptor 2 / 0.659
3zo1 SIJcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.659
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.658
2pul ACPMethylthioribose kinase 2.7.1.100 0.658
2vqd AP2Biotin carboxylase 6.3.4.14 0.658
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.658
3a7h ATPSerine/threonine-protein kinase 24 2.7.11.1 0.658
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.658
3hrc ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.657
4o1p ANPRibonuclease L / 0.657
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.656
3nie ANPMitogen-activated protein kinase / 0.655
2itn ANPEpidermal growth factor receptor 2.7.10.1 0.654
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.653
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.653
2biy ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.652
3orp AGSSerine/threonine protein kinase / 0.652
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.652
4mv3 ACPBiotin carboxylase 6.3.4.14 0.652
4mv8 ACPBiotin carboxylase 6.3.4.14 0.652
3akl ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.651
2xs0 ANPMitogen-activated protein kinase 8 2.7.11.24 0.650
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.650
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.650
4fl2 ANPTyrosine-protein kinase SYK 2.7.10.2 0.650