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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1het NAD Alcohol dehydrogenase E chain 1.1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1het NADAlcohol dehydrogenase E chain 1.1.1.1 1.308
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 1.254
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 1.254
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.254
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 1.253
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 1.252
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 1.245
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 1.237
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 1.237
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 1.237
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 1.237
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.237
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.236
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 1.234
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 1.229
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.221
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 1.220
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 1.219
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 1.203
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 1.195
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.190
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 1.189
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 1.184
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.169
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 1.151
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 1.150
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 1.146
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 1.144
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 1.139
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 1.119
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 1.085
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.947
3wle NAD(R)-specific carbonyl reductase / 0.896
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.895
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.892
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.889
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.887
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.882
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.878
3two NDPMannitol dehydrogenase / 0.877
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.867
4oaq NDPR-specific carbonyl reductase / 0.855
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.850
1yqd NAPSinapyl alcohol dehydrogenase / 0.844
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.840
3jv7 NADSecondary alcohol dehydrogenase / 0.838
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.830
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.825
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.824
4cpd NADAlcohol dehydrogenase / 0.813
1u7h NADPutative ornithine cyclodeaminase / 0.807
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.807
1x7d NADPutative ornithine cyclodeaminase / 0.805
4l0q NADAlcohol dehydrogenase class-3 / 0.805
4jji NADAlcohol dehydrogenase class-3 / 0.804
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.797
4c4o NADSADH / 0.792
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.790
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.785
1uxk NADMalate dehydrogenase / 0.783
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.780
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.778
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.778
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.774
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.761
4rqu NADAlcohol dehydrogenase class-P / 0.759
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.754
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.753
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.751
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.751
1uxj NADMalate dehydrogenase / 0.738
4gl4 NAIAlcohol dehydrogenase class-3 / 0.735
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.734
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.733
3uko NADAlcohol dehydrogenase class-3 / 0.733
1yqx NAPSinapyl alcohol dehydrogenase / 0.732
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.731
4ejm NAPPutative zinc-binding dehydrogenase / 0.730
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.729
2x0i NAIMalate dehydrogenase / 0.725
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.725
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.722
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.722
2vhx NADAlanine dehydrogenase 1.4.1.1 0.719
5a1t NAIL-lactate dehydrogenase / 0.715
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.706
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.703
2xaa NADSecondary alcohol dehydrogenase / 0.703
4b7x NAPProbable oxidoreductase / 0.703
1f8f NADBenzyl alcohol dehydrogenase / 0.702
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.702
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.700
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.699
1gv0 NADMalate dehydrogenase / 0.697
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.696
4xqc NADHomospermidine synthase 2.5.1.44 0.694
1lsj NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.693
2a92 NAIL-lactate dehydrogenase / 0.693
4xrg NADHomospermidine synthase 2.5.1.44 0.692
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.691
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.690
4i1i NADMalate dehydrogenase / 0.684
2voj NADAlanine dehydrogenase 1.4.1.1 0.683
3f3s NADLambda-crystallin homolog / 0.681
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.681
1pzh NADLactate dehydrogenase / 0.680
2o4c NADErythronate-4-phosphate dehydrogenase / 0.680
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.679
1e3e NAIAlcohol dehydrogenase 4 1.1.1.1 0.677
1o6z NADMalate dehydrogenase / 0.677
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.677
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.676
1b8v NADMalate dehydrogenase / 0.674
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.674
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.672
2rbe NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.672
3q2k NAIProbable oxidoreductase / 0.672
1wze NADMalate dehydrogenase / 0.671
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.671
2dfv NADL-threonine 3-dehydrogenase / 0.670
2hu2 NADC-terminal binding protein 1 / 0.670
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.670
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.669
2q1s NAIPutative nucleotide sugar epimerase/ dehydratase / 0.669
3sju NDPKeto reductase / 0.668
1guy NADMalate dehydrogenase / 0.667
2cda NAPGlucose 1-dehydrogenase / 0.667
2dph NADFormaldehyde dismutase / 0.667
3wsw NADL-lactate dehydrogenase / 0.667
4plp NADHomospermidine synthase 2.5.1.44 0.667
1sow NADL-lactate dehydrogenase 1.1.1.27 0.666
2p9c NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.664
4xq9 NADHomospermidine synthase 2.5.1.44 0.664
3x2f NAIAdenosylhomocysteinase / 0.663
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.662
4j4b NAIUncharacterized protein / 0.662
4tvb NADHomospermidine synthase 2.5.1.44 0.662
1i3l NADUDP-glucose 4-epimerase / 0.661
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.661
1pjc NADAlanine dehydrogenase / 0.661
2g5c NADPrephenate dehydrogenase / 0.661
2vwh NAPGlucose 1-dehydrogenase / 0.661
1dlj UGAUDP-glucose 6-dehydrogenase / 0.660
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.660
1ib6 NADMalate dehydrogenase / 0.659
1ur5 NADMalate dehydrogenase / 0.659
1obb NADAlpha-glucosidase 3.2.1.20 0.658
4uun NAIL-lactate dehydrogenase / 0.658
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.657
2x6t NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.657
3h3f NAIL-lactate dehydrogenase A chain 1.1.1.27 0.657
1ie3 NADMalate dehydrogenase / 0.656
1nah NADUDP-glucose 4-epimerase 5.1.3.2 0.656
2aa3 AP0L-lactate dehydrogenase / 0.656
3kbo NDPGlyoxylate/hydroxypyruvate reductase A / 0.654
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.654
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.654
1bsv NDPGDP-L-fucose synthase / 0.653
1b8u NADMalate dehydrogenase / 0.652
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.652
2b5v NAPGlucose 1-dehydrogenase / 0.651
3kb6 NADD-lactate dehydrogenase / 0.651
1j0x NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.650
1pzf A3DLactate dehydrogenase / 0.650
4j49 NADUncharacterized protein / 0.650
4j49 NAIUncharacterized protein / 0.650
5dt9 NADErythronate-4-phosphate dehydrogenase / 0.650