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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1axe NAD Alcohol dehydrogenase E chain 1.1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 1.377
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 1.301
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 1.277
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 1.261
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 1.256
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 1.243
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.243
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 1.243
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.243
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 1.243
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 1.243
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.242
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.242
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 1.242
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 1.242
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 1.242
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.242
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 1.240
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 1.222
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 1.209
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 1.207
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 1.186
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 1.183
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 1.171
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.170
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 1.169
1het NADAlcohol dehydrogenase E chain 1.1.1.1 1.144
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 1.140
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 1.135
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 1.128
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 1.112
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 1.032
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 1.000
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.987
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.986
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.926
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.926
3wle NAD(R)-specific carbonyl reductase / 0.926
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.925
3jv7 NADSecondary alcohol dehydrogenase / 0.916
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.913
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.902
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.890
4c4o NADSADH / 0.888
1yqd NAPSinapyl alcohol dehydrogenase / 0.873
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.868
4rqu NADAlcohol dehydrogenase class-P / 0.864
3two NDPMannitol dehydrogenase / 0.863
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.852
4oaq NDPR-specific carbonyl reductase / 0.840
1uxj NADMalate dehydrogenase / 0.836
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.835
1gv0 NADMalate dehydrogenase / 0.831
1yqx NAPSinapyl alcohol dehydrogenase / 0.826
1uxk NADMalate dehydrogenase / 0.825
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.817
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.817
4cpd NADAlcohol dehydrogenase / 0.816
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.812
1u7h NADPutative ornithine cyclodeaminase / 0.800
1x7d NADPutative ornithine cyclodeaminase / 0.798
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.786
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.783
4l0q NADAlcohol dehydrogenase class-3 / 0.779
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.775
4jji NADAlcohol dehydrogenase class-3 / 0.775
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.775
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.773
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.771
1o6z NADMalate dehydrogenase / 0.770
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.760
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.759
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.757
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.756
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.752
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.752
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.749
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.744
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.743
1pzh NADLactate dehydrogenase / 0.741
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.740
4rvu NDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) / 0.738
2vhx NADAlanine dehydrogenase 1.4.1.1 0.737
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.737
2x0i NAIMalate dehydrogenase / 0.737
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.734
1sow NADL-lactate dehydrogenase 1.1.1.27 0.727
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.727
4i1i NADMalate dehydrogenase / 0.727
4ejm NAPPutative zinc-binding dehydrogenase / 0.726
1f8f NADBenzyl alcohol dehydrogenase / 0.725
5a02 NAPGlucose-fructose oxidoreductase / 0.724
1qor NDPQuinone oxidoreductase 1 / 0.723
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.722
2y05 NAPProstaglandin reductase 1 / 0.720
2vwh NAPGlucose 1-dehydrogenase / 0.719
1pjc NADAlanine dehydrogenase / 0.718
2dph NADFormaldehyde dismutase / 0.718
3wfj NAD2-dehydropantoate 2-reductase / 0.718
4jk3 NADUncharacterized protein / 0.718
1ur5 NADMalate dehydrogenase / 0.717
3uko NADAlcohol dehydrogenase class-3 / 0.717
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.717
4b7x NAPProbable oxidoreductase / 0.716
2o4c NADErythronate-4-phosphate dehydrogenase / 0.714
3ggo NAIPrephenate dehydrogenase / 0.711
1guy NADMalate dehydrogenase / 0.710
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.709
3ggp NADPrephenate dehydrogenase / 0.708
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.706
2cdc NAPGlucose 1-dehydrogenase / 0.706
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.704
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.704
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.704
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.703
1wze NADMalate dehydrogenase / 0.703
3f3s NADLambda-crystallin homolog / 0.703
1kev NDPNADP-dependent isopropanol dehydrogenase 1.1.1.80 0.702
1c1d NAIPhenylalanine dehydrogenase / 0.701
2g5c NADPrephenate dehydrogenase / 0.701
4plp NADHomospermidine synthase 2.5.1.44 0.701
4xqc NADHomospermidine synthase 2.5.1.44 0.701
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.700
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.699
5ees NAP4-hydroxy-tetrahydrodipicolinate reductase / 0.699
1up7 NAD6-phospho-beta-glucosidase BglT 3.2.1.86 0.698
1pzg A3DLactate dehydrogenase / 0.697
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.694
1yba NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.693
3tqh NDPQuinone oxidoreductase / 0.692
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.692
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.690
3ikt NADRedox-sensing transcriptional repressor Rex / 0.689
3wid NAPGlucose 1-dehydrogenase / 0.687
1lso NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.686
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.686
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.686
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.685
3x2f NAIAdenosylhomocysteinase / 0.685
4j49 NADUncharacterized protein / 0.685
1ie3 NADMalate dehydrogenase / 0.684
1llu NADAlcohol dehydrogenase / 0.684
5a04 NDPGlucose-fructose oxidoreductase / 0.684
2vwq NAPGlucose 1-dehydrogenase / 0.682
1ryd NDPGlucose--fructose oxidoreductase 1.1.99.28 0.681
5a1t NAIL-lactate dehydrogenase / 0.681
2xaa NADSecondary alcohol dehydrogenase / 0.680
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.679
4j43 NADUncharacterized protein / 0.679
2b5v NAPGlucose 1-dehydrogenase / 0.678
1i36 NAPConserved protein / 0.677
4j4b NAIUncharacterized protein / 0.677
2yvg NADFerredoxin reductase / 0.676
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.675
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.674
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.674
1b8v NADMalate dehydrogenase / 0.673
2fkn NADUrocanate hydratase 4.2.1.49 0.672
4gl4 NAIAlcohol dehydrogenase class-3 / 0.672
2x0r NADMalate dehydrogenase / 0.671
1pzf A3DLactate dehydrogenase / 0.670
1ib6 NADMalate dehydrogenase / 0.669
2v7g NADUrocanate hydratase 4.2.1.49 0.669
1bmd NADMalate dehydrogenase / 0.668
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.668
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.667
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.667
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.666
4nu5 NADPhosphonate dehydrogenase 1.20.1.1 0.666
1lsj NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.665
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.665
4xrg NADHomospermidine synthase 2.5.1.44 0.665
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.664
3kb6 NADD-lactate dehydrogenase / 0.664
5ijz NAPNADP-specific glutamate dehydrogenase 1.4.1.4 0.664
2dbz NAPGlyoxylate reductase 1.1.1.26 0.661
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.661
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.661
4a1o AMZBifunctional purine biosynthesis protein PurH 2.1.2.3 0.661
3adp NAILambda-crystallin 1.1.1.45 0.659
1wzi NDPMalate dehydrogenase / 0.658
2aa3 AP0L-lactate dehydrogenase / 0.658
2ixb NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.658
3qv1 NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic 1.2.1.13 0.658
4tvb NADHomospermidine synthase 2.5.1.44 0.658
4xr9 NADCalS8 / 0.658
5a03 NDPGlucose-fructose oxidoreductase / 0.658
1la2 NADInositol-3-phosphate synthase 5.5.1.4 0.657
3hwr NDP2-dehydropantoate 2-reductase / 0.657
3ntq NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.655
1u8f NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.654
2ph5 NADHomospermidine synthase / 0.654
3h3f NAIL-lactate dehydrogenase A chain 1.1.1.27 0.654
2hdh NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.653
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.653
3baz NAPHydroxyphenylpyruvate reductase 1.1.1.237 0.653
4j49 NAIUncharacterized protein / 0.652
1evj NADGlucose--fructose oxidoreductase 1.1.99.28 0.651
2rir NAPDipicolinate synthase subunit A / 0.651
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.650
1qlh NADAlcohol dehydrogenase E chain 1.1.1.1 0.650
2j3i NAPNADPH-dependent oxidoreductase 2-alkenal reductase 1.3.1.74 0.650