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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4wb6ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.11

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4wb6ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.111.000
4dh5ADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.618
4iakADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.603
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.601
4iafADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.589
4iacACPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.588
1q24ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.580
4dg3ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.574
3x2wATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.573
4xw4ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.567
4iaiADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.561
4dh3ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.557
3o7lANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.552
1jbpADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.548
4wbbADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.546
4ekkANPRAC-alpha serine/threonine-protein kinase2.7.11.10.544
4iazADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.533
4iadADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.532
3x2uATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.529
4hptANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.520
3fhiANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.518
2qcsANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.517
3fjqATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.515
1bx6BA1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.513
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.513
1cdkANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.512
3idbANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.512
4dh7ANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.511
3mvjXFEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.510
5iqiGNPBifunctional AAC/APH2.3.10.509
3x2vATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.506
4xw6ADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.503
1ydrIQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.502
2vo6M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.498
3ow3SMYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.498
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.497
4yxsEMUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.497
2gnhH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.496
2uw5GVNcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.496
4xw5ATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.494
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.493
4ysjADPCalmodulin-like domain protein kinase/0.492
1jkkANPDeath-associated protein kinase 12.7.11.10.489
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.489
4crsAGSSerine/threonine-protein kinase N22.7.11.130.489
2qoqANPEphrin type-A receptor 32.7.10.10.488
3cqwCQWRAC-alpha serine/threonine-protein kinase2.7.11.10.488
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.487
3aglA03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.487
4ib3ADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.487
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.486
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.486
4s33ANPMitogen-activated protein kinase 12.7.11.240.486
1o6kANPRAC-beta serine/threonine-protein kinase2.7.11.10.485
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.484
4eooATPCyclin-dependent kinase 22.7.11.220.484
4i3zADPCyclin-dependent kinase 22.7.11.220.484
3dneLL1cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.483
5iqeGNPBifunctional AAC/APH2.3.10.483
1ydtIQBcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.482
2c1bCQPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.482
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.482
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.479
4axaRKDcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.479
4x6rATPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.479
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
3idcANPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
2f7z6EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.477
1dayGNPCasein kinase II subunit alpha2.7.11.10.476
1q8tY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.476
4jia1K3Tyrosine-protein kinase JAK2/0.476
4qnyANPMitogen activated protein kinase, putative/0.476
2uw7GVPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.475
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.475
3c4wATPRhodopsin kinase/0.475
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.474
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.473
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.473
3ncz3NCRho-associated protein kinase 12.7.11.10.473
5iqbGNPBifunctional AAC/APH2.3.10.473
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.472
2henADPEphrin type-B receptor 22.7.10.10.472
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
3lltANPProtein serine/threonine kinase-1/0.471
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.471
4orkGDPBifunctional AAC/APH2.3.10.471
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.470
4jboWPHAurora kinase A2.7.11.10.470
2c6eHPMAurora kinase A2.7.11.10.469
2gnfY27cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.469
1qmzATPCyclin-dependent kinase 22.7.11.220.468
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.468
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.468
3i587NA2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase/0.468
3qc9ADPRhodopsin kinase/0.468
5av2KMPDeath-associated protein kinase 12.7.11.10.468
2w4jADPDeath-associated protein kinase 12.7.11.10.467
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.467
2yg4FADPutrescine oxidase/0.466
4deeADPAurora kinase A2.7.11.10.466
3c4zADPRhodopsin kinase/0.465
3e8cG96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.465
2f7x4EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.464
2j0lANPFocal adhesion kinase 12.7.10.20.464
3c4xATPRhodopsin kinase/0.464
3lijANPCalcium/calmodulin dependent protein kinase with a kinase domain and 4 calmodulin like EF hands/0.464
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.464
2cciATPCyclin-dependent kinase 22.7.11.220.463
5dosATPAurora kinase A2.7.11.10.463
3dndLL2cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.462
4bbe3O4Tyrosine-protein kinase JAK2/0.461
4e6q0NVTyrosine-protein kinase JAK2/0.461
4fuyEK2Mitogen-activated protein kinase 12.7.11.240.461
5bylGCPBifunctional AAC/APH2.3.10.461
1pk8ATPSynapsin-1/0.460
2qo6CHDFatty acid-binding protein 10-A, liver basic/0.460
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.460
3bqr4RBDeath-associated protein kinase 3/0.460
4hge15VTyrosine-protein kinase JAK2/0.460
4k8aK8AFocal adhesion kinase 12.7.10.20.460
3js2VM1Fibroblast growth factor receptor 1/0.458
4bqg50QHeat shock protein HSP 90-alpha/0.458
5eg3ACPFibroblast growth factor receptor 2/0.458
2gnlH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
2j7t274Serine/threonine-protein kinase 102.7.11.10.457
4lrjANPUncharacterized protein/0.457
1cm8ANPMitogen-activated protein kinase 12/0.456
3gu7ADPDeath-associated protein kinase 12.7.11.10.456
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.456
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.456
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.456
4z34ON7Lysophosphatidic acid receptor 1/0.456
1ig1ANPDeath-associated protein kinase 12.7.11.10.455
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.455
4s32ANPMitogen-activated protein kinase 12.7.11.240.455
5c03AGSNon-receptor tyrosine-protein kinase TYK22.7.10.20.455
2uzbC75Cyclin-dependent kinase 22.7.11.220.454
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.454
3efwAK8Aurora kinase A2.7.11.10.454
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
4o0wADNAurora kinase A2.7.11.10.454
2c1aI5ScAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
2cjmATPCyclin-dependent kinase 22.7.11.220.453
2ojj82AMitogen-activated protein kinase 12.7.11.240.453
3bwjARXcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.453
1v59FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.452
2g0nGDPRas-related C3 botulinum toxin substrate 3/0.452
2ijmATPFocal adhesion kinase 12.7.10.20.452
2o2qNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.452
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.452
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.452
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.452
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.451
3my5RFZCyclin-dependent kinase 22.7.11.220.451
3orpAGSSerine/threonine protein kinase/0.451
3u2xASOGlycogenin-12.4.1.1860.451
4ek816KCyclin-dependent kinase 22.7.11.220.451
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.451
4jqlVJ6Heat shock protein HSP 90-alpha/0.451
4xlvACPInsulin receptor2.7.10.10.451
2qocANPEphrin type-A receptor 32.7.10.10.450
4l9i8PRRhodopsin kinase/0.450
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.450
4zbrNPSSerum albumin/0.450
5av3KMPDeath-associated protein kinase 12.7.11.10.450
2etrY27Rho-associated protein kinase 12.7.11.10.449
2qo7ANPEphrin type-A receptor 32.7.10.10.449
2yg7FADPutrescine oxidase/0.449
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
4bcmT7ZCyclin-dependent kinase 22.7.11.220.449
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.449
3a8wATPProtein kinase C iota type2.7.11.130.448
3ztxZTXAurora kinase B-A2.7.11.10.448
1hk2T44Serum albumin/0.447
2vvlFADMonoamine oxidase N1.4.3.40.447
3r8uZ31Cyclin-dependent kinase 22.7.11.220.447
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.447
4h3qANPMitogen-activated protein kinase 12.7.11.240.447
4ic7ANPMitogen-activated protein kinase 72.7.11.240.447
1dawANPCasein kinase II subunit alpha2.7.11.10.446
3d2rADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial2.7.11.20.446
3rhaFDAPutrescine oxidase/0.446
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.446
4hdqGNPRas-related protein Rap-1b/0.446
4o0uADNAurora kinase A2.7.11.10.446
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.445
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.445
1yvj4STTyrosine-protein kinase JAK32.7.10.20.445
3hkoANPCalcium/calmodulin-dependent protein kinase with a kinase domain and 2 calmodulin-like EF hands/0.445
4xg1LLPDiaminopimelate decarboxylase/0.445
1u5rATPSerine/threonine-protein kinase TAO22.7.11.10.444
1vebI05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
2bmbPMMFolic acid synthesis protein FOL1/0.444
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.444
4i58FADCyclohexylamine Oxidase/0.444
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.444
4zohFADPutative oxidoreductase FAD-binding subunit/0.444
1equEQIEstradiol 17-beta-dehydrogenase 11.1.1.620.443
2bx8AZQSerum albumin/0.443
4f4p0SBTyrosine-protein kinase SYK2.7.10.20.443
4iui1GQEstrogen receptor/0.443
1tvoFRZMitogen-activated protein kinase 12.7.11.240.442
4b8uIBK3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase4.2.1.590.442
4bwxAGSPAB-dependent poly(A)-specific ribonuclease subunit pan3/0.442
5cvfATPCasein kinase II subunit alpha2.7.11.10.442
5iqhGNPBifunctional AAC/APH2.3.10.442
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.441
2ojf4PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2pd7FADVivid PAS protein VVD/0.441
2pdtFADVivid PAS protein VVD/0.441
3lj3WYEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
5br7FADUDP-galactopyranose mutase/0.441
1nbmADPATP synthase subunit beta, mitochondrial3.6.3.140.440
1t90NADMalonate-semialdehyde dehydrogenase1.2.1.270.440
1uy9PU6Heat shock protein HSP 90-alpha/0.440
2j0m4STFocal adhesion kinase 12.7.10.20.440
3lpbNVBTyrosine-protein kinase JAK2/0.440
3rpr25ZCyclin-dependent kinase 22.7.11.220.440
3sa0NRAMitogen-activated protein kinase 12.7.11.240.440
4z35ON9Lysophosphatidic acid receptor 1/0.440