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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4nfn2KCTau-tubulin kinase 12.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4nfn2KCTau-tubulin kinase 12.7.11.11.000
1eh4IC1Casein kinase I homolog 12.7.11.10.516
2excJNKMitogen-activated protein kinase 102.7.11.240.507
3s4qNK0Mitogen-activated protein kinase 14/0.506
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.503
4btkDTQTau-tubulin kinase 12.7.11.10.502
4loqSB4Mitogen-activated protein kinase 14/0.496
4i22IREEpidermal growth factor receptor2.7.10.10.494
3nww3NWMitogen-activated protein kinase 14/0.491
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.488
4g95OAGDihydrofolate reductase1.5.1.30.487
1ouk084Mitogen-activated protein kinase 14/0.484
3hllI45Mitogen-activated protein kinase 14/0.483
4yuqKS1Calmodulin-like domain protein kinase/0.483
4zseANPEpidermal growth factor receptor2.7.10.10.483
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.480
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.480
4jq8KJ8Epidermal growth factor receptor2.7.10.10.479
4nka2K7Fibroblast growth factor receptor 1/0.479
1gih1PUCyclin-dependent kinase 22.7.11.220.478
1zyjBI5Mitogen-activated protein kinase 14/0.478
2balPQAMitogen-activated protein kinase 14/0.478
2o0uC0MMitogen-activated protein kinase 102.7.11.240.478
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.478
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.478
3eigMTXDihydrofolate reductase1.5.1.30.477
4nk92K5Fibroblast growth factor receptor 1/0.476
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.474
4hyu1BKMitogen-activated protein kinase 82.7.11.240.474
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.474
5e8xSTUTGF-beta receptor type-12.7.11.300.474
2h96893Mitogen-activated protein kinase 82.7.11.240.473
1disBDMDihydrofolate reductase1.5.1.30.472
1yw2PGJMitogen-activated protein kinase 14/0.472
3hl7I47Mitogen-activated protein kinase 14/0.472
4cd2FOLDihydrofolate reductase1.5.1.30.472
1ai9NDPDihydrofolate reductase1.5.1.30.471
1dr2TAPDihydrofolate reductase1.5.1.30.471
3ezrEZRCyclin-dependent kinase 22.7.11.220.470
3fln3FNMitogen-activated protein kinase 14/0.470
1v1k3FPCyclin-dependent kinase 22.7.11.220.469
3oafOAGDihydrofolate reductase1.5.1.30.469
3ttiKBIMitogen-activated protein kinase 102.7.11.240.469
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.469
2btrU73Cyclin-dependent kinase 22.7.11.220.468
3d84NDPDihydrofolate reductase1.5.1.30.468
3fklFKLMitogen-activated protein kinase 14/0.468
3ncgBK1Calmodulin-domain protein kinase 1, putative/0.468
2c475IDCasein kinase I isoform gamma-2/0.467
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.467
4qmnDB8Serine/threonine-protein kinase 242.7.11.10.467
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.466
4nks2M2Fibroblast growth factor receptor 1/0.466
1dr3HBIDihydrofolate reductase1.5.1.30.465
4f640S8Fibroblast growth factor receptor 1/0.465
4hnf16WCasein kinase I isoform delta2.7.11.10.465
1pxmCK5Cyclin-dependent kinase 22.7.11.220.464
2q0bACPFibroblast growth factor receptor 2/0.464
3pgqGY3Acetyl-CoA carboxylase/0.464
4riyADPEpidermal growth factor receptor2.7.10.10.464
2ivvPP1Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.463
2py3ACPFibroblast growth factor receptor 2/0.463
2xp2VGHALK tyrosine kinase receptor2.7.10.10.463
3gubGUBDeath-associated protein kinase 12.7.11.10.463
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.463
3mpaSB2Mitogen-activated protein kinase 14/0.463
3qlrNDPDihydrofolate reductase1.5.1.30.463
3qlsNDPDihydrofolate reductase1.5.1.30.463
4eh60ONMitogen-activated protein kinase 14/0.463
4j97ACPFibroblast growth factor receptor 2/0.463
2itzIREEpidermal growth factor receptor2.7.10.10.462
3ddqRRCCyclin-dependent kinase 22.7.11.220.462
3mvl38PMitogen-activated protein kinase 14/0.462
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.462
4hvh19RTyrosine-protein kinase JAK32.7.10.20.462
2znq401Peroxisome proliferator-activated receptor delta/0.461
3dxmN24Actin-related protein 3/0.461
3sp9IL2Peroxisome proliferator-activated receptor delta/0.461
3ukuC69Actin-related protein 3/0.461
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.461
1dr3TAPDihydrofolate reductase1.5.1.30.460
3roc29AMitogen-activated protein kinase 14/0.460
3tm5SFGUncharacterized protein/0.460
3ttjJBIMitogen-activated protein kinase 102.7.11.240.460
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.459
4anqVGHALK tyrosine kinase receptor2.7.10.10.459
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.459
4kbk1QGCasein kinase I isoform delta2.7.11.10.459
5aacVGHALK tyrosine kinase receptor2.7.10.10.459
1ia3TQ5Dihydrofolate reductase1.5.1.30.458
1m17AQ4Epidermal growth factor receptor2.7.10.10.458
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.458
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.458
3uyt0CKCasein kinase I isoform delta2.7.11.10.458
1pkdUCNCyclin-dependent kinase 22.7.11.220.457
3be9P04Casein kinase II subunit alpha2.7.11.10.457
3dt1P40Mitogen-activated protein kinase 14/0.457
3flsFLSMitogen-activated protein kinase 14/0.457
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.457
4fod0UVALK tyrosine kinase receptor2.7.10.10.457
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.457
1draMTXDihydrofolate reductase1.5.1.30.456
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.456
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.456
3qqkX02Cyclin-dependent kinase 22.7.11.220.456
3rm719ZCyclin-dependent kinase 22.7.11.220.456
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.456
1ove358Mitogen-activated protein kinase 14/0.455
3atyFMNProstaglandin F2a synthase/0.455
3cjfSAVVascular endothelial growth factor receptor 22.7.10.10.455
4ansVGHALK tyrosine kinase receptor2.7.10.10.455
4ia2BIVVitamin D3 receptor A/0.455
4kl9NDPDihydrofolate reductase1.5.1.30.455
1vyzN5BCyclin-dependent kinase 22.7.11.220.454
2cig1DGDihydrofolate reductase1.5.1.30.454
3flyFLYMitogen-activated protein kinase 14/0.454
3gwfFADCyclohexanone monooxygenase/0.454
3l8xN4DMitogen-activated protein kinase 14/0.454
4bcpT3CCyclin-dependent kinase 22.7.11.220.454
4g160VMCasein kinase I isoform gamma-32.7.11.10.454
4xxvNAD3-isopropylmalate dehydrogenase/0.454
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.453
3atzFMNProstaglandin F2a synthase/0.453
4a6nFADTetX family tetracycline inactivation enzyme/0.453
1ke6LS2Cyclin-dependent kinase 22.7.11.220.452
1ouy094Mitogen-activated protein kinase 14/0.452
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
2b1pAIZMitogen-activated protein kinase 102.7.11.240.452
2pwlACPFibroblast growth factor receptor 2/0.452
3v3vMYUMitogen-activated protein kinase 82.7.11.240.452
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.452
4aa4QC0Mitogen-activated protein kinase 14/0.452
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.452
4c02TAKActivin receptor type-12.7.11.300.452
4dfrMTXDihydrofolate reductase1.5.1.30.452
4g3e0WCMitogen-activated protein kinase kinase kinase 142.7.11.250.452
4kba1QMCasein kinase I isoform delta2.7.11.10.452
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.452
5e8wSTUTGF-beta receptor type-12.7.11.300.452
1n4hREANuclear receptor ROR-beta/0.451
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.451
3fmn530Mitogen-activated protein kinase 14/0.451
4fkt48KCyclin-dependent kinase 22.7.11.220.451
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.451
4gk2L66Ephrin type-A receptor 32.7.10.10.451
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.451
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.451
1tdrMTXDihydrofolate reductase1.5.1.30.450
2pvhP19Casein kinase II subunit alpha2.7.11.10.450
3fc152PMitogen-activated protein kinase 14/0.450
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.450
4eubCOASuccinyl-CoA:acetate CoA-transferase/0.450
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.450
5hi6MTXDihydrofolate reductase/0.450
1ddsMTXDihydrofolate reductase1.5.1.30.449
1k6cMK1Gag-Pol polyprotein3.4.23.160.449
1k6pXN3Gag-Pol polyprotein3.4.23.160.449
3kf7L9GMitogen-activated protein kinase 14/0.449
3zewSTUEphrin type-B receptor 42.7.10.10.449
4aacAAVMitogen-activated protein kinase 14/0.449
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.449
4fkr45KCyclin-dependent kinase 22.7.11.220.449
4k33ACPFibroblast growth factor receptor 32.7.10.10.449
4wkqIREEpidermal growth factor receptor2.7.10.10.449
4y93746Tyrosine-protein kinase/0.449
1pagFMPAntiviral protein I3.2.2.220.448
1rx1NAPDihydrofolate reductase1.5.1.30.448
2hcdBIVVitamin D3 receptor A/0.448
3r7eX88Cyclin-dependent kinase 22.7.11.220.448
4l03NAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.448
1diuBDMDihydrofolate reductase1.5.1.30.447
1dr5NAPDihydrofolate reductase1.5.1.30.447
1fvt106Cyclin-dependent kinase 22.7.11.220.447
1p2a5BNCyclin-dependent kinase 22.7.11.220.447
1zemNADXylitol dehydrogenase/0.447
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.447
3flwFLWMitogen-activated protein kinase 14/0.447
3id8MRKGlucokinase2.7.1.20.447
3ral04ZCyclin-dependent kinase 22.7.11.220.447
3rmf20ZCyclin-dependent kinase 22.7.11.220.447
3t1tGDPProbable gliding protein mglA/0.447
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.447
4g170VNCasein kinase I isoform gamma-32.7.11.10.447
4hjoAQ4Epidermal growth factor receptor2.7.10.10.447
4nb6444Nuclear receptor ROR-gamma/0.447
1r78FMDCyclin-dependent kinase 22.7.11.220.446
2fgiPD1Fibroblast growth factor receptor 1/0.446
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.446
2of4979Tyrosine-protein kinase Lck2.7.10.20.446
2y7jB49Phosphorylase b kinase gamma catalytic chain, liver/testis isoform2.7.11.190.446
2yfxVGHALK tyrosine kinase receptor2.7.10.10.446
3och2MXDihydrofolate reductase1.5.1.30.446
3qx2X63Cyclin-dependent kinase 22.7.11.220.446
3uvp048Mitogen-activated protein kinase 14/0.446
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.446
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.446
4fob0USALK tyrosine kinase receptor2.7.10.10.446
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.446
4g47TZFMycocyclosin synthase1.14.21.90.446
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.445
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.445
2q9fC3SCholesterol 24-hydroxylase/0.445
2zbzVDXVitamin D3 dihydroxylase/0.445
3qxoX65Cyclin-dependent kinase 22.7.11.220.445
4e730NRMitogen-activated protein kinase 82.7.11.240.445
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.445
4jr3KJREpidermal growth factor receptor2.7.10.10.445
2iw84SPCyclin-dependent kinase 22.7.11.220.444
2zjwREFCasein kinase II subunit alpha2.7.11.10.444
3cv9VDXVitamin D3 dihydroxylase/0.444
3ey9TDPPyruvate dehydrogenase [ubiquinone]1.2.5.10.444
3hk1B64Fatty acid-binding protein, adipocyte/0.444
3qly55VUncharacterized protein/0.444
3rpv26ZCyclin-dependent kinase 22.7.11.220.444
3zuxTCHTransporter/0.444
4f7iNAD3-isopropylmalate dehydrogenase1.1.1.850.444
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.444
1bvrTHTEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
1jioDEB6-deoxyerythronolide B hydroxylase/0.443
1k6tXN1Gag-Pol polyprotein3.4.23.160.443
1mvsDTMDihydrofolate reductase1.5.1.30.443
1rb3MTXDihydrofolate reductase1.5.1.30.443
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.443
2ittAEEEpidermal growth factor receptor2.7.10.10.443
2wotZZGTGF-beta receptor type-12.7.11.300.443
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.443
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.443
3l8p0CEAngiopoietin-1 receptor2.7.10.10.443
3o8tBMUMitogen-activated protein kinase 14/0.443
3r6xX84Cyclin-dependent kinase 22.7.11.220.443
3s1dZIRCytokinin dehydrogenase 11.5.99.120.443
3tea4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.443
3unk0BYCyclin-dependent kinase 22.7.11.220.443
4i5hG17Mitogen-activated protein kinase 12.7.11.240.443
4ia3BIVVitamin D3 receptor A/0.443
1dirNADDihydropteridine reductase1.5.1.340.442
1pn3TYDdTDP-epi-vancosaminyltransferase2.4.1.3110.442
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.260.442
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.442
3dogNNNCyclin-dependent kinase 22.7.11.220.442
3gstGPRGlutathione S-transferase Mu 12.5.1.180.442
3hcrCHDFerrochelatase, mitochondrial4.99.1.10.442
3tz3B36Acetyl-CoA carboxylase/0.442
4k0y1OASerine/threonine-protein kinase pim-12.7.11.10.442
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.442
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.442
1bygSTUTyrosine-protein kinase CSK/0.441
1ddrMTXDihydrofolate reductase1.5.1.30.441
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.441
2qo9ANPEphrin type-A receptor 32.7.10.10.441
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.441
3gxlQIGTGF-beta receptor type-12.7.11.300.441
3hadNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.441
3kxw1ZZSaframycin Mx1 synthetase B/0.441
3uzp0CKCasein kinase I isoform delta2.7.11.10.441
3vasADNPutative adenosine kinase/0.441
4bcoT6QCyclin-dependent kinase 22.7.11.220.441
4bgg844Activin receptor type-12.7.11.300.441
4c2xNHWGlycylpeptide N-tetradecanoyltransferase 2/0.441
4gub0Y4Casein kinase II subunit alpha2.7.11.10.441
4lopSB4Mitogen-activated protein kinase 14/0.441
5eccNAPDehydrofolate reductase type I/0.441
1j3jNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440
3ac1KZITyrosine-protein kinase Lck2.7.10.20.440
3gc9B45Mitogen-activated protein kinase 112.7.11.240.440
3gu6ADPDeath-associated protein kinase 12.7.11.10.440
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.440