sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4l44 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 4l44 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 1.000 | |
| 4l3l | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.583 | |
| 4l43 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.581 | |
| 3we4 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.568 | |
| 4l45 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.551 | |
| 4l3j | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.533 | |
| 3cqw | CQW | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.524 | |
| 3mvh | WFE | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.513 | |
| 4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.509 | |
| 3js2 | VM1 | Fibroblast growth factor receptor 1 | / | 0.507 | |
| 3tkh | 07S | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.506 | |
| 4fsn | A58 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.506 | |
| 1q8w | M77 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.502 | |
| 4k11 | 0J9 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.500 | |
| 4oti | MI1 | Serine/threonine-protein kinase N1 | / | 0.496 | |
| 1wvx | BD4 | Death-associated protein kinase 1 | 2.7.11.1 | 0.492 | |
| 4yhj | AN2 | G protein-coupled receptor kinase 4 | 2.7.11.16 | 0.491 | |
| 3nux | 3NV | Cyclin-dependent kinase 6 | 2.7.11.22 | 0.488 | |
| 4fti | H7K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.488 | |
| 3mv5 | XFE | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.487 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.487 | |
| 1yt9 | OIS | Gag-Pol polyprotein | / | 0.486 | |
| 3cyx | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.486 | |
| 2etr | Y27 | Rho-associated protein kinase 1 | 2.7.11.1 | 0.484 | |
| 3qp0 | NI8 | Gag-Pol polyprotein | 3.4.23.16 | 0.484 | |
| 3t11 | 3T1 | Gag-Pol polyprotein | 3.4.23.16 | 0.484 | |
| 2ym6 | YM6 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.483 | |
| 3nwx | KVS | Gag-Pol polyprotein | 3.4.23.16 | 0.483 | |
| 4fsr | HKC | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.483 | |
| 4ezj | 0SC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.481 | |
| 2cgu | 3A3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.480 | |
| 3zo1 | SIJ | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.480 | |
| 2uzu | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.477 | |
| 3vs7 | KS1 | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.476 | |
| 2ayp | 43A | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.475 | |
| 2hxl | 422 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.474 | |
| 3nxe | 2NC | Protease | / | 0.474 | |
| 4gv1 | 0XZ | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.474 | |
| 1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.473 | |
| 3a62 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.473 | |
| 2f3k | RO1 | Protease | / | 0.472 | |
| 2ydi | YDI | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.472 | |
| 4k1b | 1OC | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.472 | |
| 2uw4 | L15 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.471 | |
| 3el5 | 1UN | Gag-Pol polyprotein | / | 0.471 | |
| 3qbf | JHG | Gag-Pol polyprotein | 3.4.23.16 | 0.471 | |
| 3zew | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.471 | |
| 1t7j | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.470 | |
| 2hog | 710 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.470 | |
| 2oh0 | 2PY | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.470 | |
| 3nu9 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.469 | |
| 5av2 | KMP | Death-associated protein kinase 1 | 2.7.11.1 | 0.469 | |
| 1ida | 0PO | Gag-Pol polyprotein | 3.4.23.47 | 0.468 | |
| 2csn | CKI | Casein kinase I homolog 1 | 2.7.11.1 | 0.468 | |
| 2fxd | DR7 | Pol polyprotein | / | 0.468 | |
| 2qnq | QN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.468 | |
| 3lcd | BDY | Macrophage colony-stimulating factor 1 receptor | 2.7.10.1 | 0.468 | |
| 2pwc | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.467 | |
| 4ekl | 0RF | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.467 | |
| 4ft9 | H4K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.467 | |
| 4j5j | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.467 | |
| 2hxq | 373 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.466 | |
| 3ggx | GGX | Gag-Pol polyprotein | / | 0.466 | |
| 3igo | ANP | Calmodulin-domain protein kinase 1, putative | / | 0.466 | |
| 3vs5 | VSG | Tyrosine-protein kinase HCK | 2.7.10.2 | 0.466 | |
| 4ftj | H8K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.466 | |
| 1qpj | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.465 | |
| 2bpz | 3IN | Gag-Pol polyprotein | 3.4.23.16 | 0.465 | |
| 2f7e | 2EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.465 | |
| 2qak | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.465 | |
| 3d1x | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.465 | |
| 3el9 | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.465 | |
| 2ijm | ADP | Focal adhesion kinase 1 | 2.7.10.2 | 0.464 | |
| 2pyn | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.464 | |
| 2wmq | ZYQ | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.464 | |
| 3el4 | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.464 | |
| 1q8u | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.463 | |
| 2q63 | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.463 | |
| 2uw0 | GVK | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.463 | |
| 4fg7 | ATP | Calcium/calmodulin-dependent protein kinase type 1 | 2.7.11.17 | 0.463 | |
| 1c6x | 3IN | Protease | / | 0.462 | |
| 1q3w | ATU | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.462 | |
| 2nnp | ROC | Protease | / | 0.462 | |
| 4gu9 | 4GU | Focal adhesion kinase 1 | 2.7.10.2 | 0.462 | |
| 4l7s | G7K | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.462 | |
| 1fvv | 107 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.461 | |
| 1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.461 | |
| 1sdt | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.461 | |
| 2bpv | 1IN | Gag-Pol polyprotein | 3.4.23.16 | 0.461 | |
| 2pym | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.461 | |
| 3eb0 | DRK | Uncharacterized protein | / | 0.461 | |
| 3v2y | ML5 | Sphingosine 1-phosphate receptor 1 | / | 0.461 | |
| 1hpo | UNI | Gag-Pol polyprotein | 3.4.23.16 | 0.460 | |
| 2cmw | OLP | Casein kinase I isoform gamma-1 | 2.7.11.1 | 0.460 | |
| 2r3w | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.460 | |
| 2uzv | SS5 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.460 | |
| 2vo0 | M03 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.460 | |
| 3s85 | LK0 | Gag-Pol polyprotein | / | 0.460 | |
| 1fin | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.459 | |
| 1sdv | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.459 | |
| 3c4x | ATP | Rhodopsin kinase | / | 0.459 | |
| 2r43 | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 3ckx | STU | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.458 | |
| 3nyn | SGV | G protein-coupled receptor kinase 6 | 2.7.11.16 | 0.458 | |
| 3qrm | NK7 | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
| 1yvj | 4ST | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.457 | |
| 2aid | THK | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 2r3t | G4G | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
| 3t8o | ATP | Rhodopsin kinase | / | 0.457 | |
| 1c6z | ROC | Protease | / | 0.456 | |
| 3gga | GGW | Gag-Pol polyprotein | / | 0.456 | |
| 4qys | PLR | Tryptophan synthase beta chain 2 | 4.2.1.20 | 0.456 | |
| 1sgu | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 1z1r | HBH | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 3aid | ARQ | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 3bxs | DRS | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 3ckt | YDP | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 3jy0 | LYG | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.455 | |
| 3ndu | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
| 3qlg | 1N1 | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.455 | |
| 3u9e | COA | Lmo1369 protein | / | 0.455 | |
| 3ucb | 017 | Gag-Pol polyprotein | / | 0.455 | |
| 3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.455 | |
| 4ii5 | ADP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 4l9i | 8PR | Rhodopsin kinase | / | 0.455 | |
| 1z1h | HBB | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 2q64 | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
| 3ufn | ROC | Gag-Pol polyprotein | / | 0.454 | |
| 1vij | BAY | Gag-Pol polyprotein | / | 0.453 | |
| 2bpy | 3IN | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 2h8h | H8H | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.453 | |
| 2qd8 | 065 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 2r5p | MK1 | Gag-Pol polyprotein | / | 0.453 | |
| 4a6b | QG8 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
| 1c6y | MK1 | Protease | / | 0.452 | |
| 1sbg | IM1 | Gag-Pol polyprotein | / | 0.452 | |
| 1uyr | D1L | Acetyl-CoA carboxylase | / | 0.452 | |
| 3kn5 | ANP | Ribosomal protein S6 kinase alpha-5 | 2.7.11.1 | 0.452 | |
| 3oxv | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 3qpj | N4I | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
| 4yzc | STU | Serine/threonine-protein kinase/endoribonuclease IRE1 | 2.7.11.1 | 0.452 | |
| 1k6v | XN2 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 1vik | BAY | Gag-Pol polyprotein | / | 0.451 | |
| 2jds | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.451 | |
| 2vv9 | IM9 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 3ekx | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 3nuo | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 3qrs | NK8 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
| 3tnw | F18 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.451 | |
| 4fsu | HK5 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.451 | |
| 4h4x | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.451 | |
| 2qhc | AB1 | Protease | / | 0.450 | |
| 3e8e | G98 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.450 | |
| 3qih | FG7 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 4bbe | 3O4 | Tyrosine-protein kinase JAK2 | / | 0.450 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.450 | |
| 4j55 | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
| 2b7z | MK1 | Gag-Pol polyprotein | / | 0.449 | |
| 2bpw | 1IN | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 3ekw | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 3lix | E17 | Protease | / | 0.449 | |
| 3vf5 | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 4eut | BX7 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.449 | |
| 4gmy | 0X5 | Tyrosine-protein kinase JAK2 | / | 0.449 | |
| 4hvh | 19R | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.449 | |
| 4i3z | ADP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.449 | |
| 5av3 | KMP | Death-associated protein kinase 1 | 2.7.11.1 | 0.449 | |
| 1ec3 | MS3 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 1hii | C20 | Gag-Pol polyprotein | / | 0.448 | |
| 1hos | PHP | Gag-Pol polyprotein | / | 0.448 | |
| 1k1u | 0Q4 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 1xr1 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.448 | |
| 2pnj | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.448 | |
| 2r5q | 1UN | Gag-Pol polyprotein | / | 0.448 | |
| 3b2w | 9NH | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.448 | |
| 3bqr | 4RB | Death-associated protein kinase 3 | / | 0.448 | |
| 3juh | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.448 | |
| 3oxx | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 3zpt | M8Y | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 3zpu | M8B | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
| 4bcm | T7Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.448 | |
| 4fsm | HK1 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 4ft3 | H1K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
| 4xx0 | COA | Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial | 6.2.1.4 | 0.448 | |
| 1a8g | 2Z4 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 2f8g | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 2j0l | ANP | Focal adhesion kinase 1 | 2.7.10.2 | 0.447 | |
| 2qe6 | SAM | Uncharacterized protein | / | 0.447 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 3s54 | 017 | Protease | / | 0.447 | |
| 3vf7 | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
| 4dit | 0KD | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.447 | |
| 1bv7 | XV6 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 1xl2 | 189 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
| 1ydr | IQP | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 2dq7 | STU | Tyrosine-protein kinase Fyn | 2.7.10.2 | 0.446 | |
| 2f2u | M77 | Rho-associated protein kinase 2 | 2.7.11.1 | 0.446 | |
| 3kkv | B99 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.446 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.446 | |
| 4e4n | 0NL | Tyrosine-protein kinase JAK1 | / | 0.446 | |
| 4fjy | FJY | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.446 | |
| 5auz | GEN | Death-associated protein kinase 1 | 2.7.11.1 | 0.446 | |
| 2bdf | 24A | Proto-oncogene tyrosine-protein kinase Src | 2.7.10.2 | 0.445 | |
| 2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.445 | |
| 3em4 | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 3qih | NI7 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
| 4bib | IEO | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.445 | |
| 4h4r | FAD | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.445 | |
| 1hsg | MK1 | Gag-Pol polyprotein | / | 0.444 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 1mtr | PI6 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 1ohr | 1UN | V-1 PROTEASE protein | / | 0.444 | |
| 2fdd | 385 | Pol protein | / | 0.444 | |
| 3a2o | KNJ | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3el1 | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 3lj3 | WYE | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.444 | |
| 3pwr | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
| 1o6y | ACP | Serine/threonine-protein kinase PknB | 2.7.11.1 | 0.443 | |
| 2aqu | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 2hy0 | 306 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
| 2j9m | PY8 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.443 | |
| 2p3a | 3TL | Pol protein | / | 0.443 | |
| 2pvn | P63 | Casein kinase II subunit alpha | 2.7.11.1 | 0.443 | |
| 2uw6 | GVO | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 2vo7 | M05 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
| 3nu4 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
| 3oxc | ROC | Protease | / | 0.443 | |
| 4k8a | K8A | Focal adhesion kinase 1 | 2.7.10.2 | 0.443 | |
| 1t7i | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 1yw2 | PGJ | Mitogen-activated protein kinase 14 | / | 0.442 | |
| 2hs2 | 017 | Protease | / | 0.442 | |
| 3c4z | ADP | Rhodopsin kinase | / | 0.442 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.442 | |
| 3vfb | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
| 3zw3 | ZW3 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.442 | |
| 4e6d | 0NU | Tyrosine-protein kinase JAK2 | / | 0.442 | |
| 4mk0 | 29X | Beta-adrenergic receptor kinase 1 | 2.7.11.15 | 0.442 | |
| 1meu | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 2aqh | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.441 | |
| 2nmy | ROC | Protease | / | 0.441 | |
| 2pwr | G4G | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 2rkf | AB1 | Pol protein | / | 0.441 | |
| 2xye | CXG | Gag-Pol polyprotein | / | 0.441 | |
| 3jvw | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 3sa3 | 23X | Protease | / | 0.441 | |
| 4f7l | 0SO | Cyclin-dependent kinase 8 | 2.7.11.22 | 0.441 | |
| 4k4p | 3TL | Gag-Pol polyprotein | / | 0.441 | |
| 1ivp | 1ZK | Gag-Pol polyprotein | / | 0.440 | |
| 2cen | 4AH | Protease | / | 0.440 | |
| 2pqz | G0G | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3amb | VX6 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 3bhe | BZN | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 3kfs | 3TL | Gag-Pol polyprotein | / | 0.440 | |
| 3n7u | NAD | Formate dehydrogenase, chloroplastic/mitochondrial | / | 0.440 | |
| 3zps | EQM | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
| 4ftt | 6HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.440 | |
| 4fv9 | E71 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.440 |