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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4achKDIGlycogen synthase kinase-3 beta2.7.11.26

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
4achKDIGlycogen synthase kinase-3 beta2.7.11.261.000
4acdGR9Glycogen synthase kinase-3 beta2.7.11.260.630
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.617
3l1sZ92Glycogen synthase kinase-3 beta2.7.11.260.613
3gb2G3BGlycogen synthase kinase-3 beta2.7.11.260.612
4acc7YGGlycogen synthase kinase-3 beta2.7.11.260.602
3f7z34OGlycogen synthase kinase-3 beta2.7.11.260.597
4acg6LQGlycogen synthase kinase-3 beta2.7.11.260.594
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.585
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.582
3f883HTGlycogen synthase kinase-3 beta2.7.11.260.578
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.576
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.572
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.555
3du8553Glycogen synthase kinase-3 beta2.7.11.260.547
4b7tCWTGlycogen synthase kinase-3 beta2.7.11.260.547
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.545
1r0eDFNGlycogen synthase kinase-3 beta2.7.11.260.540
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.538
1q5kTMUGlycogen synthase kinase-3 beta2.7.11.260.537
3zrkZRKGlycogen synthase kinase-3 beta2.7.11.260.536
4j1rI5RGlycogen synthase kinase-3 beta2.7.11.260.532
3sd0TSKGlycogen synthase kinase-3 beta2.7.11.260.529
4j711JXGlycogen synthase kinase-3 beta2.7.11.260.529
2ow3BIMGlycogen synthase kinase-3 beta2.7.11.260.524
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.520
3zrlZRLGlycogen synthase kinase-3 beta2.7.11.260.515
3zrmZRMGlycogen synthase kinase-3 beta2.7.11.260.515
4nm0ADPGlycogen synthase kinase-3 beta2.7.11.260.512
2hog710Serine/threonine-protein kinase Chk12.7.11.10.509
1q4l679Glycogen synthase kinase-3 beta2.7.11.260.508
2dwbANPAurora kinase A2.7.11.10.499
4gmy0X5Tyrosine-protein kinase JAK2/0.498
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.498
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.496
3q3b55EGlycogen synthase kinase-3 beta2.7.11.260.493
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.493
5drdATPAurora kinase A2.7.11.10.490
2i0ePDSProtein kinase C beta type2.7.11.130.489
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.489
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.488
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.488
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.488
3p8jFMNPentaerythritol tetranitrate reductase/0.487
3pjcPJCTyrosine-protein kinase JAK32.7.10.20.487
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.487
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.486
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.486
3iw4LW4Protein kinase C alpha type2.7.11.130.485
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.485
1oiuN76Cyclin-dependent kinase 22.7.11.220.484
2c3kABOSerine/threonine-protein kinase Chk12.7.11.10.484
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.482
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.481
4j97ACPFibroblast growth factor receptor 2/0.480
5dt4ATPAurora kinase A2.7.11.10.480
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.479
3a60STURibosomal protein S6 kinase beta-12.7.11.10.479
4jbpYPHAurora kinase A2.7.11.10.479
5dr9SKEAurora kinase A2.7.11.10.478
1pkdUCNCyclin-dependent kinase 22.7.11.220.477
4qmySTUSerine/threonine-protein kinase 242.7.11.10.477
4ftkH9KSerine/threonine-protein kinase Chk12.7.11.10.476
4ftm1HKSerine/threonine-protein kinase Chk12.7.11.10.476
4qnaX11Serine/threonine-protein kinase 242.7.11.10.476
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.475
1nxkSTUMAP kinase-activated protein kinase 22.7.11.10.474
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.474
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.474
2c6tDT5Cyclin-dependent kinase 22.7.11.220.473
2xchCKG3-phosphoinositide-dependent protein kinase 12.7.11.10.473
3vf9477Tyrosine-protein kinase SYK2.7.10.20.473
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.473
4qmxH8HSerine/threonine-protein kinase 242.7.11.10.473
4n702HXSerine/threonine-protein kinase pim-12.7.11.10.472
4qmlANPSerine/threonine-protein kinase 242.7.11.10.472
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.471
2x6dX6DAurora kinase A2.7.11.10.471
3k5uPFQAurora kinase A2.7.11.10.471
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.471
1h1r6CPCyclin-dependent kinase 22.7.11.220.470
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.470
3eb0DRKUncharacterized protein/0.470
4e4m0NHTyrosine-protein kinase JAK2/0.470
4ftn2HKSerine/threonine-protein kinase Chk12.7.11.10.470
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.469
2gdo12CSerine/threonine-protein kinase Chk12.7.11.10.469
3l0lHC3Nuclear receptor ROR-gamma/0.469
4jbqVX6Aurora kinase A2.7.11.10.469
4wboANWRhodopsin kinase/0.469
2broDF2Serine/threonine-protein kinase Chk12.7.11.10.468
4nm7ADPGlycogen synthase kinase-3 beta2.7.11.260.468
4qmpDKISerine/threonine-protein kinase 242.7.11.10.468
4qmzB49Serine/threonine-protein kinase 242.7.11.10.468
2wmtZYTSerine/threonine-protein kinase Chk12.7.11.10.467
3efwAK8Aurora kinase A2.7.11.10.466
3mdvCL6Cholesterol 24-hydroxylase/0.466
4aguD15Cyclin-dependent kinase-like 1/0.466
2acxANPG protein-coupled receptor kinase 62.7.11.160.465
4jqeANPCasein kinase II subunit alpha2.7.11.10.465
1nvqUCNSerine/threonine-protein kinase Chk12.7.11.10.464
2pvnP63Casein kinase II subunit alpha2.7.11.10.464
2qo9ANPEphrin type-A receptor 32.7.10.10.464
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.464
2wmwZYWSerine/threonine-protein kinase Chk12.7.11.10.464
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.464
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.464
5e8wSTUTGF-beta receptor type-12.7.11.300.464
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.463
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.463
4jajXU1Aurora kinase A2.7.11.10.463
2qblCAMCamphor 5-monooxygenase1.14.15.10.462
4fob0USALK tyrosine kinase receptor2.7.10.10.462
2xikJ60Serine/threonine-protein kinase 252.7.11.10.461
3vid4TTVascular endothelial growth factor receptor 22.7.10.10.461
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.461
4fstHK4Serine/threonine-protein kinase Chk12.7.11.10.461
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.461
4i22IREEpidermal growth factor receptor2.7.10.10.461
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.461
2wmxZY6Serine/threonine-protein kinase Chk12.7.11.10.460
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.460
3a7jADPSerine/threonine-protein kinase 242.7.11.10.460
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.460
3zdiUGJGlycogen synthase kinase-3 beta2.7.11.260.460
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.460
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.460
1oi9N20Cyclin-dependent kinase 22.7.11.220.459
1yi3LY2Serine/threonine-protein kinase pim-12.7.11.10.459
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.459
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.459
4dgmAGICasein kinase II subunit alpha2.7.11.10.459
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.459
2brgDFYSerine/threonine-protein kinase Chk12.7.11.10.458
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.458
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.458
4c02TAKActivin receptor type-12.7.11.300.458
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.458
3c4eC4ESerine/threonine-protein kinase pim-12.7.11.10.457
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.457
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.457
4enhFVXCholesterol 24-hydroxylase/0.457
4gk2L66Ephrin type-A receptor 32.7.10.10.457
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.457
5ar4SB2Receptor-interacting serine/threonine-protein kinase 22.7.11.10.457
1h74ADPHomoserine kinase2.7.1.390.456
2jedLG8Protein kinase C theta type2.7.11.130.456
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.456
2ym3YM3Serine/threonine-protein kinase Chk12.7.11.10.456
3l8p0CEAngiopoietin-1 receptor2.7.10.10.456
4bcpT3CCyclin-dependent kinase 22.7.11.220.456
2j2iLY4Serine/threonine-protein kinase pim-12.7.11.10.455
2vd5BI8Myotonin-protein kinase2.7.11.10.455
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.455
4dgo0JWCasein kinase II subunit alpha2.7.11.10.455
4erwSTUCyclin-dependent kinase 22.7.11.220.455
2uzlC94Cyclin-dependent kinase 22.7.11.220.454
2ym7YM7Serine/threonine-protein kinase Chk12.7.11.10.454
3cy3JN5Serine/threonine-protein kinase pim-12.7.11.10.454
3e5aVX6Aurora kinase A2.7.11.10.454
3t8oATPRhodopsin kinase/0.454
4bgg844Activin receptor type-12.7.11.300.454
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.454
4dn5AGSMitogen-activated protein kinase kinase kinase 142.7.11.250.454
4jq8KJ8Epidermal growth factor receptor2.7.10.10.454
1yhsSTUSerine/threonine-protein kinase pim-12.7.11.10.453
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.453
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.453
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.453
3c7qXINVascular endothelial growth factor receptor 22.7.10.10.453
3jxwLXGSerine/threonine-protein kinase pim-12.7.11.10.453
4eufNADTrans-2-enoyl-CoA reductase [NADH]/0.453
4i0s1B5Tyrosine-protein kinase SYK2.7.10.20.453
4oavACP2-5A-dependent ribonuclease3.1.260.453
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.453
5dt3ATPAurora kinase A2.7.11.10.453
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.452
3oom507Activin receptor type-12.7.11.300.452
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.452
4nka2K7Fibroblast growth factor receptor 1/0.452
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
1mq4ADPAurora kinase A2.7.11.10.451
2of4979Tyrosine-protein kinase Lck2.7.10.20.451
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.451
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.451
5dn3ATPAurora kinase A2.7.11.10.451
5dr6SKEAurora kinase A2.7.11.10.451
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.450
3nga3NGCasein kinase II subunit alpha2.7.11.10.450
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.450
4deeADPAurora kinase A2.7.11.10.450
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.450
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.450
4hvh19RTyrosine-protein kinase JAK32.7.10.20.450
5dosATPAurora kinase A2.7.11.10.450
1jpaANPEphrin type-B receptor 22.7.10.10.449
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.449
2xa4AZ5Tyrosine-protein kinase JAK2/0.449
2xj1XJ1Serine/threonine-protein kinase pim-12.7.11.10.449
3ag9A02cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
4gg70J8Hepatocyte growth factor receptor2.7.10.10.449
4l4cCAMCamphor 5-monooxygenase1.14.15.10.449
5e8xSTUTGF-beta receptor type-12.7.11.300.449
1oiyN41Cyclin-dependent kinase 22.7.11.220.448
2br1PFPSerine/threonine-protein kinase Chk12.7.11.10.448
2brhDFWSerine/threonine-protein kinase Chk12.7.11.10.448
2chlDKICasein kinase I isoform gamma-32.7.11.10.448
2h96893Mitogen-activated protein kinase 82.7.11.240.448
2o65MYFSerine/threonine-protein kinase pim-12.7.11.10.448
2xf04UBSerine/threonine-protein kinase Chk12.7.11.10.448
3bhtMFRCyclin-dependent kinase 22.7.11.220.448
3zuyTCHTransporter/0.448
4bchT7ZCyclin-dependent kinase 92.7.11.220.448
4nm5ADPGlycogen synthase kinase-3 beta2.7.11.260.448
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
1okySTU3-phosphoinositide-dependent protein kinase 12.7.11.10.447
2bikBI1Serine/threonine-protein kinase pim-12.7.11.10.447
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.447
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.447
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.447
4nb6444Nuclear receptor ROR-gamma/0.447
4r8qADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.447
4utdACPAurora kinase A2.7.11.10.447
2q9fC3SCholesterol 24-hydroxylase/0.446
3bgpVX1Serine/threonine-protein kinase pim-12.7.11.10.446
3unj0BXCyclin-dependent kinase 22.7.11.220.446
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.446
4bqpNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.446
4c3rACPAurora kinase A2.7.11.10.446
4c62XWWTyrosine-protein kinase JAK2/0.446
4qo9627Serine/threonine-protein kinase 242.7.11.10.446
1lp4ANPCasein kinase II subunit alpha2.7.11.10.445
1ol5ADPAurora kinase A2.7.11.10.445
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.445
1t86CAMCamphor 5-monooxygenase1.14.15.10.445
2a1nCAMCamphor 5-monooxygenase1.14.15.10.445
2ev9NAPShikimate dehydrogenase (NADP(+))/0.445
3qaqQAQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.445
5auwQUEDeath-associated protein kinase 12.7.11.10.445
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.444
4fjyFJYPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4fsmHK1Serine/threonine-protein kinase Chk12.7.11.10.444
4g2fC07Ephrin type-A receptor 32.7.10.10.444
4hyi1AOSerine/threonine-protein kinase Chk12.7.11.10.444
2ayp43ASerine/threonine-protein kinase Chk12.7.11.10.443
2iw84SPCyclin-dependent kinase 22.7.11.220.443
4bcnT9NCyclin-dependent kinase 22.7.11.220.443
4ftcH6KSerine/threonine-protein kinase Chk12.7.11.10.443
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.443
4y93746Tyrosine-protein kinase/0.443
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.442
2xru400Aurora kinase A2.7.11.10.442
3dtcVINMitogen-activated protein kinase kinase kinase 92.7.11.250.442
3f03FMNPentaerythritol tetranitrate reductase/0.442
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
3i60E86Mitogen-activated protein kinase 12.7.11.240.442
3sheI85MAP kinase-activated protein kinase 32.7.11.10.442
3ufnROCGag-Pol polyprotein/0.442
3zptM8YGag-Pol polyprotein3.4.23.160.442
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.442
4lopSB4Mitogen-activated protein kinase 14/0.442
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.441
2wotZZGTGF-beta receptor type-12.7.11.300.441
2yerTQ1Serine/threonine-protein kinase Chk12.7.11.10.441
2znpK55Peroxisome proliferator-activated receptor delta/0.441
3a62STURibosomal protein S6 kinase beta-12.7.11.10.441
3emg685Tyrosine-protein kinase SYK2.7.10.20.441
3uo50BXAurora kinase A2.7.11.10.441
1ol7ADPAurora kinase A2.7.11.10.440
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.440
2y6o1N1Ephrin type-A receptor 42.7.10.10.440
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.440
2z3uCRRCytochrome P450/0.440
3a7hATPSerine/threonine-protein kinase 242.7.11.10.440
4deaNHIAurora kinase A2.7.11.10.440
4idtT28Mitogen-activated protein kinase kinase kinase 142.7.11.250.440
5cu6ATPCasein kinase II subunit alpha2.7.11.10.440