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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3w2o03PEpidermal growth factor receptor2.7.10.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3w2o03PEpidermal growth factor receptor2.7.10.11.000
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.529
2vrx447Aurora kinase B-A2.7.11.10.513
4aotGW8Serine/threonine-protein kinase 102.7.11.10.504
2j7t274Serine/threonine-protein kinase 102.7.11.10.496
4ansVGHALK tyrosine kinase receptor2.7.10.10.496
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.489
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.489
4bc6XZNSerine/threonine-protein kinase 102.7.11.10.480
4joa3DKALK tyrosine kinase receptor2.7.10.10.478
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.478
3ictCOACoenzyme A disulfide reductase/0.477
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.476
3zewSTUEphrin type-B receptor 42.7.10.10.475
3icrCOACoenzyme A disulfide reductase/0.474
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.474
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.473
3icsCOACoenzyme A disulfide reductase/0.472
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.472
4gt3ATPMitogen-activated protein kinase 12.7.11.240.470
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.470
1mqbANPEphrin type-A receptor 22.7.10.10.469
2c6eHPMAurora kinase A2.7.11.10.469
2yfxVGHALK tyrosine kinase receptor2.7.10.10.468
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.468
4anqVGHALK tyrosine kinase receptor2.7.10.10.468
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.467
4b99R4LMitogen-activated protein kinase 72.7.11.240.466
4c3pACPAurora kinase A2.7.11.10.463
2qocANPEphrin type-A receptor 32.7.10.10.460
4o0uADNAurora kinase A2.7.11.10.460
2xvdAS6Ephrin type-B receptor 42.7.10.10.458
3gxoMQAMitomycin biosynthesis 6-O-methyltransferase/0.458
4bdiHAUSerine/threonine-protein kinase Chk22.7.11.10.458
2qo7ANPEphrin type-A receptor 32.7.10.10.457
3begANPSRSF protein kinase 12.7.11.10.457
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.457
1k6pXN3Gag-Pol polyprotein3.4.23.160.456
1sm2STUTyrosine-protein kinase ITK/TSK2.7.10.20.456
4gk4L90Ephrin type-A receptor 32.7.10.10.455
4jia1K3Tyrosine-protein kinase JAK2/0.455
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.455
2c7xNRBCytochrome P450 monooxygenase PikC/0.454
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.454
4jbqVX6Aurora kinase A2.7.11.10.454
4qo9627Serine/threonine-protein kinase 242.7.11.10.454
4btjATPTau-tubulin kinase 12.7.11.10.452
4jboWPHAurora kinase A2.7.11.10.451
1i44ACPInsulin receptor2.7.10.10.450
3erkSB4Mitogen-activated protein kinase 12.7.11.240.450
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.450
1rekB8LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.449
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.449
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.449
4nka2K7Fibroblast growth factor receptor 1/0.449
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.449
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.448
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.448
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.448
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.447
4c4f7CEDual specificity protein kinase TTK2.7.12.10.447
2j0m4STFocal adhesion kinase 12.7.10.20.446
2vzmNRBCytochrome P450 monooxygenase PikC/0.445
4bddZ0OSerine/threonine-protein kinase Chk22.7.11.10.445
1fvv107Cyclin-dependent kinase 22.7.11.220.444
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.444
4id71G0Activated CDC42 kinase 1/0.444
4bdfH3RSerine/threonine-protein kinase Chk22.7.11.10.442
4grb0XGCasein kinase II subunit alpha2.7.11.10.442
2ijmADPFocal adhesion kinase 12.7.10.20.441
2y03Y01Beta-1 adrenergic receptor/0.441
3d7tSTUTyrosine-protein kinase CSK/0.441
4b7dQLECytochrome P450 monooxygenase PikC/0.441
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.440
3a4oSTUTyrosine-protein kinase Lyn2.7.10.20.440
3qa2XNAKetohexokinase/0.440
4b4oNDPEpimerase family protein SDR39U1/0.440
4ubsDIFPentalenic acid synthase1.14.15.110.440