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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3vs7KS1Tyrosine-protein kinase HCK2.7.10.2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3vs7KS1Tyrosine-protein kinase HCK2.7.10.21.000
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.595
3vs5VSGTyrosine-protein kinase HCK2.7.10.20.593
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.579
2c0iL1GTyrosine-protein kinase HCK2.7.10.20.576
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.575
4k110J9Proto-oncogene tyrosine-protein kinase Src2.7.10.20.574
3vs0VS0Tyrosine-protein kinase HCK2.7.10.20.565
3w2sW2REpidermal growth factor receptor2.7.10.10.564
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.561
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.553
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.534
3vs1VSATyrosine-protein kinase HCK2.7.10.20.533
3vs4VSFTyrosine-protein kinase HCK2.7.10.20.525
3w33W19Epidermal growth factor receptor2.7.10.10.524
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.522
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.520
1xkkFMMEpidermal growth factor receptor2.7.10.10.519
4gmy0X5Tyrosine-protein kinase JAK2/0.519
2c0tL3GTyrosine-protein kinase HCK2.7.10.20.510
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.510
4fic0ULProto-oncogene tyrosine-protein kinase Src2.7.10.20.508
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.507
4mxyDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.507
4mxzDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.507
4nka2K7Fibroblast growth factor receptor 1/0.506
3vryB43Tyrosine-protein kinase HCK2.7.10.20.504
3poz03PEpidermal growth factor receptor2.7.10.10.502
4bbe3O4Tyrosine-protein kinase JAK2/0.502
4id71G0Activated CDC42 kinase 1/0.502
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.501
1bygSTUTyrosine-protein kinase CSK/0.500
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.498
3ue4DB8Tyrosine-protein kinase ABL12.7.10.20.496
4jia1K3Tyrosine-protein kinase JAK2/0.496
4y93746Tyrosine-protein kinase/0.496
4mcv29KProto-oncogene tyrosine-protein kinase Src2.7.10.20.495
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.494
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.493
3lcdBDYMacrophage colony-stimulating factor 1 receptor2.7.10.10.493
2of4979Tyrosine-protein kinase Lck2.7.10.20.491
4i22IREEpidermal growth factor receptor2.7.10.10.491
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.490
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.489
4ic7ANPMitogen-activated protein kinase 72.7.11.240.489
2c6eHPMAurora kinase A2.7.11.10.487
3lmgANPReceptor tyrosine-protein kinase erbB-32.7.10.10.486
3zewSTUEphrin type-B receptor 42.7.10.10.485
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.483
4cd0AWJALK tyrosine kinase receptor2.7.10.10.483
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.483
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.482
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.481
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.480
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.479
4c57FEFCyclin-G-associated kinase2.7.11.10.479
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.479
3t8oATPRhodopsin kinase/0.477
4f640S8Fibroblast growth factor receptor 1/0.477
4yuqKS1Calmodulin-like domain protein kinase/0.477
1u54ACPActivated CDC42 kinase 1/0.476
2ivuZD6Proto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.476
4hvh19RTyrosine-protein kinase JAK32.7.10.20.476
4k33ACPFibroblast growth factor receptor 32.7.10.10.476
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.475
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.474
2j0m4STFocal adhesion kinase 12.7.10.20.474
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.474
4fob0USALK tyrosine kinase receptor2.7.10.10.474
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.474
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.474
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.473
3oroAGSSerine/threonine protein kinase/0.472
4j97ACPFibroblast growth factor receptor 2/0.472
2w05FRTCyclin-dependent kinase 22.7.11.220.471
4xli1N1Abelson tyrosine-protein kinase 22.7.10.20.471
2itnANPEpidermal growth factor receptor2.7.10.10.470
2itqITQEpidermal growth factor receptor2.7.10.10.470
4riyADPEpidermal growth factor receptor2.7.10.10.470
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.470
1aq1STUCyclin-dependent kinase 22.7.11.220.469
4g1wG1WMitogen-activated protein kinase 82.7.11.240.469
4gk2L66Ephrin type-A receptor 32.7.10.10.469
4y95746Tyrosine-protein kinase/0.469
2zm1KSFTyrosine-protein kinase Lck2.7.10.20.468
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.468
2h96893Mitogen-activated protein kinase 82.7.11.240.467
2wouZZFTGF-beta receptor type-12.7.11.300.467
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.466
4nks2M2Fibroblast growth factor receptor 1/0.466
2henADPEphrin type-B receptor 22.7.10.10.465
2xp2VGHALK tyrosine kinase receptor2.7.10.10.465
2zva1N1Tyrosine-protein kinase Lyn2.7.10.20.465
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.465
3uvqFS8Mitogen-activated protein kinase 14/0.465
4c62XWWTyrosine-protein kinase JAK2/0.465
4erwSTUCyclin-dependent kinase 22.7.11.220.465
4riyANPReceptor tyrosine-protein kinase erbB-32.7.10.10.465
2c0oL2GTyrosine-protein kinase HCK2.7.10.20.464
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.464
2vwu7X1Ephrin type-B receptor 42.7.10.10.464
3zh8C58Protein kinase C iota type2.7.11.130.464
4gk4L90Ephrin type-A receptor 32.7.10.10.464
2fvdLIACyclin-dependent kinase 22.7.11.220.463
2hog710Serine/threonine-protein kinase Chk12.7.11.10.463
2j7t274Serine/threonine-protein kinase 102.7.11.10.463
5auwQUEDeath-associated protein kinase 12.7.11.10.463
2of2547Tyrosine-protein kinase Lck2.7.10.20.462
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.462
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.462
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.462
4hvi19STyrosine-protein kinase JAK32.7.10.20.462
2vu3LZECyclin-dependent kinase 22.7.11.220.461
4anqVGHALK tyrosine kinase receptor2.7.10.10.461
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.460
2gcdSTUSerine/threonine-protein kinase TAO22.7.11.10.460
3gc9B45Mitogen-activated protein kinase 112.7.11.240.460
3nwxKVSGag-Pol polyprotein3.4.23.160.460
3vjoANPEpidermal growth factor receptor2.7.10.10.460
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.460
4jbqVX6Aurora kinase A2.7.11.10.460
2hk51BMTyrosine-protein kinase HCK2.7.10.20.459
4mxoDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.459
4otwDB8Receptor tyrosine-protein kinase erbB-32.7.10.10.459
5aaaVGHALK tyrosine kinase receptor2.7.10.10.459
2xvdAS6Ephrin type-B receptor 42.7.10.10.458
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.458
4ansVGHALK tyrosine kinase receptor2.7.10.10.458
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.458
1pmn984Mitogen-activated protein kinase 102.7.11.240.457
3t113T1Gag-Pol polyprotein3.4.23.160.457
3ttjJBIMitogen-activated protein kinase 102.7.11.240.457
2x9fX9FEphrin type-B receptor 42.7.10.10.456
2y6o1N1Ephrin type-A receptor 42.7.10.10.456
3nwq2NCGag-Pol polyprotein3.4.23.160.456
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.456
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.456
4e730NRMitogen-activated protein kinase 82.7.11.240.456
4wkqIREEpidermal growth factor receptor2.7.10.10.456
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.455
2itzIREEpidermal growth factor receptor2.7.10.10.455
2j0lANPFocal adhesion kinase 12.7.10.20.455
4k181OBSerine/threonine-protein kinase pim-12.7.11.10.455
4mxxDB8Proto-oncogene tyrosine-protein kinase Src2.7.10.20.455
5e8xSTUTGF-beta receptor type-12.7.11.300.455
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.454
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.454
2ycsNXPSerine/threonine-protein kinase Chk22.7.11.10.454
3tkh07SSerine/threonine-protein kinase Chk12.7.11.10.454
4bcmT7ZCyclin-dependent kinase 22.7.11.220.454
4gk3L87Ephrin type-A receptor 32.7.10.10.454
4jrvKJVEpidermal growth factor receptor2.7.10.10.454
4xey1N1Tyrosine-protein kinase ABL12.7.10.20.454
1wvxBD4Death-associated protein kinase 12.7.11.10.453
2eb3ANPEpidermal growth factor receptor2.7.10.10.453
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.453
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.453
4hjoAQ4Epidermal growth factor receptor2.7.10.10.453
4hyu1BKMitogen-activated protein kinase 82.7.11.240.453
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.452
2wotZZGTGF-beta receptor type-12.7.11.300.452
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.452
2xa4AZ5Tyrosine-protein kinase JAK2/0.451
3oom507Activin receptor type-12.7.11.300.451
3ormAGSSerine/threonine protein kinase/0.451
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.451
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.451
5e8wSTUTGF-beta receptor type-12.7.11.300.451
2yn8STUEphrin type-B receptor 42.7.10.10.450
3mtfA3FActivin receptor type-12.7.11.300.450
3zlyYSODual specificity mitogen-activated protein kinase kinase 12.7.12.20.450
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.450
2py3ACPFibroblast growth factor receptor 2/0.449
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.449
2zv9PP2Tyrosine-protein kinase Lyn2.7.10.20.449
3gubGUBDeath-associated protein kinase 12.7.11.10.449
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.449
4w9wYDJBMP-2-inducible protein kinase2.7.11.10.449
5dr9SKEAurora kinase A2.7.11.10.449
2itpAEEEpidermal growth factor receptor2.7.10.10.448
2qoqANPEphrin type-A receptor 32.7.10.10.448
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
4anmWULCasein kinase II subunit alpha2.7.11.10.448
4fv9E71Mitogen-activated protein kinase 12.7.11.240.448
4gu94GUFocal adhesion kinase 12.7.10.20.448
4jq7KJQEpidermal growth factor receptor2.7.10.10.448
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
3igoANPCalmodulin-domain protein kinase 1, putative/0.447
3rkb12ZCyclin-dependent kinase 22.7.11.220.447
3zep1NXTyrosine-protein kinase JAK32.7.10.20.447
4bi0Z0WDual specificity protein kinase TTK2.7.12.10.447
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.447
1py5PY1TGF-beta receptor type-12.7.11.300.446
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.446
4m69ANPReceptor-interacting serine/threonine-protein kinase 32.7.11.10.446
4o0uADNAurora kinase A2.7.11.10.446
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.446
1dkfBMSRetinoic acid receptor alpha/0.445
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.445
2ghmLICMitogen-activated protein kinase 14/0.445
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.445
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.445
3r9dX6BCyclin-dependent kinase 22.7.11.220.445
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4jlcSU6Serine/threonine-protein kinase TBK12.7.11.10.445
1rw8580TGF-beta receptor type-12.7.11.300.444
1zyjBI5Mitogen-activated protein kinase 14/0.444
3ac5KZMTyrosine-protein kinase Lck2.7.10.20.444
3axwTIDCasein kinase II subunit alpha2.7.11.10.444
4ftjH8KSerine/threonine-protein kinase Chk12.7.11.10.444
4hvg19QTyrosine-protein kinase JAK32.7.10.20.444
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.444
2ittAEEEpidermal growth factor receptor2.7.10.10.443
3hx4ANPCalmodulin-domain protein kinase 1/0.443
4c61LMMTyrosine-protein kinase JAK2/0.443
6cp4CAMCamphor 5-monooxygenase1.14.15.10.443
1xjdSTUProtein kinase C theta type2.7.11.130.442
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.442
2pvlP55Casein kinase II subunit alpha2.7.11.10.442
2yfxVGHALK tyrosine kinase receptor2.7.10.10.442
3gxlQIGTGF-beta receptor type-12.7.11.300.442
4c4g7RODual specificity protein kinase TTK2.7.12.10.442
4c4h7RODual specificity protein kinase TTK2.7.12.10.442
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.442
4jboWPHAurora kinase A2.7.11.10.442
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.10.442
1oecAA2Fibroblast growth factor receptor 2/0.441
2izrBRKCasein kinase I isoform gamma-32.7.11.10.441
2wmsZYSSerine/threonine-protein kinase Chk12.7.11.10.441
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.441
3eb0DRKUncharacterized protein/0.441
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.441
3uvp048Mitogen-activated protein kinase 14/0.441
4dk50KOPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4jbpYPHAurora kinase A2.7.11.10.441
5auxKMPDeath-associated protein kinase 12.7.11.10.441
3uzcT4EAdenosine receptor A2a/0.441
2wqeADPAurora kinase A2.7.11.10.440
3a7hATPSerine/threonine-protein kinase 242.7.11.10.440
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.440
3ggfGVDSerine/threonine-protein kinase 26/0.440
3gu6ADPDeath-associated protein kinase 12.7.11.10.440
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.440
4nj32KDCyclin-dependent kinase 22.7.11.220.440