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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
3owk18ECasein kinase II subunit alpha2.7.11.1

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
3owk18ECasein kinase II subunit alpha2.7.11.11.000
1lp4ANPCasein kinase II subunit alpha2.7.11.10.609
3at3ATKCasein kinase II subunit alpha2.7.11.10.606
3be9P04Casein kinase II subunit alpha2.7.11.10.592
5cvhADPCasein kinase II subunit alpha2.7.11.10.587
3u4uLNHCasein kinase II subunit alpha2.7.11.10.586
3q9xEMOCasein kinase II subunit alpha2.7.11.10.584
2pvlP55Casein kinase II subunit alpha2.7.11.10.582
4dgmAGICasein kinase II subunit alpha2.7.11.10.577
4dgo0JWCasein kinase II subunit alpha2.7.11.10.569
4anmWULCasein kinase II subunit alpha2.7.11.10.563
5cshATPCasein kinase II subunit alpha2.7.11.10.562
4grb0XGCasein kinase II subunit alpha2.7.11.10.560
3nga3NGCasein kinase II subunit alpha2.7.11.10.558
3wowANPCasein kinase II subunit alpha2.7.11.10.558
2pvnP63Casein kinase II subunit alpha2.7.11.10.557
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.551
4gub0Y4Casein kinase II subunit alpha2.7.11.10.551
3at4CCKCasein kinase II subunit alpha2.7.11.10.548
3owj1ELCasein kinase II subunit alpha2.7.11.10.543
5cu6ATPCasein kinase II subunit alpha2.7.11.10.543
4dgnLU2Casein kinase II subunit alpha2.7.11.10.541
3axwTIDCasein kinase II subunit alpha2.7.11.10.538
4jqeANPCasein kinase II subunit alpha2.7.11.10.538
1m2qMNXCasein kinase II subunit alpha2.7.11.10.537
4jr7GNPCasein kinase II subunit alpha2.7.11.10.524
1m2rMNYCasein kinase II subunit alpha2.7.11.10.523
3r0tFU9Casein kinase II subunit alpha2.7.11.10.521
1dayGNPCasein kinase II subunit alpha2.7.11.10.515
1dawANPCasein kinase II subunit alpha2.7.11.10.514
3owl19ECasein kinase II subunit alpha2.7.11.10.511
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.509
3pe13NGCasein kinase II subunit alpha2.7.11.10.507
1m2pHNACasein kinase II subunit alpha2.7.11.10.506
3pe2E1BCasein kinase II subunit alpha2.7.11.10.506
1om1IQACasein kinase II subunit alpha2.7.11.10.505
3q9zTXQCasein kinase II subunit alpha2.7.11.10.505
4mwhATPCasein kinase II subunit alpha2.7.11.10.498
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.493
4fi1ATPCasein kinase II subunit alpha2.7.11.10.492
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.491
3vt9YI4Vitamin D3 receptor/0.489
2zjwREFCasein kinase II subunit alpha2.7.11.10.487
3nszANPCasein kinase II subunit alpha2.7.11.10.487
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.486
4ez50RSCyclin-dependent kinase 62.7.11.220.484
1y0s331Peroxisome proliferator-activated receptor delta/0.482
4neuQ1AReceptor-interacting serine/threonine-protein kinase 12.7.11.10.481
4lfiGNPCasein kinase II subunit alpha2.7.11.10.476
3sp9IL2Peroxisome proliferator-activated receptor delta/0.474
4bcoT6QCyclin-dependent kinase 22.7.11.220.473
1oi9N20Cyclin-dependent kinase 22.7.11.220.471
2znpK55Peroxisome proliferator-activated receptor delta/0.470
2iw94SPCyclin-dependent kinase 22.7.11.220.469
3uli1N3Cyclin-dependent kinase 22.7.11.220.469
3vt8YI3Vitamin D3 receptor/0.469
2btsU32Cyclin-dependent kinase 22.7.11.220.467
3amyAGICasein kinase II subunit alpha2.7.11.10.467
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.467
1di8DTQCyclin-dependent kinase 22.7.11.220.466
2pvjP44Casein kinase II subunit alpha2.7.11.10.466
3mb601ICasein kinase II subunit alpha2.7.11.10.465
3r3f4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.465
2pvrANPCasein kinase II subunit alpha2.7.11.10.464
4eop1ROCyclin-dependent kinase 22.7.11.220.464
3ddpRC8Cyclin-dependent kinase 22.7.11.220.463
4eon1ROCyclin-dependent kinase 22.7.11.220.463
2iw84SPCyclin-dependent kinase 22.7.11.220.462
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.462
1gij2PUCyclin-dependent kinase 22.7.11.220.461
2dwbANPAurora kinase A2.7.11.10.461
3q9yTXQCasein kinase II subunit alpha2.7.11.10.461
4hle17VPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.461
1h1q2A6Cyclin-dependent kinase 22.7.11.220.460
1oguST8Cyclin-dependent kinase 22.7.11.220.460
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.460
4bcrWY1Peroxisome proliferator-activated receptor alpha/0.460
2w05FRTCyclin-dependent kinase 22.7.11.220.459
4i8vBHFCytochrome P450 1A11.14.14.10.459
3ral04ZCyclin-dependent kinase 22.7.11.220.458
4i3wNADAldehyde dehydrogenase (NAD+)/0.458
1e9hINRCyclin-dependent kinase 22.7.11.220.457
1urwI1PCyclin-dependent kinase 22.7.11.220.457
5cvfATPCasein kinase II subunit alpha2.7.11.10.457
1h1r6CPCyclin-dependent kinase 22.7.11.220.456
1oiuN76Cyclin-dependent kinase 22.7.11.220.456
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.456
3rmf20ZCyclin-dependent kinase 22.7.11.220.456
4bcmT7ZCyclin-dependent kinase 22.7.11.220.456
5drdATPAurora kinase A2.7.11.10.456
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.455
2znq401Peroxisome proliferator-activated receptor delta/0.455
4bchT7ZCyclin-dependent kinase 92.7.11.220.455
1e7vLY2Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
3ma301ISerine/threonine-protein kinase pim-12.7.11.10.454
3w1f1O5Dual specificity protein kinase TTK2.7.12.10.454
4h9814QUncharacterized protein/0.454
3rpv26ZCyclin-dependent kinase 22.7.11.220.453
1oiyN41Cyclin-dependent kinase 22.7.11.220.452
1uv5BRWGlycogen synthase kinase-3 beta2.7.11.260.452
2j0j4STFocal adhesion kinase 12.7.10.20.452
3pm0BHFCytochrome P450 1B1/0.452
1ckpPVBCyclin-dependent kinase 22.7.11.220.451
1vzdCB3Thymidylate synthase/0.451
3gwfNAPCyclohexanone monooxygenase/0.451
3qqkX02Cyclin-dependent kinase 22.7.11.220.451
4cd2FOLDihydrofolate reductase1.5.1.30.451
4eok4SPCyclin-dependent kinase 22.7.11.220.451
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.450
3r9dX6BCyclin-dependent kinase 22.7.11.220.450
4bcpT3CCyclin-dependent kinase 22.7.11.220.450
4y12AGSSerine/threonine-protein kinase PknG2.7.11.10.449
1ke6LS2Cyclin-dependent kinase 22.7.11.220.448
2bdjHETProto-oncogene tyrosine-protein kinase Src2.7.10.20.448
2izsBRQCasein kinase I isoform gamma-32.7.11.10.448
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.448
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.448
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.448
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.448
4fjz4FJPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4flh14KPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4jajXU1Aurora kinase A2.7.11.10.448
1j91TBSCasein kinase II subunit alpha2.7.11.10.447
1xddAAYIntegrin alpha-L/0.447
2b9wFADPutative aminooxidase/0.447
2f2cAP9Cyclin-dependent kinase 62.7.11.220.447
2zb45OPProstaglandin reductase 21.3.1.480.447
3a99ANPSerine/threonine-protein kinase pim-12.7.11.10.447
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.447
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.447
1h1pCMGCyclin-dependent kinase 22.7.11.220.446
1pkdUCNCyclin-dependent kinase 22.7.11.220.446
1v1k3FPCyclin-dependent kinase 22.7.11.220.446
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.446
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.446
4eol1ROCyclin-dependent kinase 22.7.11.220.446
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.446
4ure1PSCyclohexanol dehydrogenase/0.446
1g67TZPThiamine-phosphate synthase/0.445
2b55D31Cyclin-dependent kinase 22.7.11.220.445
2bdf24AProto-oncogene tyrosine-protein kinase Src2.7.10.20.445
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.445
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.445
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.445
4eoi1ROCyclin-dependent kinase 22.7.11.220.445
1g6cTZPThiamine-phosphate synthase/0.444
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.444
2pvmP29Casein kinase II subunit alpha2.7.11.10.444
3l08ZIGPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
3nup3NUCyclin-dependent kinase 62.7.11.220.444
3th8TH9Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.444
3vt7VDXVitamin D3 receptor/0.444
4hgt15GCasein kinase I isoform delta2.7.11.10.444
5dt4ATPAurora kinase A2.7.11.10.444
1zgaHMKIsoflavone 4'-O-methyltransferase/0.443
3r1sX73Cyclin-dependent kinase 22.7.11.220.443
3sqq99ZCyclin-dependent kinase 22.7.11.220.443
1g6cIFPThiamine-phosphate synthase/0.442
2c4g514Cyclin-dependent kinase 22.7.11.220.442
3s0o50ZCyclin-dependent kinase 22.7.11.220.442
4eos1ROCyclin-dependent kinase 22.7.11.220.442
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.442
5e8ySTUTGF-beta receptor type-22.7.11.300.442
1ia3TQ5Dihydrofolate reductase1.5.1.30.441
2hasC3OVitamin D3 receptor/0.441
3r3b4CO4-hydroxybenzoyl-CoA thioesterase3.1.2.230.441
3rukAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.441
3s2a2NQPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
3um5CP6Bifunctional dihydrofolate reductase-thymidylate synthase/0.441
4afjSJJGlycogen synthase kinase-3 beta2.7.11.260.441
4ezl0SEPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.441
4ix6ADPUncharacterized protein/0.441
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.441
3hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.440
3vrwYS5Vitamin D3 receptor/0.440
4at3LTIBDNF/NT-3 growth factors receptor2.7.10.10.440
4cfnJYMCyclin-dependent kinase 22.7.11.220.440
4mf029ZTyrosine-protein kinase ITK/TSK2.7.10.20.440
4y8wSTRSteroid 21-hydroxylase/0.440