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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2w06FRVCyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2w06FRVCyclin-dependent kinase 22.7.11.221.000
4fkj11KCyclin-dependent kinase 22.7.11.220.607
3sw418KCyclin-dependent kinase 22.7.11.220.595
4acm7YGCyclin-dependent kinase 22.7.11.220.584
3rmf20ZCyclin-dependent kinase 22.7.11.220.574
4fkq42KCyclin-dependent kinase 22.7.11.220.569
4fkr45KCyclin-dependent kinase 22.7.11.220.557
3qtzX42Cyclin-dependent kinase 22.7.11.220.554
2a0cCK9Cyclin-dependent kinase 22.7.11.220.551
3ral04ZCyclin-dependent kinase 22.7.11.220.550
1pxmCK5Cyclin-dependent kinase 22.7.11.220.548
3qzgX67Cyclin-dependent kinase 22.7.11.220.548
2btsU32Cyclin-dependent kinase 22.7.11.220.545
3rak03ZCyclin-dependent kinase 22.7.11.220.544
1ke6LS2Cyclin-dependent kinase 22.7.11.220.542
3ig7EFPCyclin-dependent kinase 22.7.11.220.542
3qu0X40Cyclin-dependent kinase 22.7.11.220.542
4fkt48KCyclin-dependent kinase 22.7.11.220.542
3iggEFQCyclin-dependent kinase 22.7.11.220.540
3sqq99ZCyclin-dependent kinase 22.7.11.220.539
4fkg4CKCyclin-dependent kinase 22.7.11.220.539
3qtxX43Cyclin-dependent kinase 22.7.11.220.538
1urwI1PCyclin-dependent kinase 22.7.11.220.535
3r8lZ30Cyclin-dependent kinase 22.7.11.220.535
3r9dX6BCyclin-dependent kinase 22.7.11.220.535
2c6o4SPCyclin-dependent kinase 22.7.11.220.533
2r3lSCWCyclin-dependent kinase 22.7.11.220.533
3s1h56ZCyclin-dependent kinase 22.7.11.220.533
3unk0BYCyclin-dependent kinase 22.7.11.220.533
3lfnA27Cyclin-dependent kinase 22.7.11.220.531
3qxoX65Cyclin-dependent kinase 22.7.11.220.530
3rk507ZCyclin-dependent kinase 22.7.11.220.529
3s0o50ZCyclin-dependent kinase 22.7.11.220.529
2r64740Cyclin-dependent kinase 22.7.11.220.527
1h0w207Cyclin-dependent kinase 22.7.11.220.525
3r7yZ04Cyclin-dependent kinase 22.7.11.220.525
3r83Z14Cyclin-dependent kinase 22.7.11.220.525
3rk708ZCyclin-dependent kinase 22.7.11.220.525
4fko20KCyclin-dependent kinase 22.7.11.220.525
3pj8404Cyclin-dependent kinase 22.7.11.220.524
3rni21ZCyclin-dependent kinase 22.7.11.220.524
4fkpLS5Cyclin-dependent kinase 22.7.11.220.524
4fkv61KCyclin-dependent kinase 22.7.11.220.524
1ke5LS1Cyclin-dependent kinase 22.7.11.220.523
1oirHDYCyclin-dependent kinase 22.7.11.220.522
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.522
2uzoC62Cyclin-dependent kinase 22.7.11.220.521
3ezvEZVCyclin-dependent kinase 22.7.11.220.521
3qzhX69Cyclin-dependent kinase 22.7.11.220.521
3unj0BXCyclin-dependent kinase 22.7.11.220.521
3rjc06ZCyclin-dependent kinase 22.7.11.220.520
1ke7LS3Cyclin-dependent kinase 22.7.11.220.518
3r1sX73Cyclin-dependent kinase 22.7.11.220.518
3s2pPMUCyclin-dependent kinase 22.7.11.220.518
3qtuX44Cyclin-dependent kinase 22.7.11.220.517
2b53D23Cyclin-dependent kinase 22.7.11.220.516
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.516
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.515
4ek816KCyclin-dependent kinase 22.7.11.220.515
1oiyN41Cyclin-dependent kinase 22.7.11.220.514
3rpy27ZCyclin-dependent kinase 22.7.11.220.514
4fki09KCyclin-dependent kinase 22.7.11.220.514
1w0xOLOCyclin-dependent kinase 22.7.11.220.512
2r3kSCQCyclin-dependent kinase 22.7.11.220.511
3sw719KCyclin-dependent kinase 22.7.11.220.509
4ez30S0Cyclin-dependent kinase 22.7.11.220.508
1oi9N20Cyclin-dependent kinase 22.7.11.220.507
1v1k3FPCyclin-dependent kinase 22.7.11.220.507
2fvdLIACyclin-dependent kinase 22.7.11.220.507
3rpv26ZCyclin-dependent kinase 22.7.11.220.507
1gih1PUCyclin-dependent kinase 22.7.11.220.505
3rm719ZCyclin-dependent kinase 22.7.11.220.505
4bgh3I6Cyclin-dependent kinase 22.7.11.220.505
1p2a5BNCyclin-dependent kinase 22.7.11.220.504
3qqfX07Cyclin-dependent kinase 22.7.11.220.504
3r7iX9ICyclin-dependent kinase 22.7.11.220.504
1gii1PUCyclin-dependent kinase 22.7.11.220.503
2vthLZ2Cyclin-dependent kinase 22.7.11.220.503
3r9hZ67Cyclin-dependent kinase 22.7.11.220.503
2w1hL0FCyclin-dependent kinase 22.7.11.220.502
2iw84SPCyclin-dependent kinase 22.7.11.220.501
2xmyCDKCyclin-dependent kinase 22.7.11.220.501
1ke8LS4Cyclin-dependent kinase 22.7.11.220.500
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.500
1e1xNW1Cyclin-dependent kinase 22.7.11.220.499
3roy22ZCyclin-dependent kinase 22.7.11.220.498
1h1r6CPCyclin-dependent kinase 22.7.11.220.497
3r7uX96Cyclin-dependent kinase 22.7.11.220.497
1ke9LS5Cyclin-dependent kinase 22.7.11.220.496
3ezrEZRCyclin-dependent kinase 22.7.11.220.495
3dogNNNCyclin-dependent kinase 22.7.11.220.493
1oitHDTCyclin-dependent kinase 22.7.11.220.492
2vttLZDCyclin-dependent kinase 22.7.11.220.492
3rk909ZCyclin-dependent kinase 22.7.11.220.492
1di8DTQCyclin-dependent kinase 22.7.11.220.491
3ddpRC8Cyclin-dependent kinase 22.7.11.220.491
1oguST8Cyclin-dependent kinase 22.7.11.220.490
3r73X87Cyclin-dependent kinase 22.7.11.220.490
4ek610KCyclin-dependent kinase 22.7.11.220.490
4fkw62KCyclin-dependent kinase 22.7.11.220.489
3raiX85Cyclin-dependent kinase 22.7.11.220.487
4fks46KCyclin-dependent kinase 22.7.11.220.487
1vyzN5BCyclin-dependent kinase 22.7.11.220.486
1pxoCK7Cyclin-dependent kinase 22.7.11.220.485
1vyw292Cyclin-dependent kinase 22.7.11.220.485
2a4lRRCCyclin-dependent kinase 22.7.11.220.485
2w05FRTCyclin-dependent kinase 22.7.11.220.485
3r28XA0Cyclin-dependent kinase 22.7.11.220.485
2r3jSCJCyclin-dependent kinase 22.7.11.220.484
3rpo24ZCyclin-dependent kinase 22.7.11.220.484
1ykr628Cyclin-dependent kinase 22.7.11.220.483
3qxpX64Cyclin-dependent kinase 22.7.11.220.483
3r1yX76Cyclin-dependent kinase 22.7.11.220.483
1pxlCK4Cyclin-dependent kinase 22.7.11.220.482
3qqkX02Cyclin-dependent kinase 22.7.11.220.482
2r3p3SCCyclin-dependent kinase 22.7.11.220.481
3r6xX84Cyclin-dependent kinase 22.7.11.220.481
3lfqA28Cyclin-dependent kinase 22.7.11.220.480
3ti1B49Cyclin-dependent kinase 22.7.11.220.479
1b38ATPCyclin-dependent kinase 22.7.11.220.478
1g5sI17Cyclin-dependent kinase 22.7.11.220.478
2w17I19Cyclin-dependent kinase 22.7.11.220.478
3r7vZ02Cyclin-dependent kinase 22.7.11.220.478
1ckpPVBCyclin-dependent kinase 22.7.11.220.477
3wblPDYCyclin-dependent kinase 22.7.11.220.477
2bhhRYUCyclin-dependent kinase 22.7.11.220.476
2duv371Cyclin-dependent kinase 22.7.11.220.476
3qruX19Cyclin-dependent kinase 22.7.11.220.475
1h1s4SPCyclin-dependent kinase 22.7.11.220.474
3r8vZ62Cyclin-dependent kinase 22.7.11.220.473
3rahO1ZCyclin-dependent kinase 22.7.11.220.473
1fvt106Cyclin-dependent kinase 22.7.11.220.472
3rm618ZCyclin-dependent kinase 22.7.11.220.472
2btrU73Cyclin-dependent kinase 22.7.11.220.471
2exmZIPCyclin-dependent kinase 22.7.11.220.471
3qx2X63Cyclin-dependent kinase 22.7.11.220.471
2r3mSCXCyclin-dependent kinase 22.7.11.220.470
3ddqRRCCyclin-dependent kinase 22.7.11.220.470
3qqlX03Cyclin-dependent kinase 22.7.11.220.470
4lyn1YGCyclin-dependent kinase 22.7.11.220.470
2iw94SPCyclin-dependent kinase 22.7.11.220.469
3r71X86Cyclin-dependent kinase 22.7.11.220.469
1w8cN69Cyclin-dependent kinase 22.7.11.220.468
2b55D31Cyclin-dependent kinase 22.7.11.220.468
3py0SU9Cyclin-dependent kinase 22.7.11.220.468
3ql8X01Cyclin-dependent kinase 22.7.11.220.468
3r1qX75Cyclin-dependent kinase 22.7.11.220.467
4eor4SPCyclin-dependent kinase 22.7.11.220.467
1pxpCK8Cyclin-dependent kinase 22.7.11.220.466
3qqhX0ACyclin-dependent kinase 22.7.11.220.466
3qwjX6ACyclin-dependent kinase 22.7.11.220.466
2vu3LZECyclin-dependent kinase 22.7.11.220.465
3qtrX36Cyclin-dependent kinase 22.7.11.220.465
3r9oZ71Cyclin-dependent kinase 22.7.11.220.464
4eon1ROCyclin-dependent kinase 22.7.11.220.462
1unlRRCCyclin-dependent-like kinase 52.7.11.10.460
3fz1B98Cyclin-dependent kinase 22.7.11.220.460
3r7eX88Cyclin-dependent kinase 22.7.11.220.460
2uznC96Cyclin-dependent kinase 22.7.11.220.459
2c6iDT1Cyclin-dependent kinase 22.7.11.220.458
2vv9IM9Cyclin-dependent kinase 22.7.11.220.458
4fx360KCyclin-dependent kinase 22.7.11.220.458
2j9mPY8Cyclin-dependent kinase 22.7.11.220.456
2c5yMTWCyclin-dependent kinase 22.7.11.220.454
1oiuN76Cyclin-dependent kinase 22.7.11.220.453
2bheBRYCyclin-dependent kinase 22.7.11.220.453
2vtnLZ7Cyclin-dependent kinase 22.7.11.220.453
1fvv107Cyclin-dependent kinase 22.7.11.220.451
2c6lDT4Cyclin-dependent kinase 22.7.11.220.451
2r3iSCFCyclin-dependent kinase 22.7.11.220.451
3pxyJWSCyclin-dependent kinase 22.7.11.220.451
4fklCK2Cyclin-dependent kinase 22.7.11.220.450
1y8yCT7Cyclin-dependent kinase 22.7.11.220.449
2wxvWXVCyclin-dependent kinase 22.7.11.220.449
3lfsA07Cyclin-dependent kinase 22.7.11.220.449
3uli1N3Cyclin-dependent kinase 22.7.11.220.449
2c5nCK8Cyclin-dependent kinase 22.7.11.220.448
3qziX72Cyclin-dependent kinase 22.7.11.220.445
3rkb12ZCyclin-dependent kinase 22.7.11.220.445
1oiqHDUCyclin-dependent kinase 22.7.11.220.444
2wpa889Cyclin-dependent kinase 22.7.11.220.444
3r9nZ68Cyclin-dependent kinase 22.7.11.220.444
4bcpT3CCyclin-dependent kinase 22.7.11.220.443
3tiz3TICyclin-dependent kinase 22.7.11.220.442
4qmpDKISerine/threonine-protein kinase 242.7.11.10.442
2b52D42Cyclin-dependent kinase 22.7.11.220.441
1r78FMDCyclin-dependent kinase 22.7.11.220.440
2c6kDT2Cyclin-dependent kinase 22.7.11.220.440
4aua4AUCyclin-dependent kinase 62.7.11.220.440