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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.17

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.171.000
2w05FRTCyclin-dependent kinase 22.7.11.220.526
3be9P04Casein kinase II subunit alpha2.7.11.10.523
2pvnP63Casein kinase II subunit alpha2.7.11.10.511
3le62BZCyclin-dependent kinase 22.7.11.220.511
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.510
1aq1STUCyclin-dependent kinase 22.7.11.220.507
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.507
1y91CT9Cyclin-dependent kinase 22.7.11.220.506
4dgnLU2Casein kinase II subunit alpha2.7.11.10.506
2x1nX1NCyclin-dependent kinase 22.7.11.220.502
4dgo0JWCasein kinase II subunit alpha2.7.11.10.498
4erwSTUCyclin-dependent kinase 22.7.11.220.496
2pvhP19Casein kinase II subunit alpha2.7.11.10.495
1gih1PUCyclin-dependent kinase 22.7.11.220.492
3lfqA28Cyclin-dependent kinase 22.7.11.220.492
1g5sI17Cyclin-dependent kinase 22.7.11.220.491
1oirHDYCyclin-dependent kinase 22.7.11.220.491
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.488
3lfnA27Cyclin-dependent kinase 22.7.11.220.486
3r9dX6BCyclin-dependent kinase 22.7.11.220.486
4dgmAGICasein kinase II subunit alpha2.7.11.10.486
2bheBRYCyclin-dependent kinase 22.7.11.220.485
4jqeANPCasein kinase II subunit alpha2.7.11.10.484
1om1IQACasein kinase II subunit alpha2.7.11.10.483
2xikJ60Serine/threonine-protein kinase 252.7.11.10.483
3sheI85MAP kinase-activated protein kinase 32.7.11.10.483
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.483
1pxoCK7Cyclin-dependent kinase 22.7.11.220.480
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.480
2uzeC95Cyclin-dependent kinase 22.7.11.220.479
4anmWULCasein kinase II subunit alpha2.7.11.10.479
4ek816KCyclin-dependent kinase 22.7.11.220.478
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.477
2btsU32Cyclin-dependent kinase 22.7.11.220.476
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.476
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.476
2a0cCK9Cyclin-dependent kinase 22.7.11.220.475
2pvlP55Casein kinase II subunit alpha2.7.11.10.475
4fkv61KCyclin-dependent kinase 22.7.11.220.474
4gub0Y4Casein kinase II subunit alpha2.7.11.10.474
4e4m0NHTyrosine-protein kinase JAK2/0.473
2r3jSCJCyclin-dependent kinase 22.7.11.220.472
2r64740Cyclin-dependent kinase 22.7.11.220.472
4g170VNCasein kinase I isoform gamma-32.7.11.10.472
3gubGUBDeath-associated protein kinase 12.7.11.10.471
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.471
2uznC96Cyclin-dependent kinase 22.7.11.220.470
4iwd1JCHepatocyte growth factor receptor2.7.10.10.470
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.469
2c5nCK8Cyclin-dependent kinase 22.7.11.220.469
1xjdSTUProtein kinase C theta type2.7.11.130.468
2c6tDT5Cyclin-dependent kinase 22.7.11.220.468
2iw94SPCyclin-dependent kinase 22.7.11.220.468
4fkg4CKCyclin-dependent kinase 22.7.11.220.468
4l521ULMitogen-activated protein kinase kinase kinase 72.7.11.250.468
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.467
4fkt48KCyclin-dependent kinase 22.7.11.220.467
4ek610KCyclin-dependent kinase 22.7.11.220.466
1m2pHNACasein kinase II subunit alpha2.7.11.10.465
1m2rMNYCasein kinase II subunit alpha2.7.11.10.465
3rmf20ZCyclin-dependent kinase 22.7.11.220.465
3uli1N3Cyclin-dependent kinase 22.7.11.220.465
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.465
2btrU73Cyclin-dependent kinase 22.7.11.220.464
2vttLZDCyclin-dependent kinase 22.7.11.220.464
2x2lX2LProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.464
1gii1PUCyclin-dependent kinase 22.7.11.220.463
2uzbC75Cyclin-dependent kinase 22.7.11.220.463
2vu3LZECyclin-dependent kinase 22.7.11.220.463
1pxlCK4Cyclin-dependent kinase 22.7.11.220.462
2dwbANPAurora kinase A2.7.11.10.462
2j9mPY8Cyclin-dependent kinase 22.7.11.220.462
3nynSGVG protein-coupled receptor kinase 62.7.11.160.462
4hvh19RTyrosine-protein kinase JAK32.7.10.20.462
3rni21ZCyclin-dependent kinase 22.7.11.220.461
3s2pPMUCyclin-dependent kinase 22.7.11.220.461
1u59STUTyrosine-protein kinase ZAP-702.7.10.20.460
3ormAGSSerine/threonine protein kinase/0.460
1e9hINRCyclin-dependent kinase 22.7.11.220.459
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.459
4g160VMCasein kinase I isoform gamma-32.7.11.10.459
1u4dDBQActivated CDC42 kinase 1/0.457
2ds11CDCyclin-dependent kinase 22.7.11.220.457
3rk708ZCyclin-dependent kinase 22.7.11.220.457
4bcoT6QCyclin-dependent kinase 22.7.11.220.457
1h1s4SPCyclin-dependent kinase 22.7.11.220.456
2e9uA25Serine/threonine-protein kinase Chk12.7.11.10.456
2w1hL0FCyclin-dependent kinase 22.7.11.220.456
3rvg17PTyrosine-protein kinase JAK2/0.456
3s1h56ZCyclin-dependent kinase 22.7.11.220.456
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.456
1oiyN41Cyclin-dependent kinase 22.7.11.220.455
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.455
2e9n76ASerine/threonine-protein kinase Chk12.7.11.10.455
3v8t477Tyrosine-protein kinase ITK/TSK2.7.10.20.455
1h1r6CPCyclin-dependent kinase 22.7.11.220.454
2vuw5IDSerine/threonine-protein kinase haspin2.7.11.10.454
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.454
3r83Z14Cyclin-dependent kinase 22.7.11.220.454
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.454
4ez50RSCyclin-dependent kinase 62.7.11.220.454
3m42HGFMAP kinase-activated protein kinase 22.7.11.10.453
3rk507ZCyclin-dependent kinase 22.7.11.220.453
4hge15VTyrosine-protein kinase JAK2/0.453
1v1k3FPCyclin-dependent kinase 22.7.11.220.452
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.452
3ezvEZVCyclin-dependent kinase 22.7.11.220.452
4acm7YGCyclin-dependent kinase 22.7.11.220.452
1m2qMNXCasein kinase II subunit alpha2.7.11.10.451
1oguST8Cyclin-dependent kinase 22.7.11.220.451
2cchATPCyclin-dependent kinase 22.7.11.220.451
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.451
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.451
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.451
3hztJ60Calmodulin-like domain protein kinase isoform 3/0.451
3rpv26ZCyclin-dependent kinase 22.7.11.220.451
4bgh3I6Cyclin-dependent kinase 22.7.11.220.451
4eok4SPCyclin-dependent kinase 22.7.11.220.451
4fki09KCyclin-dependent kinase 22.7.11.220.451
4grb0XGCasein kinase II subunit alpha2.7.11.10.451
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.451
1eh4IC1Casein kinase I homolog 12.7.11.10.450
1oi9N20Cyclin-dependent kinase 22.7.11.220.450
1py5PY1TGF-beta receptor type-12.7.11.300.450
2duv371Cyclin-dependent kinase 22.7.11.220.450
3axwTIDCasein kinase II subunit alpha2.7.11.10.450
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.449
2a4lRRCCyclin-dependent kinase 22.7.11.220.449
2x8iX8ISerine/threonine-protein kinase Chk12.7.11.10.449
3eyhIZATyrosine-protein kinase JAK1/0.449
3qtzX42Cyclin-dependent kinase 22.7.11.220.449
4hvi19STyrosine-protein kinase JAK32.7.10.20.449
1di8DTQCyclin-dependent kinase 22.7.11.220.448
1p4fDRGDeath-associated protein kinase 12.7.11.10.448
1pyePM1Cyclin-dependent kinase 22.7.11.220.448
2ckeIQUDeath-associated protein kinase 2/0.448
2h96893Mitogen-activated protein kinase 82.7.11.240.448
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.448
3r9oZ71Cyclin-dependent kinase 22.7.11.220.447
3vw6IM6Mitogen-activated protein kinase kinase kinase 52.7.11.250.447
4c02TAKActivin receptor type-12.7.11.300.447
1nvrSTUSerine/threonine-protein kinase Chk12.7.11.10.446
1oitHDTCyclin-dependent kinase 22.7.11.220.446
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.446
2b55D31Cyclin-dependent kinase 22.7.11.220.446
2j0m4STFocal adhesion kinase 12.7.10.20.446
3mfuANPPeripheral plasma membrane protein CASK2.7.11.10.446
4gfg0XFTyrosine-protein kinase SYK2.7.10.20.446
4jr7GNPCasein kinase II subunit alpha2.7.11.10.446
4k33ACPFibroblast growth factor receptor 32.7.10.10.446
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.446
4y93746Tyrosine-protein kinase/0.446
1ke5LS1Cyclin-dependent kinase 22.7.11.220.445
2uzoC62Cyclin-dependent kinase 22.7.11.220.445
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.445
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.445
3ezrEZRCyclin-dependent kinase 22.7.11.220.445
4fkj11KCyclin-dependent kinase 22.7.11.220.445
1pkdUCNCyclin-dependent kinase 22.7.11.220.444
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3rak03ZCyclin-dependent kinase 22.7.11.220.444
3wi6YRZMAP kinase-activated protein kinase 22.7.11.10.444
4aua4AUCyclin-dependent kinase 62.7.11.220.444
4bf2STUMitogen-activated protein kinase kinase kinase 52.7.11.250.444
4fkpLS5Cyclin-dependent kinase 22.7.11.220.444
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.444
3ddpRC8Cyclin-dependent kinase 22.7.11.220.443
3rjc06ZCyclin-dependent kinase 22.7.11.220.443
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.443
4hgs15GCasein kinase I isoform gamma-32.7.11.10.443
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.443
2b53D23Cyclin-dependent kinase 22.7.11.220.442
2iw84SPCyclin-dependent kinase 22.7.11.220.442
2vagV25Dual specificity protein kinase CLK12.7.12.10.442
3gxlQIGTGF-beta receptor type-12.7.11.300.442
3lfsA07Cyclin-dependent kinase 22.7.11.220.442
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.442
3r7yZ04Cyclin-dependent kinase 22.7.11.220.442
4aojV4ZHigh affinity nerve growth factor receptor2.7.10.10.442
4aw1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.442
4bieIE6Mitogen-activated protein kinase kinase kinase 52.7.11.250.442
4jajXU1Aurora kinase A2.7.11.10.442
1pxmCK5Cyclin-dependent kinase 22.7.11.220.441
1pxpCK8Cyclin-dependent kinase 22.7.11.220.441
2zjwREFCasein kinase II subunit alpha2.7.11.10.441
3sw719KCyclin-dependent kinase 22.7.11.220.441
4bdgP3JSerine/threonine-protein kinase Chk22.7.11.10.441
4eor4SPCyclin-dependent kinase 22.7.11.220.441
1oiuN76Cyclin-dependent kinase 22.7.11.220.440
2c5yMTWCyclin-dependent kinase 22.7.11.220.440
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.440
2vtqLZACyclin-dependent kinase 22.7.11.220.440
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.440
3i60E86Mitogen-activated protein kinase 12.7.11.240.440
3k5uPFQAurora kinase A2.7.11.10.440
3rkb12ZCyclin-dependent kinase 22.7.11.220.440
4mq22C4Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.440
5cshATPCasein kinase II subunit alpha2.7.11.10.440