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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2uzbC75Cyclin-dependent kinase 22.7.11.22

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2uzbC75Cyclin-dependent kinase 22.7.11.221.000
3my5RFZCyclin-dependent kinase 22.7.11.220.551
4bcmT7ZCyclin-dependent kinase 22.7.11.220.545
1fvv107Cyclin-dependent kinase 22.7.11.220.539
2uzdC85Cyclin-dependent kinase 22.7.11.220.534
4eooATPCyclin-dependent kinase 22.7.11.220.524
3nux3NVCyclin-dependent kinase 62.7.11.220.517
2vv9IM9Cyclin-dependent kinase 22.7.11.220.515
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.507
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.507
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.505
4ii5ADPCyclin-dependent kinase 22.7.11.220.505
1qmzATPCyclin-dependent kinase 22.7.11.220.504
2w17I19Cyclin-dependent kinase 22.7.11.220.504
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.504
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.496
2cjmATPCyclin-dependent kinase 22.7.11.220.493
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.492
2w05FRTCyclin-dependent kinase 22.7.11.220.491
3qxpX64Cyclin-dependent kinase 22.7.11.220.489
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.489
3i60E86Mitogen-activated protein kinase 12.7.11.240.488
4fv6E57Mitogen-activated protein kinase 12.7.11.240.486
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.486
2wmrZYRSerine/threonine-protein kinase Chk12.7.11.10.484
2vu3LZECyclin-dependent kinase 22.7.11.220.482
4f081RSTyrosine-protein kinase JAK2/0.481
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.480
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.480
2ckeIQUDeath-associated protein kinase 2/0.479
3eb0DRKUncharacterized protein/0.479
3at4CCKCasein kinase II subunit alpha2.7.11.10.478
3s1h56ZCyclin-dependent kinase 22.7.11.220.478
3be9P04Casein kinase II subunit alpha2.7.11.10.477
5av2KMPDeath-associated protein kinase 12.7.11.10.477
3axwTIDCasein kinase II subunit alpha2.7.11.10.475
3bqr4RBDeath-associated protein kinase 3/0.475
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.475
3rak03ZCyclin-dependent kinase 22.7.11.220.475
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.474
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.474
3lltANPProtein serine/threonine kinase-1/0.473
4dgmAGICasein kinase II subunit alpha2.7.11.10.473
1stcSTUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.471
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.470
3gu83GUDeath-associated protein kinase 12.7.11.10.470
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.469
4hge15VTyrosine-protein kinase JAK2/0.469
4jia1K3Tyrosine-protein kinase JAK2/0.469
4grb0XGCasein kinase II subunit alpha2.7.11.10.468
4ifcADPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.468
2cciATPCyclin-dependent kinase 22.7.11.220.467
4aqc88ATyrosine-protein kinase JAK2/0.467
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.466
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.466
4hvi19STyrosine-protein kinase JAK32.7.10.20.465
5cvfATPCasein kinase II subunit alpha2.7.11.10.464
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.463
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.463
4qnyANPMitogen activated protein kinase, putative/0.463
5ap7SVEDual specificity protein kinase TTK2.7.12.10.463
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.462
4ehzJAKTyrosine-protein kinase JAK1/0.461
1finATPCyclin-dependent kinase 22.7.11.220.460
3lpbNVBTyrosine-protein kinase JAK2/0.460
4e4n0NLTyrosine-protein kinase JAK1/0.460
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.459
4anmWULCasein kinase II subunit alpha2.7.11.10.458
4fk60UJTyrosine-protein kinase JAK1/0.458
4i3zADPCyclin-dependent kinase 22.7.11.220.458
4i5cC5ITyrosine-protein kinase JAK1/0.458
3rkb12ZCyclin-dependent kinase 22.7.11.220.457
4b99R4LMitogen-activated protein kinase 72.7.11.240.457
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.456
3gu7ADPDeath-associated protein kinase 12.7.11.10.456
3pe2E1BCasein kinase II subunit alpha2.7.11.10.456
4btkDTQTau-tubulin kinase 12.7.11.10.456
1yvj4STTyrosine-protein kinase JAK32.7.10.20.455
3mb714ICasein kinase II subunit alpha2.7.11.10.455
4fv9E71Mitogen-activated protein kinase 12.7.11.240.455
4ijp1EHSerine/threonine-protein kinase PRP4 homolog2.7.11.10.455
1jklANPDeath-associated protein kinase 12.7.11.10.454
4ysjADPCalmodulin-like domain protein kinase/0.454
2pvlP55Casein kinase II subunit alpha2.7.11.10.453
4ez50RSCyclin-dependent kinase 62.7.11.220.453
4btjATPTau-tubulin kinase 12.7.11.10.452
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.452
2j9mPY8Cyclin-dependent kinase 22.7.11.220.451
4jik1KOSerine/threonine-protein kinase Chk12.7.11.10.451
1om1IQACasein kinase II subunit alpha2.7.11.10.450
2pvmP29Casein kinase II subunit alpha2.7.11.10.450
4bbfO19Tyrosine-protein kinase JAK2/0.450
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.450
3bu5ATPInsulin receptor2.7.10.10.449
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.449
2yaaATPDeath-associated protein kinase 2/0.447
5av3KMPDeath-associated protein kinase 12.7.11.10.447
2zjwREFCasein kinase II subunit alpha2.7.11.10.446
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.446
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.445
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.444
4l9i8PRRhodopsin kinase/0.444
2fvdLIACyclin-dependent kinase 22.7.11.220.443
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.443
2cchATPCyclin-dependent kinase 22.7.11.220.442
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.442
3juhANPCasein kinase II subunit alpha2.7.11.10.442
3q9xEMOCasein kinase II subunit alpha2.7.11.10.442
2btsU32Cyclin-dependent kinase 22.7.11.220.441
2pvhP19Casein kinase II subunit alpha2.7.11.10.441
2pvjP44Casein kinase II subunit alpha2.7.11.10.441
1qcfPP1Tyrosine-protein kinase HCK2.7.10.20.440
2j0m4STFocal adhesion kinase 12.7.10.20.440