Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1nasASESepiapterin reductase1.1.1.153

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
1nasASESepiapterin reductase1.1.1.1531.000
1sepBIOSepiapterin reductase1.1.1.1530.735
4j7uYTZSepiapterin reductase1.1.1.1530.612
4hwkSFYSepiapterin reductase1.1.1.1530.596
4j7xSASSepiapterin reductase1.1.1.1530.523
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.497
2xvw9NRSerum albumin/0.496
2rkiTT1Gag-Pol polyprotein2.7.7.490.493
2prh238Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.492
2xvv9DNSerum albumin/0.490
3b9lAZZSerum albumin/0.486
2hl2SSAThreonine--tRNA ligase6.1.1.30.483
3h3qH13Collagen type IV alpha-3-binding protein/0.480
1nw6SFGModification methylase RsrI2.1.1.720.477
3csdEMOPutative ketoacyl reductase1.3.10.477
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.477
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.477
1ppjANYCytochrome b/0.476
3w5p4OAVitamin D3 receptor/0.476
4pnmNU1Tankyrase-22.4.2.300.476
3djfBC3Purine nucleoside phosphorylase/0.475
3p8zSAHGenome polyprotein2.1.1.560.475
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.473
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.473
1qyw5SDEstradiol 17-beta-dehydrogenase 11.1.1.620.472
1rx8FOLDihydrofolate reductase1.5.1.30.471
2ydoADNAdenosine receptor A2a/0.471
2z4y252Geranylgeranyl pyrophosphate synthase/0.471
3w1wCHDFerrochelatase, mitochondrial4.99.1.10.471
5cb3APRO-acetyl-ADP-ribose deacetylase/0.471
1cqp803Integrin alpha-L/0.470
3vtdTKDVitamin D3 receptor/0.470
2bxqIMNSerum albumin/0.469
1h9zRWFSerum albumin/0.468
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.468
1xddAAYIntegrin alpha-L/0.468
3h3t16HCollagen type IV alpha-3-binding protein/0.468
2rdn1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.467
1d3hA26Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.466
1x8lOXRRetinol dehydratase/0.466
3ekuCY9Actin-5C/0.466
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.465
4h9506UDihydrofolate reductase1.5.1.30.465
4lvg20ONicotinamide phosphoribosyltransferase2.4.2.120.465
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.465
1cq7PY5Aspartate aminotransferase2.6.1.10.464
1fmlRTLRetinol dehydratase/0.464
2o1xTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.464
1ve3SAMUncharacterized protein/0.463
2gjnFMNNitronate monooxygenase1.13.12.160.463
1nw5SAMModification methylase RsrI2.1.1.720.462
1s1vTNKGag-Pol polyprotein2.7.7.490.462
2bfmTOPPteridine reductase 11.5.1.330.462
4jlm1NNDeoxycytidine kinase2.7.1.740.462
1rr6IMHPurine nucleoside phosphorylase2.4.2.10.461
1swtBTNStreptavidin/0.461
3bk2U5PRibonuclease J/0.461
3lzwNAPFerredoxin--NADP reductase 21.18.1.20.461
1b2lNDCAlcohol dehydrogenase1.1.1.10.460
2k1qGLU_LEU_IBU_OBF_FE3Polyprotein/0.460
2ydbNAP2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.460
3fhxPLPPyridoxal kinase2.7.1.350.460
3zs7ATPPyridoxine/pyridoxal/pyridoxamine kinase/0.460
1gvv0GMEndothiapepsin3.4.23.220.459
2ea1GPGRibonuclease I3.1.27.60.459
3i587NA2,7-dihydroxy-5-methyl-1-naphthoate 7-O-methyltransferase/0.459
4bfzZVZPantothenate kinase2.7.1.330.459
1qjgEQUSteroid Delta-isomerase5.3.3.10.458
1srjNABStreptavidin/0.458
1tvrTB9Gag-Pol polyprotein2.7.7.490.458
3jpuTY4Transcriptional activator protein LasR/0.458
3uic09TEnoyl-[acyl-carrier-protein] reductase [NADH]/0.458
1d3gBREDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.457
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.457
1kqwRTLCellular retinol-binding protein type II/0.457
1r2jFADFkbI/0.457
3l9lL9LcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
4ax8SAMO-antigen chain terminator bifunctional methyltransferase/kinase WbdD/0.457
4bj9UHBTankyrase-22.4.2.300.457
1kphSAHCyclopropane mycolic acid synthase 12.1.1.790.456
1opbRETRetinol-binding protein 2/0.456
1u2rSO1Elongation factor 2/0.456
2po7CHDFerrochelatase, mitochondrial4.99.1.10.456
3gy9COAGCN5-related N-acetyltransferase/0.456
3vtcTK3Vitamin D3 receptor/0.456
4azwATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD/0.456
1rx6DDFDihydrofolate reductase1.5.1.30.455
1umlFR4Adenosine deaminase3.5.4.40.455
3dhaC6LN-acyl homoserine lactonase AiiA3.1.1.810.455
3exnACOProbable acetyltransferase/0.455
1lkeDOGBilin-binding protein/0.454
2rqfJH3Hemolymph juvenile hormone binding protein/0.454
2v58LZJBiotin carboxylase6.3.4.140.454
4a31MYAGlycylpeptide N-tetradecanoyltransferase/0.454
5pahLDPPhenylalanine-4-hydroxylase1.14.16.10.454
1pxxDIFProstaglandin G/H synthase 21.14.99.10.453
2bf7HBIPteridine reductase 11.5.1.330.453
2bfpH4BPteridine reductase 11.5.1.330.453
2ym1FADPhenylacetone monooxygenase1.14.13.920.453
4bfvZVVPantothenate kinase2.7.1.330.453
4cf23GMIntegrase/0.453
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.453
4qemHC4Phospholipase A2 VRV-PL-VIIIa/0.453
2g1n1IGRenin3.4.23.150.452
3dd0EZLCarbonic anhydrase 24.2.1.10.452
3r5yF42Uncharacterized protein/0.452
3up3XCAaceDAF-12/0.452
4bfuZVUPantothenate kinase2.7.1.330.452
4prxADPDNA gyrase subunit B/0.452
1bwlFMNNADPH dehydrogenase 11.6.99.10.451
1cjwCOTSerotonin N-acetyltransferase/0.451
3ix3OHNTranscriptional activator protein LasR/0.451
3tm5SFGUncharacterized protein/0.451
4ha6PXMPyridoxine 4-oxidase/0.451
4k0tD9ZCarbonic anhydrase 24.2.1.10.451
4rrgA3TThreonine--tRNA ligase6.1.1.30.451
1ove358Mitogen-activated protein kinase 14/0.450
1uyhPU0Heat shock protein HSP 90-alpha/0.450
2uxiG50HTH-type transcriptional regulator TtgR/0.450
2yg3FADPutrescine oxidase/0.450
3cseN22Uncharacterized protein/0.450
3jzfJZKBiotin carboxylase6.3.4.140.450
3pgiF41Endothiapepsin3.4.23.220.450
3vtbTKAVitamin D3 receptor/0.450
4anv751Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.450
4iah1DXAlr2278 protein/0.450
4k5y1Q5Corticotropin-releasing factor receptor 1/0.450
3sn6P0GBeta-2 adrenergic receptor/0.450
1fkwPURAdenosine deaminase3.5.4.40.449
1mraAPGMandelate racemase/0.449
2ea2F77Methionine aminopeptidase 2/0.449
2oadGTBGlutathione S-transferase P 12.5.1.180.449
2uxpCLMHTH-type transcriptional regulator TtgR/0.449
2vb8TLM3-oxoacyl-[acyl-carrier-protein] synthase 12.3.1.410.449
3dr1C5DVitamin D3 receptor A/0.449
3gyaCOAGCN5-related N-acetyltransferase/0.449
3q2jCKIAminoglycoside 3'-phosphotransferase2.7.1.950.449
3vgnFNNSteroid Delta-isomerase5.3.3.10.449
4askK0ILysine-specific demethylase 6B1.14.110.449
4b67NAPL-ornithine N(5)-monooxygenase/0.449
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.449
4pahLNRPhenylalanine-4-hydroxylase1.14.16.10.449
1b87ACOAac(6')-Ii protein/0.448
2ab8MTPAdenosine kinase2.7.1.200.448
2uxoTACHTH-type transcriptional regulator TtgR/0.448
3cmfPDN3-oxo-5-beta-steroid 4-dehydrogenase/0.448
3elbC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.448
3ix8TX3Transcriptional activator protein LasR/0.448
4a8v2ANMajor pollen allergen Bet v 1-J/0.448
4h6rFDAProline dehydrogenase/0.448
4nbb9CATerminal oxygenase component of carbazole/0.448
1rk3VDXVitamin D3 receptor/0.447
1tg2H2BPhenylalanine-4-hydroxylase1.14.16.10.447
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
2wo7ASVIsopenicillin N synthase1.21.3.10.447
3c3ySAHO-methyltransferase/0.447
3dyaPZLGag-Pol polyprotein2.7.7.490.447
3vt8YI3Vitamin D3 receptor/0.447
3vt9YI4Vitamin D3 receptor/0.447
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.447
4rr7A3SProbable threonine--tRNA ligase 26.1.1.30.447
4tjy3GNTankyrase-22.4.2.300.447
1dggNDPCatalase1.11.1.60.446
1esmCOAPantothenate kinase2.7.1.330.446
1fdsESTEstradiol 17-beta-dehydrogenase 11.1.1.620.446
1jkx138Phosphoribosylglycinamide formyltransferase/0.446
1l0lFMXCytochrome b/0.446
1l8qADPChromosomal replication initiator protein DnaA/0.446
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
2a2sGSNGlutathione S-transferase P2.5.1.180.446
2z4sADPChromosomal replication initiator protein DnaA/0.446
2z4w749Geranylgeranyl pyrophosphate synthase/0.446
3af1GDPPantothenate kinase2.7.1.330.446
3bgxMEFThymidylate synthase/0.446
3dokGWJPol protein/0.446
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
3lanKBTGag-Pol polyprotein2.7.7.490.446
3lfm3DTAlpha-ketoglutarate-dependent dioxygenase FTO/0.446
3p9tTCLRepressor/0.446
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
4bfxZVXPantothenate kinase2.7.1.330.446
4li81XQTankyrase-12.4.2.300.446
4psbGA3Cytokinin-specific binding protein/0.446
1n5sADLActVA 6 protein/0.445
1txtCAAHMG-CoA synthase/0.445
1zdwFLVPrenyltransferase/0.445
1zprCB3Thymidylate synthase/0.445
2b0qADPAminoglycoside 3'-phosphotransferase2.7.1.950.445
2wi72KLHeat shock protein HSP 90-alpha/0.445
3qwbNDPProbable quinone oxidoreductase1.6.5.50.445
4mihFADPyranose 2-oxidase1.1.3.100.445
4qzuRTLRetinol-binding protein 2/0.445
1dajMOTDihydrofolate reductase1.5.1.30.444
1e82M90Endothiapepsin3.4.23.220.444
1fvpFMANon-fluorescent flavoprotein/0.444
1h85FADFerredoxin--NADP reductase1.18.1.20.444
1i2cUPGUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.444
1s7gNADNAD-dependent protein deacylase 2/0.444
2tscCB3Thymidylate synthase/0.444
3br3ETHTH-type transcriptional regulator QacR/0.444
3tm4SAMUncharacterized protein/0.444
3vt65YIVitamin D3 receptor/0.444
4a83DXCMajor pollen allergen Bet v 1-A/0.444
4ap1NAPSteroid monooxygenase/0.444
4b4dFADFerredoxin-NADP reductase/0.444
4ia3BIVVitamin D3 receptor A/0.444
1e3rANDSteroid Delta-isomerase5.3.3.10.443
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.443
1xh5R68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
2bxmIMNSerum albumin/0.443
3dlgGWEGag-Pol polyprotein2.7.7.490.443
3gphOIDCytochrome P450 2E11.14.130.443
4cf8V7HIntegrase/0.443
4gg1TZDBenzoylformate decarboxylase4.1.1.70.443
4la7A1OAbscisic acid receptor PYL2/0.443
4n1gCEIObelin/0.443
4rw4494Gag-Pol polyprotein2.7.7.490.443
4uhrNGIAdenosine receptor A2a/0.443
1a72PADAlcohol dehydrogenase E chain1.1.1.10.442
1dduCB3Thymidylate synthase/0.442
1ib0FADNADH-cytochrome b5 reductase 31.6.2.20.442
1kt7RTLRetinol-binding protein 4/0.442
1thnADPAnti-sigma F factor/0.442
1wsvTHHAminomethyltransferase, mitochondrial/0.442
1y2d4DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
2p8uCOAHydroxymethylglutaryl-CoA synthase, cytoplasmic2.3.3.100.442
2rds1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.442
2vigFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.10.442
2zbaZBATrichothecene 3-O-acetyltransferase/0.442
3dcwEZLCarbonic anhydrase 24.2.1.10.442
3dleGFAGag-Pol polyprotein2.7.7.490.442
3g1rFIT3-oxo-5-beta-steroid 4-dehydrogenase/0.442
3hub469Mitogen-activated protein kinase 14/0.442
3w78CBDFMN-dependent NADH-azoreductase/0.442
4bcaFADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.442
4fl0PLPAminotransferase ALD1, chloroplastic2.6.10.442
5dbfNDPIridoid synthase1.3.1.990.442
2ahvCOAAcetate CoA-transferase YdiF2.8.3.80.441
2h3wHC5Carnitine O-acetyltransferase2.3.1.70.441
2jji0QSEndothiapepsin3.4.23.220.441
2oc9IMHPurine nucleoside phosphorylase2.4.2.10.441
2qd5CHDFerrochelatase, mitochondrial4.99.1.10.441
3gieACPSensor histidine kinase DesK2.7.13.30.441
3r7cFADFAD-linked sulfhydryl oxidase ALR1.8.3.20.441
3sqyQ11Dihydrofolate reductase1.5.1.30.441
3t7x4SHEndothiapepsin3.4.23.220.441
4l0qNADAlcohol dehydrogenase class-3/0.441
4mprTPPBenzoylformate decarboxylase4.1.1.70.441
1akcPPEAspartate aminotransferase, mitochondrial2.6.1.10.440
1e7wMTXPteridine reductase 11.5.1.330.440
1g2vTTPGlucose-1-phosphate thymidylyltransferase/0.440
1mczTDPBenzoylformate decarboxylase4.1.1.70.440
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.440
2b0m201Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.440
2izfBTNStreptavidin/0.440
2jfz003Glutamate racemase/0.440
2onfCOAUncharacterized protein/0.440
2pk3A2RGDP-6-deoxy-D-mannose reductase/0.440
2vcmM11Isopenicillin N synthase1.21.3.10.440
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.440
2zcvNDPQuinone oxidoreductase 21.6.5.20.440
3af0GDPPantothenate kinase2.7.1.330.440
4a81DXCMajor pollen allergen Bet v 1-A/0.440
4bwaN0BPyrrolysine--tRNA ligase/0.440
4ia7BIVVitamin D3 receptor A/0.440
4j3mAJ8Tankyrase-22.4.2.300.440
4o71CPBBromodomain-containing protein 4/0.440
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.440
5cuqNSCGenome polyprotein/0.440