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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5lc1NADL-threonine 3-dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5lc1NADL-threonine 3-dehydrogenase/1.000
3a4vNADNDP-sugar epimerase/0.594
2yy7NADL-threonine dehydrogenase/0.569
3a1nNADNDP-sugar epimerase/0.568
4yr9NADL-threonine 3-dehydrogenase, mitochondrial1.1.1.1030.560
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.535
2wsbNADGalactitol dehydrogenase/0.533
4gh5NADShort-chain dehydrogenase/reductase SDR/0.527
3rj5NADAlcohol dehydrogenase1.1.1.10.525
5jlaNADPutative short-chain dehydrogenase/reductase/0.525
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.521
3rj9NADAlcohol dehydrogenase1.1.1.10.517
1zemNADXylitol dehydrogenase/0.516
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.514
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.512
2ewmNAD(S)-1-Phenylethanol dehydrogenase1.1.1.3110.510
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.510
3uxyNADShort-chain dehydrogenase/reductase SDR/0.510
3wdsNADNADH-dependent quinuclidinone reductase/0.509
1iy8NADLevodione reductase/0.508
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.502
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.501
2dteNAIGlucose 1-dehydrogenase related protein/0.501
1wntNAPL-xylulose reductase1.1.1.100.500
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.499
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.498
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.494
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.494
1pr9NAPL-xylulose reductase1.1.1.100.493
1b15NAEAlcohol dehydrogenase1.1.1.10.491
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.491
2ag5NAD3-hydroxybutyrate dehydrogenase type 2/0.491
1sbyNADAlcohol dehydrogenase1.1.1.10.490
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.489
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.486
1b16NAQAlcohol dehydrogenase1.1.1.10.485
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.485
3d3wNAPL-xylulose reductase1.1.1.100.485
3gy0NAPNAD(P)-dependent oxidoreductase/0.485
3qrwNDPPutative ketoacyl reductase1.3.10.484
2yutNAPPutative short-chain oxidoreductase/0.483
4yaiNAIC alpha-dehydrogenase/0.483
3a9wNADNDP-sugar epimerase/0.482
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.480
1z7eATPBifunctional polymyxin resistance protein ArnA/0.480
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.480
3wmxNADNAD dependent epimerase/dehydratase/0.480
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.480
3ggoNAIPrephenate dehydrogenase/0.479
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.478
4ajp88NL-lactate dehydrogenase A chain1.1.1.270.478
4fn4NADShort chain dehydrogenase/0.477
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.476
5jy1NADPutative short-chain dehydrogenase/reductase/0.476
3ak4NADNADH-dependent quinuclidinone reductase/0.474
3aw9NADNAD-dependent epimerase/dehydratase/0.473
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.473
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.473
5js6NAD17-beta-hydroxysteroid dehydrogenase 141.1.10.473
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.472
1mg5NAIAlcohol dehydrogenase1.1.1.10.472
3ndrNADPyridoxal 4-dehydrogenase1.1.1.1070.472
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.472
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.472
1w4zNAPPutative ketoacyl reductase1.3.10.470
4yagNAIC alpha-dehydrogenase/0.470
3ajrNADNDP-sugar epimerase/0.469
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.468
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.467
2wdzNADGalactitol dehydrogenase/0.466
3s55NADPutative short-chain dehydrogenase/reductase/0.465
4dc1NDPPutative ketoacyl reductase1.3.10.465
2a92NAIL-lactate dehydrogenase/0.464
4nbwNADShort-chain dehydrogenase/reductase SDR/0.464
4qecNAPElxO/0.464
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.463
1b14NADAlcohol dehydrogenase1.1.1.10.462
1n5dNDPCarbonyl reductase [NADPH] 1/0.462
3sjuNDPKeto reductase/0.462
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.461
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.460
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.459
4wlvNADMalate dehydrogenase, mitochondrial1.1.1.370.459
1rwbNADGlucose 1-dehydrogenase1.1.1.470.458
1xg5NAPDehydrogenase/reductase SDR family member 11/0.458
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.458
3vdqNAD3-hydroxybutyrate dehydrogenase/0.458
2bd0NAPSepiapterin reductase/0.455
2q2qNADBeta-D-hydroxybutyrate dehydrogenase/0.455
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.455
4ej0NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.455
4wluNADMalate dehydrogenase, mitochondrial1.1.1.370.455
3w8dNAD3-hydroxybutyrate dehydrogenase/0.454
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.454
4j7uNAPSepiapterin reductase1.1.1.1530.454
3w8eNAD3-hydroxybutyrate dehydrogenase/0.453
4j7xNAPSepiapterin reductase1.1.1.1530.453
1gypNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.452
2aa3AP0L-lactate dehydrogenase/0.452
1sowNADL-lactate dehydrogenase1.1.1.270.451
1x7gNAPPutative ketoacyl reductase1.3.10.451
5jydNADShort chain dehydrogenase/0.451
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.450
1ae1NAPTropinone reductase 1/0.448
1ipeNDPTropinone reductase 21.1.1.2360.448
2g5cNADPrephenate dehydrogenase/0.448
4b8zNAPGDP-L-fucose synthase1.1.1.2710.448
4lisNADUDP-glucose 4-epimerase (Eurofung)/0.448
1oaaNAPSepiapterin reductase1.1.1.1530.447
1rkxNADCDP-D-glucose-4,6-dehydratase/0.447
1snyNAPLD36273p/0.447
1x7hNDPPutative ketoacyl reductase1.3.10.447
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.447
4hwkNAPSepiapterin reductase1.1.1.1530.447
1xkqNDPUncharacterized protein/0.446
3ggpNADPrephenate dehydrogenase/0.446
3p19NDPPutative blue fluorescent protein/0.446
4esoNAPPutative oxidoreductase/0.446
1gcoNADGlucose 1-dehydrogenase1.1.1.470.445
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.445
4nd2A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.445
4p8rNADGlyceraldehyde-3-phosphate dehydrogenase/0.445
5ig2NADShort-chain dehydrogenase/reductase SDR/0.445
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.444
4pvdNDPNADPH-dependent methylglyoxal reductase GRE2/0.444
2fzeAPRAlcohol dehydrogenase class-31.1.1.10.443
2p5uNADUDP-glucose 4-epimerase/0.443
3f1kNAPUncharacterized oxidoreductase YciK10.443
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.443
3ojlNADCap5O/0.443
4cr8NADN-acylmannosamine 1-dehydrogenase1.1.1.2330.443
4gl4NAIAlcohol dehydrogenase class-3/0.443
1g1aNADdTDP-glucose 4,6-dehydratase/0.442
1kvrNADUDP-glucose 4-epimerase5.1.3.20.442
3toxNAPPutative oxidoreductase/0.442
3cpsNADGlyceraldehyde-3-phosphate dehydrogenase/0.441
1qxsNADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal1.2.1.120.440
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.440
2x86NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.440
3w8fNAD3-hydroxybutyrate dehydrogenase/0.440
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.440
4bmvNAPShort-chain dehydrogenase/0.440
4xq9NADHomospermidine synthase2.5.1.440.440