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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4xo7ASDAldo-keto reductase family 1 member C2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4xo7ASDAldo-keto reductase family 1 member C2/1.000
1mrqSTRAldo-keto reductase family 1 member C1/0.613
4jtrIBPAldo-keto reductase family 1 member C2/0.604
4jq2SUZAldo-keto reductase family 1 member C2/0.582
4jtrIZPAldo-keto reductase family 1 member C2/0.581
1ihiIU5Aldo-keto reductase family 1 member C2/0.576
4jq1NPSAldo-keto reductase family 1 member C2/0.538
4jq3ZOMAldo-keto reductase family 1 member C2/0.535
2ipjFFAAldo-keto reductase family 1 member C2/0.530
4l1xSTRAldo-keto reductase family 1 member C2/0.517
4jtqFLPAldo-keto reductase family 1 member C2/0.507
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.489
2yq92AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.487
4jqaID8Aldo-keto reductase family 1 member C2/0.486
4bfwZVWPantothenate kinase2.7.1.330.485
1touB1VFatty acid-binding protein, adipocyte/0.484
2ea4F79Methionine aminopeptidase 2/0.484
3ekuCY9Actin-5C/0.483
5stdUNNScytalone dehydratase4.2.1.940.482
3eksCY9Actin-5C/0.481
3zkuHCVIsopenicillin N synthase1.21.3.10.480
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.477
2rqfJH3Hemolymph juvenile hormone binding protein/0.476
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.474
4q0kGA3Phytohormone-binding protein/0.474
1hb3SCVIsopenicillin N synthase1.21.3.10.473
3q9bB3NAcetylpolyamine amidohydrolase/0.473
2jb4A14Isopenicillin N synthase1.21.3.10.472
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.472
2xuoTZ4Acetylcholinesterase3.1.1.70.471
3ufl508Beta-secretase 13.4.23.460.471
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.470
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.470
2ejzSAHDiphthine synthase/0.469
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.469
1so2666cGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.468
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.468
3c3xNAPEugenol synthase 11.1.1.3180.468
4bfvZVVPantothenate kinase2.7.1.330.468
1y2e5DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.467
3qeoLLTDeoxycytidine kinase2.7.1.740.467
3fr5I4AFatty acid-binding protein, adipocyte/0.466
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.465
2y60M8FIsopenicillin N synthase1.21.3.10.465
3cmfPDN3-oxo-5-beta-steroid 4-dehydrogenase/0.465
3q7fED2Uncharacterized protein/0.465
2a9y26AAdenosine kinase2.7.1.200.464
2xlsFADPutative flavin-containing monooxygenase/0.464
4bftZVTPantothenate kinase2.7.1.330.464
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.464
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.463
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.463
3sfy3FYUncharacterized protein/0.463
4bfuZVUPantothenate kinase2.7.1.330.463
4wda2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.463
2iviACWIsopenicillin N synthase1.21.3.10.462
3fr4F8AFatty acid-binding protein, adipocyte/0.462
3mjrAC2Deoxycytidine kinase2.7.1.740.462
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.462
3mytEQUSteroid Delta-isomerase5.3.3.10.461
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.461
4psbGA3Cytokinin-specific binding protein/0.461
2a5kAZPReplicase polyprotein 1ab3.4.220.460
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
2q1sNAIPutative nucleotide sugar epimerase/ dehydratase/0.460
3arvSAUChitinase A/0.460
3dy85GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.460
3tvxPNXcAMP-specific 3',5'-cyclic phosphodiesterase 4A3.1.4.530.460
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.460
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.459
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.459
3b9oFMNAlkane monoxygenase/0.459
3l6jZ90Alr2278 protein/0.459
3ozd4CTS-methyl-5'-thioadenosine phosphorylase/0.459
1x8lOXRRetinol dehydratase/0.458
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
3hl0NADMaleylacetate reductase/0.458
3u9fCLMChloramphenicol acetyltransferase2.3.1.280.458
3w0tHPULactoylglutathione lyase4.4.1.50.458
5cc9DDFDihydrofolate reductase1.5.1.30.458
1oc1ASVIsopenicillin N synthase1.21.3.10.457
2pnjCHDFerrochelatase, mitochondrial4.99.1.10.457
2uxoTACHTH-type transcriptional regulator TtgR/0.457
3cavCI23-oxo-5-beta-steroid 4-dehydrogenase/0.457
4bfxZVXPantothenate kinase2.7.1.330.457
4cdmFO1Deoxyribodipyrimidine photolyase/0.457
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.457
2po7CHDFerrochelatase, mitochondrial4.99.1.10.456
2v59LZKBiotin carboxylase6.3.4.140.456
2zu9GDPMannosyl-3-phosphoglycerate synthase2.4.1.2170.456
1o5rFR9Adenosine deaminase3.5.4.40.455
2w6qOA5Biotin carboxylase6.3.4.140.455
3oiaA31Camphor 5-monooxygenase1.14.15.10.455
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.455
4c1iEH9cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.455
4fhf0TTSpore photoproduct lyase/0.455
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.455
1fmlRTLRetinol dehydratase/0.454
1hb1OCVIsopenicillin N synthase1.21.3.10.454
1p91SAM23S rRNA (guanine(745)-N(1))-methyltransferase/0.454
1pq944BOxysterols receptor LXR-beta/0.454
1tbbROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.454
1upw444Oxysterols receptor LXR-beta/0.454
2h6iCYS_VAL_LEU_SER_GERProtein farnesyltransferase subunit beta2.5.1.580.454
3h3t16HCollagen type IV alpha-3-binding protein/0.454
4c2jCOA3-ketoacyl-CoA thiolase, mitochondrial2.3.1.160.454
1dduCB3Thymidylate synthase/0.453
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.453
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.453
2gv8NDPThiol-specific monooxygenase1.14.130.453
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.453
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.453
1f20FADNitric oxide synthase, brain1.14.13.390.452
1qiqACCIsopenicillin N synthase1.21.3.10.452
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.452
2g1n1IGRenin3.4.23.150.452
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.452
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.452
3zoiM2WIsopenicillin N synthase1.21.3.10.452
4bb3KKAIsopenicillin N synthase1.21.3.10.452
4jq4IMNAldo-keto reductase family 1 member C2/0.452
4lm4JPZcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.452
5a4vQUEGlutathione S-transferase F22.5.1.180.452
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.451
2cekN8TAcetylcholinesterase3.1.1.70.451
2rlcCHDCholoylglycine hydrolase3.5.1.240.451
3e34ED1Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha/0.451
3e34ED1Protein farnesyltransferase subunit beta2.5.1.580.451
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.451
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.451
4isf1FXGlucokinase2.7.1.20.451
4phlPILPhosphodiesterase/0.451
1culFOKAdenylate cyclase type 2/0.450
1culFOKAdenylate cyclase type 5/0.450
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.450
1r2jFADFkbI/0.450
1swtBTNStreptavidin/0.450
1xf0ASDAldo-keto reductase family 1 member C3/0.450
2z1qFADAcyl-CoA dehydrogenase/0.450
3br3ETHTH-type transcriptional regulator QacR/0.450
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.450
3h3r14HCollagen type IV alpha-3-binding protein/0.450
4a322CDGlycylpeptide N-tetradecanoyltransferase/0.450
4fhd0TTSpore photoproduct lyase/0.450
4j8tDOGUncharacterized PhzA/B-like protein PA3332/0.450
1o1t2NHProtein farnesyltransferase subunit beta2.5.1.580.449
1rf7DHFDihydrofolate reductase1.5.1.30.449
1tllFADNitric oxide synthase, brain1.14.13.390.449
1xddAAYIntegrin alpha-L/0.449
2a9z26AAdenosine kinase2.7.1.200.449
2c9zQUEAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.449
2cbqTH2Neocarzinostatin/0.449
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.449
3uzzASD3-oxo-5-beta-steroid 4-dehydrogenase/0.449
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.449
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.449
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.449
1aquESTEstrogen sulfotransferase, testis isoform2.8.2.40.448
1icqOPD12-oxophytodienoate reductase 11.3.1.420.448
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.448
1qyxASDEstradiol 17-beta-dehydrogenase 11.1.1.620.448
2weyEV1cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
3cotSTR3-oxo-5-beta-steroid 4-dehydrogenase/0.448
3tfjTHGDimethylsulfonioproprionate demethylase DmdA2.1.1.2690.448
4dbs0HVAldo-keto reductase family 1 member C3/0.448
4xsvC5PEthanolamine-phosphate cytidylyltransferase2.7.7.140.448
1cqp803Integrin alpha-L/0.447
1el4CTZObelin/0.447
1pqc444Oxysterols receptor LXR-beta/0.447
1w6hTITPlasmepsin-23.4.23.390.447
2qimZEAClass 10 plant pathogenesis-related protein/0.447
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
3oafOAGDihydrofolate reductase1.5.1.30.447
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.447
5jy1NADPutative short-chain dehydrogenase/reductase/0.447
1bk0ACVIsopenicillin N synthase1.21.3.10.446
1blzACVIsopenicillin N synthase1.21.3.10.446
1dgfNDPCatalase1.11.1.60.446
1dmwHBIPhenylalanine-4-hydroxylase1.14.16.10.446
1enoNADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.446
2f3815MAldo-keto reductase family 1 member C3/0.446
3up0D7SaceDAF-12/0.446
4fcd0T6cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
4ia05BBcGMP-specific 3',5'-cyclic phosphodiesterase/0.446
4jxxATPGlutamine--tRNA ligase6.1.1.180.446
4oew5IOcGMP-specific 3',5'-cyclic phosphodiesterase/0.446
4ri1ACOUDP-4-amino-4,6-dideoxy-N-acetyl-beta-L-altrosamine N-acetyltransferase2.3.1.2020.446
5dp2NAPCurF/0.446
1ry8RUTAldo-keto reductase family 1 member C3/0.445
1xh5R68cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
2v58LZJBiotin carboxylase6.3.4.140.445
2zf051UProthrombin3.4.21.50.445
3dhaC6LN-acyl homoserine lactonase AiiA3.1.1.810.445
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
3h3qH13Collagen type IV alpha-3-binding protein/0.445
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.445
3uzxAOM3-oxo-5-beta-steroid 4-dehydrogenase/0.445
4isg1FYGlucokinase2.7.1.20.445
5cxv0HKMuscarinic acetylcholine receptor M1/0.445
1dx6GNTAcetylcholinesterase3.1.1.70.444
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.444
1zgbA1EAcetylcholinesterase3.1.1.70.444
2h447CAcGMP-specific 3',5'-cyclic phosphodiesterase/0.444
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.444
2vqbFADPutative flavin-containing monooxygenase/0.444
3bw4FMNPutative 2-nitropropane dioxygenase/0.444
3h3sH15Collagen type IV alpha-3-binding protein/0.444
3zc3FADFerredoxin--NADP reductase1.18.1.20.444
4a83DXCMajor pollen allergen Bet v 1-A/0.444
4b65NDPL-ornithine N(5)-monooxygenase/0.444
1gky5GPGuanylate kinase2.7.4.80.443
2fs4PZ1Renin3.4.23.150.443
2o1sTDP1-deoxy-D-xylulose-5-phosphate synthase2.2.1.70.443
2yozOVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.443
3fapARDPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.443
3fapARDSerine/threonine-protein kinase mTOR2.7.11.10.443
3ha5SFGHydroxymycolate synthase MmaA42.1.10.443
3otbDGTProbable tRNA(His) guanylyltransferase2.7.7.790.443
4cvmANPUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.443
4dbw511Aldo-keto reductase family 1 member C3/0.443
4muw2F4cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
4oex5EOcGMP-specific 3',5'-cyclic phosphodiesterase/0.443
1kkq471Peroxisome proliferator-activated receptor alpha/0.442
1l2tATPUncharacterized ABC transporter ATP-binding protein MJ0796/0.442
1p0pBCHCholinesterase3.1.1.80.442
1uyePU9Heat shock protein HSP 90-alpha/0.442
2xf3J01Uncharacterized protein/0.442
3b8xG4MPutative pyridoxamine 5-phosphate-dependent dehydrase/0.442
3bgxMEFThymidylate synthase/0.442
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3hf8ML0Tryptophan 5-hydroxylase 11.14.16.40.442
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.442
1h22E10Acetylcholinesterase3.1.1.70.441
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.441
1lkeDOGBilin-binding protein/0.441
1obnASVIsopenicillin N synthase1.21.3.10.441
1oj4CDM4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.441
1q23FUAChloramphenicol acetyltransferase2.3.1.280.441
1uzwCDHIsopenicillin N synthase1.21.3.10.441
1x2eATXProline iminopeptidase3.4.11.50.441
1xl8152Peroxisomal carnitine O-octanoyltransferase2.3.1.1370.441
2g1o2IGRenin3.4.23.150.441
3c4hDRLPoly [ADP-ribose] polymerase 32.4.2.300.441
3dd0EZLCarbonic anhydrase 24.2.1.10.441
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.441
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.441
4uugPXGBranched-chain amino acid aminotransferase, putative/0.441
4x7uZM3Mycinamicin III 3''-O-methyltransferase2.1.1.2370.441
5c1mCLRMu-type opioid receptor/0.441
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.440
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.440
2ed3SAHDiphthine synthase/0.440
2iqdLPAAldose reductase1.1.1.210.440
2jl1NAPTriphenylmethane reductase/0.440
2vbdV10Isopenicillin N synthase1.21.3.10.440
2ydd2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.440
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.440
3vtbTKAVitamin D3 receptor/0.440
3w6hAZMCarbonic anhydrase 14.2.1.10.440
3wi2P98cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.440
4c5oFADPutative monooxygenase/0.440
4n82FMNRibonucleotide reductase (NrdI family protein), putative/0.440
4oztP1AEcdysone receptor, putative/0.440