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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.11.000
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.591
4qnyANPMitogen activated protein kinase, putative/0.519
5dosATPAurora kinase A2.7.11.10.513
3orpAGSSerine/threonine protein kinase/0.507
5dnrATPAurora kinase A2.7.11.10.507
4deeADPAurora kinase A2.7.11.10.492
4j99ACPFibroblast growth factor receptor 2/0.492
4lfiGNPCasein kinase II subunit alpha2.7.11.10.489
4lrjANPUncharacterized protein/0.489
4qmlANPSerine/threonine-protein kinase 242.7.11.10.489
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.485
4c3pACPAurora kinase A2.7.11.10.485
3gu7ADPDeath-associated protein kinase 12.7.11.10.484
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.483
4j95ACPFibroblast growth factor receptor 2/0.483
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.481
4eooATPCyclin-dependent kinase 22.7.11.220.479
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.478
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.478
1dayGNPCasein kinase II subunit alpha2.7.11.10.476
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.476
4ysjADPCalmodulin-like domain protein kinase/0.476
2w4jADPDeath-associated protein kinase 12.7.11.10.475
4btjADPTau-tubulin kinase 12.7.11.10.475
3dfcANPDeath-associated protein kinase 12.7.11.10.474
1jnkANPMitogen-activated protein kinase 102.7.11.240.472
2yaaATPDeath-associated protein kinase 2/0.472
2j0lANPFocal adhesion kinase 12.7.10.20.471
4fv6E57Mitogen-activated protein kinase 12.7.11.240.471
4s33ANPMitogen-activated protein kinase 12.7.11.240.471
1i44ACPInsulin receptor2.7.10.10.470
1qmzATPCyclin-dependent kinase 22.7.11.220.470
3qc9ADPRhodopsin kinase/0.470
4k2rANPTyrosine-protein kinase ZAP-702.7.10.20.470
3lpbNVBTyrosine-protein kinase JAK2/0.469
2henADPEphrin type-B receptor 22.7.10.10.468
4btjATPTau-tubulin kinase 12.7.11.10.468
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.466
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.465
5cvfATPCasein kinase II subunit alpha2.7.11.10.463
2c6lDT4Cyclin-dependent kinase 22.7.11.220.462
3kvxFMYMitogen-activated protein kinase 102.7.11.240.460
4ii5ADPCyclin-dependent kinase 22.7.11.220.460
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.460
2pvmP29Casein kinase II subunit alpha2.7.11.10.458
2qoqANPEphrin type-A receptor 32.7.10.10.458
3c4wATPRhodopsin kinase/0.458
3lltANPProtein serine/threonine kinase-1/0.458
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.458
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.457
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.457
4hge15VTyrosine-protein kinase JAK2/0.457
4ji91M3Tyrosine-protein kinase JAK2/0.457
2xrwANPMitogen-activated protein kinase 82.7.11.240.456
2ijmATPFocal adhesion kinase 12.7.10.20.455
3i60E86Mitogen-activated protein kinase 12.7.11.240.455
4anmWULCasein kinase II subunit alpha2.7.11.10.455
4fv5EK9Mitogen-activated protein kinase 12.7.11.240.455
5cnnANPEpidermal growth factor receptor2.7.10.10.455
1dawANPCasein kinase II subunit alpha2.7.11.10.454
4o0uADNAurora kinase A2.7.11.10.454
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.454
1pmn984Mitogen-activated protein kinase 102.7.11.240.453
2gu8796cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
4o1pANPRibonuclease L/0.451
4y95746Tyrosine-protein kinase/0.451
4ix5ANPUncharacterized protein/0.450
4jbpYPHAurora kinase A2.7.11.10.450
4y93746Tyrosine-protein kinase/0.450
1ny3ADPMAP kinase-activated protein kinase 22.7.11.10.448
2ozoANPTyrosine-protein kinase ZAP-702.7.10.20.448
2qo7ANPEphrin type-A receptor 32.7.10.10.448
4aqc88ATyrosine-protein kinase JAK2/0.447
4qpmADPMitotic checkpoint serine/threonine-protein kinase BUB12.7.11.10.447
4xcvNDPProbable hydroxyacid dehydrogenase protein/0.447
5cnoANPEpidermal growth factor receptor2.7.10.10.447
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.446
1gjvAGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial2.7.11.40.445
2pvnP63Casein kinase II subunit alpha2.7.11.10.445
4e6d0NUTyrosine-protein kinase JAK2/0.445
1ig1ANPDeath-associated protein kinase 12.7.11.10.444
1jkkANPDeath-associated protein kinase 12.7.11.10.444
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3ortAGSSerine/threonine protein kinase/0.444
4gt3ATPMitogen-activated protein kinase 12.7.11.240.444
4z35ON9Lysophosphatidic acid receptor 1/0.444
1finATPCyclin-dependent kinase 22.7.11.220.443
3oriAGSSerine/threonine protein kinase/0.443
1m2pHNACasein kinase II subunit alpha2.7.11.10.442
2cciATPCyclin-dependent kinase 22.7.11.220.442
3c4zADPRhodopsin kinase/0.442
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.442
2j0m4STFocal adhesion kinase 12.7.10.20.441
2vv9IM9Cyclin-dependent kinase 22.7.11.220.440
2wqeADPAurora kinase A2.7.11.10.440
3c4xATPRhodopsin kinase/0.440
4e4n0NLTyrosine-protein kinase JAK1/0.440
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.440