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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4l445FIRibosomal protein S6 kinase beta-12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
4l445FIRibosomal protein S6 kinase beta-12.7.11.11.000
4l435FIRibosomal protein S6 kinase beta-12.7.11.10.592
4l3l5FIRibosomal protein S6 kinase beta-12.7.11.10.584
3we45FIRibosomal protein S6 kinase beta-12.7.11.10.572
4l455FIRibosomal protein S6 kinase beta-12.7.11.10.556
4l3j5FIRibosomal protein S6 kinase beta-12.7.11.10.551
3mvhWFERAC-alpha serine/threonine-protein kinase2.7.11.10.528
4l425FIRibosomal protein S6 kinase beta-12.7.11.10.514
4otiMI1Serine/threonine-protein kinase N1/0.514
3cqwCQWRAC-alpha serine/threonine-protein kinase2.7.11.10.506
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.501
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.498
1wvxBD4Death-associated protein kinase 12.7.11.10.494
1q8wM77cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.490
2uzuL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.488
3nwq2NCGag-Pol polyprotein3.4.23.160.488
3t113T1Gag-Pol polyprotein3.4.23.160.488
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.488
3qp0NI8Gag-Pol polyprotein3.4.23.160.487
4gv10XZRAC-alpha serine/threonine-protein kinase2.7.11.10.486
3nwxKVSGag-Pol polyprotein3.4.23.160.485
1yt9OISGag-Pol polyprotein/0.484
2etrY27Rho-associated protein kinase 12.7.11.10.484
3cyxROCGag-Pol polyprotein3.4.23.160.483
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.483
3nux3NVCyclin-dependent kinase 62.7.11.220.482
4ezj0SCPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.482
2oh02PYcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.478
5av2KMPDeath-associated protein kinase 12.7.11.10.478
3a62STURibosomal protein S6 kinase beta-12.7.11.10.476
2f3kRO1Protease/0.475
2vo0M03cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.475
3js2VM1Fibroblast growth factor receptor 1/0.475
4bbe3O4Tyrosine-protein kinase JAK2/0.475
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.475
1k6tXN1Gag-Pol polyprotein3.4.23.160.473
1k6cMK1Gag-Pol polyprotein3.4.23.160.472
2jdsL20cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
3nxe2NCProtease/0.471
3igoANPCalmodulin-domain protein kinase 1, putative/0.470
3nu9478Gag-Pol polyprotein3.4.23.160.470
3qbfJHGGag-Pol polyprotein3.4.23.160.469
3zewSTUEphrin type-B receptor 42.7.10.10.469
3zo1SIJcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.469
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.469
2ijmADPFocal adhesion kinase 12.7.10.20.468
3el51UNGag-Pol polyprotein/0.468
1yvj4STTyrosine-protein kinase JAK32.7.10.20.467
3ggxGGXGag-Pol polyprotein/0.467
1finATPCyclin-dependent kinase 22.7.11.220.466
1ida0POGag-Pol polyprotein3.4.23.470.466
2pwcG3GGag-Pol polyprotein3.4.23.160.466
2pyn1UNGag-Pol polyprotein3.4.23.160.466
3t8oATPRhodopsin kinase/0.466
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.466
4j5j478Gag-Pol polyprotein3.4.23.160.466
2fxdDR7Pol polyprotein/0.465
2qak1UNGag-Pol polyprotein3.4.23.160.465
2qnqQN3Gag-Pol polyprotein3.4.23.160.465
3c4xATPRhodopsin kinase/0.465
3s85LK0Gag-Pol polyprotein/0.465
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.464
3d1xROCGag-Pol polyprotein3.4.23.160.464
3el4ROCGag-Pol polyprotein3.4.23.160.464
3el9DR7Gag-Pol polyprotein3.4.23.160.464
4e4n0NLTyrosine-protein kinase JAK1/0.464
2bpz3INGag-Pol polyprotein3.4.23.160.463
2r3wG3GGag-Pol polyprotein3.4.23.160.463
4ii5ADPCyclin-dependent kinase 22.7.11.220.463
4l9i8PRRhodopsin kinase/0.463
3ggaGGWGag-Pol polyprotein/0.462
3qpjN4IGag-Pol polyprotein3.4.23.160.462
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.461
1sdvMK1Gag-Pol polyprotein3.4.23.160.461
2nnpROCProtease/0.461
2q631UNGag-Pol polyprotein3.4.23.160.461
3nynSGVG protein-coupled receptor kinase 62.7.11.160.461
1c6x3INProtease/0.460
2bpv1INGag-Pol polyprotein3.4.23.160.460
1k6vXN2Gag-Pol polyprotein3.4.23.160.459
1sdtMK1Gag-Pol polyprotein3.4.23.160.459
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.459
4bcmT7ZCyclin-dependent kinase 22.7.11.220.459
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.458
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.458
2pym1UNGag-Pol polyprotein3.4.23.160.458
3juhANPCasein kinase II subunit alpha2.7.11.10.458
3zh8C58Protein kinase C iota type2.7.11.130.458
2f7e2EAcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.457
2qd8065Gag-Pol polyprotein3.4.23.160.457
2r3tG4GGag-Pol polyprotein3.4.23.160.457
2r43G3GGag-Pol polyprotein3.4.23.160.457
4ekl0RFRAC-alpha serine/threonine-protein kinase2.7.11.10.457
2zgzGNPPlasmid segregation protein ParM/0.456
1c6yMK1Protease/0.455
1z1rHBHGag-Pol polyprotein3.4.23.160.455
2uzvSS5cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.455
3c4zADPRhodopsin kinase/0.455
3cktYDPGag-Pol polyprotein3.4.23.160.455
3mv5XFERAC-alpha serine/threonine-protein kinase2.7.11.10.455
4ei7GDPPlasmid replication protein RepX/0.455
1sguMK1Gag-Pol polyprotein3.4.23.160.454
1z1hHBBGag-Pol polyprotein3.4.23.160.454
2q641UNGag-Pol polyprotein3.4.23.160.454
2uw0GVKcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.454
3aidARQGag-Pol polyprotein3.4.23.160.454
3qrmNK7Gag-Pol polyprotein3.4.23.160.454
4bbfO19Tyrosine-protein kinase JAK2/0.454
5av3KMPDeath-associated protein kinase 12.7.11.10.454
1c6zROCProtease/0.453
1hpoUNIGag-Pol polyprotein3.4.23.160.453
2vv9IM9Cyclin-dependent kinase 22.7.11.220.453
3e8eG98cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.453
3kn5ANPRibosomal protein S6 kinase alpha-52.7.11.10.453
3nuo478Gag-Pol polyprotein3.4.23.160.453
3ucb017Gag-Pol polyprotein/0.453
3ufnROCGag-Pol polyprotein/0.453
3vf5031Gag-Pol polyprotein3.4.23.160.453
4eutBX7Serine/threonine-protein kinase TBK12.7.11.10.453
4i3zADPCyclin-dependent kinase 22.7.11.220.453
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.452
2vo3M04cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.452
2ym6YM6Serine/threonine-protein kinase Chk12.7.11.10.452
3ekx1UNGag-Pol polyprotein3.4.23.160.452
3nduROCGag-Pol polyprotein3.4.23.160.452
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.452
1bv7XV6Gag-Pol polyprotein3.4.23.160.451
1jklANPDeath-associated protein kinase 12.7.11.10.451
1sbgIM1Gag-Pol polyprotein/0.451
2b7zMK1Gag-Pol polyprotein/0.451
2bpy3INGag-Pol polyprotein3.4.23.160.451
2vn0TDZCytochrome P450 2C8/0.451
3kkvB99cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.451
1fvv107Cyclin-dependent kinase 22.7.11.220.450
1k6pXN3Gag-Pol polyprotein3.4.23.160.450
1vijBAYGag-Pol polyprotein/0.450
2r5pMK1Gag-Pol polyprotein/0.450
3oxv478Gag-Pol polyprotein3.4.23.160.450
3pwrROCGag-Pol polyprotein3.4.23.160.450
3w2sW2REpidermal growth factor receptor2.7.10.10.450
3zpuM8BGag-Pol polyprotein3.4.23.160.450
4a6bQG8Gag-Pol polyprotein3.4.23.160.450
4e6d0NUTyrosine-protein kinase JAK2/0.450
4mk029XBeta-adrenergic receptor kinase 12.7.11.150.450
1hosPHPGag-Pol polyprotein/0.449
1ohr1UNV-1 PROTEASE protein/0.449
1vikBAYGag-Pol polyprotein/0.449
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.449
3bu5ATPInsulin receptor2.7.10.10.449
3ekwDR7Gag-Pol polyprotein3.4.23.160.449
3jy0LYGSerine/threonine-protein kinase pim-12.7.11.10.449
3oxxDR7Gag-Pol polyprotein3.4.23.160.449
4hvh19RTyrosine-protein kinase JAK32.7.10.20.449
4j55031Gag-Pol polyprotein3.4.23.160.449
1a8g2Z4Gag-Pol polyprotein3.4.23.160.448
1t7i017Gag-Pol polyprotein3.4.23.160.448
2aidTHKGag-Pol polyprotein3.4.23.160.448
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.448
2j0lANPFocal adhesion kinase 12.7.10.20.448
2pvnP63Casein kinase II subunit alpha2.7.11.10.448
2qd3CHDFerrochelatase, mitochondrial4.99.1.10.448
2qhcAB1Protease/0.448
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.448
3em4DR7Gag-Pol polyprotein3.4.23.160.448
3lixE17Protease/0.448
3vf7031Gag-Pol polyprotein3.4.23.160.448
1ec3MS3Gag-Pol polyprotein3.4.23.160.447
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.447
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.447
2bpw1INGag-Pol polyprotein3.4.23.160.447
2f2uM77Rho-associated protein kinase 22.7.11.10.447
1hiiC20Gag-Pol polyprotein/0.446
1k1u0Q4Gag-Pol polyprotein3.4.23.160.446
2csnCKICasein kinase I homolog 12.7.11.10.446
2yaaATPDeath-associated protein kinase 2/0.446
3d8vUD1Bifunctional protein GlmU/0.446
3s54017Protease/0.446
4eooATPCyclin-dependent kinase 22.7.11.220.446
1xl2189Gag-Pol polyprotein3.4.23.160.445
1yw2PGJMitogen-activated protein kinase 14/0.445
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.445
2r5q1UNGag-Pol polyprotein/0.445
3bxsDRSGag-Pol polyprotein3.4.23.160.445
3qihNI7Gag-Pol polyprotein3.4.23.160.445
3tnwF18Cyclin-dependent kinase 22.7.11.220.445
3u9eCOALmo1369 protein/0.445
3zptM8YGag-Pol polyprotein3.4.23.160.445
2uztSS3cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.444
3qrsNK8Gag-Pol polyprotein3.4.23.160.444
4b7sQLECytochrome P450 monooxygenase PikC/0.444
4fv9E71Mitogen-activated protein kinase 12.7.11.240.444
4k4p3TLGag-Pol polyprotein/0.444
1hsgMK1Gag-Pol polyprotein/0.443
2f8g017Gag-Pol polyprotein3.4.23.160.443
2fdd385Pol protein/0.443
2hs2017Protease/0.443
2p3a3TLPol protein/0.443
2qhm7CSSerine/threonine-protein kinase Chk12.7.11.10.443
2rkfAB1Pol protein/0.443
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
4e6q0NVTyrosine-protein kinase JAK2/0.443
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.443
4qnyANPMitogen activated protein kinase, putative/0.443
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.442
2vu3LZECyclin-dependent kinase 22.7.11.220.442
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.442
3a2oKNJGag-Pol polyprotein3.4.23.160.442
3bheBZNGag-Pol polyprotein3.4.23.160.442
3el1DR7Gag-Pol polyprotein3.4.23.160.442
3oxcROCProtease/0.442
3vfb031Gag-Pol polyprotein3.4.23.160.442
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.442
1ivp1ZKGag-Pol polyprotein/0.441
1meuDMPGag-Pol polyprotein3.4.23.160.441
1mtrPI6Gag-Pol polyprotein3.4.23.160.441
2pwrG4GGag-Pol polyprotein3.4.23.160.441
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.441
3gobHXXDdmC/0.441
3n7uNADFormate dehydrogenase, chloroplastic/mitochondrial/0.441
3qroNK9Gag-Pol polyprotein3.4.23.160.441
3sa323XProtease/0.441
4djoMK5Pol polyprotein/0.441
4hvi19STyrosine-protein kinase JAK32.7.10.20.441
4j95ACPFibroblast growth factor receptor 2/0.441
4ji91M3Tyrosine-protein kinase JAK2/0.441
4djhJDCKappa-type opioid receptor/0.441
1hvrXK2Gag-Pol polyprotein/0.440
1hxbROCGag-Pol polyprotein3.4.23.160.440
1q8uH52cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2cen4AHProtease/0.440
2fxeDR7Gag-Pol polyprotein3.4.23.160.440
2pqzG0GGag-Pol polyprotein3.4.23.160.440
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.440
3dcrKVSProtease/0.440
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.440
3k4vROCGag-Pol polyprotein3.4.23.160.440
3kfs3TLGag-Pol polyprotein/0.440
3nu4478Gag-Pol polyprotein3.4.23.160.440
3zkpERBErythromycin C-12 hydroxylase1.14.13.1540.440
3zpsEQMGag-Pol polyprotein3.4.23.160.440
4bibIEOMitogen-activated protein kinase kinase kinase 52.7.11.250.440
4fad0TBPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
4j99ACPFibroblast growth factor receptor 2/0.440