Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
PDB ID | HET | Uniprot Name | EC Number |
---|---|---|---|
4l44 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 |
PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
---|---|---|---|---|---|
4l44 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 1.000 | |
4l43 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.592 | |
4l3l | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.584 | |
3we4 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.572 | |
4l45 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.556 | |
4l3j | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.551 | |
3mvh | WFE | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.528 | |
4l42 | 5FI | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.514 | |
4oti | MI1 | Serine/threonine-protein kinase N1 | / | 0.514 | |
3cqw | CQW | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.506 | |
2cgu | 3A3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.501 | |
4yhj | AN2 | G protein-coupled receptor kinase 4 | 2.7.11.16 | 0.498 | |
1wvx | BD4 | Death-associated protein kinase 1 | 2.7.11.1 | 0.494 | |
1q8w | M77 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.490 | |
2uzu | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.488 | |
3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.488 | |
3t11 | 3T1 | Gag-Pol polyprotein | 3.4.23.16 | 0.488 | |
4fsn | A58 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.488 | |
3qp0 | NI8 | Gag-Pol polyprotein | 3.4.23.16 | 0.487 | |
4gv1 | 0XZ | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.486 | |
3nwx | KVS | Gag-Pol polyprotein | 3.4.23.16 | 0.485 | |
1yt9 | OIS | Gag-Pol polyprotein | / | 0.484 | |
2etr | Y27 | Rho-associated protein kinase 1 | 2.7.11.1 | 0.484 | |
3cyx | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.483 | |
4fti | H7K | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.483 | |
3nux | 3NV | Cyclin-dependent kinase 6 | 2.7.11.22 | 0.482 | |
4ezj | 0SC | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.482 | |
2oh0 | 2PY | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.478 | |
5av2 | KMP | Death-associated protein kinase 1 | 2.7.11.1 | 0.478 | |
3a62 | STU | Ribosomal protein S6 kinase beta-1 | 2.7.11.1 | 0.476 | |
2f3k | RO1 | Protease | / | 0.475 | |
2vo0 | M03 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.475 | |
3js2 | VM1 | Fibroblast growth factor receptor 1 | / | 0.475 | |
4bbe | 3O4 | Tyrosine-protein kinase JAK2 | / | 0.475 | |
4k1b | 1OC | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.475 | |
1k6t | XN1 | Gag-Pol polyprotein | 3.4.23.16 | 0.473 | |
1k6c | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.472 | |
2jds | L20 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.471 | |
3nxe | 2NC | Protease | / | 0.471 | |
3igo | ANP | Calmodulin-domain protein kinase 1, putative | / | 0.470 | |
3nu9 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.470 | |
3qbf | JHG | Gag-Pol polyprotein | 3.4.23.16 | 0.469 | |
3zew | STU | Ephrin type-B receptor 4 | 2.7.10.1 | 0.469 | |
3zo1 | SIJ | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.469 | |
4fg7 | ATP | Calcium/calmodulin-dependent protein kinase type 1 | 2.7.11.17 | 0.469 | |
2ijm | ADP | Focal adhesion kinase 1 | 2.7.10.2 | 0.468 | |
3el5 | 1UN | Gag-Pol polyprotein | / | 0.468 | |
1yvj | 4ST | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.467 | |
3ggx | GGX | Gag-Pol polyprotein | / | 0.467 | |
1fin | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.466 | |
1ida | 0PO | Gag-Pol polyprotein | 3.4.23.47 | 0.466 | |
2pwc | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.466 | |
2pyn | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.466 | |
3t8o | ATP | Rhodopsin kinase | / | 0.466 | |
4fsr | HKC | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.466 | |
4j5j | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.466 | |
2fxd | DR7 | Pol polyprotein | / | 0.465 | |
2qak | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.465 | |
2qnq | QN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.465 | |
3c4x | ATP | Rhodopsin kinase | / | 0.465 | |
3s85 | LK0 | Gag-Pol polyprotein | / | 0.465 | |
3ckx | STU | Serine/threonine-protein kinase 24 | 2.7.11.1 | 0.464 | |
3d1x | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.464 | |
3el4 | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.464 | |
3el9 | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.464 | |
4e4n | 0NL | Tyrosine-protein kinase JAK1 | / | 0.464 | |
2bpz | 3IN | Gag-Pol polyprotein | 3.4.23.16 | 0.463 | |
2r3w | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.463 | |
4ii5 | ADP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.463 | |
4l9i | 8PR | Rhodopsin kinase | / | 0.463 | |
3gga | GGW | Gag-Pol polyprotein | / | 0.462 | |
3qpj | N4I | Gag-Pol polyprotein | 3.4.23.16 | 0.462 | |
1qpj | STU | Tyrosine-protein kinase Lck | 2.7.10.2 | 0.461 | |
1sdv | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.461 | |
2nnp | ROC | Protease | / | 0.461 | |
2q63 | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.461 | |
3nyn | SGV | G protein-coupled receptor kinase 6 | 2.7.11.16 | 0.461 | |
1c6x | 3IN | Protease | / | 0.460 | |
2bpv | 1IN | Gag-Pol polyprotein | 3.4.23.16 | 0.460 | |
1k6v | XN2 | Gag-Pol polyprotein | 3.4.23.16 | 0.459 | |
1sdt | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.459 | |
3i4b | Z48 | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.459 | |
4bcm | T7Z | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.459 | |
1q3w | ATU | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.458 | |
1xr1 | ANP | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.458 | |
2pym | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.458 | |
3juh | ANP | Casein kinase II subunit alpha | 2.7.11.1 | 0.458 | |
3zh8 | C58 | Protein kinase C iota type | 2.7.11.13 | 0.458 | |
2f7e | 2EA | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.457 | |
2qd8 | 065 | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
2r3t | G4G | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
2r43 | G3G | Gag-Pol polyprotein | 3.4.23.16 | 0.457 | |
4ekl | 0RF | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.457 | |
2zgz | GNP | Plasmid segregation protein ParM | / | 0.456 | |
1c6y | MK1 | Protease | / | 0.455 | |
1z1r | HBH | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
2uzv | SS5 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.455 | |
3c4z | ADP | Rhodopsin kinase | / | 0.455 | |
3ckt | YDP | Gag-Pol polyprotein | 3.4.23.16 | 0.455 | |
3mv5 | XFE | RAC-alpha serine/threonine-protein kinase | 2.7.11.1 | 0.455 | |
4ei7 | GDP | Plasmid replication protein RepX | / | 0.455 | |
1sgu | MK1 | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
1z1h | HBB | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
2q64 | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
2uw0 | GVK | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.454 | |
3aid | ARQ | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
3qrm | NK7 | Gag-Pol polyprotein | 3.4.23.16 | 0.454 | |
4bbf | O19 | Tyrosine-protein kinase JAK2 | / | 0.454 | |
5av3 | KMP | Death-associated protein kinase 1 | 2.7.11.1 | 0.454 | |
1c6z | ROC | Protease | / | 0.453 | |
1hpo | UNI | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
2vv9 | IM9 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
3e8e | G98 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.453 | |
3kn5 | ANP | Ribosomal protein S6 kinase alpha-5 | 2.7.11.1 | 0.453 | |
3nuo | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
3ucb | 017 | Gag-Pol polyprotein | / | 0.453 | |
3ufn | ROC | Gag-Pol polyprotein | / | 0.453 | |
3vf5 | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.453 | |
4eut | BX7 | Serine/threonine-protein kinase TBK1 | 2.7.11.1 | 0.453 | |
4i3z | ADP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.453 | |
2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.452 | |
2vo3 | M04 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.452 | |
2ym6 | YM6 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.452 | |
3ekx | 1UN | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
3ndu | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.452 | |
4dit | 0KD | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.452 | |
1bv7 | XV6 | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
1jkl | ANP | Death-associated protein kinase 1 | 2.7.11.1 | 0.451 | |
1sbg | IM1 | Gag-Pol polyprotein | / | 0.451 | |
2b7z | MK1 | Gag-Pol polyprotein | / | 0.451 | |
2bpy | 3IN | Gag-Pol polyprotein | 3.4.23.16 | 0.451 | |
2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.451 | |
3kkv | B99 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.451 | |
1fvv | 107 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
1vij | BAY | Gag-Pol polyprotein | / | 0.450 | |
2r5p | MK1 | Gag-Pol polyprotein | / | 0.450 | |
3oxv | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
3pwr | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
3w2s | W2R | Epidermal growth factor receptor | 2.7.10.1 | 0.450 | |
3zpu | M8B | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
4a6b | QG8 | Gag-Pol polyprotein | 3.4.23.16 | 0.450 | |
4e6d | 0NU | Tyrosine-protein kinase JAK2 | / | 0.450 | |
4mk0 | 29X | Beta-adrenergic receptor kinase 1 | 2.7.11.15 | 0.450 | |
1hos | PHP | Gag-Pol polyprotein | / | 0.449 | |
1ohr | 1UN | V-1 PROTEASE protein | / | 0.449 | |
1vik | BAY | Gag-Pol polyprotein | / | 0.449 | |
2dq7 | STU | Tyrosine-protein kinase Fyn | 2.7.10.2 | 0.449 | |
3bu5 | ATP | Insulin receptor | 2.7.10.1 | 0.449 | |
3ekw | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
3jy0 | LYG | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.449 | |
3oxx | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
4hvh | 19R | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.449 | |
4j55 | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
1a8g | 2Z4 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
1t7i | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
2aid | THK | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
2cgw | 3C3 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.448 | |
2j0l | ANP | Focal adhesion kinase 1 | 2.7.10.2 | 0.448 | |
2pvn | P63 | Casein kinase II subunit alpha | 2.7.11.1 | 0.448 | |
2qd3 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.448 | |
2qhc | AB1 | Protease | / | 0.448 | |
2vo7 | M05 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.448 | |
3em4 | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
3lix | E17 | Protease | / | 0.448 | |
3vf7 | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.448 | |
1ec3 | MS3 | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
1j1c | ADP | Glycogen synthase kinase-3 beta | 2.7.11.26 | 0.447 | |
1o6y | ACP | Serine/threonine-protein kinase PknB | 2.7.11.1 | 0.447 | |
2bpw | 1IN | Gag-Pol polyprotein | 3.4.23.16 | 0.447 | |
2f2u | M77 | Rho-associated protein kinase 2 | 2.7.11.1 | 0.447 | |
1hii | C20 | Gag-Pol polyprotein | / | 0.446 | |
1k1u | 0Q4 | Gag-Pol polyprotein | 3.4.23.16 | 0.446 | |
2csn | CKI | Casein kinase I homolog 1 | 2.7.11.1 | 0.446 | |
2yaa | ATP | Death-associated protein kinase 2 | / | 0.446 | |
3d8v | UD1 | Bifunctional protein GlmU | / | 0.446 | |
3s54 | 017 | Protease | / | 0.446 | |
4eoo | ATP | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.446 | |
1xl2 | 189 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
1yw2 | PGJ | Mitogen-activated protein kinase 14 | / | 0.445 | |
2obj | VRV | Serine/threonine-protein kinase pim-1 | 2.7.11.1 | 0.445 | |
2r5q | 1UN | Gag-Pol polyprotein | / | 0.445 | |
3bxs | DRS | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
3qih | NI7 | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
3tnw | F18 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.445 | |
3u9e | COA | Lmo1369 protein | / | 0.445 | |
3zpt | M8Y | Gag-Pol polyprotein | 3.4.23.16 | 0.445 | |
2uzt | SS3 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.444 | |
3qrs | NK8 | Gag-Pol polyprotein | 3.4.23.16 | 0.444 | |
4b7s | QLE | Cytochrome P450 monooxygenase PikC | / | 0.444 | |
4fv9 | E71 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.444 | |
4k4p | 3TL | Gag-Pol polyprotein | / | 0.444 | |
1hsg | MK1 | Gag-Pol polyprotein | / | 0.443 | |
2f8g | 017 | Gag-Pol polyprotein | 3.4.23.16 | 0.443 | |
2fdd | 385 | Pol protein | / | 0.443 | |
2hs2 | 017 | Protease | / | 0.443 | |
2p3a | 3TL | Pol protein | / | 0.443 | |
2qhm | 7CS | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
2rkf | AB1 | Pol protein | / | 0.443 | |
2uzw | SS4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.443 | |
4e6q | 0NV | Tyrosine-protein kinase JAK2 | / | 0.443 | |
4ftt | 6HK | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.443 | |
4qny | ANP | Mitogen activated protein kinase, putative | / | 0.443 | |
2hy0 | 306 | Serine/threonine-protein kinase Chk1 | 2.7.11.1 | 0.442 | |
2vu3 | LZE | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.442 | |
2xbj | XBJ | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.442 | |
3a2o | KNJ | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
3bhe | BZN | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
3el1 | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
3oxc | ROC | Protease | / | 0.442 | |
3vfb | 031 | Gag-Pol polyprotein | 3.4.23.16 | 0.442 | |
5dqr | FAD | 7-hydroxymethyl chlorophyll a reductase, chloroplastic | 1.17.7.2 | 0.442 | |
1ivp | 1ZK | Gag-Pol polyprotein | / | 0.441 | |
1meu | DMP | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
1mtr | PI6 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
2pwr | G4G | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
2r7b | 253 | 3-phosphoinositide-dependent protein kinase 1 | 2.7.11.1 | 0.441 | |
3gob | HXX | DdmC | / | 0.441 | |
3n7u | NAD | Formate dehydrogenase, chloroplastic/mitochondrial | / | 0.441 | |
3qro | NK9 | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
3sa3 | 23X | Protease | / | 0.441 | |
4djo | MK5 | Pol polyprotein | / | 0.441 | |
4hvi | 19S | Tyrosine-protein kinase JAK3 | 2.7.10.2 | 0.441 | |
4j95 | ACP | Fibroblast growth factor receptor 2 | / | 0.441 | |
4ji9 | 1M3 | Tyrosine-protein kinase JAK2 | / | 0.441 | |
4djh | JDC | Kappa-type opioid receptor | / | 0.441 | |
1hvr | XK2 | Gag-Pol polyprotein | / | 0.440 | |
1hxb | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
1q8u | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
2cen | 4AH | Protease | / | 0.440 | |
2fxe | DR7 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
2pqz | G0G | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
2xm9 | LWH | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.440 | |
3dcr | KVS | Protease | / | 0.440 | |
3i5z | Z48 | Mitogen-activated protein kinase 1 | 2.7.11.24 | 0.440 | |
3k4v | ROC | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
3kfs | 3TL | Gag-Pol polyprotein | / | 0.440 | |
3nu4 | 478 | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
3zkp | ERB | Erythromycin C-12 hydroxylase | 1.14.13.154 | 0.440 | |
3zps | EQM | Gag-Pol polyprotein | 3.4.23.16 | 0.440 | |
4bib | IEO | Mitogen-activated protein kinase kinase kinase 5 | 2.7.11.25 | 0.440 | |
4fad | 0TB | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.440 | |
4j99 | ACP | Fibroblast growth factor receptor 2 | / | 0.440 |