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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4ise1FWGlucokinase2.7.1.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4ise1FWGlucokinase2.7.1.21.000
4isg1FYGlucokinase2.7.1.20.641
4isf1FXGlucokinase2.7.1.20.630
4dch4DCGlucokinase2.7.1.20.565
4mleVO1Glucokinase2.7.1.20.536
4dhyS41Glucokinase2.7.1.20.534
3h1vTK1Glucokinase2.7.1.20.519
3a0iAJIGlucokinase2.7.1.20.516
3imxB84Glucokinase2.7.1.20.509
3vev0H4Glucokinase2.7.1.20.501
3a1cACPProbable copper-exporting P-type ATPase A3.6.3.540.492
1z6tADPApoptotic protease-activating factor 1/0.487
1x1bSAHC-20 methyltransferase/0.485
3pm1ETHTH-type transcriptional regulator QacR/0.485
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.483
3ziaADPATP synthase subunit beta, mitochondrial3.6.3.140.483
1kkq471Peroxisome proliferator-activated receptor alpha/0.481
3h3sH15Collagen type IV alpha-3-binding protein/0.481
4ixc1JDGlucokinase2.7.1.20.473
3g5hYTTMycocyclosin synthase1.14.21.90.472
4ips1G4Mycocyclosin synthase1.14.21.90.472
1dnpMHFDeoxyribodipyrimidine photo-lyase4.1.99.30.470
4y9uNAPNADPH--cytochrome P450 reductase/0.470
1q0zAKAAclacinomycin methylesterase RdmC3.1.1.950.469
2yj4ATPCopper-transporting ATPase/0.469
1c7oPPGHemolysin/0.468
4bfuZVUPantothenate kinase2.7.1.330.468
3id8MRKGlucokinase2.7.1.20.467
3l6jZ90Alr2278 protein/0.467
3vey0H5Glucokinase2.7.1.20.467
4e907RGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.467
4iwv1J9Glucokinase2.7.1.20.467
1zeoC01Peroxisome proliferator-activated receptor gamma/0.466
2am22LGUDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase/0.466
4mlhVO2Glucokinase2.7.1.20.466
2vcmM11Isopenicillin N synthase1.21.3.10.465
4a83DXCMajor pollen allergen Bet v 1-A/0.465
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.464
3h3t16HCollagen type IV alpha-3-binding protein/0.464
4bfzZVZPantothenate kinase2.7.1.330.464
3s41S41Glucokinase2.7.1.20.463
4y7cNAPNADPH--cytochrome P450 reductase/0.463
3zkyWT4Isopenicillin N synthase1.21.3.10.462
4yaw2AMNADPH--cytochrome P450 reductase/0.461
1amoNAPNADPH--cytochrome P450 reductase/0.460
1fx9MJIPhospholipase A2, major isoenzyme3.1.1.40.460
1q0rAKTAclacinomycin methylesterase RdmC3.1.1.950.460
2hk9NAPShikimate dehydrogenase (NADP(+))/0.460
2jj2ANPATP synthase subunit beta, mitochondrial3.6.3.140.460
3lpiZ74Beta-secretase 13.4.23.460.460
3nr4PYVAbscisic acid receptor PYL2/0.460
4iae1DXAlr2278 protein/0.460
2xviFADPutative flavin-containing monooxygenase/0.459
2yy2IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
3dys5GPHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
1qjfACSIsopenicillin N synthase1.21.3.10.458
4bftZVTPantothenate kinase2.7.1.330.458
4bfxZVXPantothenate kinase2.7.1.330.458
1x1dSAHC-20 methyltransferase/0.457
2g1r3IGRenin3.4.23.150.457
5jqhCAUBeta-2 adrenergic receptor/0.457
1x8lOXRRetinol dehydratase/0.456
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.456
2yyeAPCSelenide, water dikinase2.7.9.30.456
3adaNADSubunit alpha of sarocosine oxidase/0.456
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.456
4iah1DXAlr2278 protein/0.456
4ipw1G7Mycocyclosin synthase1.14.21.90.456
4l3q926Glucokinase2.7.1.20.456
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.455
1nytNAPShikimate dehydrogenase (NADP(+))/0.455
1oc1ASVIsopenicillin N synthase1.21.3.10.455
1pkfEPDEpothilone C/D epoxidase1.140.455
1qiqACCIsopenicillin N synthase1.21.3.10.455
2uxoTACHTH-type transcriptional regulator TtgR/0.455
4bfwZVWPantothenate kinase2.7.1.330.455
4yal2AMNADPH--cytochrome P450 reductase/0.455
1ja1FMNNADPH--cytochrome P450 reductase/0.454
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.454
3g1rFIT3-oxo-5-beta-steroid 4-dehydrogenase/0.454
3jyoNADQuinate/shikimate dehydrogenase (NAD(+))/0.454
3lkhLT6Genome polyprotein2.7.7.480.454
1h50FMNPentaerythritol tetranitrate reductase/0.453
1lf3EH5Plasmepsin-23.4.23.390.453
4bfyZVYPantothenate kinase2.7.1.330.453
1x1aSAMC-20 methyltransferase/0.452
3junAKDPhenazine biosynthesis protein A/B/0.452
4y9rNAPNADPH--cytochrome P450 reductase/0.452
2cy0NAPShikimate dehydrogenase (NADP(+))/0.451
3c1oNAPEugenol synthase/0.451
3n39FMNProtein NrdI/0.451
1kzjCB3Thymidylate synthase/0.450
3pqbVGPPutative oxidoreductase/0.450
5bv3M7Gm7GpppX diphosphatase3.6.1.590.450
2zb8IMNProstaglandin reductase 21.3.1.480.449
3fznD7KBenzoylformate decarboxylase4.1.1.70.449
3h3r14HCollagen type IV alpha-3-binding protein/0.449
3nksACJProtoporphyrinogen oxidase1.3.3.40.449
4b67NAPL-ornithine N(5)-monooxygenase/0.449
4bfsZVSPantothenate kinase2.7.1.330.449
1amoFMNNADPH--cytochrome P450 reductase/0.448
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.448
3br3ETHTH-type transcriptional regulator QacR/0.448
3dynPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
4g2l0WLHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.448
4ktl1CQCytochrome P450/0.448
1bk0ACVIsopenicillin N synthase1.21.3.10.447
2dsiSAHDiphthine synthase/0.447
2yj5ATPCopper-transporting ATPase/0.447
2zbaZBATrichothecene 3-O-acetyltransferase/0.447
1dr3HBIDihydrofolate reductase1.5.1.30.446
1icqOPD12-oxophytodienoate reductase 11.3.1.420.446
2y60M8FIsopenicillin N synthase1.21.3.10.446
3b1dPLSBetaC-S lyase/0.446
3zvmADPBifunctional polynucleotide phosphatase/kinase2.7.1.780.446
4eagATP5'-AMP-activated protein kinase subunit gamma-1/0.446
4yau2AMNADPH--cytochrome P450 reductase/0.446
1cjkFOKAdenylate cyclase type 2/0.445
1cjkFOKAdenylate cyclase type 5/0.445
2jbsFMNp-hydroxyphenylacetate 3-hydroxylase, oxygenase component/0.445
4eb7PLPCysteine desulfurase IscS 2/0.445
4jlj1NMDeoxycytidine kinase2.7.1.740.445
1jraFADFAD-linked sulfhydryl oxidase ERV21.8.3.20.444
1x1cSAHC-20 methyltransferase/0.444
2nr4FMNConserved protein/0.444
2ov2GCPRas-related C3 botulinum toxin substrate 3/0.444
2wo7ASVIsopenicillin N synthase1.21.3.10.444
2xveFADPutative flavin-containing monooxygenase/0.444
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
1aquESTEstrogen sulfotransferase, testis isoform2.8.2.40.443
1culFOKAdenylate cyclase type 2/0.443
1culFOKAdenylate cyclase type 5/0.443
1fxfMJIPhospholipase A2, major isoenzyme3.1.1.40.443
2rqfJH3Hemolymph juvenile hormone binding protein/0.443
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.443
3phiNDPShikimate dehydrogenase (NADP(+))/0.443
3uzxAOX3-oxo-5-beta-steroid 4-dehydrogenase/0.443
4g1z0VPVitamin D3 receptor A/0.443
2a5kAZPReplicase polyprotein 1ab3.4.220.442
2hunNAD336aa long hypothetical dTDP-glucose 4,6-dehydratase/0.442
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3fhxPXLPyridoxal kinase2.7.1.350.442
4c4oNADSADH/0.442
4ict1EDMycocyclosin synthase1.14.21.90.442
4ivoACJProtoporphyrinogen oxidase1.3.3.40.442
4ocvANPAminoglycoside phosphotransferase/0.442
4yaf2AMNADPH--cytochrome P450 reductase/0.442
5cc9DDFDihydrofolate reductase1.5.1.30.442
5fd8A5APutative carboxypeptidase yocD/0.442
1enoNADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.441
1vrwNAIEnoyl-ACP reductase/0.441
2g1o2IGRenin3.4.23.150.441
2ij7TPFMycocyclosin synthase1.14.21.90.441
2jb4A14Isopenicillin N synthase1.21.3.10.441
2jizANPATP synthase subunit beta, mitochondrial3.6.3.140.441
3c3xNAPEugenol synthase 11.1.1.3180.441
4g3jVNTLanosterol 14-alpha-demethylase/0.441
4mdkU94Ubiquitin-conjugating enzyme E2 R1/0.441
1k7l544Peroxisome proliferator-activated receptor alpha/0.440
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.440
1rneC60Renin3.4.23.150.440
1ygkRRCPyridoxal kinase2.7.1.350.440
3b04OOPIsopentenyl-diphosphate delta-isomerase/0.440
3c15FOKAdenylate cyclase type 2/0.440
3c15FOKAdenylate cyclase type 5/0.440
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3ivcFG4Pantothenate synthetase6.3.2.10.440
3ox34X4Ribosyldihydronicotinamide dehydrogenase [quinone]/0.440
4b1rITCTetracycline repressor protein class D/0.440
4b66NAPL-ornithine N(5)-monooxygenase/0.440
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.440
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
4ho6UTPGlucose-1-phosphate thymidylyltransferase/0.440
4i4z2NE1,4-dihydroxy-2-naphthoyl-CoA synthase/0.440
4j0v1H7Beta-secretase 13.4.23.460.440
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.440
4k9oTPPBenzoylformate decarboxylase4.1.1.70.440