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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4hib16BUridine 5'-monophosphate synthase4.1.1.23

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4hib16BUridine 5'-monophosphate synthase4.1.1.231.000
3l0nS5PUridine 5'-monophosphate synthase4.1.1.230.605
3uwqU5POrotidine 5'-phosphate decarboxylase/0.555
3ewyU5PUridine 5'-monophosphate synthase4.1.1.230.548
2yyuC5POrotidine 5'-phosphate decarboxylase/0.525
3rv6VAESalicylate synthase/0.512
2hfuMEVMevalonate kinase/0.481
4nt03DUOrotidine 5'-phosphate decarboxylase4.1.1.230.477
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.476
5fdg0N8Polymerase acidic protein/0.470
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.469
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.467
5agaANPDNA polymerase theta/0.462
2k0gCMPCyclic nucleotide-gated potassium channel mll3241/0.461
2v3aFADRubredoxin-NAD(+) reductase1.18.1.10.460
4s34ANPMitogen-activated protein kinase 12.7.11.240.459
4g3pUD1Bifunctional protein GlmU/0.457
4ho9GDUGlucose-1-phosphate thymidylyltransferase/0.455
1e8zSTUPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.454
2ww4ADP4-diphosphocytidyl-2-C-methyl-D-erythritol kinase2.7.1.1480.454
4jb1FADUDP-N-acetylenolpyruvoylglucosamine reductase/0.453
4x2dATPFic family protein putative filamentation induced by cAMP protein/0.453
1jpaANPEphrin type-B receptor 22.7.10.10.452
1nzdUPGDNA beta-glucosyltransferase/0.452
1q43CMPPotassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2/0.452
2w6oOA3Biotin carboxylase6.3.4.140.452
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.452
1bwkFMNNADPH dehydrogenase 11.6.99.10.451
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.451
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.451
2v59LZKBiotin carboxylase6.3.4.140.451
3cr3ADPPTS-dependent dihydroxyacetone kinase, ADP-binding subunit DhaL2.70.451
3lqfNADGalactitol dehydrogenase/0.451
3r6sCMPCRP-like cAMP-activated global transcriptional regulator/0.451
1g0rTHMGlucose-1-phosphate thymidylyltransferase/0.450
2y6o1N1Ephrin type-A receptor 42.7.10.10.450
1bcpATPPertussis toxin subunit 4/0.449
1bcpATPPertussis toxin subunit 5/0.449
3iwjNADAminoaldehyde dehydrogenase/0.449
4jin1L7RIO-type serine/threonine-protein kinase Rio12.7.11.10.449
4jlpADPAdenylate kinase/0.449
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.448
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
1nzfUPGDNA beta-glucosyltransferase/0.447
3dj4UD1Bifunctional protein GlmU/0.446
3ruhNADUDP-N-acetylglucosamine 4-epimerase/0.446
1z6tADPApoptotic protease-activating factor 1/0.445
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.445
4mv8ACPBiotin carboxylase6.3.4.140.445
1giaGSPGuanine nucleotide-binding protein G(i) subunit alpha-1/0.444
1ve3SAMUncharacterized protein/0.444
2hdhNADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial1.1.1.350.444
2yvgNADFerredoxin reductase/0.444
3fhxPLPPyridoxal kinase2.7.1.350.444
4i02CMPcAMP-activated global transcriptional regulator CRP/0.444
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.443
1typFADTrypanothione reductase1.8.1.120.443
2g9uG27Glycogen phosphorylase, muscle form2.4.1.10.443
3p82FMNPentaerythritol tetranitrate reductase/0.443
4ajj88RL-lactate dehydrogenase A chain1.1.1.270.443
4yv1S4MSpermidine synthase, putative/0.443
5ayzNCNNicotinate-nucleotide pyrophosphorylase [carboxylating]2.4.2.190.443
1kh3ANPArgininosuccinate synthase/0.442
2itwITQEpidermal growth factor receptor2.7.10.10.442
2rg5279Mitogen-activated protein kinase 14/0.442
3d8vUD1Bifunctional protein GlmU/0.442
3iaaTYDCalG2/0.442
3lsiFADPyranose 2-oxidase/0.442
4bgbADPPredicted molecular chaperone distantly related to HSP70-fold metalloproteases/0.442
4m4922YL-lactate dehydrogenase A chain1.1.1.270.442
4o671SYCyclic GMP-AMP synthase/0.442
1qnfFADDeoxyribodipyrimidine photo-lyase4.1.99.30.441
1w29TS06,7-dimethyl-8-ribityllumazine synthase2.5.1.780.441
1yp4ADQGlucose-1-phosphate adenylyltransferase small subunit, chloroplastic/amyloplastic2.7.7.270.441
2ad5ADPCTP synthase/0.441
2cduFADNADH oxidase/0.441
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.441
2q1l8823-hydroxy-3-methylglutaryl-coenzyme A reductase1.1.1.340.441
3w9rA8SAbscisic acid receptor PYL9/0.441
1t0lNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.440
1u1iNADMyo-inositol-1-phosphate synthase (Ino1)/0.440
2iiqC5PAlpha-2,3/2,6-sialyltransferase/sialidase/0.440
2jirMGDPeriplasmic nitrate reductase/0.440
3a8tATPAdenylate isopentenyltransferase/0.440
3apfBMWPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.440
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.440
4a0mNADBetaine aldehyde dehydrogenase, chloroplastic1.2.1.80.440
4bfsZVSPantothenate kinase2.7.1.330.440
4jlbADPAdenylate kinase/0.440