scPDB - Distribution of Binding site Similarity values of 4ffw entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
4ffw	715	Dipeptidyl peptidase 4

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
4ffw	715	Dipeptidyl peptidase 4	/	1.000
2oae	AIL	Dipeptidyl peptidase 4	/	0.634
3f8s	PF2	Dipeptidyl peptidase 4	/	0.630
3qbj	NXZ	Dipeptidyl peptidase 4	/	0.613
3vjk	M51	Dipeptidyl peptidase 4	/	0.591
4g1f	0WG	Dipeptidyl peptidase 4	/	0.571
3opm	LUI	Dipeptidyl peptidase 4	/	0.570
3ccc	7AC	Dipeptidyl peptidase 4	/	0.568
3vjl	W94	Dipeptidyl peptidase 4	/	0.562
2rgu	356	Dipeptidyl peptidase 4	/	0.549
3g0b	T22	Dipeptidyl peptidase 4	/	0.549
4a5s	N7F	Dipeptidyl peptidase 4	/	0.539
3ccb	B2Y	Dipeptidyl peptidase 4	/	0.534
3g0d	XIH	Dipeptidyl peptidase 4	/	0.526
3g0g	RUM	Dipeptidyl peptidase 4	/	0.519
2aj8	SC3	Dipeptidyl peptidase 4	/	0.508
3vyf	VYF	Renin	3.4.23.15	0.487
4nv0	MG7	7-methylguanosine phosphate-specific 5'-nucleotidase	/	0.485
3ziu	LSS	Leucyl-tRNA synthetase	/	0.484
3fkt	SII	Beta-secretase 1	3.4.23.46	0.482
1pqc	444	Oxysterols receptor LXR-beta	/	0.479
2xup	TZ5	Acetylcholinesterase	3.1.1.7	0.479
5d4v	YGP	Uncharacterized protein MJ0489	/	0.478
3oqk	S52	Renin	3.4.23.15	0.477
2i4q	UA4	Renin	3.4.23.15	0.476
2xui	TZ5	Acetylcholinesterase	3.1.1.7	0.476
2xug	TZ4	Acetylcholinesterase	3.1.1.7	0.475
3qgf	46F	Genome polyprotein	2.7.7.48	0.474
2iku	LIY	Renin	3.4.23.15	0.473
3oqf	S51	Renin	3.4.23.15	0.472
2j3q	TFL	Acetylcholinesterase	3.1.1.7	0.471
3vsx	R32	Renin	3.4.23.15	0.471
3oad	LPO	Renin	3.4.23.15	0.470
1szg	FNS	Cytochrome b2, mitochondrial	1.1.2.3	0.469
4ey7	E20	Acetylcholinesterase	3.1.1.7	0.469
4frk	DWD	Beta-secretase 1	3.4.23.46	0.469
1lf2	R37	Plasmepsin-2	3.4.23.39	0.468
2g26	3LG	Renin	3.4.23.15	0.468
2xnv	VU3	Soluble acetylcholine receptor	/	0.468
4rvg	TYD	D-mycarose 3-C-methyltransferase	/	0.466
2g24	7IG	Renin	3.4.23.15	0.465
1tco	FK5	Peptidyl-prolyl cis-trans isomerase FKBP1A	5.2.1.8	0.464
1tco	FK5	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	3.1.3.16	0.464
2v5u	FMN	Flavodoxin	/	0.464
1odc	A8B	Acetylcholinesterase	3.1.1.7	0.463
2xuq	TZ4	Acetylcholinesterase	3.1.1.7	0.463
3udj	092	Beta-secretase 1	3.4.23.46	0.463
3apw	DP0	Alpha-1-acid glycoprotein 2	/	0.461
4gv4	MEJ	Poly [ADP-ribose] polymerase 3	2.4.2.30	0.461
3d28	B34	Genome polyprotein	2.7.7.48	0.460
4l7h	1W1	Beta-secretase 1	3.4.23.46	0.460
1xva	SAM	Glycine N-methyltransferase	2.1.1.20	0.459
2xys	SY9	Soluble acetylcholine receptor	/	0.459
2xuf	TZ4	Acetylcholinesterase	3.1.1.7	0.458
3br9	DEY	Genome polyprotein	2.7.7.48	0.458
3ufl	508	Beta-secretase 1	3.4.23.46	0.458
3v0o	4GW	Histo-blood group ABO system transferase	/	0.458
4d89	BXD	Beta-secretase 1	3.4.23.46	0.458
3g86	T18	Genome polyprotein	2.7.7.48	0.457
5ah5	LSS	Leucine--tRNA ligase	/	0.457
3pka	Y02	Methionine aminopeptidase 2	/	0.456
2cek	N8T	Acetylcholinesterase	3.1.1.7	0.455
2ha6	SCK	Acetylcholinesterase	3.1.1.7	0.455
2wzy	SQX	Soluble acetylcholine receptor	/	0.455
3d91	REM	Renin	3.4.23.15	0.455
3h0b	B35	Beta-secretase 1	3.4.23.46	0.455
4tvj	09L	Poly [ADP-ribose] polymerase 2	2.4.2.30	0.455
1ja1	FMN	NADPH--cytochrome P450 reductase	/	0.454
1x1b	SAH	C-20 methyltransferase	/	0.454
2c9z	QUE	Anthocyanidin 3-O-glucosyltransferase 2	2.4.1.115	0.454
2g1o	2IG	Renin	3.4.23.15	0.454
3g6z	A7T	Renin	3.4.23.15	0.454
3udn	09B	Beta-secretase 1	3.4.23.46	0.454
1c7o	PPG	Hemolysin	/	0.453
3ko0	TFP	Protein S100-A4	/	0.453
1pr6	XYA	Purine nucleoside phosphorylase DeoD-type	/	0.452
2fhj	H4Z	Formylmethanofuran--tetrahydromethanopterin formyltransferase	2.3.1.101	0.452
2fs4	PZ1	Renin	3.4.23.15	0.451
3hdy	GDU	UDP-galactopyranose mutase	/	0.451
3vsw	R31	Renin	3.4.23.15	0.451
4rvf	TYD	D-mycarose 3-C-methyltransferase	/	0.451
2g27	4LG	Renin	3.4.23.15	0.450
4da7	AC2	Purine nucleoside phosphorylase DeoD-type	2.4.2.1	0.450
4j0v	1H7	Beta-secretase 1	3.4.23.46	0.450
2gyw	OBI	Acetylcholinesterase	3.1.1.7	0.449
2wf0	ZY0	Beta-secretase 1	3.4.23.46	0.449
3zm6	2GN	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	/	0.449
4acx	S8Z	Beta-secretase 1	3.4.23.46	0.449
4k9h	1QU	Beta-secretase 1	3.4.23.46	0.449
2bkt	RPF	Renin	3.4.23.15	0.448
3k1w	BFX	Renin	3.4.23.15	0.448
1rne	C60	Renin	3.4.23.15	0.447
3jsw	JAR	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.447
1txt	CAA	HMG-CoA synthase	/	0.446
1vso	AT1	Glutamate receptor ionotropic, kainate 1	/	0.446
3g5s	FAD	Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO	/	0.446
3zm5	IGM	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase	/	0.446
4eb7	PLP	Cysteine desulfurase IscS 2	/	0.446
4uth	FMN	Xenobiotic reductase	/	0.446
1n2i	PAJ	Pantothenate synthetase	6.3.2.1	0.445
2vce	U2F	UDP-glycosyltransferase 72B1	/	0.445
2wvm	GDD	Mannosyl-3-phosphogylcerate synthase	/	0.445
2xuk	TZ5	Acetylcholinesterase	3.1.1.7	0.445
3gjw	GJW	Poly [ADP-ribose] polymerase 1	2.4.2.30	0.445
3nub	UD0	UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase	2.6.1.98	0.445
3v0p	4GW	Histo-blood group ABO system transferase	/	0.445
3zxi	TYA	Tyrosine--tRNA ligase, mitochondrial	6.1.1.1	0.445
4dpi	0N1	Beta-secretase 1	3.4.23.46	0.445
4j4n	D44	Peptidylprolyl isomerase	/	0.445
1jik	545	Tyrosine--tRNA ligase	/	0.444
2fw3	BUI	Carnitine O-palmitoyltransferase 2, mitochondrial	2.3.1.21	0.444
2ges	COK	Pantothenate kinase	2.7.1.33	0.444
2il2	LIX	Renin	3.4.23.15	0.444
2q1w	NAD	Putative nucleotide sugar epimerase/ dehydratase	/	0.444
2xlp	FAD	Putative flavin-containing monooxygenase	/	0.444
3zia	ATP	ATP synthase subunit alpha, mitochondrial	/	0.444
4aws	FMN	NADH:flavin oxidoreductase Sye1	/	0.444
1z6t	ADP	Apoptotic protease-activating factor 1	/	0.443
2a3b	CFF	Endochitinase B1	3.2.1.14	0.443
2ifa	FMN	Uncharacterized protein	/	0.443
2v16	C47	Renin	3.4.23.15	0.443
3pkd	Y10	Methionine aminopeptidase 2	/	0.443
4nv1	4TG	Formyl transferase	/	0.443
1fap	RAP	Peptidyl-prolyl cis-trans isomerase FKBP1A	5.2.1.8	0.442
1fap	RAP	Serine/threonine-protein kinase mTOR	2.7.11.1	0.442
1u1g	BBB	Uridine phosphorylase	2.4.2.3	0.442
3fnl	SHA	Lactoperoxidase	/	0.442
3nxq	RX4	Angiotensin-converting enzyme	3.2.1	0.442
4cax	646	Glycylpeptide N-tetradecanoyltransferase	2.3.1.97	0.442
4opi	FDA	Conserved Archaeal protein	/	0.442
4rxq	DUT	Deoxynucleoside triphosphate triphosphohydrolase SAMHD1	3.1.5	0.442
1icp	FMN	12-oxophytodienoate reductase 1	1.3.1.42	0.441
1k9s	FM1	Purine nucleoside phosphorylase DeoD-type	/	0.441
1zgb	A1E	Acetylcholinesterase	3.1.1.7	0.441
2gou	FMN	NADH:flavin oxidoreductase Sye1	/	0.441
2isc	223	Purine nucleoside phosphorylase, putative	/	0.441
2oah	QIN	Beta-secretase 1	3.4.23.46	0.441
2w6c	BM4	Acetylcholinesterase	3.1.1.7	0.441
3pkb	Y16	Methionine aminopeptidase 2	/	0.441
3vyd	VYD	Renin	3.4.23.15	0.441
4arb	C57	Acetylcholinesterase	3.1.1.7	0.441
4b79	NAD	Probable short-chain dehydrogenase	/	0.441
4fse	0VA	Beta-secretase 1	3.4.23.46	0.441
4k97	ATP	Cyclic GMP-AMP synthase	/	0.441
2jf0	HBP	Acetylcholinesterase	3.1.1.7	0.440
2y1x	845	Histone-arginine methyltransferase CARM1	/	0.440
3gyn	B42	Genome polyprotein	2.7.7.48	0.440
3qe2	FMN	NADPH--cytochrome P450 reductase	/	0.440
3rsv	3RS	Beta-secretase 1	3.4.23.46	0.440
3v2u	ATP	Protein GAL3	/	0.440
3veu	0GO	Beta-secretase 1	3.4.23.46	0.440
3vuc	HHE	Renin	3.4.23.15	0.440
3zbr	NAP	2',3'-cyclic-nucleotide 3'-phosphodiesterase	3.1.4.37	0.440
4bup	SAM	Histone-lysine N-methyltransferase KMT5B	2.1.1.43	0.440