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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4cukNAID-lactate dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4cukNAID-lactate dehydrogenase/1.000
3vt7VDXVitamin D3 receptor/0.494
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.481
4bb3KKAIsopenicillin N synthase1.21.3.10.480
2vn0TDZCytochrome P450 2C8/0.477
1nzdUPGDNA beta-glucosyltransferase/0.473
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.471
1xddAAYIntegrin alpha-L/0.467
4q71FADBifunctional protein PutA/0.466
1nuuNADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.465
2bu9HFVIsopenicillin N synthase1.21.3.10.465
2iodMYCDihydroflavonol 4-reductase1.1.1.2190.463
2v9jATP5'-AMP-activated protein kinase subunit gamma-1/0.462
3lqfNADGalactitol dehydrogenase/0.462
4b2gV1NUncharacterized protein/0.462
4zgsNADPutative D-lactate dehydrogenase/0.461
4b4dFADFerredoxin-NADP reductase/0.460
1hb3SCVIsopenicillin N synthase1.21.3.10.459
2iviACWIsopenicillin N synthase1.21.3.10.459
3gw9VNILanosterol 14-alpha-demethylase/0.459
4g7gVFVLanosterol 14-alpha-demethylase/0.459
4a83DXCMajor pollen allergen Bet v 1-A/0.457
1bw9NADPhenylalanine dehydrogenase/0.456
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.453
4i6gFADCryptochrome-2/0.453
4ia7BIVVitamin D3 receptor A/0.453
1bk0ACVIsopenicillin N synthase1.21.3.10.452
1tj0FADBifunctional protein PutA1.5.5.20.452
3c1tMYCDihydroflavonol 4-reductase1.1.1.2190.452
3zoiM2WIsopenicillin N synthase1.21.3.10.452
4e5yNDPGDP-L-fucose synthase1.1.1.2710.452
1uzwCDHIsopenicillin N synthase1.21.3.10.451
4ia1BIVVitamin D3 receptor A/0.451
1bwsNDPGDP-L-fucose synthase/0.450
3vt9YI4Vitamin D3 receptor/0.450
3zkyWT4Isopenicillin N synthase1.21.3.10.450
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
4ia3BIVVitamin D3 receptor A/0.449
3nd1SAHPrecorrin-6A synthase (Deacetylating)/0.448
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.448
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.447
3rueNADUDP-N-acetylglucosamine 4-epimerase/0.447
1nuqNXXNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.446
3gfbNADL-threonine 3-dehydrogenase/0.446
3l6jZ90Alr2278 protein/0.446
5a4kFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
5dozNDPJamJ/0.446
1hb1OCVIsopenicillin N synthase1.21.3.10.445
2zbaZBATrichothecene 3-O-acetyltransferase/0.445
4gu5FADCryptochrome-1/0.445
4ryvZEAProtein LlR18A/0.445
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1rszDIHPurine nucleoside phosphorylase2.4.2.10.444
2he5NDPAldo-keto reductase family 1 member C211.1.10.444
2v5aLZLBiotin carboxylase6.3.4.140.444
4mv8ACPBiotin carboxylase6.3.4.140.444
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
1fmlRTLRetinol dehydratase/0.443
4jqh1MFAlr2278 protein/0.443
2eklNADD-3-phosphoglycerate dehydrogenase/0.442
2y6fM9FIsopenicillin N synthase1.21.3.10.442
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.442
1nzfUPGDNA beta-glucosyltransferase/0.441
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.441
3fhxPLPPyridoxal kinase2.7.1.350.441
3gobHXXDdmC/0.441
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.441
2jb4A14Isopenicillin N synthase1.21.3.10.440
4f4dCHDFerrochelatase, mitochondrial4.99.1.10.440
4q72FADBifunctional protein PutA/0.440