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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4a9uA9USerine/threonine-protein kinase Chk22.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4a9uA9USerine/threonine-protein kinase Chk22.7.11.11.000
2wtdZZKSerine/threonine-protein kinase Chk22.7.11.10.621
2wtjWTJSerine/threonine-protein kinase Chk22.7.11.10.584
2wtiWTISerine/threonine-protein kinase Chk22.7.11.10.578
4a9tA9TSerine/threonine-protein kinase Chk22.7.11.10.572
4a9rRU5Serine/threonine-protein kinase Chk22.7.11.10.571
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.548
4a9sRU9Serine/threonine-protein kinase Chk22.7.11.10.543
2wtcVGMSerine/threonine-protein kinase Chk22.7.11.10.527
2w7xD1ASerine/threonine-protein kinase Chk22.7.11.10.526
2ycfYCFSerine/threonine-protein kinase Chk22.7.11.10.523
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.519
2pe24643-phosphoinositide-dependent protein kinase 12.7.11.10.517
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.517
2xbjXBJSerine/threonine-protein kinase Chk22.7.11.10.513
1z5mLI83-phosphoinositide-dependent protein kinase 12.7.11.10.505
2pe15173-phosphoinositide-dependent protein kinase 12.7.11.10.499
4bdhWVISerine/threonine-protein kinase Chk22.7.11.10.496
2xm9LWHSerine/threonine-protein kinase Chk22.7.11.10.494
2ydiYDISerine/threonine-protein kinase Chk12.7.11.10.494
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.494
3orzBI43-phosphoinositide-dependent protein kinase 12.7.11.10.493
4i22IREEpidermal growth factor receptor2.7.10.10.491
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.488
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.485
3cblSTUTyrosine-protein kinase Fes/Fps2.7.10.20.484
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.484
1uvrBI83-phosphoinositide-dependent protein kinase 12.7.11.10.483
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.476
4bdcODHSerine/threonine-protein kinase Chk22.7.11.10.476
3hrfATP3-phosphoinositide-dependent protein kinase 12.7.11.10.475
1uu3LY43-phosphoinositide-dependent protein kinase 12.7.11.10.474
2hxl422Serine/threonine-protein kinase Chk12.7.11.10.474
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.474
3bqr4RBDeath-associated protein kinase 3/0.474
3qcs3Q13-phosphoinositide-dependent protein kinase 12.7.11.10.473
4ft9H4KSerine/threonine-protein kinase Chk12.7.11.10.472
4ftr5HKSerine/threonine-protein kinase Chk12.7.11.10.472
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
4fv9E71Mitogen-activated protein kinase 12.7.11.240.471
3qcy3Q33-phosphoinositide-dependent protein kinase 12.7.11.10.470
4fsuHK5Serine/threonine-protein kinase Chk12.7.11.10.468
2vu3LZECyclin-dependent kinase 22.7.11.220.467
3qcq3Q03-phosphoinositide-dependent protein kinase 12.7.11.10.467
4fsnA58Serine/threonine-protein kinase Chk12.7.11.10.467
2yiqYIQSerine/threonine-protein kinase Chk22.7.11.10.466
2zjwREFCasein kinase II subunit alpha2.7.11.10.466
3u9n09HSerine/threonine-protein kinase Chk12.7.11.10.466
2wmqZYQSerine/threonine-protein kinase Chk12.7.11.10.465
4enxZ20Serine/threonine-protein kinase pim-12.7.11.10.465
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.464
3sheI85MAP kinase-activated protein kinase 32.7.11.10.464
4gh2HK0Serine/threonine-protein kinase Chk12.7.11.10.464
1h1wATP3-phosphoinositide-dependent protein kinase 12.7.11.10.463
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.463
4a06ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.463
2pe039Z3-phosphoinositide-dependent protein kinase 12.7.11.10.462
3sc13S13-phosphoinositide-dependent protein kinase 12.7.11.10.462
4ct1ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.462
1phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.461
2hog710Serine/threonine-protein kinase Chk12.7.11.10.461
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.461
4ft3H1KSerine/threonine-protein kinase Chk12.7.11.10.461
3gubGUBDeath-associated protein kinase 12.7.11.10.460
3nunJMZ3-phosphoinositide-dependent protein kinase 12.7.11.10.460
4wsqKSAAP2-associated protein kinase 12.7.11.10.460
2x8eX8ESerine/threonine-protein kinase Chk12.7.11.10.459
4fsrHKCSerine/threonine-protein kinase Chk12.7.11.10.459
2biyATP3-phosphoinositide-dependent protein kinase 12.7.11.10.458
2cgx3D3Serine/threonine-protein kinase Chk12.7.11.10.458
4dfn0K1Tyrosine-protein kinase SYK2.7.10.20.458
4ft7H3KSerine/threonine-protein kinase Chk12.7.11.10.458
4ftt6HKSerine/threonine-protein kinase Chk12.7.11.10.458
2ijmATPFocal adhesion kinase 12.7.10.20.457
3nynSGVG protein-coupled receptor kinase 62.7.11.160.457
2e9p77ASerine/threonine-protein kinase Chk12.7.11.10.456
3qlrNDPDihydrofolate reductase1.5.1.30.456
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.456
4ks8B49Serine/threonine-protein kinase PAK 62.7.11.10.456
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.455
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.455
4nd2A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.455
2e9oA58Serine/threonine-protein kinase Chk12.7.11.10.454
2j0m4STFocal adhesion kinase 12.7.10.20.454
2xp2VGHALK tyrosine kinase receptor2.7.10.10.454
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.452
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.452
4ftu7HKSerine/threonine-protein kinase Chk12.7.11.10.452
4rrvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.452
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.451
3rak03ZCyclin-dependent kinase 22.7.11.220.451
1okzUCN3-phosphoinositide-dependent protein kinase 12.7.11.10.450
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.450
4fszHK8Serine/threonine-protein kinase Chk12.7.11.10.450
4ft0HK9Serine/threonine-protein kinase Chk12.7.11.10.450
1kr2TADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.449
1uu7BI23-phosphoinositide-dependent protein kinase 12.7.11.10.449
2cgu3A3Serine/threonine-protein kinase Chk12.7.11.10.449
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.449
2qo7ANPEphrin type-A receptor 32.7.10.10.448
3cd3STUTyrosine-protein kinase Fes/Fps2.7.10.20.448
3hrcATP3-phosphoinositide-dependent protein kinase 12.7.11.10.448
3qlsNDPDihydrofolate reductase1.5.1.30.448
4mf129YTyrosine-protein kinase ITK/TSK2.7.10.20.448
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.447
3t8oATPRhodopsin kinase/0.447
1xe55FEPlasmepsin-23.4.23.390.446
1yolS03Proto-oncogene tyrosine-protein kinase Src2.7.10.20.446
2e9v85ASerine/threonine-protein kinase Chk12.7.11.10.446
2hy0306Serine/threonine-protein kinase Chk12.7.11.10.446
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.446
2wmuZYUSerine/threonine-protein kinase Chk12.7.11.10.446
3s1h56ZCyclin-dependent kinase 22.7.11.220.446
4bkz1WSMaternal embryonic leucine zipper kinase2.7.11.10.446
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.446
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.446
2ijmADPFocal adhesion kinase 12.7.10.20.445
2yaaATPDeath-associated protein kinase 2/0.445
3qxpX64Cyclin-dependent kinase 22.7.11.220.445
3rwpABQ3-phosphoinositide-dependent protein kinase 12.7.11.10.445
4bdaVFBSerine/threonine-protein kinase Chk22.7.11.10.445
1aq1STUCyclin-dependent kinase 22.7.11.220.444
1nvsUCMSerine/threonine-protein kinase Chk12.7.11.10.444
2xb7GUIALK tyrosine kinase receptor2.7.10.10.444
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.444
4hge15VTyrosine-protein kinase JAK2/0.444
4hyh1AMSerine/threonine-protein kinase Chk12.7.11.10.444
2hxq373Serine/threonine-protein kinase Chk12.7.11.10.443
2xvdAS6Ephrin type-B receptor 42.7.10.10.443
3qd33Q53-phosphoinositide-dependent protein kinase 12.7.11.10.443
3ztxZTXAurora kinase B-A2.7.11.10.443
4fsqHK3Serine/threonine-protein kinase Chk12.7.11.10.443
4fswHK6Serine/threonine-protein kinase Chk12.7.11.10.443
4fv8E63Mitogen-activated protein kinase 12.7.11.240.443
4hgl0YOCasein kinase I isoform gamma-32.7.11.10.443
4o0rX4ZSerine/threonine-protein kinase PAK 12.7.11.10.443
5av2KMPDeath-associated protein kinase 12.7.11.10.443
1ai9NDPDihydrofolate reductase1.5.1.30.442
1pyePM1Cyclin-dependent kinase 22.7.11.220.442
2cgw3C3Serine/threonine-protein kinase Chk12.7.11.10.442
4jq8KJ8Epidermal growth factor receptor2.7.10.10.442
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.441
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.441
5dt0SKEAurora kinase A2.7.11.10.441
1xjdSTUProtein kinase C theta type2.7.11.130.440
2c3lIDZSerine/threonine-protein kinase Chk12.7.11.10.440
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.440
2vv9IM9Cyclin-dependent kinase 22.7.11.220.440
2ydkYDKSerine/threonine-protein kinase Chk12.7.11.10.440
2ym5YM5Serine/threonine-protein kinase Chk12.7.11.10.440
3hx4ANPCalmodulin-domain protein kinase 1/0.440