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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3u4uLNHCasein kinase II subunit alpha2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3u4uLNHCasein kinase II subunit alpha2.7.11.11.000
3at4CCKCasein kinase II subunit alpha2.7.11.10.581
4grb0XGCasein kinase II subunit alpha2.7.11.10.579
3be9P04Casein kinase II subunit alpha2.7.11.10.572
3q9xEMOCasein kinase II subunit alpha2.7.11.10.547
3ofm4B0Casein kinase II subunit alpha'2.7.11.10.535
3at3ATKCasein kinase II subunit alpha2.7.11.10.526
4gub0Y4Casein kinase II subunit alpha2.7.11.10.523
4anmWULCasein kinase II subunit alpha2.7.11.10.519
2zjwREFCasein kinase II subunit alpha2.7.11.10.516
5cvfATPCasein kinase II subunit alpha2.7.11.10.516
3axwTIDCasein kinase II subunit alpha2.7.11.10.511
5cu6ATPCasein kinase II subunit alpha2.7.11.10.509
2pvhP19Casein kinase II subunit alpha2.7.11.10.507
3nga3NGCasein kinase II subunit alpha2.7.11.10.506
4dgnLU2Casein kinase II subunit alpha2.7.11.10.506
1pjkANPCasein kinase II subunit alpha2.7.11.10.503
2fvdLIACyclin-dependent kinase 22.7.11.220.498
2vu3LZECyclin-dependent kinase 22.7.11.220.493
3owk18ECasein kinase II subunit alpha2.7.11.10.492
4jqeANPCasein kinase II subunit alpha2.7.11.10.491
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.491
5cshATPCasein kinase II subunit alpha2.7.11.10.489
4ez50RSCyclin-dependent kinase 62.7.11.220.487
1m2pHNACasein kinase II subunit alpha2.7.11.10.482
3wowANPCasein kinase II subunit alpha2.7.11.10.482
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.481
5cvhADPCasein kinase II subunit alpha2.7.11.10.481
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.480
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.476
2pvlP55Casein kinase II subunit alpha2.7.11.10.475
2pvnP63Casein kinase II subunit alpha2.7.11.10.474
2j0m4STFocal adhesion kinase 12.7.10.20.473
1dawANPCasein kinase II subunit alpha2.7.11.10.472
3rak03ZCyclin-dependent kinase 22.7.11.220.472
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.471
3pe2E1BCasein kinase II subunit alpha2.7.11.10.471
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.471
4dgmAGICasein kinase II subunit alpha2.7.11.10.470
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.468
1om1IQACasein kinase II subunit alpha2.7.11.10.467
2hy81STSerine/threonine-protein kinase PAK 12.7.11.10.463
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.463
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.462
4aguD15Cyclin-dependent kinase-like 1/0.462
5av2KMPDeath-associated protein kinase 12.7.11.10.462
3s1h56ZCyclin-dependent kinase 22.7.11.220.461
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.461
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.460
2pvmP29Casein kinase II subunit alpha2.7.11.10.459
3sayOFTGlycogen synthase kinase-3 beta2.7.11.260.459
4bcmT7ZCyclin-dependent kinase 22.7.11.220.459
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.458
3qk0QK0Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.458
4hge15VTyrosine-protein kinase JAK2/0.458
1q3wATUGlycogen synthase kinase-3 beta2.7.11.260.456
3r04UNQSerine/threonine-protein kinase pim-12.7.11.10.456
2xa4AZ5Tyrosine-protein kinase JAK2/0.455
3lltANPProtein serine/threonine kinase-1/0.455
4dgo0JWCasein kinase II subunit alpha2.7.11.10.455
3qxpX64Cyclin-dependent kinase 22.7.11.220.454
4ftiH7KSerine/threonine-protein kinase Chk12.7.11.10.454
4hgt15GCasein kinase I isoform delta2.7.11.10.454
2pvrANPCasein kinase II subunit alpha2.7.11.10.453
1bygSTUTyrosine-protein kinase CSK/0.452
1rfvADPPyridoxal kinase2.7.1.350.452
2yaaATPDeath-associated protein kinase 2/0.452
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.452
2cdz23DSerine/threonine-protein kinase PAK 42.7.11.10.451
2j0j4STFocal adhesion kinase 12.7.10.20.451
3w0sANPHygromycin-B 4-O-kinase2.7.1.1630.451
4iaq2GM5-hydroxytryptamine receptor 1B/0.451
4mvfSTUCalcium-dependent protein kinase 22.7.11.10.451
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.450
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.450
3ormAGSSerine/threonine protein kinase/0.450
3zewSTUEphrin type-B receptor 42.7.10.10.450
4jia1K3Tyrosine-protein kinase JAK2/0.450
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.450
1oi9N20Cyclin-dependent kinase 22.7.11.220.449
2c6o4SPCyclin-dependent kinase 22.7.11.220.449
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.449
2w05FRTCyclin-dependent kinase 22.7.11.220.448
3ggfGVDSerine/threonine-protein kinase 26/0.448
3lpbNVBTyrosine-protein kinase JAK2/0.448
3r9dX6BCyclin-dependent kinase 22.7.11.220.448
3s2pPMUCyclin-dependent kinase 22.7.11.220.448
1m2rMNYCasein kinase II subunit alpha2.7.11.10.447
3gggNADPrephenate dehydrogenase/0.447
3l8p0CEAngiopoietin-1 receptor2.7.10.10.447
3mb714ICasein kinase II subunit alpha2.7.11.10.447
2r7b2533-phosphoinositide-dependent protein kinase 12.7.11.10.446
2w17I19Cyclin-dependent kinase 22.7.11.220.446
3bqr4RBDeath-associated protein kinase 3/0.446
3tmz06XCytochrome P450 2B41.14.14.10.446
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.446
1q99ANPSerine/threonine-protein kinase SKY12.7.11.10.445
2vttLZDCyclin-dependent kinase 22.7.11.220.445
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.445
3r1sX73Cyclin-dependent kinase 22.7.11.220.445
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.445
4bcoT6QCyclin-dependent kinase 22.7.11.220.445
4dfl0K0Tyrosine-protein kinase SYK2.7.10.20.445
4y12AGSSerine/threonine-protein kinase PknG2.7.11.10.445
5av3KMPDeath-associated protein kinase 12.7.11.10.445
1jklANPDeath-associated protein kinase 12.7.11.10.444
4bzo676Serine/threonine-protein kinase pim-12.7.11.10.444
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.444
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.444
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.443
3qruX19Cyclin-dependent kinase 22.7.11.220.443
4c4f7CEDual specificity protein kinase TTK2.7.12.10.443
1g5sI17Cyclin-dependent kinase 22.7.11.220.442
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.442
4hvi19STyrosine-protein kinase JAK32.7.10.20.442
4j95ACPFibroblast growth factor receptor 2/0.442
1xjdSTUProtein kinase C theta type2.7.11.130.441
3owl19ECasein kinase II subunit alpha2.7.11.10.441
3sqq99ZCyclin-dependent kinase 22.7.11.220.441
4bchT7ZCyclin-dependent kinase 92.7.11.220.441
4fg7ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.441
4jr7GNPCasein kinase II subunit alpha2.7.11.10.441
5d12G97Proto-oncogene tyrosine-protein kinase Src2.7.10.20.441
1q3dSTUGlycogen synthase kinase-3 beta2.7.11.260.440
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.440
4ia7BIVVitamin D3 receptor A/0.440
4ix6ADPUncharacterized protein/0.440
4ji91M3Tyrosine-protein kinase JAK2/0.440