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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3nlcFADUncharacterized protein

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3nlcFADUncharacterized protein/1.000
2c3cFAD2-oxopropyl-CoM reductase, carboxylating1.8.1.50.551
1mo9FAD2-oxopropyl-CoM reductase, carboxylating1.8.1.50.546
1d4dFADFumarate reductase flavoprotein subunit1.3.5.40.534
4j31FADKynurenine 3-monooxygenase/0.517
2c3dFAD2-oxopropyl-CoM reductase, carboxylating1.8.1.50.512
4bk3FADProbable salicylate monooxygenase/0.509
3gwdFADCyclohexanone monooxygenase/0.505
4bk2FADProbable salicylate monooxygenase/0.505
3fg2FADPutative rubredoxin reductase/0.503
2xdoFADTetX family tetracycline inactivation enzyme/0.498
1mokFAD2-oxopropyl-CoM reductase, carboxylating1.8.1.50.496
3lzwFADFerredoxin--NADP reductase 21.18.1.20.496
2zzcFADThioredoxin reductase 1, cytoplasmic1.8.1.90.494
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.492
3djgFADGlutathione reductase, mitochondrial1.8.1.70.491
3lshFADPyranose 2-oxidase/0.488
4u2tFADCholesterol oxidase1.1.3.60.487
3k4cFADPyranose 2-oxidase/0.486
1tdeFADThioredoxin reductase1.8.1.90.484
3f8rNAPNADH oxidase/thioredoxin reductase/0.484
2eq7FADDihydrolipoyl dehydrogenase/0.483
4opgFDAConserved Archaeal protein/0.483
3cgdFADCoenzyme A disulfide reductase/0.482
1gesFADGlutathione reductase1.8.1.70.481
3cgeFADCoenzyme A disulfide reductase/0.481
1trbFADThioredoxin reductase1.8.1.90.480
2vouFAD2,6-dihydroxypyridine 3-monooxygenase1.14.13.100.480
2npxFADNADH peroxidase1.11.1.10.478
5c2tFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.478
1feaFADTrypanothione reductase1.8.1.120.476
1getFADGlutathione reductase1.8.1.70.476
2q0lFADThioredoxin reductase1.8.1.90.476
3djjFADGlutathione reductase, mitochondrial1.8.1.70.476
2bryFAD[F-actin]-methionine sulfoxide oxidase MICAL11.14.130.475
2ylxFADPhenylacetone monooxygenase1.14.13.920.475
4nevFADTrypanothione reductase/0.475
1ju2FAD(R)-mandelonitrile lyase 24.1.2.100.474
4j34FADKynurenine 3-monooxygenase/0.474
1zmdFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.473
2ylzFADPhenylacetone monooxygenase1.14.13.920.473
4b67FADL-ornithine N(5)-monooxygenase/0.473
4b68FADL-ornithine N(5)-monooxygenase/0.473
2v3aFADRubredoxin-NAD(+) reductase1.18.1.10.472
4h4yFADBiphenyl dioxygenase ferredoxin reductase subunit/0.472
4opiFDAConserved Archaeal protein/0.472
4udrFAD5-(hydroxymethyl)furfural oxidase/0.472
3up4FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.471
5i39FADL-amino acid deaminase/0.471
1geuFADGlutathione reductase1.8.1.70.470
5fs7FADApoptosis-inducing factor 1, mitochondrial1.1.10.469
1grbFADGlutathione reductase, mitochondrial1.8.1.70.468
4udqFAD5-(hydroxymethyl)furfural oxidase/0.468
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.467
1reoFADL-amino-acid oxidase1.4.3.20.467
3axbFADPutative oxidoreductase/0.467
3ic9FADPutative dihydrolipoamide dehydrogenase/0.467
3lsiFADPyranose 2-oxidase/0.467
3nn6FB06-hydroxy-L-nicotine oxidase/0.466
1onfFADGlutathione reductase1.8.1.70.465
2cvjFADThioredoxin reductase related protein/0.465
4x9nFADUncharacterized protein MG039 homolog/0.465
1djnADPTrimethylamine dehydrogenase1.5.8.20.464
1h7wFADDihydropyrimidine dehydrogenase [NADP(+)]1.3.1.20.464
1w6hTITPlasmepsin-23.4.23.390.464
3s5wFADL-ornithine N(5)-monooxygenase/0.464
1djqADPTrimethylamine dehydrogenase1.5.8.20.463
1rp0AHZThiamine thiazole synthase, chloroplastic/0.463
1tdfFADThioredoxin reductase1.8.1.90.463
3vqrFADPutative oxidoreductase/0.463
4eqsFADCoenzyme A disulfide reductase/0.463
3dh9FADThioredoxin reductase 1, mitochondrial1.8.1.90.462
2tmdADPTrimethylamine dehydrogenase1.5.8.20.461
3oz2FADDigeranylgeranylglycerophospholipid reductase/0.461
4h50FADBiphenyl dioxygenase ferredoxin reductase subunit/0.461
4tm4FDAKtzI/0.461
4yryFADGlutamate synthase, beta subunit/0.461
2jb1FADL-amino acid oxidase/0.460
2rgjFADFlavin-containing monooxygenase/0.460
3lsmSFDPyranose 2-oxidase/0.460
4mokFADPyranose 2-oxidase/0.460
2b9wFADPutative aminooxidase/0.459
2q0kFADThioredoxin reductase1.8.1.90.459
3b6dFAECholesterol oxidase1.1.3.60.459
1cl0FADThioredoxin reductase1.8.1.90.457
1u7tTDT3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.457
3fbsFADOxidoreductase/0.457
1yqzFADCoenzyme A disulfide reductase/0.456
5eb5FAD(R)-mandelonitrile lyase 14.1.2.100.456
1iy8NADLevodione reductase/0.455
4d04FADPhenylacetone monooxygenase1.14.13.920.455
3l8kADPDihydrolipoamide dehydrogenase (PdhD-3)/0.454
3lzxFADFerredoxin--NADP reductase 21.18.1.20.454
4h4sFADBiphenyl dioxygenase ferredoxin reductase subunit/0.454
1gerFADGlutathione reductase1.8.1.70.453
4yjdFADD-amino-acid oxidase1.4.3.30.453
1e1lFADNADPH:adrenodoxin oxidoreductase, mitochondrial1.18.1.60.452
1f3pFADFerredoxin reductase/0.452
1ve9FADD-amino-acid oxidase1.4.3.30.452
3f8pNADNADH oxidase/thioredoxin reductase/0.452
3fpzAHZThiamine thiazole synthase/0.452
2i0zFADNAD(FAD)-utilizing dehydrogenases/0.451
2rabFADGlutathione amide reductase/0.451
3d8xFADThioredoxin reductase 11.8.1.90.451
3kkjFADRenalase/0.451
3lxdFADFAD-dependent pyridine nucleotide-disulfide oxidoreductase/0.451
4ap1FADSteroid monooxygenase/0.451
4tm1FDAKtzI/0.451
5j60FADThioredoxin reductase/0.451
3sglFADtRNA 5-methylaminomethyl-2-thiouridine biosynthesis bifunctional protein MnmC/0.450
4b69FADL-ornithine N(5)-monooxygenase/0.450
3sfdFADSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial/0.449
4xwzFADFructosyl amine:oxygen oxidoreductase/0.449
1q1wFADPutidaredoxin reductase1.18.1.50.448
3dghFADThioredoxin reductase 1, mitochondrial1.8.1.90.448
2zz0FADThioredoxin reductase 1, cytoplasmic1.8.1.90.447
3uovFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.447
4tlzFADKtzI/0.447
1n4wFADCholesterol oxidase1.1.3.60.446
2ooyATP5'-AMP-activated protein kinase subunit gamma/0.446
3uoxFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.446
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.446
4h4vFADBiphenyl dioxygenase ferredoxin reductase subunit/0.446
5e5h0T1Succinyl-CoA:acetate CoA-transferase/0.445
2ba9FADPutative aminooxidase/0.444
3qvpFADGlucose oxidase1.1.3.40.444
3coxFADCholesterol oxidase1.1.3.60.443
4dsgFADUncharacterized protein/0.443
4xwrFADCholesterol oxidase1.1.3.60.443
1me6IVSPlasmepsin-23.4.23.390.442
1vdcFADThioredoxin reductase 1, mitochondrial1.8.1.90.442
3ka7FADPutative oxidoreductase/0.442
1ryiFADGlycine oxidase1.4.3.190.441
3up5FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.441
4b63FADL-ornithine N(5)-monooxygenase/0.441
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.440
3vfqAR6Poly [ADP-ribose] polymerase 142.4.2.300.440
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.440