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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3k2hLYABifunctional dihydrofolate reductase-thymidylate synthase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3k2hLYABifunctional dihydrofolate reductase-thymidylate synthase/1.000
2aazCB3Thymidylate synthase2.1.1.450.575
2ftoCB3Thymidylate synthase/0.561
4fqsLYAThymidylate synthase ThyA/0.559
1tysDHFThymidylate synthase/0.551
1dnaCB3Thymidylate synthase/0.540
4gevCB3Thymidylate synthase/0.540
2bbqPFGThymidylate synthase/0.538
1ju6LYAThymidylate synthase2.1.1.450.537
1qzfCB3Bifunctional dihydrofolate reductase-thymidylate synthase/0.535
1trgCB3Thymidylate synthase/0.535
1nceCB3Thymidylate synthase/0.531
4knzCB3Thymidylate synthase/0.528
1jtqLY3Thymidylate synthase/0.527
3bgxMEFThymidylate synthase/0.524
1jutLYDThymidylate synthase/0.518
1kziTHGThymidylate synthase/0.512
1kzjCB3Thymidylate synthase/0.510
1kceCB3Thymidylate synthase/0.505
1f4fTP3Thymidylate synthase/0.503
2kceD16Thymidylate synthase/0.501
1hvyD16Thymidylate synthase2.1.1.450.499
1jujLYAThymidylate synthase2.1.1.450.494
4isk1JYThymidylate synthase/0.488
4ez8DHFThymidylate synthase2.1.1.450.487
1aiqCB3Thymidylate synthase/0.486
2z3uCRRCytochrome P450/0.484
3a1l2CCCytochrome P450/0.484
1jtuLYBThymidylate synthase/0.482
4fogC2FThymidylate synthase ThyA/0.482
3uwlFOZThymidylate synthase/0.480
1sejF89Bifunctional dihydrofolate reductase-thymidylate synthase/0.478
1fwmCB3Thymidylate synthase/0.476
4l8u9AZSerum albumin/0.475
3iaeD7KBenzaldehyde lyase/0.472
1f4gTP4Thymidylate synthase/0.469
3bhlTHGThymidylate synthase/0.465
3bhrTHGThymidylate synthase/0.465
3cinNADMyo-inositol-1-phosphate synthase-related protein/0.465
2tscCB3Thymidylate synthase/0.464
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.464
1nzdUPGDNA beta-glucosyltransferase/0.463
3etdNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.462
3mdmFJZCholesterol 24-hydroxylase/0.462
4nh82LCHeat shock protein HSP 90-alpha/0.462
1k6tXN1Gag-Pol polyprotein3.4.23.160.460
4ambDUDPutative glycosyl transferase/0.460
1an5CB3Thymidylate synthase/0.459
1f28F89Thymidylate synthase2.1.1.450.459
1zprCB3Thymidylate synthase/0.459
1tduCB3Thymidylate synthase/0.458
2w9sTOPDihydrofolate reductase type 1 from Tn40031.5.1.30.458
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.457
1uyePU9Heat shock protein HSP 90-alpha/0.455
4eilCB3Bifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.455
3eteNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.454
1gufNDPEnoyl-[acyl-carrier-protein] reductase 1, mitochondrial1.3.1.100.452
1xe55FEPlasmepsin-23.4.23.390.452
3l0lHC3Nuclear receptor ROR-gamma/0.452
4j03FVSBifunctional epoxide hydrolase 23.1.3.760.452
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.450
3zc3NAPFerredoxin--NADP reductase1.18.1.20.450
4uyf73BBromodomain-containing protein 2/0.450
1e3eNAIAlcohol dehydrogenase 41.1.1.10.449
1uymPU3Heat shock protein HSP 90-beta/0.449
4uymVOR14-alpha sterol demethylase Cyp51B/0.449
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.448
4eb4D16Thymidylate synthase2.1.1.450.448
4o1mNADEnoyl-acyl carrier reductase/0.448
3umoATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.447
3v9v21LPeroxisome proliferator-activated receptor gamma/0.447
1bxkNADdTDP-glucose 4,6-dehydratase 2/0.446
3d7kD7KBenzaldehyde lyase/0.446
4g1z0VPVitamin D3 receptor A/0.446
4o7uTHFThymidylate synthase/0.446
4r20AERCytochrome P450 family 17 polypeptide 2/0.446
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
2h55DZ8Heat shock protein HSP 90-alpha/0.445
3vt9YI4Vitamin D3 receptor/0.445
4l9q9TPSerum albumin/0.445
5hs1VORLanosterol 14-alpha demethylase/0.445
3qlrNDPDihydrofolate reductase1.5.1.30.444
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.444
1uydPU8Heat shock protein HSP 90-alpha/0.443
2hb7O1CVitamin D3 receptor/0.443
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.443
1dduCB3Thymidylate synthase/0.442
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
2ok7FADFerredoxin--NADP reductase, apicoplast/0.442
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.442
1ejiTHFSerine hydroxymethyltransferase, cytosolic/0.441
2wsbNADGalactitol dehydrogenase/0.441
3bg7FADPyranose 2-oxidase/0.441
3ft8MOJHeat shock protein HSP 90-alpha/0.441
4l9kEHFSerum albumin/0.441
3s1dZIRCytokinin dehydrogenase 11.5.99.120.440
3vt8YI3Vitamin D3 receptor/0.440
4tuvCPZCytochrome P450 1191.140.440