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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2prh238Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
2prh238Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.21.000
2b0m201Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.626
1d3gBREDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.599
1uuoBRFDihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.569
1d3hA26Dihydroorotate dehydrogenase (quinone), mitochondrial1.3.5.20.507
1lriCLRBeta-elicitin cryptogein/0.494
5jlaNADPutative short-chain dehydrogenase/reductase/0.493
3icrCOACoenzyme A disulfide reductase/0.487
2aibERGBeta-elicitin cinnamomin/0.486
2c6hPXICytochrome P450 monooxygenase PikC/0.485
1yb5NAPQuinone oxidoreductase1.6.5.50.480
2wesFADTryptophan 5-halogenase/0.479
1kzuRG1Light-harvesting protein B-800/850 alpha chain/0.477
1kzuRG1Light-harvesting protein B-800/850 beta chain/0.477
2b9wFADPutative aminooxidase/0.475
1tw4CHDFatty acid-binding protein, liver/0.474
1iyzNDPProbable quinone oxidoreductase/0.473
1ppjANYCytochrome b/0.473
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.473
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.473
1jolFFODihydrofolate reductase1.5.1.30.472
2c7xNRBCytochrome P450 monooxygenase PikC/0.472
3icsCOACoenzyme A disulfide reductase/0.472
2c0cNAPProstaglandin reductase 310.471
2c12FADNitroalkane oxidase1.7.3.10.471
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.470
1osvCHCBile acid receptor/0.469
3ictCOACoenzyme A disulfide reductase/0.469
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.469
4jbtASDCytochrome P450 monooxygenase/0.469
4ia2BIVVitamin D3 receptor A/0.468
5br4NADLactaldehyde reductase1.1.1.770.468
2f4bEHAPeroxisome proliferator-activated receptor gamma/0.467
3cxhSMACytochrome b/0.467
1nkzRG1Light-harvesting protein B-800/850 alpha chain/0.466
1nkzRG1Light-harvesting protein B-800/850 beta chain/0.466
1tj0FADBifunctional protein PutA1.5.5.20.466
3jynNDPQuinone oxidoreductase/0.466
4mihFADPyranose 2-oxidase1.1.3.100.466
3pwhZMAAdenosine receptor A2a/0.466
3fcoIIGCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.465
3sz0FADSulfide-quinone reductase/0.465
3t14FADSulfide-quinone reductase/0.465
4q71FADBifunctional protein PutA/0.465
4q72FADBifunctional protein PutA/0.464
4qi5FADCellobiose dehydrogenase/0.464
1ot7CHCBile acid receptor/0.463
2j3kNAPNADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.463
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.463
3kpkFADSulfide-quinone reductase/0.462
3vt7VDXVitamin D3 receptor/0.462
4jvb1M0Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.462
5hes032Mitogen-activated protein kinase kinase kinase 202.7.11.250.462
3fcjFADNitroalkane oxidase1.7.3.10.461
4hfmNAP2-alkenal reductase (NADP(+)-dependent)/0.461
4i3vNADAldehyde dehydrogenase (NAD+)/0.461
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.461
1tlcF89Thymidylate synthase/0.460
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.460
1kk4ACOStreptogramin A acetyltransferase2.3.10.459
3t2zFADSulfide-quinone reductase/0.459
4dz5NAPAldo-keto reductase family 1 member C3/0.459
4gddFADUDP-galactopyranose mutase/0.459
4ktoFADPutative isovaleryl-CoA dehydrogenase protein/0.459
2ardFDAFlavin-dependent tryptophan halogenase PrnA1.14.19.90.458
3uteFADUDP-galactopyranose mutase/0.458
4iaq2GM5-hydroxytryptamine receptor 1B/0.458
1khrCOAStreptogramin A acetyltransferase2.3.10.457
2vnaNAPProstaglandin reductase 21.3.1.480.457
3h1jSMACytochrome b/0.457
3t2yFADSulfide-quinone reductase/0.457
4f7iNAD3-isopropylmalate dehydrogenase1.1.1.850.457
4iarERM5-hydroxytryptamine receptor 1B/0.457
5k2cZMAAdenosine receptor A2a/0.457
2c3qGTXGlutathione S-transferase theta-12.5.1.180.456
2chx090Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.456
2x9dITCTetracycline repressor protein class D/0.456
3d3eD3ECorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.456
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.456
3p6pA6BCamphor 5-monooxygenase1.14.15.10.456
3q44D50M1 family aminopeptidase3.4.110.456
1i7iAZ2Peroxisome proliferator-activated receptor gamma/0.455
2qd4CHDFerrochelatase, mitochondrial4.99.1.10.455
2zb3NDPProstaglandin reductase 21.3.1.480.455
3och2MXDihydrofolate reductase1.5.1.30.455
3r9dX6BCyclin-dependent kinase 22.7.11.220.455
4at0FADPossible succinate dehydrogenase/0.455
4ku5DCC3-oxoacyl-[ACP] synthase III/0.455
2ibzSMACytochrome b/0.454
2jn3JN3Fatty acid-binding protein, liver/0.454
2k5tCOAPanD regulatory factor/0.454
2p2bPRXAcetyl-coenzyme A synthetase/0.454
3oq13OQCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.454
3syiFADSulfide-quinone reductase/0.454
3zkpERBErythromycin C-12 hydroxylase1.14.13.1540.454
4eevL1XHepatocyte growth factor receptor2.7.10.10.454
4kuhCAA3-hydroxybutyryl-CoA dehydrogenase/0.454
4o8aFADBifunctional protein PutA1.2.1.880.454
5a3bAPRSIR2 family protein/0.454
1jqiFADShort-chain specific acyl-CoA dehydrogenase, mitochondrial/0.453
1pz1NAPGeneral stress protein 69/0.453
1yc2NADNAD-dependent protein deacylase 2/0.453
2cig1DGDihydrofolate reductase1.5.1.30.453
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.453
3gmd2M3Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.453
3p6nDSOCamphor 5-monooxygenase1.14.15.10.453
3tvuB37Acetyl-CoA carboxylase/0.453
3vs1VSATyrosine-protein kinase HCK2.7.10.20.453
4b7dQLECytochrome P450 monooxygenase PikC/0.453
4elf35IDihydrofolate reductase/0.453
5a3cNADSIR2 family protein/0.453
5k2bZMAAdenosine receptor A2a/0.453
1n5dNDPCarbonyl reductase [NADPH] 1/0.452
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.452
2wsa646Glycylpeptide N-tetradecanoyltransferase/0.452
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.452
3t8xT8XT-cell surface glycoprotein CD1b/0.452
3w2cN15Aurora kinase A2.7.11.10.452
1f4fTP3Thymidylate synthase/0.451
3bgxMEFThymidylate synthase/0.451
3e2sFADBifunctional protein PutA1.5.5.20.451
3vtdTKDVitamin D3 receptor/0.451
4fdnFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.451
1xu7CPSCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.450
1xuoLA1Integrin alpha-L/0.450
2j3iNAPNADPH-dependent oxidoreductase 2-alkenal reductase1.3.1.740.450
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.450
2y05NAPProstaglandin reductase 1/0.450
3vrzVRZTyrosine-protein kinase HCK2.7.10.20.450
4jvf17XRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.450
5g53NECAdenosine receptor A2a/0.450
1t7i017Gag-Pol polyprotein3.4.23.160.449
2hwrDRDPeroxisome proliferator-activated receptor gamma/0.449
3lu8IQXSerum albumin/0.449
3qrwNDPPutative ketoacyl reductase1.3.10.449
4gevCB3Thymidylate synthase/0.449
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.449
4xumIMNPeroxisome proliferator-activated receptor gamma/0.449
1v5eFADPyruvate oxidase/0.448
2a1tFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.448
2ix5FADAcyl-coenzyme A oxidase 4, peroxisomal1.3.3.60.448
2qo5CHDFatty acid-binding protein 10-A, liver basic/0.448
3inmNDPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.448
3pqbVGPPutative oxidoreductase/0.448
3sdkP3NProteasome subunit beta type-53.4.25.10.448
3sdkP3NProteasome subunit beta type-63.4.25.10.448
3w8wFADPutative FAD-dependent oxygenase EncM/0.448
4aw3MYVMycinamicin IV hydroxylase/epoxidase/0.448
4b7sQLECytochrome P450 monooxygenase PikC/0.448
4ocvANPAminoglycoside phosphotransferase/0.448
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.448
1cf3FADGlucose oxidase1.1.3.40.447
2ev9NAPShikimate dehydrogenase (NADP(+))/0.447
2q5g1FAPeroxisome proliferator-activated receptor delta/0.447
3f5p741Insulin-like growth factor 1 receptor2.7.10.10.447
3kljFADNADH-rubredoxin oxidoreductase1.18.1.10.447
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.447
4mzuCOAWxcM-like protein/0.447
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.446
1zmcNADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.446
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.446
2ylwFADPhenylacetone monooxygenase1.14.13.920.446
3clhNAD3-dehydroquinate synthase4.2.3.40.446
3ctj320Hepatocyte growth factor receptor2.7.10.10.446
3gw9VNILanosterol 14-alpha-demethylase/0.446
3tmz06XCytochrome P450 2B41.14.14.10.446
3vtbTKAVitamin D3 receptor/0.446
3vtcTK3Vitamin D3 receptor/0.446
4aosFADSteroid monooxygenase/0.446
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.446
4j6dTESCytochrome P450 monooxygenase/0.446
4jkt04AGlutaminase kidney isoform, mitochondrial3.5.1.20.446
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.445
1x8lOXRRetinol dehydratase/0.445
2xclANPPhosphoribosylamine--glycine ligase/0.445
3p3zP3ZPutative cytochrome P450/0.445
3r7kFDAProbable acyl CoA dehydrogenase/0.445
3ua506XCytochrome P450 2B61.14.130.445
3vt8YI3Vitamin D3 receptor/0.445
4fc00T2Serine/threonine-protein kinase B-raf2.7.11.10.445
4g1y0VOVitamin D3 receptor A/0.445
4nb6444Nuclear receptor ROR-gamma/0.445
4nkvAERSteroid 17-alpha-hydroxylase/17,20 lyase/0.445
4q73FADBifunctional protein PutA/0.445
5k2aZMAAdenosine receptor A2a/0.445
4uhrNGIAdenosine receptor A2a/0.445
1m13HYFNuclear receptor subfamily 1 group I member 2/0.444
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.444
3u4cNDPNADPH-dependent reductase BacG/0.444
3zk5Z18Cytochrome P450 monooxygenase PikC/0.444
4b7xNAPProbable oxidoreductase/0.444
4j6cSTRCytochrome P450 monooxygenase/0.444
4o2z046Mitogen-activated protein kinase/0.444
4plpNADHomospermidine synthase2.5.1.440.444
1felFENRetinol-binding protein 4/0.443
1t0lNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.443
2q9fC3SCholesterol 24-hydroxylase/0.443
2xk9XK9Serine/threonine-protein kinase Chk22.7.11.10.443
3tfyCOAN-alpha-acetyltransferase 502.3.10.443
4cnjFADL-amino acid oxidase/0.443
4gmgNAPYersiniabactin biosynthetic protein YbtU/0.443
4ruoBIVVitamin D3 receptor A/0.443
5dozNDPJamJ/0.443
1kr2TADNicotinamide/nicotinic acid mononucleotide adenylyltransferase 12.7.7.10.442
1udyFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.442
2i4pDRHPeroxisome proliferator-activated receptor gamma/0.442
2q4wFADCytokinin dehydrogenase 71.5.99.120.442
2qo4CHDFatty acid-binding protein 10-A, liver basic/0.442
3ggoNAIPrephenate dehydrogenase/0.442
3mkhFADNitroalkane oxidase/0.442
3tm4SAMUncharacterized protein/0.442
3u1y03IUDP-3-O-acyl-N-acetylglucosamine deacetylase/0.442
3vt9YI4Vitamin D3 receptor/0.442
4c4h7RODual specificity protein kinase TTK2.7.12.10.442
4dplNAPMalonyl-CoA reductase1.2.1.750.442
4ejn0R4RAC-alpha serine/threonine-protein kinase2.7.11.10.442
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.442
4ia1BIVVitamin D3 receptor A/0.442
4o7uTHFThymidylate synthase/0.442
4r20AERCytochrome P450 family 17 polypeptide 2/0.442
2ebaFADPutative glutaryl-CoA dehydrogenase/0.441
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.441
2igoFADPyranose 2-oxidase/0.441
2o4rVD5Vitamin D3 receptor/0.441
3ar5TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.441
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.441
3lshFADPyranose 2-oxidase/0.441
3nalDBKCalcium-transporting ATPase/0.441
3sgx0FWDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.441
4caxMYAGlycylpeptide N-tetradecanoyltransferase2.3.1.970.441
4h3c0YZDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.441
4jbqVX6Aurora kinase A2.7.11.10.441
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.441
1egdFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.440
1fm4DXCMajor pollen allergen Bet v 1-L/0.440
1ppjSMACytochrome b/0.440
2ntjP1HEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.440
2w0jZATSerine/threonine-protein kinase Chk22.7.11.10.440
2ylwNAPPhenylacetone monooxygenase1.14.13.920.440
2ym1NAPPhenylacetone monooxygenase1.14.13.920.440
3bbtFMMReceptor tyrosine-protein kinase erbB-42.7.10.10.440
3hazFADBifunctional protein PutA/0.440
3pm9FADPutative oxidoreductase/0.440
3t2kFADSulfide-quinone reductase/0.440
4a6bQG8Gag-Pol polyprotein3.4.23.160.440
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440