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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2i16LDTAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
2i16LDTAldose reductase1.1.1.211.000
1z3n3NAAldose reductase1.1.1.210.799
3ghrLDTAldose reductase1.1.1.210.790
2qxwLDTAldose reductase1.1.1.210.778
2fz8ZSTAldose reductase1.1.1.210.768
3ld5LDTAldose reductase1.1.1.210.756
3ghuLDTAldose reductase1.1.1.210.731
3g5eQ74Aldose reductase1.1.1.210.726
3ghsLDTAldose reductase1.1.1.210.709
3ghtLDTAldose reductase1.1.1.210.706
2duzZSTAldose reductase1.1.1.210.702
1us0LDTAldose reductase1.1.1.210.701
2iki388Aldose reductase1.1.1.210.694
2hv5ZSTAldose reductase1.1.1.210.691
2i17LDTAldose reductase1.1.1.210.675
2hvnZSTAldose reductase1.1.1.210.670
1t40ID5Aldose reductase1.1.1.210.668
2duxZSTAldose reductase1.1.1.210.660
2dv0ZSTAldose reductase1.1.1.210.657
2pdlTOLAldose reductase1.1.1.210.656
3lboLDTAldose reductase1.1.1.210.650
2pzn393Aldose reductase1.1.1.210.649
1pwlBFIAldose reductase1.1.1.210.644
3lqlLDTAldose reductase1.1.1.210.644
3mb9ZSTAldose reductase1.1.1.210.643
2pdmZSTAldose reductase1.1.1.210.640
2pdiZSTAldose reductase1.1.1.210.636
1z8962PAldose reductase1.1.1.210.629
2pdu393Aldose reductase1.1.1.210.616
2fz9ZSTAldose reductase1.1.1.210.605
2hvoZSTAldose reductase1.1.1.210.604
4gca2X9Aldose reductase1.1.1.210.604
2ikhLITAldose reductase1.1.1.210.603
2pdxZSTAldose reductase1.1.1.210.602
3m4h388Aldose reductase1.1.1.210.602
3mc5393Aldose reductase1.1.1.210.601
2pdh47DAldose reductase1.1.1.210.600
2pdn47DAldose reductase1.1.1.210.597
1ieiZESAldose reductase1.1.1.210.596
2pdc393Aldose reductase1.1.1.210.595
2pdp393Aldose reductase1.1.1.210.594
2pdbZSTAldose reductase1.1.1.210.589
3lenZSTAldose reductase1.1.1.210.588
3m0iZSTAldose reductase1.1.1.210.583
3m64393Aldose reductase1.1.1.210.577
2ikj393Aldose reductase1.1.1.210.573
2pd5ZSTAldose reductase1.1.1.210.572
2pdfZSTAldose reductase1.1.1.210.572
1frbZSTAldose reductase-related protein 2/0.571
1t41ID5Aldose reductase1.1.1.210.571
3t423T4Aldose reductase1.1.1.210.565
2pdg47DAldose reductase1.1.1.210.564
4yu153NAldose reductase1.1.1.210.564
2pdj393Aldose reductase1.1.1.210.559
1ah3TOLAldose reductase1.1.1.210.548
2pdq47DAldose reductase1.1.1.210.545
1zuaTOLAldo-keto reductase family 1 member B101.1.10.538
2fzdTOLAldose reductase1.1.1.210.532
2pdwFIDAldose reductase1.1.1.210.517
2fzbTOLAldose reductase1.1.1.210.515
2iqdLPAAldose reductase1.1.1.210.509
2inzOHPAldose reductase1.1.1.210.507
2pdyFIDAldose reductase1.1.1.210.505
3lz5LDTAldose reductase1.1.1.210.501
4ga8SBIAldo-keto reductase family 1 member B101.1.10.501
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.498
2o8h227cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.485
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.485
1xorZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.482
2f2kTGGAldose reductase1.1.1.210.482
1lnmDTXBilin-binding protein/0.481
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.478
2aot2PMHistamine N-methyltransferase2.1.1.80.474
2aovC2MHistamine N-methyltransferase2.1.1.80.474
2f3815MAldo-keto reductase family 1 member C3/0.473
4fcb0T7cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.473
3hxeBD8Geranylgeranyl transferase type-2 subunit beta2.5.1.600.472
4jq4IMNAldo-keto reductase family 1 member C2/0.472
1p91SAM23S rRNA (guanine(745)-N(1))-methyltransferase/0.471
1pwmFIDAldose reductase1.1.1.210.471
3s3gTLTAldose reductase1.1.1.210.471
5liu388Aldo-keto reductase family 1 member B101.1.10.471
1ro6ROLcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.470
3g58988cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.470
4a959MTGlycylpeptide N-tetradecanoyltransferase/0.470
1ekoI84Aldose reductase1.1.1.210.469
3qpnPFKcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.469
3qpoPFRcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.469
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.467
1q9mROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.466
2cekN8TAcetylcholinesterase3.1.1.70.466
3g4iD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.466
3g4kROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.466
3lz6A0DCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.465
4pabTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.465
1oynROLcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.464
1xf0ASDAldo-keto reductase family 1 member C3/0.464
2agtFIDAldose reductase1.1.1.210.464
2w6cBM4Acetylcholinesterase3.1.1.70.463
1c7oPPGHemolysin/0.462
1xoqROFcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.462
2ct8MSPMethionine--tRNA ligase6.1.1.100.462
3f3y4OABile salt sulfotransferase2.8.2.140.462
4xwtU5PRibonuclease J/0.462
2xujTZ5Acetylcholinesterase3.1.1.70.461
4dbw511Aldo-keto reductase family 1 member C3/0.461
4li61XOTankyrase-12.4.2.300.461
1el3I84Aldose reductase1.1.1.210.460
4pnrG18Tankyrase-22.4.2.300.460
1p8dCO1Oxysterols receptor LXR-beta/0.459
1al7HSTPeroxisomal (S)-2-hydroxy-acid oxidase1.1.3.150.458
1lkeDOGBilin-binding protein/0.458
1q84TZ4Acetylcholinesterase3.1.1.70.458
1x8lOXRRetinol dehydratase/0.458
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.458
3n3zIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.458
4dbuBT9Aldo-keto reductase family 1 member C3/0.458
4mvh2F5cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.458
5c1gGDUHisto-blood group ABO system transferase/0.458
1o6qR17Squalene--hopene cyclase4.2.1.1290.457
1zknIBMcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
1ry0PG2Aldo-keto reductase family 1 member C3/0.456
1zklIBMHigh affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A3.1.4.530.456
2xupTZ5Acetylcholinesterase3.1.1.70.456
3n0hTOPDihydrofolate reductase1.5.1.30.456
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.456
1u65CP0Acetylcholinesterase3.1.1.70.455
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.455
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.455
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.454
2xnvVU3Soluble acetylcholine receptor/0.454
4araC56Acetylcholinesterase3.1.1.70.454
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.454
4oex5EOcGMP-specific 3',5'-cyclic phosphodiesterase/0.454
2y0jAXCcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.453
3uzzTES3-oxo-5-beta-steroid 4-dehydrogenase/0.453
4jt81NRNAD-dependent protein deacetylase sirtuin-3, mitochondrial3.5.10.453
4stdBFSScytalone dehydratase4.2.1.940.453
1h22E10Acetylcholinesterase3.1.1.70.452
1ry8RUTAldo-keto reductase family 1 member C3/0.452
2aouCQAHistamine N-methyltransferase2.1.1.80.452
2ea4F79Methionine aminopeptidase 2/0.452
3g493G4Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.452
3ituIBMcGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.452
3pz3PZ3Geranylgeranyl transferase type-2 subunit beta2.5.1.600.452
4lsaBLDProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.452
2y6fM9FIsopenicillin N synthase1.21.3.10.451
3qppPFWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.451
1pqc444Oxysterols receptor LXR-beta/0.450
1re0AFBADP-ribosylation factor 1/0.450
1re0AFBARF guanine-nucleotide exchange factor 1/0.450
3tfuPL8Adenosylmethionine-8-amino-7-oxononanoate aminotransferase2.6.1.620.450
3v35NTIAldose reductase1.1.1.210.450
4zzi1NSNAD-dependent protein deacetylase sirtuin-13.5.10.450
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.449
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.449
1sojIBMcGMP-inhibited 3',5'-cyclic phosphodiesterase B3.1.4.170.448
2nvcITAAldose reductase1.1.1.210.448
2r2lPB9Protein farnesyltransferase subunit beta2.5.1.580.448
2xufTZ4Acetylcholinesterase3.1.1.70.448
2xuiTZ5Acetylcholinesterase3.1.1.70.448
3p2vDOYAldose reductase1.1.1.210.448
3zkyWT4Isopenicillin N synthase1.21.3.10.448
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.448
4heu15JcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.448
4hhy15RPoly [ADP-ribose] polymerase 12.4.2.300.448
1ef3FIDAldose reductase1.1.1.210.447
2xuhTZ4Acetylcholinesterase3.1.1.70.447
3dy8IBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
3u2cSUZAldose reductase1.1.1.210.447
3wi2P98cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
4ajdF04cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.447
4ey7E20Acetylcholinesterase3.1.1.70.447
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.446
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.446
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.446
4ajgF07cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.446
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.446
4dbs0HVAldo-keto reductase family 1 member C3/0.446
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.445
3c72CX1Geranylgeranyl transferase type-2 subunit beta2.5.1.600.445
3hiiPNTAmiloride-sensitive amine oxidase [copper-containing]/0.445
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.445
1ihiIU5Aldo-keto reductase family 1 member C2/0.444
1odcA8BAcetylcholinesterase3.1.1.70.444
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.444
2ovyPFJcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.444
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.444
3ghvGHCDihydrofolate reductase1.5.1.30.444
4kn0MTXFolate receptor beta/0.444
4li71XPTankyrase-12.4.2.300.444
4paaTHGDimethylglycine dehydrogenase, mitochondrial1.5.8.40.444
2ga2A19Methionine aminopeptidase 2/0.443
2is72CLAldose reductase1.1.1.210.443
2ourCMPcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.443
2vcmM11Isopenicillin N synthase1.21.3.10.443
3af0GDPPantothenate kinase2.7.1.330.443
3g1rFIT3-oxo-5-beta-steroid 4-dehydrogenase/0.443
3h3r14HCollagen type IV alpha-3-binding protein/0.443
4gn6TYLLactoperoxidase1.11.1.70.443
4kn2LYAFolate receptor beta/0.443
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
4myq19TcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.443
4u140HKMuscarinic acetylcholine receptor M3/0.443
1synF89Thymidylate synthase/0.442
2jf0HBPAcetylcholinesterase3.1.1.70.442
3hxdBD7Geranylgeranyl transferase type-2 subunit beta2.5.1.600.442
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
3q9bB3NAcetylpolyamine amidohydrolase/0.442
3v94WYQPhosphodiesterase/0.442
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
4mt92D6Tankyrase-12.4.2.300.442
1t47NTD4-hydroxyphenylpyruvate dioxygenase1.13.11.270.441
1udtVIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.441
2g21L1BRenin3.4.23.150.441
2psjCEIRenilla-luciferin 2-monooxygenase1.13.12.50.441
3pz23PZGeranylgeranyl transferase type-2 subunit beta2.5.1.600.441
4kn104JFolate receptor beta/0.441
4llkMEWcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.441
1ndzFR5Adenosine deaminase3.5.4.40.440
1pq944BOxysterols receptor LXR-beta/0.440
4b7zQ4QAcetylcholinesterase3.1.1.70.440
4e0u0MVCyclic dipeptide N-prenyltransferase/0.440
4jtrIZPAldo-keto reductase family 1 member C2/0.440
4l5b1UXDeoxycytidine kinase2.7.1.740.440
4m0f1YKAcetylcholinesterase3.1.1.70.440
4pnmNU1Tankyrase-22.4.2.300.440