Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
PDB ID | HET | Uniprot Name | EC Number |
---|---|---|---|
2i16 | LDT | Aldose reductase | 1.1.1.21 |
PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
---|---|---|---|---|---|
2i16 | LDT | Aldose reductase | 1.1.1.21 | 1.000 | |
1z3n | 3NA | Aldose reductase | 1.1.1.21 | 0.799 | |
3ghr | LDT | Aldose reductase | 1.1.1.21 | 0.790 | |
2qxw | LDT | Aldose reductase | 1.1.1.21 | 0.778 | |
2fz8 | ZST | Aldose reductase | 1.1.1.21 | 0.768 | |
3ld5 | LDT | Aldose reductase | 1.1.1.21 | 0.756 | |
3ghu | LDT | Aldose reductase | 1.1.1.21 | 0.731 | |
3g5e | Q74 | Aldose reductase | 1.1.1.21 | 0.726 | |
3ghs | LDT | Aldose reductase | 1.1.1.21 | 0.709 | |
3ght | LDT | Aldose reductase | 1.1.1.21 | 0.706 | |
2duz | ZST | Aldose reductase | 1.1.1.21 | 0.702 | |
1us0 | LDT | Aldose reductase | 1.1.1.21 | 0.701 | |
2iki | 388 | Aldose reductase | 1.1.1.21 | 0.694 | |
2hv5 | ZST | Aldose reductase | 1.1.1.21 | 0.691 | |
2i17 | LDT | Aldose reductase | 1.1.1.21 | 0.675 | |
2hvn | ZST | Aldose reductase | 1.1.1.21 | 0.670 | |
1t40 | ID5 | Aldose reductase | 1.1.1.21 | 0.668 | |
2dux | ZST | Aldose reductase | 1.1.1.21 | 0.660 | |
2dv0 | ZST | Aldose reductase | 1.1.1.21 | 0.657 | |
2pdl | TOL | Aldose reductase | 1.1.1.21 | 0.656 | |
3lbo | LDT | Aldose reductase | 1.1.1.21 | 0.650 | |
2pzn | 393 | Aldose reductase | 1.1.1.21 | 0.649 | |
1pwl | BFI | Aldose reductase | 1.1.1.21 | 0.644 | |
3lql | LDT | Aldose reductase | 1.1.1.21 | 0.644 | |
3mb9 | ZST | Aldose reductase | 1.1.1.21 | 0.643 | |
2pdm | ZST | Aldose reductase | 1.1.1.21 | 0.640 | |
2pdi | ZST | Aldose reductase | 1.1.1.21 | 0.636 | |
1z89 | 62P | Aldose reductase | 1.1.1.21 | 0.629 | |
2pdu | 393 | Aldose reductase | 1.1.1.21 | 0.616 | |
2fz9 | ZST | Aldose reductase | 1.1.1.21 | 0.605 | |
2hvo | ZST | Aldose reductase | 1.1.1.21 | 0.604 | |
4gca | 2X9 | Aldose reductase | 1.1.1.21 | 0.604 | |
2ikh | LIT | Aldose reductase | 1.1.1.21 | 0.603 | |
2pdx | ZST | Aldose reductase | 1.1.1.21 | 0.602 | |
3m4h | 388 | Aldose reductase | 1.1.1.21 | 0.602 | |
3mc5 | 393 | Aldose reductase | 1.1.1.21 | 0.601 | |
2pdh | 47D | Aldose reductase | 1.1.1.21 | 0.600 | |
2pdn | 47D | Aldose reductase | 1.1.1.21 | 0.597 | |
1iei | ZES | Aldose reductase | 1.1.1.21 | 0.596 | |
2pdc | 393 | Aldose reductase | 1.1.1.21 | 0.595 | |
2pdp | 393 | Aldose reductase | 1.1.1.21 | 0.594 | |
2pdb | ZST | Aldose reductase | 1.1.1.21 | 0.589 | |
3len | ZST | Aldose reductase | 1.1.1.21 | 0.588 | |
3m0i | ZST | Aldose reductase | 1.1.1.21 | 0.583 | |
3m64 | 393 | Aldose reductase | 1.1.1.21 | 0.577 | |
2ikj | 393 | Aldose reductase | 1.1.1.21 | 0.573 | |
2pd5 | ZST | Aldose reductase | 1.1.1.21 | 0.572 | |
2pdf | ZST | Aldose reductase | 1.1.1.21 | 0.572 | |
1frb | ZST | Aldose reductase-related protein 2 | / | 0.571 | |
1t41 | ID5 | Aldose reductase | 1.1.1.21 | 0.571 | |
3t42 | 3T4 | Aldose reductase | 1.1.1.21 | 0.565 | |
2pdg | 47D | Aldose reductase | 1.1.1.21 | 0.564 | |
4yu1 | 53N | Aldose reductase | 1.1.1.21 | 0.564 | |
2pdj | 393 | Aldose reductase | 1.1.1.21 | 0.559 | |
1ah3 | TOL | Aldose reductase | 1.1.1.21 | 0.548 | |
2pdq | 47D | Aldose reductase | 1.1.1.21 | 0.545 | |
1zua | TOL | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.538 | |
2fzd | TOL | Aldose reductase | 1.1.1.21 | 0.532 | |
2pdw | FID | Aldose reductase | 1.1.1.21 | 0.517 | |
2fzb | TOL | Aldose reductase | 1.1.1.21 | 0.515 | |
2iqd | LPA | Aldose reductase | 1.1.1.21 | 0.509 | |
2inz | OHP | Aldose reductase | 1.1.1.21 | 0.507 | |
2pdy | FID | Aldose reductase | 1.1.1.21 | 0.505 | |
3lz5 | LDT | Aldose reductase | 1.1.1.21 | 0.501 | |
4ga8 | SBI | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.501 | |
3wav | DWV | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | 3.1.4.39 | 0.498 | |
2o8h | 227 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.485 | |
3jsx | CC2 | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.485 | |
1xor | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.482 | |
2f2k | TGG | Aldose reductase | 1.1.1.21 | 0.482 | |
1lnm | DTX | Bilin-binding protein | / | 0.481 | |
4hf4 | 15H | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.478 | |
2aot | 2PM | Histamine N-methyltransferase | 2.1.1.8 | 0.474 | |
2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.474 | |
2f38 | 15M | Aldo-keto reductase family 1 member C3 | / | 0.473 | |
4fcb | 0T7 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.473 | |
3hxe | BD8 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.472 | |
4jq4 | IMN | Aldo-keto reductase family 1 member C2 | / | 0.472 | |
1p91 | SAM | 23S rRNA (guanine(745)-N(1))-methyltransferase | / | 0.471 | |
1pwm | FID | Aldose reductase | 1.1.1.21 | 0.471 | |
3s3g | TLT | Aldose reductase | 1.1.1.21 | 0.471 | |
5liu | 388 | Aldo-keto reductase family 1 member B10 | 1.1.1 | 0.471 | |
1ro6 | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.470 | |
3g58 | 988 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.470 | |
4a95 | 9MT | Glycylpeptide N-tetradecanoyltransferase | / | 0.470 | |
1eko | I84 | Aldose reductase | 1.1.1.21 | 0.469 | |
3qpn | PFK | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.469 | |
3qpo | PFR | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.469 | |
2ouu | 35G | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.467 | |
1q9m | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
2cek | N8T | Acetylcholinesterase | 3.1.1.7 | 0.466 | |
3g4i | D71 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
3g4k | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.466 | |
3lz6 | A0D | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.465 | |
4pab | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.465 | |
1oyn | ROL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.464 | |
1xf0 | ASD | Aldo-keto reductase family 1 member C3 | / | 0.464 | |
2agt | FID | Aldose reductase | 1.1.1.21 | 0.464 | |
2w6c | BM4 | Acetylcholinesterase | 3.1.1.7 | 0.463 | |
1c7o | PPG | Hemolysin | / | 0.462 | |
1xoq | ROF | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.462 | |
2ct8 | MSP | Methionine--tRNA ligase | 6.1.1.10 | 0.462 | |
3f3y | 4OA | Bile salt sulfotransferase | 2.8.2.14 | 0.462 | |
4xwt | U5P | Ribonuclease J | / | 0.462 | |
2xuj | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.461 | |
4dbw | 511 | Aldo-keto reductase family 1 member C3 | / | 0.461 | |
4li6 | 1XO | Tankyrase-1 | 2.4.2.30 | 0.461 | |
1el3 | I84 | Aldose reductase | 1.1.1.21 | 0.460 | |
4pnr | G18 | Tankyrase-2 | 2.4.2.30 | 0.460 | |
1p8d | CO1 | Oxysterols receptor LXR-beta | / | 0.459 | |
1al7 | HST | Peroxisomal (S)-2-hydroxy-acid oxidase | 1.1.3.15 | 0.458 | |
1lke | DOG | Bilin-binding protein | / | 0.458 | |
1q84 | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.458 | |
1x8l | OXR | Retinol dehydratase | / | 0.458 | |
3k4s | 0MO | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.458 | |
3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.458 | |
4dbu | BT9 | Aldo-keto reductase family 1 member C3 | / | 0.458 | |
4mvh | 2F5 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.458 | |
5c1g | GDU | Histo-blood group ABO system transferase | / | 0.458 | |
1o6q | R17 | Squalene--hopene cyclase | 4.2.1.129 | 0.457 | |
1zkn | IBM | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
2fm5 | M99 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.457 | |
1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.456 | |
1zkl | IBM | High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A | 3.1.4.53 | 0.456 | |
2xup | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.456 | |
3n0h | TOP | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
4bbh | YBN | Glycylpeptide N-tetradecanoyltransferase | / | 0.456 | |
1u65 | CP0 | Acetylcholinesterase | 3.1.1.7 | 0.455 | |
1uho | VDN | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.455 | |
4eil | FOL | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.455 | |
1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.454 | |
2xnv | VU3 | Soluble acetylcholine receptor | / | 0.454 | |
4ara | C56 | Acetylcholinesterase | 3.1.1.7 | 0.454 | |
4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.454 | |
4oex | 5EO | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.454 | |
2y0j | AXC | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.453 | |
3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.453 | |
4jt8 | 1NR | NAD-dependent protein deacetylase sirtuin-3, mitochondrial | 3.5.1 | 0.453 | |
4std | BFS | Scytalone dehydratase | 4.2.1.94 | 0.453 | |
1h22 | E10 | Acetylcholinesterase | 3.1.1.7 | 0.452 | |
1ry8 | RUT | Aldo-keto reductase family 1 member C3 | / | 0.452 | |
2aou | CQA | Histamine N-methyltransferase | 2.1.1.8 | 0.452 | |
2ea4 | F79 | Methionine aminopeptidase 2 | / | 0.452 | |
3g49 | 3G4 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
3itu | IBM | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.452 | |
3pz3 | PZ3 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.452 | |
4lsa | BLD | Protein BRASSINOSTEROID INSENSITIVE 1 | 2.7.10.1 | 0.452 | |
2y6f | M9F | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
3qpp | PFW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.451 | |
1pqc | 444 | Oxysterols receptor LXR-beta | / | 0.450 | |
1re0 | AFB | ADP-ribosylation factor 1 | / | 0.450 | |
1re0 | AFB | ARF guanine-nucleotide exchange factor 1 | / | 0.450 | |
3tfu | PL8 | Adenosylmethionine-8-amino-7-oxononanoate aminotransferase | 2.6.1.62 | 0.450 | |
3v35 | NTI | Aldose reductase | 1.1.1.21 | 0.450 | |
4zzi | 1NS | NAD-dependent protein deacetylase sirtuin-1 | 3.5.1 | 0.450 | |
1xon | PIL | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.449 | |
3zec | ANP | Adenosine monophosphate-protein transferase SoFic | 2.7.7.n1 | 0.449 | |
4b11 | 7I1 | Glycylpeptide N-tetradecanoyltransferase | / | 0.449 | |
1soj | IBM | cGMP-inhibited 3',5'-cyclic phosphodiesterase B | 3.1.4.17 | 0.448 | |
2nvc | ITA | Aldose reductase | 1.1.1.21 | 0.448 | |
2r2l | PB9 | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.448 | |
2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
2xui | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.448 | |
3p2v | DOY | Aldose reductase | 1.1.1.21 | 0.448 | |
3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.448 | |
4b13 | X25 | Glycylpeptide N-tetradecanoyltransferase | / | 0.448 | |
4heu | 15J | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.448 | |
4hhy | 15R | Poly [ADP-ribose] polymerase 1 | 2.4.2.30 | 0.448 | |
1ef3 | FID | Aldose reductase | 1.1.1.21 | 0.447 | |
2xuh | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.447 | |
3u2c | SUZ | Aldose reductase | 1.1.1.21 | 0.447 | |
3wi2 | P98 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
4ajd | F04 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.447 | |
4ey7 | E20 | Acetylcholinesterase | 3.1.1.7 | 0.447 | |
3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.446 | |
3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.446 | |
3w5e | NVW | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.446 | |
4ajg | F07 | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.446 | |
4c2z | 646 | Glycylpeptide N-tetradecanoyltransferase 1 | / | 0.446 | |
4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.446 | |
2yne | YNE | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
3c72 | CX1 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.445 | |
3hii | PNT | Amiloride-sensitive amine oxidase [copper-containing] | / | 0.445 | |
4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
1ihi | IU5 | Aldo-keto reductase family 1 member C2 | / | 0.444 | |
1odc | A8B | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
1y2k | 7DE | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.444 | |
2ovy | PFJ | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.444 | |
3dyq | PCG | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
3ghv | GHC | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
4kn0 | MTX | Folate receptor beta | / | 0.444 | |
4li7 | 1XP | Tankyrase-1 | 2.4.2.30 | 0.444 | |
4paa | THG | Dimethylglycine dehydrogenase, mitochondrial | 1.5.8.4 | 0.444 | |
2ga2 | A19 | Methionine aminopeptidase 2 | / | 0.443 | |
2is7 | 2CL | Aldose reductase | 1.1.1.21 | 0.443 | |
2our | CMP | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.443 | |
2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.443 | |
3af0 | GDP | Pantothenate kinase | 2.7.1.33 | 0.443 | |
3g1r | FIT | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.443 | |
3h3r | 14H | Collagen type IV alpha-3-binding protein | / | 0.443 | |
4gn6 | TYL | Lactoperoxidase | 1.11.1.7 | 0.443 | |
4kn2 | LYA | Folate receptor beta | / | 0.443 | |
4ky4 | 04J | Bifunctional dihydrofolate reductase-thymidylate synthase | 1.5.1.3 | 0.443 | |
4myq | 19T | cAMP-specific 3',5'-cyclic phosphodiesterase 4B | 3.1.4.53 | 0.443 | |
4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.443 | |
1syn | F89 | Thymidylate synthase | / | 0.442 | |
2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.442 | |
3hxd | BD7 | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.442 | |
3iak | EV1 | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.442 | |
3q9b | B3N | Acetylpolyamine amidohydrolase | / | 0.442 | |
3v94 | WYQ | Phosphodiesterase | / | 0.442 | |
4hfr | 14M | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
4mt9 | 2D6 | Tankyrase-1 | 2.4.2.30 | 0.442 | |
1t47 | NTD | 4-hydroxyphenylpyruvate dioxygenase | 1.13.11.27 | 0.441 | |
1udt | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.441 | |
2g21 | L1B | Renin | 3.4.23.15 | 0.441 | |
2psj | CEI | Renilla-luciferin 2-monooxygenase | 1.13.12.5 | 0.441 | |
3pz2 | 3PZ | Geranylgeranyl transferase type-2 subunit beta | 2.5.1.60 | 0.441 | |
4kn1 | 04J | Folate receptor beta | / | 0.441 | |
4llk | MEW | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A | 3.1.4.17 | 0.441 | |
1ndz | FR5 | Adenosine deaminase | 3.5.4.4 | 0.440 | |
1pq9 | 44B | Oxysterols receptor LXR-beta | / | 0.440 | |
4b7z | Q4Q | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
4e0u | 0MV | Cyclic dipeptide N-prenyltransferase | / | 0.440 | |
4jtr | IZP | Aldo-keto reductase family 1 member C2 | / | 0.440 | |
4l5b | 1UX | Deoxycytidine kinase | 2.7.1.74 | 0.440 | |
4m0f | 1YK | Acetylcholinesterase | 3.1.1.7 | 0.440 | |
4pnm | NU1 | Tankyrase-2 | 2.4.2.30 | 0.440 |