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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2c6o4SPCyclin-dependent kinase 22.7.11.22

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2c6o4SPCyclin-dependent kinase 22.7.11.221.000
2vtpLZ9Cyclin-dependent kinase 22.7.11.220.610
1ke7LS3Cyclin-dependent kinase 22.7.11.220.588
2vtoLZ8Cyclin-dependent kinase 22.7.11.220.587
2uzoC62Cyclin-dependent kinase 22.7.11.220.582
3lfnA27Cyclin-dependent kinase 22.7.11.220.582
1v1k3FPCyclin-dependent kinase 22.7.11.220.580
1ke6LS2Cyclin-dependent kinase 22.7.11.220.578
1w8cN69Cyclin-dependent kinase 22.7.11.220.563
2w06FRVCyclin-dependent kinase 22.7.11.220.558
1oitHDTCyclin-dependent kinase 22.7.11.220.557
1p2a5BNCyclin-dependent kinase 22.7.11.220.551
3r7yZ04Cyclin-dependent kinase 22.7.11.220.550
2a0cCK9Cyclin-dependent kinase 22.7.11.220.549
2r3lSCWCyclin-dependent kinase 22.7.11.220.544
3qtzX42Cyclin-dependent kinase 22.7.11.220.544
3r73X87Cyclin-dependent kinase 22.7.11.220.543
3s2pPMUCyclin-dependent kinase 22.7.11.220.542
2b55D31Cyclin-dependent kinase 22.7.11.220.541
2c6mDT5Cyclin-dependent kinase 22.7.11.220.541
1pxmCK5Cyclin-dependent kinase 22.7.11.220.540
2w1hL0FCyclin-dependent kinase 22.7.11.220.538
3r71X86Cyclin-dependent kinase 22.7.11.220.538
3qtuX44Cyclin-dependent kinase 22.7.11.220.537
3rm719ZCyclin-dependent kinase 22.7.11.220.537
2r64740Cyclin-dependent kinase 22.7.11.220.534
3lfqA28Cyclin-dependent kinase 22.7.11.220.534
3qzhX69Cyclin-dependent kinase 22.7.11.220.534
3rahO1ZCyclin-dependent kinase 22.7.11.220.534
3s1h56ZCyclin-dependent kinase 22.7.11.220.534
3sqq99ZCyclin-dependent kinase 22.7.11.220.534
4ek816KCyclin-dependent kinase 22.7.11.220.534
1di8DTQCyclin-dependent kinase 22.7.11.220.532
3r7vZ02Cyclin-dependent kinase 22.7.11.220.532
3rni21ZCyclin-dependent kinase 22.7.11.220.530
3sw418KCyclin-dependent kinase 22.7.11.220.528
3r8lZ30Cyclin-dependent kinase 22.7.11.220.527
3r9dX6BCyclin-dependent kinase 22.7.11.220.525
4fko20KCyclin-dependent kinase 22.7.11.220.524
2vthLZ2Cyclin-dependent kinase 22.7.11.220.523
2b52D42Cyclin-dependent kinase 22.7.11.220.522
4fkv61KCyclin-dependent kinase 22.7.11.220.522
1y91CT9Cyclin-dependent kinase 22.7.11.220.521
3rpv26ZCyclin-dependent kinase 22.7.11.220.520
2r3jSCJCyclin-dependent kinase 22.7.11.220.519
3r8vZ62Cyclin-dependent kinase 22.7.11.220.519
2a4lRRCCyclin-dependent kinase 22.7.11.220.518
4fkq42KCyclin-dependent kinase 22.7.11.220.518
4fkr45KCyclin-dependent kinase 22.7.11.220.517
1gih1PUCyclin-dependent kinase 22.7.11.220.516
3r1sX73Cyclin-dependent kinase 22.7.11.220.516
3roy22ZCyclin-dependent kinase 22.7.11.220.515
3r83Z14Cyclin-dependent kinase 22.7.11.220.514
1g5sI17Cyclin-dependent kinase 22.7.11.220.512
4kd11QKCyclin-dependent kinase 22.7.11.220.511
2duv371Cyclin-dependent kinase 22.7.11.220.510
3rak03ZCyclin-dependent kinase 22.7.11.220.510
3ral04ZCyclin-dependent kinase 22.7.11.220.510
3rk708ZCyclin-dependent kinase 22.7.11.220.510
3qqfX07Cyclin-dependent kinase 22.7.11.220.509
3qxoX65Cyclin-dependent kinase 22.7.11.220.509
1h0w207Cyclin-dependent kinase 22.7.11.220.508
3rjc06ZCyclin-dependent kinase 22.7.11.220.508
3wblPDYCyclin-dependent kinase 22.7.11.220.508
1pxpCK8Cyclin-dependent kinase 22.7.11.220.506
3qu0X40Cyclin-dependent kinase 22.7.11.220.506
3rmf20ZCyclin-dependent kinase 22.7.11.220.506
2uznC96Cyclin-dependent kinase 22.7.11.220.505
3ezvEZVCyclin-dependent kinase 22.7.11.220.504
1gii1PUCyclin-dependent kinase 22.7.11.220.503
4acm7YGCyclin-dependent kinase 22.7.11.220.502
2c6iDT1Cyclin-dependent kinase 22.7.11.220.501
3iggEFQCyclin-dependent kinase 22.7.11.220.501
2r3p3SCCyclin-dependent kinase 22.7.11.220.499
1w0xOLOCyclin-dependent kinase 22.7.11.220.498
3sw719KCyclin-dependent kinase 22.7.11.220.498
4fkpLS5Cyclin-dependent kinase 22.7.11.220.498
2r3kSCQCyclin-dependent kinase 22.7.11.220.497
3qtxX43Cyclin-dependent kinase 22.7.11.220.497
3r7uX96Cyclin-dependent kinase 22.7.11.220.497
3qqlX03Cyclin-dependent kinase 22.7.11.220.496
3raiX85Cyclin-dependent kinase 22.7.11.220.496
3rm618ZCyclin-dependent kinase 22.7.11.220.496
4eor4SPCyclin-dependent kinase 22.7.11.220.496
2xmyCDKCyclin-dependent kinase 22.7.11.220.495
3qqkX02Cyclin-dependent kinase 22.7.11.220.495
3qruX19Cyclin-dependent kinase 22.7.11.220.495
4fkw62KCyclin-dependent kinase 22.7.11.220.495
1ke9LS5Cyclin-dependent kinase 22.7.11.220.494
3pj8404Cyclin-dependent kinase 22.7.11.220.494
3r6xX84Cyclin-dependent kinase 22.7.11.220.494
1e1xNW1Cyclin-dependent kinase 22.7.11.220.493
1oirHDYCyclin-dependent kinase 22.7.11.220.493
2vtsLZCCyclin-dependent kinase 22.7.11.220.493
3qqhX0ACyclin-dependent kinase 22.7.11.220.493
2b53D23Cyclin-dependent kinase 22.7.11.220.491
2vtrLZBCyclin-dependent kinase 22.7.11.220.491
3qzgX67Cyclin-dependent kinase 22.7.11.220.491
3s0o50ZCyclin-dependent kinase 22.7.11.220.491
2btsU32Cyclin-dependent kinase 22.7.11.220.490
1h1s4SPCyclin-dependent kinase 22.7.11.220.489
1oiyN41Cyclin-dependent kinase 22.7.11.220.489
3ezrEZRCyclin-dependent kinase 22.7.11.220.489
2exmZIPCyclin-dependent kinase 22.7.11.220.488
2r3iSCFCyclin-dependent kinase 22.7.11.220.488
2c6kDT2Cyclin-dependent kinase 22.7.11.220.487
2vv9IM9Cyclin-dependent kinase 22.7.11.220.487
4fks46KCyclin-dependent kinase 22.7.11.220.486
1urwI1PCyclin-dependent kinase 22.7.11.220.484
3rpo24ZCyclin-dependent kinase 22.7.11.220.484
1pxlCK4Cyclin-dependent kinase 22.7.11.220.483
1oguST8Cyclin-dependent kinase 22.7.11.220.482
3fz1B98Cyclin-dependent kinase 22.7.11.220.482
3lfsA07Cyclin-dependent kinase 22.7.11.220.482
3qwjX6ACyclin-dependent kinase 22.7.11.220.482
1r78FMDCyclin-dependent kinase 22.7.11.220.481
2c6lDT4Cyclin-dependent kinase 22.7.11.220.481
2w17I19Cyclin-dependent kinase 22.7.11.220.481
3ig7EFPCyclin-dependent kinase 22.7.11.220.481
3qx2X63Cyclin-dependent kinase 22.7.11.220.480
3v5l0G1Tyrosine-protein kinase ITK/TSK2.7.10.20.479
2r3gSC9Cyclin-dependent kinase 22.7.11.220.478
2r3r6SCCyclin-dependent kinase 22.7.11.220.477
2w05FRTCyclin-dependent kinase 22.7.11.220.477
1pxkCK3Cyclin-dependent kinase 22.7.11.220.476
2vtiLZ3Cyclin-dependent kinase 22.7.11.220.476
3r9hZ67Cyclin-dependent kinase 22.7.11.220.476
3rk507ZCyclin-dependent kinase 22.7.11.220.476
4lyn1YGCyclin-dependent kinase 22.7.11.220.476
1h1r6CPCyclin-dependent kinase 22.7.11.220.474
3qxpX64Cyclin-dependent kinase 22.7.11.220.474
3rk909ZCyclin-dependent kinase 22.7.11.220.474
2iw94SPCyclin-dependent kinase 22.7.11.220.473
3r8pZ46Cyclin-dependent kinase 22.7.11.220.473
1b38ATPCyclin-dependent kinase 22.7.11.220.472
3r1yX76Cyclin-dependent kinase 22.7.11.220.472
3ti1B49Cyclin-dependent kinase 22.7.11.220.472
1aq1STUCyclin-dependent kinase 22.7.11.220.470
3ddpRC8Cyclin-dependent kinase 22.7.11.220.470
3r8uZ31Cyclin-dependent kinase 22.7.11.220.470
3r28XA0Cyclin-dependent kinase 22.7.11.220.469
1ykr628Cyclin-dependent kinase 22.7.11.220.468
3qtrX36Cyclin-dependent kinase 22.7.11.220.466
3r1qX75Cyclin-dependent kinase 22.7.11.220.466
3unk0BYCyclin-dependent kinase 22.7.11.220.466
1ke5LS1Cyclin-dependent kinase 22.7.11.220.465
4bgh3I6Cyclin-dependent kinase 22.7.11.220.465
1ckpPVBCyclin-dependent kinase 22.7.11.220.464
4fx360KCyclin-dependent kinase 22.7.11.220.464
2c69CT8Cyclin-dependent kinase 22.7.11.220.461
1oiuN76Cyclin-dependent kinase 22.7.11.220.460
2iw84SPCyclin-dependent kinase 22.7.11.220.460
3r9nZ68Cyclin-dependent kinase 22.7.11.220.460
4fkt48KCyclin-dependent kinase 22.7.11.220.460
2fvdLIACyclin-dependent kinase 22.7.11.220.459
3le62BZCyclin-dependent kinase 22.7.11.220.459
3r7eX88Cyclin-dependent kinase 22.7.11.220.459
2btrU73Cyclin-dependent kinase 22.7.11.220.458
2vtjLZ4Cyclin-dependent kinase 22.7.11.220.458
3qwkX62Cyclin-dependent kinase 22.7.11.220.458
1fvt106Cyclin-dependent kinase 22.7.11.220.457
1vyzN5BCyclin-dependent kinase 22.7.11.220.457
2bheBRYCyclin-dependent kinase 22.7.11.220.457
4eok4SPCyclin-dependent kinase 22.7.11.220.457
4erwSTUCyclin-dependent kinase 22.7.11.220.457
2bhhRYUCyclin-dependent kinase 22.7.11.220.456
2r3o2SCCyclin-dependent kinase 22.7.11.220.456
3r7iX9ICyclin-dependent kinase 22.7.11.220.456
3rpr25ZCyclin-dependent kinase 22.7.11.220.456
4bcmT7ZCyclin-dependent kinase 22.7.11.220.456
1y8yCT7Cyclin-dependent kinase 22.7.11.220.455
3ggfGVDSerine/threonine-protein kinase 26/0.455
4eon1ROCyclin-dependent kinase 22.7.11.220.455
1oi9N20Cyclin-dependent kinase 22.7.11.220.454
3r9oZ71Cyclin-dependent kinase 22.7.11.220.454
1hckATPCyclin-dependent kinase 22.7.11.220.453
1oiqHDUCyclin-dependent kinase 22.7.11.220.453
2r3mSCXCyclin-dependent kinase 22.7.11.220.453
4ez50RSCyclin-dependent kinase 62.7.11.220.452
3ddqRRCCyclin-dependent kinase 22.7.11.220.451
2c5yMTWCyclin-dependent kinase 22.7.11.220.450
3uli1N3Cyclin-dependent kinase 22.7.11.220.450
1fvv107Cyclin-dependent kinase 22.7.11.220.449
2c68CT6Cyclin-dependent kinase 22.7.11.220.449
3qtsX46Cyclin-dependent kinase 22.7.11.220.449
3dogNNNCyclin-dependent kinase 22.7.11.220.448
3unj0BXCyclin-dependent kinase 22.7.11.220.448
1ke8LS4Cyclin-dependent kinase 22.7.11.220.447
1pxoCK7Cyclin-dependent kinase 22.7.11.220.445
2i40BLZCyclin-dependent kinase 22.7.11.220.445
3nynSGVG protein-coupled receptor kinase 62.7.11.160.445
1pyePM1Cyclin-dependent kinase 22.7.11.220.444
3py0SU9Cyclin-dependent kinase 22.7.11.220.444
4fklCK2Cyclin-dependent kinase 22.7.11.220.444
1pkdUCNCyclin-dependent kinase 22.7.11.220.443
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.443
2x1nX1NCyclin-dependent kinase 22.7.11.220.443
3s00Z60Cyclin-dependent kinase 22.7.11.220.443
3sheI85MAP kinase-activated protein kinase 32.7.11.10.443
4ek610KCyclin-dependent kinase 22.7.11.220.443
2r3fSC8Cyclin-dependent kinase 22.7.11.220.442
2vtqLZACyclin-dependent kinase 22.7.11.220.442
1b39ATPCyclin-dependent kinase 22.7.11.220.441
1gij2PUCyclin-dependent kinase 22.7.11.220.441
3qrtX14Cyclin-dependent kinase 22.7.11.220.441
4kioG5KTyrosine-protein kinase ITK/TSK2.7.10.20.441
2iw6QQ2Cyclin-dependent kinase 22.7.11.220.440
2vu3LZECyclin-dependent kinase 22.7.11.220.440