scPDB - Distribution of Binding site Similarity values of 2bbf entry / Site 1

Distribution of Binding site similarity measured by Shaper

You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2bbf	344	Queuine tRNA-ribosyltransferase	2.4.2.29

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
2bbf	344	Queuine tRNA-ribosyltransferase	2.4.2.29	1.000
2qzr	S79	Queuine tRNA-ribosyltransferase	2.4.2.29	0.662
1k4h	APQ	Queuine tRNA-ribosyltransferase	2.4.2.29	0.644
1efz	PRF	Queuine tRNA-ribosyltransferase	2.4.2.29	0.622
2z1x	PRF	Queuine tRNA-ribosyltransferase	2.4.2.29	0.609
1k4g	AIQ	Queuine tRNA-ribosyltransferase	2.4.2.29	0.607
1y5w	NEZ	Queuine tRNA-ribosyltransferase	2.4.2.29	0.594
1y5x	E89	Queuine tRNA-ribosyltransferase	2.4.2.29	0.585
4gh1	0WX	Queuine tRNA-ribosyltransferase	2.4.2.29	0.582
3ge7	AFQ	Queuine tRNA-ribosyltransferase	2.4.2.29	0.577
4gg9	0WW	Queuine tRNA-ribosyltransferase	2.4.2.29	0.575
4giy	0WY	Queuine tRNA-ribosyltransferase	2.4.2.29	0.573
4hsh	QEI	Queuine tRNA-ribosyltransferase	2.4.2.29	0.573
3gc5	2MQ	Queuine tRNA-ribosyltransferase	2.4.2.29	0.570
3gc4	AAQ	Queuine tRNA-ribosyltransferase	2.4.2.29	0.564
2z1w	BDI	Queuine tRNA-ribosyltransferase	2.4.2.29	0.562
2pot	GUN	Queuine tRNA-ribosyltransferase	2.4.2.29	0.552
4fr1	0V2	Queuine tRNA-ribosyltransferase	2.4.2.29	0.552
4fsa	0V3	Queuine tRNA-ribosyltransferase	2.4.2.29	0.550
1n2v	BDI	Queuine tRNA-ribosyltransferase	2.4.2.29	0.547
1q63	AIQ	Queuine tRNA-ribosyltransferase	2.4.2.29	0.547
4fps	0UX	Queuine tRNA-ribosyltransferase	2.4.2.29	0.546
4q8p	CKR	Queuine tRNA-ribosyltransferase	2.4.2.29	0.544
4gcx	PRF	Queuine tRNA-ribosyltransferase	2.4.2.29	0.537
1q66	KMB	Queuine tRNA-ribosyltransferase	2.4.2.29	0.535
4gkt	0O1	Queuine tRNA-ribosyltransferase	2.4.2.29	0.532
4gi4	0EX	Queuine tRNA-ribosyltransferase	2.4.2.29	0.531
4gh3	0EV	Queuine tRNA-ribosyltransferase	2.4.2.29	0.530
1r5y	DQU	Queuine tRNA-ribosyltransferase	2.4.2.29	0.528
3sm0	AEK	Queuine tRNA-ribosyltransferase	2.4.2.29	0.522
4hvx	QEI	Queuine tRNA-ribosyltransferase	2.4.2.29	0.522
1p0e	PRF	Queuine tRNA-ribosyltransferase	2.4.2.29	0.517
1y5v	NE8	Queuine tRNA-ribosyltransferase	2.4.2.29	0.517
1ozq	PRF	Queuine tRNA-ribosyltransferase	2.4.2.29	0.516
3bll	BPQ	Queuine tRNA-ribosyltransferase	2.4.2.29	0.513
1f3e	DPZ	Queuine tRNA-ribosyltransferase	2.4.2.29	0.512
4hqv	QEI	Queuine tRNA-ribosyltransferase	2.4.2.29	0.508
1q4w	DQU	Queuine tRNA-ribosyltransferase	2.4.2.29	0.501
1q65	BHB	Queuine tRNA-ribosyltransferase	2.4.2.29	0.484
3exh	TPP	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial	1.2.4.1	0.484
3exh	TPP	Pyruvate dehydrogenase E1 component subunit beta, mitochondrial	1.2.4.1	0.484
4gki	0JN	Aminoglycoside 3'-phosphotransferase AphA1-IAB	/	0.483
1ygj	RMC	Pyridoxal kinase	2.7.1.35	0.480
4h6p	FMN	Chromate reductase	/	0.478
3t4e	NAD	Quinate/shikimate dehydrogenase	/	0.474
1ex7	5GP	Guanylate kinase	2.7.4.8	0.473
1gky	5GP	Guanylate kinase	2.7.4.8	0.472
3bld	PRF	Queuine tRNA-ribosyltransferase	2.4.2.29	0.472
4h7z	GUN	Queuine tRNA-ribosyltransferase	2.4.2.29	0.471
4ug9	1EW	Nitric oxide synthase oxygenase	1.14.13.165	0.471
3qgt	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.470
1j3j	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.467
1lb9	DNQ	Glutamate receptor 2	/	0.467
1fw0	KAI	Glutamate receptor 2	/	0.466
3cow	52H	Pantothenate synthetase	6.3.2.1	0.464
3q2j	CKI	Aminoglycoside 3'-phosphotransferase	2.7.1.95	0.462
1xdu	SFG	Aclacinomycin 10-hydroxylase RdmB	4.1.1	0.461
1xzq	FON	tRNA modification GTPase MnmE	3.6.5	0.461
2cle	F6F	Tryptophan synthase alpha chain	/	0.461
2xiq	5AD	Methylmalonyl-CoA mutase, mitochondrial	/	0.461
3a26	MTA	tRNA(Phe) (4-demethylwyosine(37)-C(7)) aminocarboxypropyltransferase	/	0.461
1zy5	ANP	eIF-2-alpha kinase GCN2	/	0.460
3coy	53H	Pantothenate synthetase	6.3.2.1	0.458
3ufl	508	Beta-secretase 1	3.4.23.46	0.458
4bgb	ADP	Predicted molecular chaperone distantly related to HSP70-fold metalloproteases	/	0.458
1cjc	FAD	NADPH:adrenodoxin oxidoreductase, mitochondrial	1.18.1.6	0.457
2w3a	TOP	Dihydrofolate reductase	1.5.1.3	0.457
3sxj	SAM	Putative methyltransferase	/	0.457
4kfj	1R0	Dihydrofolate reductase	1.5.1.3	0.457
1pxg	PRF	Queuine tRNA-ribosyltransferase	2.4.2.29	0.456
2azz	TCH	Phospholipase A2, major isoenzyme	3.1.1.4	0.456
3dqr	JI2	Nitric oxide synthase, brain	1.14.13.39	0.456
4ndn	SAM	S-adenosylmethionine synthase isoform type-2	2.5.1.6	0.456
3zj6	VM2	Raucaffricine-O-beta-D-glucosidase	3.2.1.125	0.454
4g09	0VD	Histidinol dehydrogenase	/	0.454
4gkh	0J9	Aminoglycoside 3'-phosphotransferase AphA1-IAB	/	0.454
3oaf	OAG	Dihydrofolate reductase	1.5.1.3	0.453
3um5	CP6	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.453
5c1m	CLR	Mu-type opioid receptor	/	0.453
1xi2	CB1	Ribosyldihydronicotinamide dehydrogenase [quinone]	/	0.451
2fs4	PZ1	Renin	3.4.23.15	0.451
3zxi	TYA	Tyrosine--tRNA ligase, mitochondrial	6.1.1.1	0.451
4b1e	6T6	Beta-secretase 1	3.4.23.46	0.451
4lut	DCS	Alanine racemase	/	0.451
1ygk	RRC	Pyridoxal kinase	2.7.1.35	0.450
2ojg	19A	Mitogen-activated protein kinase 1	2.7.11.24	0.450
4uga	Q05	Nitric oxide synthase oxygenase	1.14.13.165	0.450
3blo	QEI	Queuine tRNA-ribosyltransferase	2.4.2.29	0.449
3uxe	465	Ribosyldihydronicotinamide dehydrogenase [quinone]	/	0.449
5e8j	SAH	mRNA cap guanine-N7 methyltransferase	2.1.1.56	0.449
1ay0	TPP	Transketolase 1	2.2.1.1	0.448
1v3q	2DI	Purine nucleoside phosphorylase	2.4.2.1	0.447
2a1y	5GP	GMP reductase	/	0.447
3coz	54H	Pantothenate synthetase	6.3.2.1	0.447
3irm	1CY	Bifunctional dihydrofolate reductase-thymidylate synthase	1.5.1.3	0.447
4dph	P65	Bifunctional dihydrofolate reductase-thymidylate synthase	/	0.447
3uq9	TBN	Putative adenosine kinase	/	0.446
4f3g	KAI	Glutamate receptor 3	/	0.446
4jsi	Q05	Nitric oxide synthase, brain	1.14.13.39	0.446
5esd	TDP	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase	/	0.446
1ez0	NAP	NADP-dependent fatty aldehyde dehydrogenase	1.2.1.4	0.445
1vi2	NAD	Quinate/shikimate dehydrogenase	/	0.445
1kqu	BR4	Phospholipase A2, membrane associated	/	0.444
4gd9	BTN	Streptavidin	/	0.444
4u7w	NDP	MxaA	/	0.444
1w1r	ZEA	Cytokinin dehydrogenase 1	1.5.99.12	0.443
2g25	TDK	Pyruvate dehydrogenase E1 component	1.2.4.1	0.443
2yj5	ATP	Copper-transporting ATPase	/	0.443
3hwx	TPP	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase	/	0.443
2ejz	SAH	Diphthine synthase	/	0.442
2uyq	SAM	Putative S-adenosyl-L-methionine-dependent methyltransferase ML2640	2.1.1	0.442
3ar6	12D	Sarcoplasmic/endoplasmic reticulum calcium ATPase 1	3.6.3.8	0.442
4a4o	664	Serine/threonine-protein kinase PLK1	2.7.11.21	0.442
4jlk	1NO	Deoxycytidine kinase	2.7.1.74	0.442
4jsg	Q10	Nitric oxide synthase, brain	1.14.13.39	0.442
3isj	A8D	Pantothenate synthetase	6.3.2.1	0.441
3jun	AJD	Phenazine biosynthesis protein A/B	/	0.441
3s00	Z60	Cyclin-dependent kinase 2	2.7.11.22	0.441
4gmg	NAP	Yersiniabactin biosynthetic protein YbtU	/	0.441
3eig	MTX	Dihydrofolate reductase	1.5.1.3	0.440
3n87	N87	3-dehydroquinate dehydratase	4.2.1.10	0.440
4dyp	0MS	Nucleoprotein	/	0.440
4fev	PP1	Aminoglycoside 3'-phosphotransferase AphA1-IAB	/	0.440
4jlm	1NN	Deoxycytidine kinase	2.7.1.74	0.440
5eja	TD6	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase	/	0.440
3rfm	CFF	Adenosine receptor A2a	/	0.440