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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2ay5IOPAromatic-amino-acid aminotransferase2.6.1.57

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2ay5IOPAromatic-amino-acid aminotransferase2.6.1.571.000
2ay2CXPAromatic-amino-acid aminotransferase2.6.1.570.683
2ay95PVAromatic-amino-acid aminotransferase2.6.1.570.579
4ge90L0Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.573
1ahgTYR_PLPAspartate aminotransferase2.6.1.10.561
2ay3MPPAromatic-amino-acid aminotransferase2.6.1.570.550
1x28PGUAspartate aminotransferase2.6.1.10.519
2ay84TBAromatic-amino-acid aminotransferase2.6.1.570.517
1cq7PY5Aspartate aminotransferase2.6.1.10.515
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.510
1maqPGUAspartate aminotransferase, mitochondrial2.6.1.10.508
4emyPLPAminotransferase class I and II/0.502
3b1dPLSBetaC-S lyase/0.501
3ei8PL5LL-diaminopimelate aminotransferase, chloroplastic/0.498
1akbPPDAspartate aminotransferase, mitochondrial2.6.1.10.495
1cq8PY6Aspartate aminotransferase2.6.1.10.495
1arhPPDAspartate aminotransferase2.6.1.10.494
1toiHCIAspartate aminotransferase2.6.1.10.494
1mapKETAspartate aminotransferase, mitochondrial2.6.1.10.489
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.486
4b144XBGlycylpeptide N-tetradecanoyltransferase/0.485
1akaPLPAspartate aminotransferase, mitochondrial2.6.1.10.484
1akcPPEAspartate aminotransferase, mitochondrial2.6.1.10.484
1cq6PY4Aspartate aminotransferase2.6.1.10.484
2a59LMZ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.484
3pkaY02Methionine aminopeptidase 2/0.484
4gdy0X1Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.483
3kt3TYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.480
4w5kPLPAspartate aminotransferase, mitochondrial/0.478
1c7oPPGHemolysin/0.477
2yneYNEGlycylpeptide N-tetradecanoyltransferase/0.477
1ascNPLAspartate aminotransferase2.6.1.10.476
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.473
3dr7GPDGDP-perosamine synthase/0.472
3e32ED2Protein farnesyltransferase subunit beta2.5.1.580.472
2e8uIPEGeranylgeranyl pyrophosphate synthase/0.471
2q7oIMHPurine nucleoside phosphorylase2.4.2.10.469
2rdn1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.468
2xjeU5PCytosolic purine 5'-nucleotidase3.1.3.50.468
4rkdKETAminotransferase/0.468
2zrxFMNIsopentenyl-diphosphate delta-isomerase/0.467
4aoaIK2Beta-phenylalanine transaminase2.6.10.466
4qfzTTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.465
4dbc3QPAspartate aminotransferase2.6.1.10.464
4fl0PLPAminotransferase ALD1, chloroplastic2.6.10.464
4hcy0YNTransketolase/0.464
1ej2NADNicotinamide-nucleotide adenylyltransferase2.7.7.10.463
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.463
1ni1HFPProtein farnesyltransferase subunit beta2.5.1.580.462
4b12C23Glycylpeptide N-tetradecanoyltransferase/0.462
4b64NAPL-ornithine N(5)-monooxygenase/0.462
4rphGDUUDP-galactopyranose mutase5.4.99.90.462
5c1mCLRMu-type opioid receptor/0.462
1oxoIK2Aspartate aminotransferase, mitochondrial2.6.1.10.461
1yw8A75Methionine aminopeptidase 2/0.461
3nubUD0UDP-2-acetamido-2-deoxy-3-oxo-D-glucuronate aminotransferase2.6.1.980.460
4bfzZVZPantothenate kinase2.7.1.330.460
4kq6DLZ6,7-dimethyl-8-ribityllumazine synthase/0.460
4lzwTHMUridine phosphorylase/0.460
4to0DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.460
4xbjIN5Alanine racemase, biosynthetic/0.460
1tojHCIAspartate aminotransferase2.6.1.10.459
2r7pANPNon-structural protein 23.6.40.459
2zevIPEGeranylgeranyl pyrophosphate synthase/0.459
3qpg3QPAspartate aminotransferase2.6.1.10.459
4c7xTPPTransketolase/0.459
1w19T2P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.458
2re8GSUGlutamine--tRNA ligase6.1.1.180.458
3ai0PNWBeta-glucosidase/0.458
4stdBFSScytalone dehydratase4.2.1.940.458
5a4vQUEGlutathione S-transferase F22.5.1.180.458
1r6uTYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.456
2a5hSAML-lysine 2,3-aminomutase5.4.3.20.456
4b68NAPL-ornithine N(5)-monooxygenase/0.456
1touB1VFatty acid-binding protein, adipocyte/0.455
2z4sADPChromosomal replication initiator protein DnaA/0.454
2w6qOA5Biotin carboxylase6.3.4.140.453
3phjDHKShikimate dehydrogenase (NADP(+))/0.453
4bfuZVUPantothenate kinase2.7.1.330.453
1x27ASP_ASP_TYR_VAL_PTRTyrosine-protein kinase Lck2.7.10.20.452
2q1uNADPutative nucleotide sugar epimerase/ dehydratase/0.452
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
4xczT3QQdtf/0.452
4ycoFMNtRNA-dihydrouridine(16) synthase/0.452
5hg0SAMPantothenate synthetase/0.452
1m8jNADNicotinamide-nucleotide adenylyltransferase2.7.7.10.451
1umaIN2Prothrombin3.4.21.50.451
2pgtGPRGlutathione S-transferase P2.5.1.180.451
3pkdY10Methionine aminopeptidase 2/0.451
4je5PLPAromatic/aminoadipate aminotransferase 12.6.1.390.451
4nhyPD2Prolyl 3-hydroxylase OGFOD11.14.110.451
1r58AO5Methionine aminopeptidase 2/0.450
1u1gBBBUridine phosphorylase2.4.2.30.450
2xyd3ESAngiotensin-converting enzyme3.2.10.450
3jzdNADMaleylacetate reductase/0.450
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.450
4flkY10Methionine aminopeptidase 1/0.450
4rp8ASCAscorbate-specific PTS system EIIC component/0.450
1argPPDAspartate aminotransferase2.6.1.10.449
2g8yNADHydroxycarboxylate dehydrogenase B/0.449
2ifaFMNUncharacterized protein/0.449
2v3oI26Prothrombin3.4.21.50.449
3hl0NADMaleylacetate reductase/0.449
4bqzGNPEctonucleoside triphosphate diphosphohydrolase 2/0.449
4uugPXGBranched-chain amino acid aminotransferase, putative/0.449
5kgpACOPredicted acetyltransferase/0.449
1g7uPEP2-dehydro-3-deoxyphosphooctonate aldolase2.5.1.550.448
3daaPDDD-alanine aminotransferase2.6.1.210.448
2anb5GPGuanylate kinase2.7.4.80.447
2gv8NDPThiol-specific monooxygenase1.14.130.447
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
4to5DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.447
1t4cCOAFormyl-CoA:oxalate CoA-transferase/0.446
1tllFMNNitric oxide synthase, brain1.14.13.390.446
3rtnRTNBeta-secretase 13.4.23.460.446
4b4w9L9Bifunctional protein FolD/0.446
4to1DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.446
4yfy0FXVioF/0.446
1enoNADEnoyl-[acyl-carrier-protein] reductase [NADH], chloroplastic1.3.1.90.445
1ld8U49Protein farnesyltransferase subunit beta2.5.1.580.445
1qrsATPGlutamine--tRNA ligase6.1.1.180.445
2ea2F77Methionine aminopeptidase 2/0.445
3br3ETHTH-type transcriptional regulator QacR/0.445
3pkbY16Methionine aminopeptidase 2/0.445
4mrm2BYGamma-aminobutyric acid type B receptor subunit 1/0.445
1c9wNAPAldose reductase-related protein 2/0.444
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.444
1nahNADUDP-glucose 4-epimerase5.1.3.20.444
1w87FADFerredoxin--NADP reductase1.18.1.20.444
1xjqADPBifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 12.7.1.250.444
2gmsP0PPutative pyridoxamine 5-phosphate-dependent dehydrase/0.444
4c13UMLUDP-N-acetylmuramoyl-L-alanyl-D-glutamate--L-lysine ligase/0.444
4tnzTTPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.444
4uz6SCRPalmitoleoyl-protein carboxylesterase NOTUM/0.444
1icqOPD12-oxophytodienoate reductase 11.3.1.420.443
1jcq739Protein farnesyltransferase subunit beta2.5.1.580.443
1rr6IMHPurine nucleoside phosphorylase2.4.2.10.443
3q43D66M1 family aminopeptidase3.4.110.443
4lnbED5CaaX farnesyltransferase beta subunit Ram1/0.443
1ivrCBAAspartate aminotransferase, mitochondrial2.6.1.10.442
1qorNDPQuinone oxidoreductase 1/0.442
1rzuADPGlycogen synthase 12.4.1.210.442
1u08PLPMethionine aminotransferase/0.442
1u1d181Uridine phosphorylase2.4.2.30.442
1x1cSAHC-20 methyltransferase/0.442
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.442
3fazNOSPurine nucleoside phosphorylase/0.442
3jswJARHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
3junAJDPhenazine biosynthesis protein A/B/0.442
3koyZ97D-ornithine 4,5-aminomutase subunit beta/0.442
3ogkOGKCoronatine-insensitive protein 1/0.442
3q9bB3NAcetylpolyamine amidohydrolase/0.442
3uzxAOX3-oxo-5-beta-steroid 4-dehydrogenase/0.442
4gddNAIUDP-galactopyranose mutase/0.442
1euyQSIGlutamine--tRNA ligase6.1.1.180.441
1nj5P5AProline--tRNA ligase/0.441
2hp2KE4Glutamate-1-semialdehyde 2,1-aminomutase5.4.3.80.441
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3hdyGDUUDP-galactopyranose mutase/0.441
4blcNDPCatalase1.11.1.60.441
4gdcNDPUDP-galactopyranose mutase/0.441
3uonQNBMuscarinic acetylcholine receptor M2/0.441
1gtrATPGlutamine--tRNA ligase6.1.1.180.440
1i7pFADNADH-cytochrome b5 reductase 31.6.2.20.440
2wzwNDPNitroreductase NfnB/0.440
2z7hGG3Geranylgeranyl pyrophosphate synthase/0.440
3c4vLIPD-inositol 3-phosphate glycosyltransferase2.4.1.2500.440
3dylIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440
3nt5NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase1.1.1.180.440
4dptAGSMevalonate diphosphate decarboxylase/0.440
4to4DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.440
5ah5LSSLeucine--tRNA ligase/0.440