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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.91.000
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.808
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.779
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.751
3oeyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.748
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.690
2aqiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.677
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.664
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.656
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.622
1enyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.621
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.619
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.604
2ntvP1HEnoyl-[acyl-carrier-protein] reductase [NADH]/0.603
4bqpNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.600
2idzZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.595
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.585
2h9iEADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.575
2nv6ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.575
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.571
4bgiI4IEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.568
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.558
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.557
1zidZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.552
1p44NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.551
4bgePYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.540
2ie0ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.538
1enzNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.522
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.522
2iebZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.511
2b36NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.507
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.499
2b35NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.496
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.493
2nq8ZIDEnoyl-ACP reductase/0.492
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.488
4nbwNADShort-chain dehydrogenase/reductase SDR/0.484
2ntjP1HEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.483
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.479
3oafOAGDihydrofolate reductase1.5.1.30.479
3s1dZIRCytokinin dehydrogenase 11.5.99.120.477
2y4gTIRTamL/0.475
4q72FADBifunctional protein PutA/0.475
5koiNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.475
2y3sTIRTamL/0.474
2zbaZBATrichothecene 3-O-acetyltransferase/0.474
4k6fNAPPutative Acetoacetyl-CoA reductase/0.474
4anx534Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.473
4r20AERCytochrome P450 family 17 polypeptide 2/0.473
5hs1VORLanosterol 14-alpha demethylase/0.472
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.471
4zj8SUVOrexin receptor type 1/0.471
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.470
4a81DXCMajor pollen allergen Bet v 1-A/0.469
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.468
1fm4DXCMajor pollen allergen Bet v 1-L/0.467
3gwfNAPCyclohexanone monooxygenase/0.467
4ipw1G7Mycocyclosin synthase1.14.21.90.466
3iro2CYBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.465
4g48PZBMycocyclosin synthase1.14.21.90.465
4n5nNAPAcetoacetyl-CoA reductase1.1.1.360.465
5b1yNDP3-oxoacyl-[acyl-carrier-protein] reductase/0.465
2jb4A14Isopenicillin N synthase1.21.3.10.464
4h9506UDihydrofolate reductase1.5.1.30.464
4lxjLANLanosterol 14-alpha demethylase1.14.13.700.464
4qedNAPElxO/0.463
1w6hTITPlasmepsin-23.4.23.390.462
3nr4PYVAbscisic acid receptor PYL2/0.462
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.461
3nmpPYVAbscisic acid receptor PYL2/0.461
3qlsNDPDihydrofolate reductase1.5.1.30.461
3zoiM2WIsopenicillin N synthase1.21.3.10.461
1hb1OCVIsopenicillin N synthase1.21.3.10.460
3h3t16HCollagen type IV alpha-3-binding protein/0.459
1jioDEB6-deoxyerythronolide B hydroxylase/0.458
2cchATPCyclin-dependent kinase 22.7.11.220.458
2eklNADD-3-phosphoglycerate dehydrogenase/0.458
3nj0PYVAbscisic acid receptor PYL2/0.458
1ia3TQ5Dihydrofolate reductase1.5.1.30.457
1oc1ASVIsopenicillin N synthase1.21.3.10.457
2qbmCAMCamphor 5-monooxygenase1.14.15.10.457
4g3rCAMCamphor 5-monooxygenase1.14.15.10.457
4qecNAPElxO/0.457
4yaoFMNNADPH--cytochrome P450 reductase/0.457
2hsdNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.456
3fwjCAMCamphor 5-monooxygenase1.14.15.10.456
4wriOKAOkadaic acid binding protein 2-alpha/0.456
1yb5NAPQuinone oxidoreductase1.6.5.50.455
2a1mCAMCamphor 5-monooxygenase1.14.15.10.455
2ph5NADHomospermidine synthase/0.455
3fwiCAMCamphor 5-monooxygenase1.14.15.10.455
3h3sH15Collagen type IV alpha-3-binding protein/0.455
4iteTEYVitamin D3 receptor/0.455
4ktkKTKCytochrome P450/0.455
1jg0DDTThymidylate synthase/0.454
2ktdPUCProstaglandin-H2 D-isomerase5.3.99.20.454
1nooCAHCamphor 5-monooxygenase1.14.15.10.453
3uylTYDProbable NDP-rhamnosyltransferase/0.452
3x21FMNOxygen-insensitive NAD(P)H nitroreductase/0.452
4y8wSTRSteroid 21-hydroxylase/0.452
1fmlRTLRetinol dehydratase/0.451
1xe55FEPlasmepsin-23.4.23.390.451
3g5hYTTMycocyclosin synthase1.14.21.90.451
4nm9FADBifunctional protein PutA/0.451
4r21STRCytochrome P450 family 17 polypeptide 2/0.451
1ee9NADMethylenetetrahydrofolate dehydrogenase [NAD(+)]1.5.1.150.450
1xddAAYIntegrin alpha-L/0.450
1xe65FPPlasmepsin-23.4.23.390.450
2ft9CHDFatty acid-binding protein 2, liver/0.450
2iviACWIsopenicillin N synthase1.21.3.10.450
2jn3JN3Fatty acid-binding protein, liver/0.450
4bfzZVZPantothenate kinase2.7.1.330.450
4biiNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
1uyuCAMCamphor 5-monooxygenase1.14.15.10.449
4cdmFO1Deoxyribodipyrimidine photolyase/0.449
4kwhNAPReductase homolog/0.449
4yqfGDPSeptin-9/0.449
2vbpVB1Isopenicillin N synthase1.21.3.10.448
3t3q9PLCytochrome P450 2A61.14.130.448
2a1nCAMCamphor 5-monooxygenase1.14.15.10.447
3p84FMNPentaerythritol tetranitrate reductase/0.447
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.447
3w8dNAD3-hydroxybutyrate dehydrogenase/0.447
4ebfNADPhosphonate dehydrogenase1.20.1.10.447
4q71FADBifunctional protein PutA/0.447
1dhfFOLDihydrofolate reductase1.5.1.30.446
1jipKTN6-deoxyerythronolide B hydroxylase/0.446
2v9jATP5'-AMP-activated protein kinase subunit gamma-1/0.446
2vbdV10Isopenicillin N synthase1.21.3.10.446
3vydVYDRenin3.4.23.150.446
4ia3BIVVitamin D3 receptor A/0.446
1bk0ACVIsopenicillin N synthase1.21.3.10.445
1nyxDRFPeroxisome proliferator-activated receptor gamma/0.445
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.445
3vt7VDXVitamin D3 receptor/0.445
4enhFVXCholesterol 24-hydroxylase/0.445
4g1z0VPVitamin D3 receptor A/0.445
4m55NADUDP-glucuronic acid decarboxylase 14.1.1.350.445
1hb3SCVIsopenicillin N synthase1.21.3.10.444
1t85CAMCamphor 5-monooxygenase1.14.15.10.444
2gjlFMNNitronate monooxygenase1.13.12.160.444
2ij7TPFMycocyclosin synthase1.14.21.90.444
2y37A54Nitric oxide synthase, inducible1.14.13.390.444
3fwgCAMCamphor 5-monooxygenase1.14.15.10.444
3gobHXXDdmC/0.444
4a862ANMajor pollen allergen Bet v 1-A/0.444
4anwO92Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.444
4i1iNADMalate dehydrogenase/0.444
4m6jNDPDihydrofolate reductase1.5.1.30.444
4tqgNDPPutative dTDP-d-glucose 4 6-dehydratase/0.444
4ure1PSCyclohexanol dehydrogenase/0.444
4uymVOR14-alpha sterol demethylase Cyp51B/0.444
1bim0QBRenin3.4.23.150.443
1f20FADNitric oxide synthase, brain1.14.13.390.443
1phgMYTCamphor 5-monooxygenase1.14.15.10.443
1t88CAMCamphor 5-monooxygenase1.14.15.10.443
2fy4COACholine O-acetyltransferase2.3.1.60.443
2lbaCHOFatty acid binding protein 6/0.443
2qimZEAClass 10 plant pathogenesis-related protein/0.443
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.443
3d84NDPDihydrofolate reductase1.5.1.30.443
4ead0NPThymidine phosphorylase2.4.2.40.443
4q73FADBifunctional protein PutA/0.443
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
1t87CAMCamphor 5-monooxygenase1.14.15.10.442
2lfoGCHFatty acid-binding protein, liver/0.442
2wpxACOOrf14/0.442
2y1oT26UDP-N-acetylmuramoylalanine--D-glutamate ligase6.3.2.90.442
3l63CAMCamphor 5-monooxygenase1.14.15.10.442
3nxxNDPDihydrofolate reductase1.5.1.30.442
3s8cCDPRibonucleoside-diphosphate reductase large chain 11.17.4.10.442
4hbm0Y7E3 ubiquitin-protein ligase Mdm26.3.20.442
5akk1P8Bifunctional epoxide hydrolase 23.1.3.760.442
1ia4TQ6Dihydrofolate reductase1.5.1.30.441
1nptNADGlyceraldehyde-3-phosphate dehydrogenase/0.441
3sgv2BJDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.441
1bil0IURenin3.4.23.150.440
1cqp803Integrin alpha-L/0.440
1o76CAMCamphor 5-monooxygenase1.14.15.10.440
1u71MXADihydrofolate reductase1.5.1.30.440
1x8lOXRRetinol dehydratase/0.440
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.440
3a1l2CCCytochrome P450/0.440
3d7kD7KBenzaldehyde lyase/0.440
3drcMTXDihydrofolate reductase1.5.1.30.440
3tqaNDPDihydrofolate reductase/0.440
4e5yNDPGDP-L-fucose synthase1.1.1.2710.440
4gh6LUOHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.440