scPDB - Distribution of Binding site Similarity values of 2a5k entry / Site 1

Distribution of Binding site similarity measured by Shaper

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Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :

PDB ID	HET	Uniprot Name	EC Number
2a5k	AZP	Replicase polyprotein 1ab	3.4.22

Complex with similar binding sites

PDB ID	HET	Uniprot Name	EC Number	Binding Site Similarity
2a5k	AZP	Replicase polyprotein 1ab	3.4.22	1.000
2gtb	AZP	Orf1ab polyprotein	/	0.621
2qiq	CYV	Replicase polyprotein 1ab	/	0.505
2cf6	NAP	Cinnamyl alcohol dehydrogenase 5	1.1.1.195	0.501
3v3m	0EN	Replicase polyprotein 1a	3.4.19.12	0.497
2c20	NAD	UDP-glucose 4-epimerase	/	0.490
4acx	S8Z	Beta-secretase 1	3.4.23.46	0.475
1xe5	5FE	Plasmepsin-2	3.4.23.39	0.472
1xe6	5FP	Plasmepsin-2	3.4.23.39	0.472
2qim	ZEA	Class 10 plant pathogenesis-related protein	/	0.470
4uym	VOR	14-alpha sterol demethylase Cyp51B	/	0.467
3tjz	GNP	ADP-ribosylation factor 1	/	0.466
1bws	NDP	GDP-L-fucose synthase	/	0.465
2c54	NAD	GDP-mannose 3,5-epimerase	5.1.3.18	0.464
2f7x	4EA	cAMP-dependent protein kinase catalytic subunit alpha	2.7.11.11	0.464
1w6h	TIT	Plasmepsin-2	3.4.23.39	0.463
2g1r	3IG	Renin	3.4.23.15	0.463
5kwv	ANP	Pantothenate synthetase	/	0.463
4nwz	FAD	FAD-dependent pyridine nucleotide-disulfide oxidoreductase	/	0.462
4lut	DCS	Alanine racemase	/	0.461
1u8v	FAD	4-hydroxybutyryl-CoA dehydratase/vinylacetyl-CoA-Delta-isomerase	/	0.460
3h3s	H15	Collagen type IV alpha-3-binding protein	/	0.460
4ke1	1R6	Beta-secretase 1	3.4.23.46	0.460
3mpi	FAD	Glutaryl-CoA dehydrogenase	1.3.99.32	0.459
4bv9	NDP	Ketimine reductase mu-crystallin	1.5.1.25	0.459
1rfu	ADP	Pyridoxal kinase	2.7.1.35	0.458
2op9	WR1	Orf1ab polyprotein	/	0.457
3kb1	ADP	Iron-sulfur cluster carrier protein	/	0.457
4a83	DXC	Major pollen allergen Bet v 1-A	/	0.457
4acu	QN7	Beta-secretase 1	3.4.23.46	0.457
4q71	FAD	Bifunctional protein PutA	/	0.457
1hb3	SCV	Isopenicillin N synthase	1.21.3.1	0.456
1xdd	AAY	Integrin alpha-L	/	0.455
4rlh	0WE	Enoyl-[acyl-carrier-protein] reductase [NADH]	/	0.455
3ruf	NAD	UDP-N-acetylglucosamine 4-epimerase	/	0.454
1ege	FAD	Medium-chain specific acyl-CoA dehydrogenase, mitochondrial	1.3.8.7	0.453
2iyf	ERY	Oleandomycin glycosyltransferase	2.4.1	0.453
3ajr	NAD	NDP-sugar epimerase	/	0.453
3tr0	5GP	Guanylate kinase	/	0.452
4frk	DWD	Beta-secretase 1	3.4.23.46	0.452
1bxk	NAD	dTDP-glucose 4,6-dehydratase 2	/	0.451
4bfv	ZVV	Pantothenate kinase	2.7.1.33	0.451
5a9s	NAP	Putative dehydrogenase	/	0.451
2d29	FAD	Acyl-CoA dehydrogenase	/	0.450
3ruc	NAD	UDP-N-acetylglucosamine 4-epimerase	/	0.450
3te5	NAI	5'-AMP-activated protein kinase subunit gamma	/	0.450
1nup	NMN	Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3	/	0.449
2hk9	NAP	Shikimate dehydrogenase (NADP(+))	/	0.449
2xc3	RT8	Steroid C26-monooxygenase	1.14.13.141	0.449
3t3r	9PL	Cytochrome P450 2A6	1.14.13	0.449
4jnk	ZHK	L-lactate dehydrogenase A chain	1.1.1.27	0.449
1e3e	NAI	Alcohol dehydrogenase 4	1.1.1.1	0.448
2e9d	B76	Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)	2.5.1.31	0.448
2egs	SAH	Diphthine synthase	/	0.448
2pnc	CLU	Primary amine oxidase, liver isozyme	/	0.448
2q7o	IMH	Purine nucleoside phosphorylase	2.4.2.1	0.448
2uxo	TAC	HTH-type transcriptional regulator TtgR	/	0.448
3hl0	NAD	Maleylacetate reductase	/	0.448
3vqs	JT1	Genome polyprotein	/	0.448
4a81	DXC	Major pollen allergen Bet v 1-A	/	0.448
4gyz	D5M	Tyrosyl-DNA phosphodiesterase 2	3.1.4	0.448
4hfr	14M	Corticosteroid 11-beta-dehydrogenase isozyme 1	1.1.1.146	0.448
1l2t	ATP	Uncharacterized ABC transporter ATP-binding protein MJ0796	/	0.447
1vbi	NAD	Malate/L-lactate dehydrogenase family protein	/	0.447
2dft	ADP	Shikimate kinase	2.7.1.71	0.447
2gv8	NDP	Thiol-specific monooxygenase	1.14.13	0.447
3dy8	IBM	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.447
3h3t	16H	Collagen type IV alpha-3-binding protein	/	0.447
3otb	DGT	Probable tRNA(His) guanylyltransferase	2.7.7.79	0.447
4bb3	KKA	Isopenicillin N synthase	1.21.3.1	0.447
1qor	NDP	Quinone oxidoreductase 1	/	0.446
5eio	NAP	[LysW]-L-2-aminoadipate 6-phosphate reductase	/	0.446
1fm4	DXC	Major pollen allergen Bet v 1-L	/	0.445
1lbc	CYZ	Glutamate receptor 2	/	0.445
1n2h	PAJ	Pantothenate synthetase	6.3.2.1	0.445
1noo	CAH	Camphor 5-monooxygenase	1.14.15.1	0.445
2ejz	SAH	Diphthine synthase	/	0.445
3f03	FMN	Pentaerythritol tetranitrate reductase	/	0.445
4eak	ATP	5'-AMP-activated protein kinase subunit gamma-1	/	0.445
1hb1	OCV	Isopenicillin N synthase	1.21.3.1	0.444
1tqf	32P	Beta-secretase 1	3.4.23.46	0.444
3owa	FAD	Acyl-CoA dehydrogenase	/	0.444
3vyf	VYF	Renin	3.4.23.15	0.444
4iv6	FDA	Isovaleryl-CoA dehydrogenase	/	0.444
4yqf	GDP	Septin-9	/	0.444
1bk0	ACV	Isopenicillin N synthase	1.21.3.1	0.443
1qiq	ACC	Isopenicillin N synthase	1.21.3.1	0.443
2c59	NAD	GDP-mannose 3,5-epimerase	5.1.3.18	0.443
2egl	SAH	Diphthine synthase	/	0.443
2iku	LIY	Renin	3.4.23.15	0.443
2vwq	NAP	Glucose 1-dehydrogenase	/	0.443
4ipw	1G7	Mycocyclosin synthase	1.14.21.9	0.443
4is3	NAD	3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 2	1.17.98.1	0.443
1zxm	ANP	DNA topoisomerase 2-alpha	5.99.1.3	0.442
2xlr	FAD	Putative flavin-containing monooxygenase	/	0.442
4bfu	ZVU	Pantothenate kinase	2.7.1.33	0.442
1kbo	340	NAD(P)H dehydrogenase [quinone] 1	1.6.5.2	0.441
2q5g	1FA	Peroxisome proliferator-activated receptor delta	/	0.441
3dys	IBM	High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A	/	0.441
3omu	IBD	Heat shock protein 83	/	0.441
3qgf	46F	Genome polyprotein	2.7.7.48	0.441
3r96	ACO	MccE protein	/	0.441
4a6b	QG8	Gag-Pol polyprotein	3.4.23.16	0.441
1pqc	444	Oxysterols receptor LXR-beta	/	0.440
3u9e	COA	Lmo1369 protein	/	0.440
4c3f	7KW	Tyrosine-protein kinase Lck	2.7.10.2	0.440