sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 2a1m | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 1.000 | |
| 2a1o | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.782 | |
| 1t87 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.763 | |
| 2a1n | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.708 | |
| 4l4f | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.692 | |
| 4l4e | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.683 | |
| 1o76 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.682 | |
| 1dz8 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.679 | |
| 1dz6 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.676 | |
| 2zax | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.665 | |
| 3fwf | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.663 | |
| 3wrj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.663 | |
| 1dz4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.660 | |
| 3fwg | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.660 | |
| 3wrh | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.657 | |
| 4g3r | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.656 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.653 | |
| 1t88 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.652 | |
| 2feu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.649 | |
| 1t85 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.648 | |
| 1yrd | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.648 | |
| 1noo | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.647 | |
| 1t86 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.643 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.642 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.640 | |
| 1yrc | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.639 | |
| 4kky | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.639 | |
| 3fwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.637 | |
| 1uyu | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.636 | |
| 3wrl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.635 | |
| 2qbo | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.633 | |
| 2m56 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.632 | |
| 4c9p | CAM | Cytochrome P450 | / | 0.630 | |
| 3wrm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.629 | |
| 4ek1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.628 | |
| 3cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.626 | |
| 4l4d | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.626 | |
| 2qbm | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.621 | |
| 5cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.619 | |
| 2qbl | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.616 | |
| 2qbn | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.616 | |
| 4l4c | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.615 | |
| 2cpp | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.614 | |
| 1iwi | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.613 | |
| 2zaw | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.613 | |
| 4jx1 | CAH | Camphor 5-monooxygenase | 1.14.15.1 | 0.608 | |
| 4l4a | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.608 | |
| 1iwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.607 | |
| 4l49 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.605 | |
| 1phg | MYT | Camphor 5-monooxygenase | 1.14.15.1 | 0.604 | |
| 4jx1 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.604 | |
| 4cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.599 | |
| 4l4b | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.598 | |
| 2zui | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.588 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.587 | |
| 3ol5 | SAW | Camphor 5-monooxygenase | 1.14.15.1 | 0.587 | |
| 1geb | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.581 | |
| 1phe | PIY | Camphor 5-monooxygenase | 1.14.15.1 | 0.578 | |
| 2z97 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.576 | |
| 3p6p | A6B | Camphor 5-monooxygenase | 1.14.15.1 | 0.556 | |
| 3p6m | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.537 | |
| 4c9o | CAM | Cytochrome P450 | / | 0.537 | |
| 3mdm | FJZ | Cholesterol 24-hydroxylase | / | 0.523 | |
| 1jio | DEB | 6-deoxyerythronolide B hydroxylase | / | 0.521 | |
| 4enh | FVX | Cholesterol 24-hydroxylase | / | 0.521 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.506 | |
| 3tk3 | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.501 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.499 | |
| 3ruk | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.498 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.497 | |
| 3gw9 | VNI | Lanosterol 14-alpha-demethylase | / | 0.495 | |
| 1jip | KTN | 6-deoxyerythronolide B hydroxylase | / | 0.494 | |
| 1eup | ASD | 6-deoxyerythronolide B hydroxylase | / | 0.493 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.492 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.491 | |
| 4tuv | CPZ | Cytochrome P450 119 | 1.14 | 0.490 | |
| 4g3j | VNT | Lanosterol 14-alpha-demethylase | / | 0.489 | |
| 2w0b | CMW | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.487 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.487 | |
| 4ejh | 0QA | Cytochrome P450 2A13 | 1.14.14.1 | 0.486 | |
| 3t3r | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.485 | |
| 4i8v | BHF | Cytochrome P450 1A1 | 1.14.14.1 | 0.485 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.485 | |
| 4y8w | STR | Steroid 21-hydroxylase | / | 0.484 | |
| 4l6g | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.482 | |
| 2gna | GDU | UDP-N-acetylglucosamine 4,6-dehydratase (inverting) | 4.2.1.115 | 0.481 | |
| 3t3q | 9PL | Cytochrome P450 2A6 | 1.14.13 | 0.480 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.479 | |
| 4lht | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.479 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.478 | |
| 1u3c | FAD | Cryptochrome-1 | / | 0.477 | |
| 1suo | CPZ | Cytochrome P450 2B4 | 1.14.14.1 | 0.474 | |
| 3ibd | CPZ | Cytochrome P450 2B6 | 1.14.13 | 0.474 | |
| 1u3d | FAD | Cryptochrome-1 | / | 0.472 | |
| 2zba | ZBA | Trichothecene 3-O-acetyltransferase | / | 0.466 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.466 | |
| 4r20 | AER | Cytochrome P450 family 17 polypeptide 2 | / | 0.466 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.464 | |
| 4egn | TWO | Cytochrome P450 | / | 0.463 | |
| 4px9 | ADP | ATP-dependent RNA helicase DDX3X | 3.6.4.13 | 0.463 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.462 | |
| 3p99 | LNP | Lanosterol 14-alpha-demethylase | / | 0.462 | |
| 2aq8 | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.461 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.459 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.459 | |
| 1tdr | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.456 | |
| 2hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.456 | |
| 2hmy | SAM | Modification methylase HhaI | 2.1.1.37 | 0.456 | |
| 4r21 | STR | Cytochrome P450 family 17 polypeptide 2 | / | 0.456 | |
| 2ph5 | NAD | Homospermidine synthase | / | 0.455 | |
| 4fw8 | NAI | 3-oxoacyl-(Acyl-carrier-protein) reductase | / | 0.455 | |
| 4lxj | LAN | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.454 | |
| 5c8w | PCG | cGMP-dependent protein kinase 2 | 2.7.11.12 | 0.454 | |
| 1t2b | CNL | 1,8-cineole 2-endo-monooxygenase | 1.14.13.156 | 0.453 | |
| 2uxo | TAC | HTH-type transcriptional regulator TtgR | / | 0.453 | |
| 3tjs | D0R | Cytochrome P450 3A4 | / | 0.453 | |
| 4jbt | ASD | Cytochrome P450 monooxygenase | / | 0.453 | |
| 2ft9 | CHD | Fatty acid-binding protein 2, liver | / | 0.452 | |
| 4qq3 | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.452 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.451 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.450 | |
| 1p44 | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 4dja | FAD | (6-4) photolyase | / | 0.450 | |
| 4g7g | VFV | Lanosterol 14-alpha-demethylase | / | 0.449 | |
| 4j6d | TES | Cytochrome P450 monooxygenase | / | 0.449 | |
| 4ly9 | 1YY | Glucokinase regulatory protein | / | 0.449 | |
| 2cib | CM6 | Lanosterol 14-alpha demethylase | 1.14.13.70 | 0.448 | |
| 2c7x | NRB | Cytochrome P450 monooxygenase PikC | / | 0.447 | |
| 3wec | AUI | Cytochrome P450 | / | 0.447 | |
| 4dre | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.447 | |
| 4nd2 | A3D | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.447 | |
| 1nzd | UPG | DNA beta-glucosyltransferase | / | 0.446 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.446 | |
| 3mvq | NDP | Glutamate dehydrogenase 1, mitochondrial | 1.4.1.3 | 0.446 | |
| 3oew | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 3oey | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.446 | |
| 3qm4 | PN0 | Cytochrome P450 2D6 | / | 0.446 | |
| 3zk5 | Z18 | Cytochrome P450 monooxygenase PikC | / | 0.446 | |
| 2y3s | TIR | TamL | / | 0.445 | |
| 3drc | MTX | Dihydrofolate reductase | 1.5.1.3 | 0.445 | |
| 4dti | NAI | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.445 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.445 | |
| 1jol | FFO | Dihydrofolate reductase | 1.5.1.3 | 0.444 | |
| 1aj8 | COA | Citrate synthase | / | 0.443 | |
| 1hfq | MOT | Dihydrofolate reductase | 1.5.1.3 | 0.443 | |
| 3nxu | RIT | Cytochrome P450 3A4 | / | 0.443 | |
| 2he5 | NDP | Aldo-keto reductase family 1 member C21 | 1.1.1 | 0.442 | |
| 3frq | ERY | Erythromycin resistance repressor protein | / | 0.442 | |
| 3ii4 | 3II | Dihydrolipoyl dehydrogenase | 1.8.1.4 | 0.442 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.442 | |
| 4ipw | 1G7 | Mycocyclosin synthase | 1.14.21.9 | 0.442 | |
| 1fml | RTL | Retinol dehydratase | / | 0.441 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.441 | |
| 1w2x | RCP | Acetyl-CoA carboxylase | / | 0.440 | |
| 4rcv | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | / | 0.440 |