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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1qrqNDPVoltage-gated potassium channel subunit beta-2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1qrqNDPVoltage-gated potassium channel subunit beta-2/1.000
4jtdNAPVoltage-gated potassium channel subunit beta-2/0.631
4jtcNAPVoltage-gated potassium channel subunit beta-2/0.613
4jtaNAPVoltage-gated potassium channel subunit beta-2/0.604
3lnmNAPVoltage-gated potassium channel subunit beta-2/0.590
1ye6NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.535
1ye4NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.530
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.529
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.526
1az2NAPAldose reductase1.1.1.210.524
1a80NDP2,5-diketo-D-gluconic acid reductase A1.1.1.3460.520
2acuNAPAldose reductase1.1.1.210.515
1m9hNAD2,5-diketo-D-gluconic acid reductase A1.1.1.3460.513
1sm9NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.513
3lutNAPVoltage-gated potassium channel subunit beta-2/0.507
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.504
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.502
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.492
1c9wNAPAldose reductase-related protein 2/0.490
4l1xNAPAldo-keto reductase family 1 member C2/0.486
3o3rNAPAldose reductase-related protein 11.1.1.210.485
4xo7NAPAldo-keto reductase family 1 member C2/0.485
4xnw2IDP2Y purinoceptor 1/0.483
1lqaNDPProtein tas/0.482
1ye6NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.481
1kyxCRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.479
2vcmM11Isopenicillin N synthase1.21.3.10.478
3v36NAPAldose reductase1.1.1.210.474
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.473
4itxIN5Cystathionine beta-lyase MetC4.4.1.80.473
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.472
4jq3NAPAldo-keto reductase family 1 member C2/0.472
1vp5NAPOxidoreductase, aldo/keto reductase family/0.471
1hqtNAPAlcohol dehydrogenase [NADP(+)]1.1.1.20.469
2hdjNDPAldo-keto reductase family 1 member C2/0.467
4b2gV1NUncharacterized protein/0.467
4jtqNAPAldo-keto reductase family 1 member C2/0.467
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.466
2bgsNDPAldose reductase1.1.1.210.465
1obnASVIsopenicillin N synthase1.21.3.10.463
1pq944BOxysterols receptor LXR-beta/0.462
2bp1NDPAflatoxin B1 aldehyde reductase member 2/0.462
2clpNDPAflatoxin B1 aldehyde reductase member 3/0.462
3qkzNAPAldose reductase-related protein 11.1.1.210.462
4bfyZVYPantothenate kinase2.7.1.330.462
1s1rNAPAldo-keto reductase family 1 member C3/0.460
3h7rNAPAldo-keto reductase family 4 member C8/0.459
3zoiM2WIsopenicillin N synthase1.21.3.10.459
5dp2NAPCurF/0.459
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.458
1swpBTNStreptavidin/0.457
2a57CRM6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.457
4dlcUMPDeoxyuridine triphosphatase, putative/0.457
1hb3SCVIsopenicillin N synthase1.21.3.10.456
4bb3KKAIsopenicillin N synthase1.21.3.10.456
4phlPILPhosphodiesterase/0.456
5d7q4I5NAD-dependent protein deacetylase sirtuin-23.5.10.456
1kruIPTGalactoside O-acetyltransferase2.3.1.180.455
2zrzFNRIsopentenyl-diphosphate delta-isomerase/0.455
4dz5NAPAldo-keto reductase family 1 member C3/0.455
7catNDPCatalase1.11.1.60.455
1ejbINJ6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.453
2e0nSAHPrecorrin-2 C20-methyltransferase/0.453
4a2zVIQGlycylpeptide N-tetradecanoyltransferase/0.453
4b6uM7GEukaryotic translation initiation factor 4E type 3/0.453
4r81FMNPredicted NADH dehydrogenase/0.453
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.452
3qdzPRO_ALA_PRO_ARGProthrombin3.4.21.50.452
5dozNDPJamJ/0.452
1gveNAPAflatoxin B1 aldehyde reductase member 310.451
1pr4MTPPurine nucleoside phosphorylase DeoD-type/0.450
1w29TS06,7-dimethyl-8-ribityllumazine synthase2.5.1.780.450
1yqzCOACoenzyme A disulfide reductase/0.450
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.450
1blzACVIsopenicillin N synthase1.21.3.10.449
3e6eDCSAlanine racemase/0.449
4u8iFDAUDP-galactopyranose mutase/0.449
1kyyINI6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.448
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.448
2cjeDUNDUTPase/0.448
1pz0NAPProtein IolS1.1.10.447
2uxoTACHTH-type transcriptional regulator TtgR/0.447
2y6fM9FIsopenicillin N synthase1.21.3.10.447
3bgxMEFThymidylate synthase/0.447
3k3hBYEHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.447
4a2aATPCell division protein FtsA/0.447
1hb1OCVIsopenicillin N synthase1.21.3.10.446
1pqc444Oxysterols receptor LXR-beta/0.446
1qiqACCIsopenicillin N synthase1.21.3.10.446
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.446
2xiq5ADMethylmalonyl-CoA mutase, mitochondrial/0.446
3rvhHQ2Lysine-specific demethylase 4A1.14.110.446
2zrxFMNIsopentenyl-diphosphate delta-isomerase/0.445
3zkyWT4Isopenicillin N synthase1.21.3.10.445
4b68FADL-ornithine N(5)-monooxygenase/0.445
4eqwCOACoenzyme A disulfide reductase/0.445
1eioGCHGastrotropin/0.444
1oc1ASVIsopenicillin N synthase1.21.3.10.444
2y60M8FIsopenicillin N synthase1.21.3.10.444
4f7iNAD3-isopropylmalate dehydrogenase1.1.1.850.443
4g090VDHistidinol dehydrogenase/0.443
8catNDPCatalase1.11.1.60.443
2cvzNDP3-hydroxyisobutyrate dehydrogenase/0.442
2zrvFNRIsopentenyl-diphosphate delta-isomerase/0.442
3biy01KHistone acetyltransferase p300/0.442
4bv9NDPKetimine reductase mu-crystallin1.5.1.250.442
4dvi2IWTankyrase-12.4.2.300.442
4to5DCPDeoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.442
1r4lXX5Angiotensin-converting enzyme 23.4.17.230.441
2vbpVB1Isopenicillin N synthase1.21.3.10.441
3cr0809Wee1-like protein kinase2.7.10.20.441
5ao1DG3Deoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.441
1bk0ACVIsopenicillin N synthase1.21.3.10.440
1hzzNAPNAD(P) transhydrogenase subunit beta1.6.1.20.440
1i59ANPChemotaxis protein CheA2.7.13.30.440
2ptfFMNUncharacterized protein MTH_863/0.440
2vuuNAPNitrogen metabolite repression protein nmrA/0.440
3hu1AGSTransitional endoplasmic reticulum ATPase3.6.4.60.440
3hu2AGSTransitional endoplasmic reticulum ATPase3.6.4.60.440
3jzdNADMaleylacetate reductase/0.440
4ug91EWNitric oxide synthase oxygenase1.14.13.1650.440
5epeSAHUncharacterized protein/0.440