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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
1qf4RPDAdenylosuccinate synthetase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
1qf4RPDAdenylosuccinate synthetase/1.000
1qf5RPLAdenylosuccinate synthetase/0.836
1cg1IMOAdenylosuccinate synthetase/0.631
1cg4IMOAdenylosuccinate synthetase/0.585
1kszPGSAdenylosuccinate synthetase/0.581
1nhtPGSAdenylosuccinate synthetase/0.581
1cg0IMOAdenylosuccinate synthetase/0.577
1cg3IMOAdenylosuccinate synthetase/0.576
1p9bIMOAdenylosuccinate synthetase/0.576
2dgnDOIAdenylosuccinate synthetase isozyme 1/0.549
2gcqDOIAdenylosuccinate synthetase/0.547
1lonIMOAdenylosuccinate synthetase isozyme 1/0.534
5dp2NAPCurF/0.479
4ambDUDPutative glycosyl transferase/0.477
3r95ACOMccE protein/0.469
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.466
3up5FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.465
4tm4FDAKtzI/0.463
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.462
3r7kFDAProbable acyl CoA dehydrogenase/0.462
3uceNDPDehydrogenase/0.462
4nxuADPMitochondrial dynamics protein MID51/0.462
1ae1NAPTropinone reductase 1/0.461
3fstFAD5,10-methylenetetrahydrofolate reductase1.5.1.200.460
4i8zG08Gag-Pol polyprotein3.4.23.160.460
3lqsPSZD-alanine aminotransferase2.6.1.210.459
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.458
3toxNAPPutative oxidoreductase/0.458
4yaiNAIC alpha-dehydrogenase/0.458
1rx1NAPDihydrofolate reductase1.5.1.30.457
1n5dNDPCarbonyl reductase [NADPH] 1/0.456
5jscFADPutative acyl-CoA dehydrogenase/0.456
1dapNDPMeso-diaminopimelate D-dehydrogenase1.4.1.160.454
1e5qNDPSaccharopine dehydrogenase [NADP(+), L-glutamate-forming]1.5.1.100.454
2gjlFMNNitronate monooxygenase1.13.12.160.454
4dpwAGSMevalonate diphosphate decarboxylase/0.453
4nxxGDPMitochondrial dynamics protein MID51/0.453
4xq9NADHomospermidine synthase2.5.1.440.453
1ia1NDPDihydrofolate reductase1.5.1.30.452
2bfqAR6[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.452
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.452
3mw9NAIGlutamate dehydrogenase 1, mitochondrial1.4.1.30.452
4bfxZVXPantothenate kinase2.7.1.330.452
3d3wNAPL-xylulose reductase1.1.1.100.451
3gw9VNILanosterol 14-alpha-demethylase/0.451
4u0mGTPCyclic GMP-AMP synthase/0.451
1ma0NADAlcohol dehydrogenase class-31.1.1.10.450
3b70NAPEnoyl reductase LovC10.450
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.450
5eccNAPDehydrofolate reductase type I/0.450
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.449
3phiNDPShikimate dehydrogenase (NADP(+))/0.449
4cpdNADAlcohol dehydrogenase/0.449
4ejmNAPPutative zinc-binding dehydrogenase/0.449
4jnkZHKL-lactate dehydrogenase A chain1.1.1.270.449
1g1aNADdTDP-glucose 4,6-dehydratase/0.448
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.448
2jkvNAP6-phosphogluconate dehydrogenase, decarboxylating1.1.1.440.448
4h4uFADBiphenyl dioxygenase ferredoxin reductase subunit/0.448
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.448
3l7dDK5Glycogen phosphorylase, muscle form2.4.1.10.447
1dorFMNDihydroorotate dehydrogenase A (fumarate)1.3.98.10.446
2q7vFADThioredoxin reductase/0.446
4nesUD1UDP-N-acetylglucosamine 2-epimerase5.1.3.140.446
4xguADPPutative pachytene checkpoint protein 2/0.446
1dr3TAPDihydrofolate reductase1.5.1.30.445
2jahNDPClavaldehyde dehydrogenase/0.445
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.445
3ms421NGlycogen phosphorylase, muscle form2.4.1.10.445
4eqwFADCoenzyme A disulfide reductase/0.445
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.445
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.445
4xd2NAIAlcohol dehydrogenase E chain1.1.1.10.445
1jueFMNDihydroorotate dehydrogenase A (fumarate)1.3.98.10.444
2b3dFADModulator of drug activity B/0.444
3qlrNDPDihydrofolate reductase1.5.1.30.444
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.443
2nuaCOASuccinate--CoA ligase [ADP-forming] subunit alpha6.2.1.50.443
2y0mACOHistone acetyltransferase KAT8/0.443
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.443
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.443
3tneRITCandidapepsin-13.4.23.240.443
3vdqNAD3-hydroxybutyrate dehydrogenase/0.443
4bfsZVSPantothenate kinase2.7.1.330.443
4ge70K5Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.443
5kjfNAJAlcohol dehydrogenase E chain1.1.1.10.443
1h6cNDPGlucose--fructose oxidoreductase1.1.99.280.442
1i2bNADUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.442
1p0hACOMycothiol acetyltransferase2.3.1.1890.442
1xddAAYIntegrin alpha-L/0.442
1xh7R96cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
2b7aIZATyrosine-protein kinase JAK2/0.442
2q4bNAPUncharacterized protein At5g02240/0.442
3qwbNDPProbable quinone oxidoreductase1.6.5.50.442
3to6LYS_CMCHistone acetyltransferase ESA1/0.442
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.442
4yagNAIC alpha-dehydrogenase/0.442
1lbcCYZGlutamate receptor 2/0.441
1p0fNAPNADP-dependent alcohol dehydrogenase1.1.1.20.441
1qorNDPQuinone oxidoreductase 1/0.441
1xe55FEPlasmepsin-23.4.23.390.441
2c29NAPDihydroflavonol 4-reductase/0.441
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.441
2givACOHistone acetyltransferase KAT8/0.441
2gv8NDPThiol-specific monooxygenase1.14.130.441
2huvSAHDiphthine synthase/0.441
3f3sNADLambda-crystallin homolog/0.441
3nxxNDPDihydrofolate reductase1.5.1.30.441
3uylTYDProbable NDP-rhamnosyltransferase/0.441
1phhFADp-hydroxybenzoate hydroxylase/0.440
2e8rSAHDiphthine synthase/0.440
2g1r3IGRenin3.4.23.150.440
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.440
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.440
5kjcNAJAlcohol dehydrogenase E chain1.1.1.10.440