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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5a04 NDP Glucose-fructose oxidoreductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5a04 NDPGlucose-fructose oxidoreductase / 1.386
5a03 NDPGlucose-fructose oxidoreductase / 1.361
5a05 NDPGlucose-fructose oxidoreductase / 1.360
5a02 NAPGlucose-fructose oxidoreductase / 1.343
5a06 NDPGlucose-fructose oxidoreductase / 1.339
1h6c NDPGlucose--fructose oxidoreductase 1.1.99.28 1.160
1ryd NDPGlucose--fructose oxidoreductase 1.1.99.28 1.138
1h6d NDPGlucose--fructose oxidoreductase 1.1.99.28 1.135
1h6a NDPGlucose--fructose oxidoreductase 1.1.99.28 1.050
1ofg NDPGlucose--fructose oxidoreductase 1.1.99.28 1.048
1evj NADGlucose--fructose oxidoreductase 1.1.99.28 1.035
1h6b NDPGlucose--fructose oxidoreductase 1.1.99.28 0.959
1zh8 NAPUncharacterized protein / 0.882
1rye NDPGlucose--fructose oxidoreductase 1.1.99.28 0.842
2glx NDP1,5-anhydro-D-fructose reductase / 0.842
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.816
3q2k NAIProbable oxidoreductase / 0.791
2ixb NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.779
1nvm NADAcetaldehyde dehydrogenase 1.2.1.10 0.741
3oa2 NADUDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase / 0.734
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.718
3o9z NADLipopolysaccaride biosynthesis protein wbpB / 0.706
5bsf NADPyrroline-5-carboxylate reductase / 0.703
2w3b NDPDihydrofolate reductase 1.5.1.3 0.700
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.698
4gmg NAPYersiniabactin biosynthetic protein YbtU / 0.698
2rcy NAPPyrroline-5-carboxylate reductase / 0.697
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.697
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.696
3two NDPMannitol dehydrogenase / 0.696
1yjq NAP2-dehydropantoate 2-reductase 1.1.1.169 0.695
1yqx NAPSinapyl alcohol dehydrogenase / 0.694
3b1j NADGlyceraldehyde-3-phosphate dehydrogenase / 0.693
1q0q NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267 0.689
3f3s NADLambda-crystallin homolog / 0.688
4hwk NAPSepiapterin reductase 1.1.1.153 0.687
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.686
2voj NADAlanine dehydrogenase 1.4.1.1 0.685
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.684
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.683
3keo NADRedox-sensing transcriptional repressor Rex / 0.683
3m2t NADProbable dehydrogenase / 0.682
4xgi NADGlutamate dehydrogenase / 0.682
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.681
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.681
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.681
3ec7 NADInositol 2-dehydrogenase / 0.680
1qr6 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.678
3wfj NAD2-dehydropantoate 2-reductase / 0.678
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.677
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.676
3ulk NDPKetol-acid reductoisomerase (NADP(+)) / 0.676
3nt2 NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.675
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.674
3cea NADMyo-inositol 2-dehydrogenase-like (Promiscuous) / 0.674
4pxz CLRP2Y purinoceptor 12 / 0.674
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.674
2c29 NAPDihydroflavonol 4-reductase / 0.673
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.673
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.673
2ydx NAPMethionine adenosyltransferase 2 subunit beta / 0.672
2yjz NAPMetalloreductase STEAP4 1.16.1 0.672
2yut NAPPutative short-chain oxidoreductase / 0.672
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.671
2x6t NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.669
3bts NADGalactose/lactose metabolism regulatory protein GAL80 / 0.669
5bsg NAPPyrroline-5-carboxylate reductase / 0.669
4gae NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic 1.1.1.267 0.668
1muu GDXGDP-mannose 6-dehydrogenase 1.1.1.132 0.667
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.667
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.667
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.667
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.666
1mv8 GDXGDP-mannose 6-dehydrogenase 1.1.1.132 0.665
4om8 NAD3-hydroxybutyryl-coA dehydrogenase / 0.665
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.665
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.664
3adp NAILambda-crystallin 1.1.1.45 0.664
3wle NAD(R)-specific carbonyl reductase / 0.664
2f1k NAPPrephenate dehydrogenase / 0.663
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.663
3r3s NADPutative oxidoreductase / 0.662
1ye6 NAPNAD(P)H-dependent D-xylose reductase 1.1.1.307 0.661
4y1b NAPAntE / 0.661
4z3d NDPCarbonyl reductase [NADPH] 1 1.1.1.184 0.661
5idw NAPShort-chain dehydrogenase/reductase SDR / 0.661
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.659
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.659
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.659
4kqw NAPKetol-acid reductoisomerase (NADP(+)) / 0.659
5hws NAP2-dehydropantoate 2-reductase / 0.659
2j3k NAPNADPH-dependent oxidoreductase 2-alkenal reductase 1.3.1.74 0.658
4o4l GTPTubulin alpha-1B chain / 0.658
1c1d NAIPhenylalanine dehydrogenase / 0.655
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.655
1pjc NADAlanine dehydrogenase / 0.655
3ggp NADPrephenate dehydrogenase / 0.655
1nah NADUDP-glucose 4-epimerase 5.1.3.2 0.654
1xse NDPCorticosteroid 11-beta-dehydrogenase isozyme 1 1.1.1.146 0.654
2ekp NAD2-deoxy-D-gluconate 3-dehydrogenase / 0.654
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.654
2vq3 NAPMetalloreductase STEAP3 / 0.654
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.653
3p19 NDPPutative blue fluorescent protein / 0.653
3ket NADRedox-sensing transcriptional repressor Rex / 0.652
4oaq NDPR-specific carbonyl reductase / 0.652
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.651
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.651
4imp NDPPolyketide synthase extender modules 3-4 / 0.651
1dap NDPMeso-diaminopimelate D-dehydrogenase 1.4.1.16 0.650
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.650
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.650
1oaa NAPSepiapterin reductase 1.1.1.153 0.650
2c0c NAPProstaglandin reductase 3 1 0.650
2h2a DNDProbable nicotinate-nucleotide adenylyltransferase / 0.650
2hdh NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.650
3h2s NDPPutative NADH-flavin reductase / 0.650
3ing NDPHomoserine dehydrogenase related protein / 0.650
4i3v NADAldehyde dehydrogenase (NAD+) / 0.650