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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
5a03 NDP Glucose-fructose oxidoreductase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
5a03 NDPGlucose-fructose oxidoreductase / 1.419
5a05 NDPGlucose-fructose oxidoreductase / 1.393
5a04 NDPGlucose-fructose oxidoreductase / 1.361
5a06 NDPGlucose-fructose oxidoreductase / 1.319
5a02 NAPGlucose-fructose oxidoreductase / 1.304
1h6c NDPGlucose--fructose oxidoreductase 1.1.99.28 1.171
1ryd NDPGlucose--fructose oxidoreductase 1.1.99.28 1.155
1h6d NDPGlucose--fructose oxidoreductase 1.1.99.28 1.151
1h6a NDPGlucose--fructose oxidoreductase 1.1.99.28 1.116
1evj NADGlucose--fructose oxidoreductase 1.1.99.28 0.996
1h6b NDPGlucose--fructose oxidoreductase 1.1.99.28 0.985
1ofg NDPGlucose--fructose oxidoreductase 1.1.99.28 0.895
1zh8 NAPUncharacterized protein / 0.874
2glx NDP1,5-anhydro-D-fructose reductase / 0.812
1rye NDPGlucose--fructose oxidoreductase 1.1.99.28 0.799
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.790
2ixb NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.790
3q2k NAIProbable oxidoreductase / 0.751
1yqd NAPSinapyl alcohol dehydrogenase / 0.749
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.747
1nvm NADAcetaldehyde dehydrogenase 1.2.1.10 0.745
3oa2 NADUDP-N-acetyl-2-amino-2-deoxy-D-glucuronate oxidase / 0.736
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.723
3cea NADMyo-inositol 2-dehydrogenase-like (Promiscuous) / 0.715
1m76 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.714
3o9z NADLipopolysaccaride biosynthesis protein wbpB / 0.706
5bsf NADPyrroline-5-carboxylate reductase / 0.703
1qr6 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.700
3ec7 NADInositol 2-dehydrogenase / 0.699
8dfr NDPDihydrofolate reductase 1.5.1.3 0.698
2x6t NAPADP-L-glycero-D-manno-heptose-6-epimerase / 0.697
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.694
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.693
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.690
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.686
3keo NADRedox-sensing transcriptional repressor Rex / 0.686
2voj NADAlanine dehydrogenase 1.4.1.1 0.684
1kvr NADUDP-glucose 4-epimerase 5.1.3.2 0.683
2rcy NAPPyrroline-5-carboxylate reductase / 0.683
4gmg NAPYersiniabactin biosynthetic protein YbtU / 0.683
3m2t NADProbable dehydrogenase / 0.682
1do8 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.681
3wbf NAPMeso-diaminopimelate D-dehydrogenase / 0.681
2c29 NAPDihydroflavonol 4-reductase / 0.679
1nah NADUDP-glucose 4-epimerase 5.1.3.2 0.677
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.676
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.675
2yjz NAPMetalloreductase STEAP4 1.16.1 0.675
3pvz NADUDP-N-acetylglucosamine 4,6-dehydratase / 0.675
4xgi NADGlutamate dehydrogenase / 0.675
2w3b NDPDihydrofolate reductase 1.5.1.3 0.674
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.674
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.672
1xag NAD3-dehydroquinate synthase / 0.671
2nnl NAPDihydroflavonol 4-reductase 1.1.1.219 0.670
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.668
3bts NADGalactose/lactose metabolism regulatory protein GAL80 / 0.668
3h2s NDPPutative NADH-flavin reductase / 0.668
1muu GDXGDP-mannose 6-dehydrogenase 1.1.1.132 0.667
1pj2 NAINAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.667
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.667
1dr5 NAPDihydrofolate reductase 1.5.1.3 0.666
3wfj NAD2-dehydropantoate 2-reductase / 0.665
5lc1 NADL-threonine 3-dehydrogenase / 0.665
4edf UPGUDP-glucose 6-dehydrogenase 1.1.1.22 0.664
1pj3 NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.663
3sxp NADADP-L-glycero-D-mannoheptose-6-epimerase / 0.663
4py0 6ATP2Y purinoceptor 12 / 0.663
1q0q NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase 1.1.1.267 0.662
2vq3 NAPMetalloreductase STEAP3 / 0.662
2q1t NADPutative nucleotide sugar epimerase/ dehydratase / 0.661
3b1j NADGlyceraldehyde-3-phosphate dehydrogenase / 0.661
3nt2 NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.661
3tn7 NJPShort-chain alcohol dehydrogenase / 0.661
2q1w NADPutative nucleotide sugar epimerase/ dehydratase / 0.660
3ptz UDXUDP-glucose 6-dehydrogenase 1.1.1.22 0.659
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.658
2ggs NDPdTDP-4-dehydrorhamnose reductase / 0.658
3mvq NDPGlutamate dehydrogenase 1, mitochondrial 1.4.1.3 0.658
1kc1 NDPdTDP-4-dehydrorhamnose reductase 1.1.1.133 0.657
3kjr NAPBifunctional dihydrofolate reductase-thymidylate synthase / 0.657
3phi NDPShikimate dehydrogenase (NADP(+)) / 0.657
1xg5 NAPDehydrogenase/reductase SDR family member 11 / 0.656
3nxx NDPDihydrofolate reductase 1.5.1.3 0.656
4gae NDP1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic 1.1.1.267 0.656
3nx4 NAPPutative oxidoreductase / 0.655
3ru9 NADUDP-N-acetylglucosamine 4-epimerase / 0.655
2i3g NAPN-acetyl-gamma-glutamyl-phosphate reductase 1.2.1.38 0.654
2q3e NAIUDP-glucose 6-dehydrogenase 1.1.1.22 0.654
1dr3 TAPDihydrofolate reductase 1.5.1.3 0.653
1n2s NAIdTDP-4-dehydrorhamnose reductase 1.1.1.133 0.653
3l77 NJPShort-chain alcohol dehydrogenase / 0.653
3pgx NADUncharacterized NAD-dependent oxidoreductase MAP_4146 / 0.653
3zu2 NAIEnoyl-[acyl-carrier-protein] reductase [NADH] / 0.653
4imp NDPPolyketide synthase extender modules 3-4 / 0.653
1rkx NADCDP-D-glucose-4,6-dehydratase / 0.652
2q3e UPGUDP-glucose 6-dehydrogenase 1.1.1.22 0.652
3had NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.652
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.652
1c1d NAIPhenylalanine dehydrogenase / 0.651
1mv8 GDXGDP-mannose 6-dehydrogenase 1.1.1.132 0.651
2gn8 NAPUDP-N-acetylglucosamine 4,6-dehydratase (inverting) 4.2.1.115 0.651
4i3v NADAldehyde dehydrogenase (NAD+) / 0.651
5bsg NAPPyrroline-5-carboxylate reductase / 0.651
1ipe NDPTropinone reductase 2 1.1.1.236 0.650
3ulk NDPKetol-acid reductoisomerase (NADP(+)) / 0.650
4bmv NAPShort-chain dehydrogenase / 0.650