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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4xw4 ANP cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4xw4 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.168
3x2w ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.059
3x2v ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.038
4dh5 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 1.016
4dg3 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.987
4dh7 ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.970
4iac ACPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.969
3idb ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.957
4iaf ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.933
4iai ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.928
4hpt ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.924
4iak ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.919
4iay ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.908
3fhi ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.903
4iad ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.901
4xw6 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.891
4xw5 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.888
3fjq ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.887
3x2u ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.876
4x6r ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.870
2qcs ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.863
4dh3 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.857
1phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.851
1o6k ANPRAC-beta serine/threonine-protein kinase 2.7.11.1 0.848
3idc ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.846
2phk ATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform 2.7.11.19 0.844
4ib3 ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.842
4iaz ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.837
1cdk ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.830
4uak ADPSerine/threonine-protein kinase MRCK beta 2.7.11.1 0.820
4gvj ADPNon-receptor tyrosine-protein kinase TYK2 2.7.10.2 0.813
1q24 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.809
5awm ANPStress-activated protein kinase JNK 2.7.11.24 0.789
4wbb ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.785
3o7l ANPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.784
1j1c ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.783
4oa9 ANPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.782
1jkk ANPDeath-associated protein kinase 1 2.7.11.1 0.781
1jbp ADPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.777
4wb6 ATPcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.775
4iir ANPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.774
1q8y ADPSerine/threonine-protein kinase SKY1 2.7.11.1 0.766
4f9a ADPCell division cycle 7-related protein kinase 2.7.11.1 0.765
4qny ANPMitogen activated protein kinase, putative / 0.764
4f99 ADPCell division cycle 7-related protein kinase 2.7.11.1 0.763
2b9f ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.762
3agl A03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.761
3bwj ARXcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.755
4qpm ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.754
5e92 ANPTGF-beta receptor type-2 2.7.11.30 0.752
3t9a ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.751
2b9j ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.748
3tm0 ANPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.748
4c5b ADPD-alanine--D-alanine ligase B 6.3.2.4 0.748
4ifc ADPSerine/threonine-protein kinase PRP4 homolog 2.7.11.1 0.748
4krc AGSCyclin-dependent protein kinase PHO85 2.7.11.22 0.748
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.746
1u5r ATPSerine/threonine-protein kinase TAO2 2.7.11.1 0.742
4fl1 ANPTyrosine-protein kinase SYK 2.7.10.2 0.741
4i3z ADPCyclin-dependent kinase 2 2.7.11.22 0.741
2pml ANPUncharacterized protein / 0.740
4c5c ATPD-alanine--D-alanine ligase B 6.3.2.4 0.738
4ekk ANPRAC-alpha serine/threonine-protein kinase 2.7.11.1 0.738
1zth ADPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.736
4nm7 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.736
3gu5 ANPDeath-associated protein kinase 1 2.7.11.1 0.734
3gu6 ADPDeath-associated protein kinase 1 2.7.11.1 0.731
3t9d ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.731
1m0w ANPGlutathione synthetase 6.3.2.3 0.730
2vo7 M05cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.730
1cm8 ANPMitogen-activated protein kinase 12 / 0.729
3f5u ANPDeath-associated protein kinase 1 2.7.11.1 0.729
1pyx ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.726
2w4j ADPDeath-associated protein kinase 1 2.7.11.1 0.726
4azw ATPO-antigen chain terminator bifunctional methyltransferase/kinase WbdD / 0.726
4eoo ATPCyclin-dependent kinase 2 2.7.11.22 0.726
4lfi GNPCasein kinase II subunit alpha 2.7.11.1 0.725
5iqh GNPBifunctional AAC/APH 2.3.1 0.725
1jkl ANPDeath-associated protein kinase 1 2.7.11.1 0.724
1q97 ATPSerine/threonine-protein kinase SKY1 2.7.11.1 0.724
2pui ADPMethylthioribose kinase 2.7.1.100 0.723
4h3q ANPMitogen-activated protein kinase 1 2.7.11.24 0.723
3hrf ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.719
4otp ADPSerine/threonine-protein kinase RIO1 2.7.11.1 0.719
1jnk ANPMitogen-activated protein kinase 10 2.7.11.24 0.718
3i12 ADPD-alanine--D-alanine ligase A 6.3.2.4 0.718
5iqf GDPBifunctional AAC/APH 2.3.1 0.718
1ig1 ANPDeath-associated protein kinase 1 2.7.11.1 0.717
1j1b ANPGlycogen synthase kinase-3 beta 2.7.11.26 0.717
3nsz ANPCasein kinase II subunit alpha 2.7.11.1 0.717
4btj ADPTau-tubulin kinase 1 2.7.11.1 0.716
2io9 ADPBifunctional glutathionylspermidine synthetase/amidase / 0.715
4fi1 ATPCasein kinase II subunit alpha 2.7.11.1 0.715
4mwh ATPCasein kinase II subunit alpha 2.7.11.1 0.715
1xr1 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.713
5byl GCPBifunctional AAC/APH 2.3.1 0.713
3zo1 SIJcAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.712
1lp4 ANPCasein kinase II subunit alpha 2.7.11.1 0.711
3gu7 ADPDeath-associated protein kinase 1 2.7.11.1 0.711
4utd ACPAurora kinase A 2.7.11.1 0.711
1daw ANPCasein kinase II subunit alpha 2.7.11.1 0.709
1zp9 ATPRIO-type serine/threonine-protein kinase Rio1 2.7.11.1 0.709
3vpb ADPGlutamate--LysW ligase ArgX 6.3.2 0.709
5ce3 ADPProtein kinase YopO / 0.709
4ii5 ADPCyclin-dependent kinase 2 2.7.11.22 0.706
4q4c ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.706
4r8q ADPMitotic checkpoint serine/threonine-protein kinase BUB1 2.7.11.1 0.705
4ysj ADPCalmodulin-like domain protein kinase / 0.705
4ceg ADPAurora kinase A 2.7.11.1 0.704
4aw1 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.702
4bl1 ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.702
2b9i ADPMitogen-activated protein kinase FUS3 2.7.11.24 0.701
1o6y ACPSerine/threonine-protein kinase PknB 2.7.11.1 0.699
2y9q ANPMitogen-activated protein kinase 1 2.7.11.24 0.699
3niz ADPCdc2-like CDK2/CDC28 like protein kinase / 0.699
4dn5 AGSMitogen-activated protein kinase kinase kinase 14 2.7.11.25 0.699
4nm5 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.699
4o4d ATPKinase / 0.699
1ir3 ANPInsulin receptor 2.7.10.1 0.698
1qmz ATPCyclin-dependent kinase 2 2.7.11.22 0.698
2a19 ANPInterferon-induced, double-stranded RNA-activated protein kinase 2.7.11.1 0.697
3t99 ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.697
4xlv ACPInsulin receptor 2.7.10.1 0.697
1mq4 ADPAurora kinase A 2.7.11.1 0.696
3dnt ATPSerine/threonine-protein kinase toxin HipA / 0.696
1csn ATPCasein kinase I homolog 1 2.7.11.1 0.695
2w4k ADPDeath-associated protein kinase 1 2.7.11.1 0.695
3vjn ANPEpidermal growth factor receptor 2.7.10.1 0.695
3gub GUBDeath-associated protein kinase 1 2.7.11.1 0.694
1pk8 ATPSynapsin-1 / 0.693
2xrw ANPMitogen-activated protein kinase 8 2.7.11.24 0.693
4ux9 ANPMitogen-activated protein kinase 8 2.7.11.24 0.693
2vuw 5IDSerine/threonine-protein kinase haspin 2.7.11.1 0.692
4ork GDPBifunctional AAC/APH 2.3.1 0.692
4pzk SAHPutative tRNA (cytidine(34)-2'-O)-methyltransferase / 0.691
5iqb GNPBifunctional AAC/APH 2.3.1 0.691
1i44 ACPInsulin receptor 2.7.10.1 0.689
1z2p ACPInositol-tetrakisphosphate 1-kinase 2.7.1.134 0.689
2vo0 M03cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.689
5dr2 ATPAurora kinase A 2.7.11.1 0.688
3c50 ADPRhodopsin kinase / 0.687
3dqw AGSProto-oncogene tyrosine-protein kinase Src 2.7.10.2 0.686
3k5h ATPPhosphoribosyl-aminoimidazole carboxylase / 0.686
3t9e ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.686
2egl SAHDiphthine synthase / 0.685
2pz5 ACPFibroblast growth factor receptor 2 / 0.685
2vnw M01cAMP-dependent protein kinase catalytic subunit alpha 2.7.11.11 0.685
3udz ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.685
2ijm ADPFocal adhesion kinase 1 2.7.10.2 0.684
3t9f ADPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.684
4bfm ANPMaternal embryonic leucine zipper kinase 2.7.11.1 0.684
3cly ACPFibroblast growth factor receptor 2 / 0.682
4nzo ANPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.682
4oac ADPProtein BRASSINOSTEROID INSENSITIVE 1 2.7.10.1 0.681
1tqm ANPRIO-type serine/threonine-protein kinase Rio2 2.7.11.1 0.680
3qc9 ADPRhodopsin kinase / 0.680
4ej7 ATPAminoglycoside 3'-phosphotransferase AphA1-IAB / 0.680
1q99 ANPSerine/threonine-protein kinase SKY1 2.7.11.1 0.679
2q7h YLYPyrrolysine--tRNA ligase / 0.679
2pup ADPMethylthioribose kinase 2.7.1.100 0.678
3crz FADFerredoxin--NADP+ reductase / 0.678
5c1o ANPD-alanine--D-alanine ligase / 0.678
2pyw ADPMethylthioribose kinase 2.7.1.100 0.677
3bu5 ATPInsulin receptor 2.7.10.1 0.676
5cvf ATPCasein kinase II subunit alpha 2.7.11.1 0.676
2p6i SAHDiphthine synthase / 0.675
4o1p ANPRibonuclease L / 0.675
4q5h ANPProtein kinase OspG 2.7 0.674
1mp8 ADPFocal adhesion kinase 1 2.7.10.2 0.673
2eeq SAHDiphthine synthase / 0.673
2py3 ACPFibroblast growth factor receptor 2 / 0.673
4lv7 ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.673
5dn3 ATPAurora kinase A 2.7.11.1 0.673
5iqa GNPBifunctional AAC/APH 2.3.1 0.673
2emu SAHDiphthine synthase / 0.672
3t54 ATPInositol hexakisphosphate and diphosphoinositol-pentakisphosphate kinase 2 / 0.672
5cno ANPEpidermal growth factor receptor 2.7.10.1 0.672
5dt3 ATPAurora kinase A 2.7.11.1 0.672
2ioa ADPBifunctional glutathionylspermidine synthetase/amidase / 0.671
2pun ACPMethylthioribose kinase 2.7.1.100 0.671
4jr7 GNPCasein kinase II subunit alpha 2.7.11.1 0.671
4ocp ADPN-acetylhexosamine 1-kinase 2.7.1.162 0.670
4s33 ANPMitogen-activated protein kinase 1 2.7.11.24 0.670
2rio ADPSerine/threonine-protein kinase/endoribonuclease IRE1 2.7.11.1 0.669
3gu4 ANPDeath-associated protein kinase 1 2.7.11.1 0.668
4jqe ANPCasein kinase II subunit alpha 2.7.11.1 0.668
5drd ATPAurora kinase A 2.7.11.1 0.668
1a9x ADPCarbamoyl-phosphate synthase large chain / 0.667
1ol6 ATPAurora kinase A 2.7.11.1 0.667
2vqd AP2Biotin carboxylase 6.3.4.14 0.667
3c4z ADPRhodopsin kinase / 0.667
1w2d ADPInositol-trisphosphate 3-kinase A 2.7.1.127 0.666
2b0q ADPAminoglycoside 3'-phosphotransferase 2.7.1.95 0.666
2dv5 SAHDiphthine synthase / 0.666
4s26 SAHPhosphomethylpyrimidine synthase, chloroplastic 4.1.99.17 0.666
2ek4 SAHDiphthine synthase / 0.665
3c4w ATPRhodopsin kinase / 0.665
2hen ADPEphrin type-B receptor 2 2.7.10.1 0.664
2pb5 SAHDiphthine synthase / 0.664
4riy ADPEpidermal growth factor receptor 2.7.10.1 0.664
2xuu ADPDeath-associated protein kinase 1 2.7.11.1 0.663
3akk ADPSerine/threonine-protein kinase CtkA 2.7.11.1 0.663
4rrv ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.663
3wo1 ADPAlanine--anticapsin ligase / 0.662
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.662
4o8a FADBifunctional protein PutA 1.2.1.88 0.662
4rqk ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.662
1mru AGSSerine/threonine-protein kinase PknB 2.7.11.1 0.661
2ek3 SAHDiphthine synthase / 0.661
2pul ACPMethylthioribose kinase 2.7.1.100 0.661
4bn1 ADPAurora kinase A 2.7.11.1 0.661
4ct2 ATP3-phosphoinositide-dependent protein kinase 1 2.7.11.1 0.661
2en5 SAHDiphthine synthase / 0.660
2ijm ATPFocal adhesion kinase 1 2.7.10.2 0.660
2j0l ANPFocal adhesion kinase 1 2.7.10.2 0.660
2pb6 SAHDiphthine synthase / 0.660
2pcg SAHDiphthine synthase / 0.660
2qo7 ANPEphrin type-A receptor 3 2.7.10.1 0.660
3nyn SGVG protein-coupled receptor kinase 6 2.7.11.16 0.660
3ort AGSSerine/threonine protein kinase / 0.660
3w8q AGSDual specificity mitogen-activated protein kinase kinase 1 2.7.12.2 0.660
4jlp ADPAdenylate kinase / 0.660
4s32 ANPMitogen-activated protein kinase 1 2.7.11.24 0.660
1olt SAMOxygen-independent coproporphyrinogen III oxidase / 0.659
1w2c ANPInositol-trisphosphate 3-kinase A 2.7.1.127 0.659
2c2a ADPSensor histidine kinase / 0.659
2p6d SAHDiphthine synthase / 0.659
4bwa N0BPyrrolysine--tRNA ligase / 0.659
4nm0 ADPGlycogen synthase kinase-3 beta 2.7.11.26 0.659
1u54 ACPActivated CDC42 kinase 1 / 0.658
4oav ACP2-5A-dependent ribonuclease 3.1.26 0.658
1jqh ANPInsulin-like growth factor 1 receptor 2.7.10.1 0.657
2p2m PRXAcetyl-coenzyme A synthetase / 0.657
4aqk ADPInositol-pentakisphosphate 2-kinase 2.7.1.158 0.657
4ffl ADPUncharacterized protein / 0.657
5dos ATPAurora kinase A 2.7.11.1 0.657
2eh4 SAHDiphthine synthase / 0.656
1ol5 ADPAurora kinase A 2.7.11.1 0.655
2emr SAHDiphthine synthase / 0.655
4cng SAHSpoU rRNA methylase / 0.655
2eld SAHDiphthine synthase / 0.654
4h3p ANPMitogen-activated protein kinase 1 2.7.11.24 0.654
2olc ADPMethylthioribose kinase 2.7.1.100 0.653
2qoc ANPEphrin type-A receptor 3 2.7.10.1 0.653
3a99 ANPSerine/threonine-protein kinase pim-1 2.7.11.1 0.653
3mia ANPCyclin-dependent kinase 9 2.7.11.22 0.653
3sl2 ATPSensor histidine kinase WalK / 0.652
2cx8 SAHRibosomal RNA small subunit methyltransferase E / 0.651
3att ATPPutative aminoglycoside phosphotransferase 2.7.1 0.651
4btj ATPTau-tubulin kinase 1 2.7.11.1 0.651
4fl3 ANPTyrosine-protein kinase SYK 2.7.10.2 0.651
4rr8 A3SProbable threonine--tRNA ligase 2 6.1.1.3 0.651
4xeo A5AAlanine--tRNA ligase, cytoplasmic / 0.651
5cvh ADPCasein kinase II subunit alpha 2.7.11.1 0.651
5l6w AGSLIM domain kinase 1 2.7.11.1 0.650