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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4xcj ADP Heat shock cognate 90 kDa protein

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4xcj ADPHeat shock cognate 90 kDa protein / 0.908
4xcl AGSHeat shock cognate 90 kDa protein / 0.901
3t2s AGSHeat shock protein HSP 90-alpha / 0.854
4xc0 ACPHeat shock cognate 90 kDa protein / 0.835
4gqt ADPHeat shock protein 90 / 0.827
3t1k ANPHeat shock protein HSP 90-alpha / 0.813
1yt0 ADPEndoplasmin / 0.810
3t10 ACPHeat shock protein HSP 90-alpha / 0.807
1byq ADPHeat shock protein HSP 90-alpha / 0.802
2xk2 ADPHeat shock protein HSP 90-alpha / 0.798
2ior ADPChaperone protein HtpG / 0.793
5f5r ANPHeat shock protein 75 kDa, mitochondrial / 0.783
2yef ANPHeat shock protein HSP 90-alpha / 0.780
2xcm ADPCytosolic heat shock protein 90 / 0.778
4ivg ANPTNF receptor-associated protein 1 / 0.769
3t0z ATPHeat shock protein HSP 90-alpha / 0.754
1amw ADPATP-dependent molecular chaperone HSP82 / 0.744
2o1u ANPEndoplasmin / 0.734
4gt8 ADPSensor protein VraS 2.7.13.3 0.730
2zkj ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.725
2e0a ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.724
1am1 ADPATP-dependent molecular chaperone HSP82 / 0.721
2wep ADPATP-dependent molecular chaperone HSP82 / 0.720
4wuc ANPDNA gyrase subunit B / 0.717
1z5c ADPType 2 DNA topoisomerase 6 subunit B / 0.712
3d2r ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 4, mitochondrial 2.7.11.2 0.712
1y4s ADPChaperone protein HtpG / 0.708
3h4l ANPDNA mismatch repair protein PMS1 / 0.706
1z59 ADPType 2 DNA topoisomerase 6 subunit B / 0.702
4ipe ANPTNF receptor-associated protein 1 / 0.698
4wud ANPDNA gyrase subunit B / 0.696
4prv ADPDNA gyrase subunit B / 0.689
3ied AN2HSP90 / 0.687
2o1v ADPEndoplasmin / 0.686
1gjv AGS[3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial 2.7.11.4 0.681
3a0t ADPSensor histidine kinase / 0.677
3ehj ACPSensor histidine kinase DesK 2.7.13.3 0.677
1jm6 ADP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.670
3crl ANP[Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 2, mitochondrial 2.7.11.2 0.668
1mx0 ANPType 2 DNA topoisomerase 6 subunit B / 0.666
4prx ADPDNA gyrase subunit B / 0.665
1i59 ANPChemotaxis protein CheA 2.7.13.3 0.661
1qy5 NECEndoplasmin / 0.661
1pvg ANPDNA topoisomerase 2 5.99.1.3 0.660
1u2o NECEndoplasmin / 0.658
4bix ADPSensor histidine kinase CpxA / 0.658
1i58 ACPChemotaxis protein CheA 2.7.13.3 0.657
3sl2 ATPSensor histidine kinase WalK / 0.657
4crs AGSSerine/threonine-protein kinase N2 2.7.11.13 0.651
1ea6 ADPMismatch repair endonuclease PMS2 3.1 0.650
1zxm ANPDNA topoisomerase 2-alpha 5.99.1.3 0.650
4oau ADP2-5A-dependent ribonuclease 3.1.26 0.650