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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4oe2 NAD 2-aminomuconate 6-semialdehyde dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 1.229
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 1.171
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 0.999
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 0.993
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 0.987
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 0.987
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.953
4pz2 NADAldehyde dehydrogenase 2-6 / 0.947
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 0.943
4i8q NADPutative betaine aldehyde dehyrogenase / 0.929
4i8p NADAminoaldehyde dehydrogenase 1 / 0.923
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.920
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.911
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.906
3b4w NADAldehyde dehydrogenase family protein / 0.903
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.901
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.897
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.892
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.847
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.843
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.838
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.837
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.834
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.822
2jg7 NADAntiquitin / 0.813
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.808
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.807
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.805
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.804
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.800
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.797
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.792
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.789
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.789
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.788
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.787
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.786
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.785
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.785
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.784
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.780
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.780
3haz NADBifunctional protein PutA / 0.779
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.778
4nmj NAPAldehyde dehydrogenase / 0.777
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.770
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.769
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.761
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.760
4i9b NADPutative betaine aldehyde dehyrogenase / 0.758
4zz7 NADMethylmalonate-semialdehyde dehydrogenase / 0.758
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.756
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.756
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.752
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.751
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.750
4i3w NADAldehyde dehydrogenase (NAD+) / 0.750
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.749
4pxl NADAldehyde dehydrogenase3 / 0.749
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.744
5eyu NADBetaine-aldehyde dehydrogenase / 0.744
1wnb NAIGamma-aminobutyraldehyde dehydrogenase 1.2.1.19 0.741
4i3v NADAldehyde dehydrogenase (NAD+) / 0.740
4f3x NADPutative aldehyde dehydrogenase / 0.735
3ju8 NADN-succinylglutamate 5-semialdehyde dehydrogenase 1.2.1.71 0.734
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.727
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.726
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.724
2w8r ADPSuccinate-semialdehyde dehydrogenase, mitochondrial 1.2.1.24 0.721
4pt0 NADAldehyde dehydrogenase / 0.721
4nmk NAPAldehyde dehydrogenase / 0.719
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.711
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.711
4h73 NDPAldehyde dehydrogenase / 0.711
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.710
2wme NAPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.709
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.707
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.705
5ez4 NADBetaine-aldehyde dehydrogenase / 0.705
3iwj NADAminoaldehyde dehydrogenase / 0.701
4c3s NADAldehyde Dehydrogenase / 0.699
5dib NADBetaine-aldehyde dehydrogenase / 0.699
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.695
2bja NAD1-pyrroline-5-carboxylate dehydrogenase / 0.689
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.689
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.688
3h4v NAPPteridine reductase 1 1.5.1.33 0.687
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.685
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.682
2onm ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.672
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.670
1bi9 NADRetinal dehydrogenase 2 / 0.666
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.663
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.660
1i6l TYMTryptophan--tRNA ligase 6.1.1.2 0.656
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.656