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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4nfh NAJ Alcohol dehydrogenase E chain 1.1.1.1

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.362
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 1.356
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.355
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 1.355
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 1.355
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 1.354
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 1.354
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 1.354
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.354
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 1.353
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.353
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 1.353
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 1.348
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 1.319
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 1.318
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 1.308
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 1.304
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 1.297
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 1.296
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 1.294
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 1.281
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 1.269
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 1.259
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 1.246
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 1.242
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 1.241
1het NADAlcohol dehydrogenase E chain 1.1.1.1 1.236
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 1.200
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 1.149
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 1.149
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 1.108
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 1.079
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.990
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.984
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.976
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.945
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.944
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.939
1yqd NAPSinapyl alcohol dehydrogenase / 0.936
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.935
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.913
3jv7 NADSecondary alcohol dehydrogenase / 0.898
3two NDPMannitol dehydrogenase / 0.881
4c4o NADSADH / 0.874
4oaq NDPR-specific carbonyl reductase / 0.873
1yqx NAPSinapyl alcohol dehydrogenase / 0.871
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.868
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.865
3wle NAD(R)-specific carbonyl reductase / 0.864
2xaa NADSecondary alcohol dehydrogenase / 0.846
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.838
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.835
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.834
1uxj NADMalate dehydrogenase / 0.817
1u7h NADPutative ornithine cyclodeaminase / 0.814
1o6z NADMalate dehydrogenase / 0.813
1uxk NADMalate dehydrogenase / 0.813
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.809
1x7d NADPutative ornithine cyclodeaminase / 0.807
1gv0 NADMalate dehydrogenase / 0.804
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.798
4cpd NADAlcohol dehydrogenase / 0.796
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.794
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.791
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.789
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.786
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.785
4l0q NADAlcohol dehydrogenase class-3 / 0.778
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.776
1p0f NAPNADP-dependent alcohol dehydrogenase 1.1.1.2 0.773
4jji NADAlcohol dehydrogenase class-3 / 0.773
1pzh NADLactate dehydrogenase / 0.771
4rqu NADAlcohol dehydrogenase class-P / 0.764
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.759
2dph NADFormaldehyde dismutase / 0.758
2o4c NADErythronate-4-phosphate dehydrogenase / 0.756
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.755
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.752
5ees NAP4-hydroxy-tetrahydrodipicolinate reductase / 0.752
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.750
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.745
2voj NADAlanine dehydrogenase 1.4.1.1 0.744
2vwh NAPGlucose 1-dehydrogenase / 0.744
4ejm NAPPutative zinc-binding dehydrogenase / 0.744
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.742
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.742
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.742
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.742
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.741
1ur5 NADMalate dehydrogenase / 0.739
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.738
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.735
4j49 NADUncharacterized protein / 0.735
1llu NADAlcohol dehydrogenase / 0.734
1yl7 NAI4-hydroxy-tetrahydrodipicolinate reductase / 0.733
2vhx NADAlanine dehydrogenase 1.4.1.1 0.730
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.730
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.730
4b7x NAPProbable oxidoreductase / 0.730
4i1i NADMalate dehydrogenase / 0.730
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.729
1guy NADMalate dehydrogenase / 0.727
1c1d NAIPhenylalanine dehydrogenase / 0.722
1f0y NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.721
4j43 NADUncharacterized protein / 0.721
3uko NADAlcohol dehydrogenase class-3 / 0.719
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.718
2fze APRAlcohol dehydrogenase class-3 1.1.1.1 0.717
3wsw NADL-lactate dehydrogenase / 0.714
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.711
2ejv NADL-threonine 3-dehydrogenase / 0.710
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.710
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.709
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.708
4k28 NADShikimate dehydrogenase family protein / 0.708
1wze NADMalate dehydrogenase / 0.707
4jk3 NADUncharacterized protein / 0.707
2x0r NADMalate dehydrogenase / 0.706
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.706
1lsj NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.704
4xrg NADHomospermidine synthase 2.5.1.44 0.704
1pjc NADAlanine dehydrogenase / 0.698
3wfj NAD2-dehydropantoate 2-reductase / 0.698
3pef NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.697
5bsg NAPPyrroline-5-carboxylate reductase / 0.696
3ikt NADRedox-sensing transcriptional repressor Rex / 0.694
4plp NADHomospermidine synthase 2.5.1.44 0.694
4xq9 NADHomospermidine synthase 2.5.1.44 0.694
4tvb NADHomospermidine synthase 2.5.1.44 0.693
1ie3 NADMalate dehydrogenase / 0.692
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.692
3f3s NADLambda-crystallin homolog / 0.692
4xqc NADHomospermidine synthase 2.5.1.44 0.691
1i2b NADUDP-sulfoquinovose synthase, chloroplastic 3.13.1.1 0.690
2aa3 AP0L-lactate dehydrogenase / 0.690
3ggo NAIPrephenate dehydrogenase / 0.686
2yy7 NADL-threonine dehydrogenase / 0.685
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.685
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.685
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.684
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.683
2dfv NADL-threonine 3-dehydrogenase / 0.683
2zb3 NDPProstaglandin reductase 2 1.3.1.48 0.682
1pzg A3DLactate dehydrogenase / 0.681
1b8u NADMalate dehydrogenase / 0.680
1sc6 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.679
4j4b NAIUncharacterized protein / 0.679
1kev NDPNADP-dependent isopropanol dehydrogenase 1.1.1.80 0.678
2cdc NAPGlucose 1-dehydrogenase / 0.678
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.678
3kb6 NADD-lactate dehydrogenase / 0.678
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.677
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.677
2x0i NAIMalate dehydrogenase / 0.677
2fkn NADUrocanate hydratase 4.2.1.49 0.676
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.675
3pdu NAPGlyoxalate/3-oxopropanoate/4-oxobutanoate reductase / 0.675
1la2 NADInositol-3-phosphate synthase 5.5.1.4 0.674
3cin NADMyo-inositol-1-phosphate synthase-related protein / 0.673
3ulk NDPKetol-acid reductoisomerase (NADP(+)) / 0.673
4gi2 NAPCrotonyl-CoA carboxylase/reductase / 0.673
5a1t NAIL-lactate dehydrogenase / 0.673
1sow NADL-lactate dehydrogenase 1.1.1.27 0.672
3ec7 NADInositol 2-dehydrogenase / 0.672
3baz NAPHydroxyphenylpyruvate reductase 1.1.1.237 0.671
4ros APRMalate dehydrogenase / 0.670
5ijz NAPNADP-specific glutamate dehydrogenase 1.4.1.4 0.669
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.667
3ggp NADPrephenate dehydrogenase / 0.667
3jyp NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.667
4j49 NAIUncharacterized protein / 0.667
5a04 NDPGlucose-fructose oxidoreductase / 0.667
1il0 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.666
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.666
1bdb NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase / 0.665
2gsd NADFormate dehydrogenase / 0.665
3tqh NDPQuinone oxidoreductase / 0.665
3d64 NADAdenosylhomocysteinase / 0.664
3x2f NAIAdenosylhomocysteinase / 0.664
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.663
2yvg NADFerredoxin reductase / 0.663
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.662
1ryd NDPGlucose--fructose oxidoreductase 1.1.99.28 0.662
2c29 NAPDihydroflavonol 4-reductase / 0.662
1pzf A3DLactate dehydrogenase / 0.661
3qvw NADMyo-inositol-1-phosphate synthase (Ino1) / 0.661
1n5d NDPCarbonyl reductase [NADPH] 1 / 0.660
2cda NAPGlucose 1-dehydrogenase / 0.660
1psd NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.659
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.658
5c7o NADGlyceraldehyde-3-phosphate dehydrogenase, testis-specific 1.2.1.12 0.658
2v7g NADUrocanate hydratase 4.2.1.49 0.657
4e5n NADPhosphonate dehydrogenase 1.20.1.1 0.657
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.656
3l4s NADGlyceraldehyde-3-phosphate dehydrogenase 1 / 0.656
4p8r NADGlyceraldehyde-3-phosphate dehydrogenase / 0.656
1bw9 NADPhenylalanine dehydrogenase / 0.655
1dxy NADD-2-hydroxyisocaproate dehydrogenase 1.1.1 0.655
3keo NADRedox-sensing transcriptional repressor Rex / 0.655
4weq NAPNAD-dependent dehydrogenase / 0.654
1wzi NDPMalate dehydrogenase / 0.653
2hu2 NADC-terminal binding protein 1 / 0.653
2uyy NA7Putative oxidoreductase GLYR1 1 0.653
5br7 FADUDP-galactopyranose mutase / 0.653
1p1h NADInositol-3-phosphate synthase 5.5.1.4 0.651
3qvx NADMyo-inositol-1-phosphate synthase (Ino1) / 0.651
3w8f NAD3-hydroxybutyrate dehydrogenase / 0.651
4wji NAPPutative cyclohexadienyl dehydrogenase and ADH prephenate dehydrogenase / 0.651
2q1t NADPutative nucleotide sugar epimerase/ dehydratase / 0.650
4nu5 NADPhosphonate dehydrogenase 1.20.1.1 0.650
4o63 NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.650
4yai NAIC alpha-dehydrogenase / 0.650