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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4l4s NAI L-lactate dehydrogenase A chain 1.1.1.27

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 1.144
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.852
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.833
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.831
2x0i NAIMalate dehydrogenase / 0.794
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.794
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.793
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.792
3h3f NAIL-lactate dehydrogenase A chain 1.1.1.27 0.788
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.787
1ib6 NADMalate dehydrogenase / 0.785
4xd2 NAIAlcohol dehydrogenase E chain 1.1.1.1 0.784
1het NADAlcohol dehydrogenase E chain 1.1.1.1 0.780
2jhf NADAlcohol dehydrogenase E chain 1.1.1.1 0.764
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.763
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.763
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.763
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.761
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.760
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.759
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.759
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.752
5a1t NAIL-lactate dehydrogenase / 0.751
1t2c NAIL-lactate dehydrogenase 1.1.1.27 0.749
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.749
1uxk NADMalate dehydrogenase / 0.748
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.748
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.747
1hdz NADAlcohol dehydrogenase 1B 1.1.1.1 0.746
1uxj NADMalate dehydrogenase / 0.746
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.746
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.746
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.746
2a94 AP0L-lactate dehydrogenase 1.1.1.27 0.744
3wsw NADL-lactate dehydrogenase / 0.744
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.743
1heu NADAlcohol dehydrogenase E chain 1.1.1.1 0.742
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.742
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.742
1f8f NADBenzyl alcohol dehydrogenase / 0.741
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.739
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.737
4cpd NADAlcohol dehydrogenase / 0.737
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.737
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.736
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.735
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.735
1pzh NADLactate dehydrogenase / 0.734
1vjt NADAlpha-glucosidase, putative / 0.734
3pvz NADUDP-N-acetylglucosamine 4,6-dehydratase / 0.734
2a92 NAIL-lactate dehydrogenase / 0.733
4dl9 NADS-(hydroxymethyl)glutathione dehydrogenase / 0.732
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.732
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.731
1u7h NADPutative ornithine cyclodeaminase / 0.731
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.731
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.731
3jyp NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.730
1p1h NADInositol-3-phosphate synthase 5.5.1.4 0.729
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.729
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.729
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.725
1sow NADL-lactate dehydrogenase 1.1.1.27 0.724
1gv0 NADMalate dehydrogenase / 0.722
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.722
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.721
4gl4 NAIAlcohol dehydrogenase class-3 / 0.719
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.718
1x7d NADPutative ornithine cyclodeaminase / 0.717
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.714
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.712
1o6z NADMalate dehydrogenase / 0.711
4j49 NAIUncharacterized protein / 0.711
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.710
1ie3 NADMalate dehydrogenase / 0.710
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.704
4ros APRMalate dehydrogenase / 0.703
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.702
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.700
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.700
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.699
3jyq NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.698
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.696
2voj NADAlanine dehydrogenase 1.4.1.1 0.696
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.696
1agn NADAlcohol dehydrogenase class 4 mu/sigma chain 1.1.1.1 0.694
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.694
3wle NAD(R)-specific carbonyl reductase / 0.694
1guy NADMalate dehydrogenase / 0.692
4j49 NADUncharacterized protein / 0.692
4jji NADAlcohol dehydrogenase class-3 / 0.691
1bdb NADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase / 0.690
2vhx NADAlanine dehydrogenase 1.4.1.1 0.690
2aa3 AP0L-lactate dehydrogenase / 0.689
1e3l NADAlcohol dehydrogenase 4 1.1.1.1 0.688
1ez4 NADL-lactate dehydrogenase 1.1.1.27 0.686
3m2t NADProbable dehydrogenase / 0.684
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.684
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.681
1obb NADAlpha-glucosidase 3.2.1.20 0.681
3qw2 NADMyo-inositol-1-phosphate synthase (Ino1) / 0.680
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.679
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.679
3jv7 NADSecondary alcohol dehydrogenase / 0.679
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.678
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.678
4lcj NADC-terminal-binding protein 2 / 0.677
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.676
3icp NADNAD-dependent epimerase/dehydratase / 0.676
2c54 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.675
3tri NAPPyrroline-5-carboxylate reductase / 0.673
4njo NADD-3-phosphoglycerate dehydrogenase, putative / 0.673
1pzf A3DLactate dehydrogenase / 0.672
3ggo NAIPrephenate dehydrogenase / 0.672
3oet NADErythronate-4-phosphate dehydrogenase / 0.671
1bdm NAXMalate dehydrogenase / 0.670
2c59 NADGDP-mannose 3,5-epimerase 5.1.3.18 0.670
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.669
4jk3 NADUncharacterized protein / 0.669
1j0x NADGlyceraldehyde-3-phosphate dehydrogenase 1.2.1.12 0.667
2hjr APRMalate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase / 0.667
3sxp NADADP-L-glycero-D-mannoheptose-6-epimerase / 0.667
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.665
2yy7 NADL-threonine dehydrogenase / 0.665
1pzg A3DLactate dehydrogenase / 0.664
3nt2 NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.664
3ru9 NADUDP-N-acetylglucosamine 4-epimerase / 0.664
3ruc NADUDP-N-acetylglucosamine 4-epimerase / 0.664
1b8v NADMalate dehydrogenase / 0.663
2q1u NADPutative nucleotide sugar epimerase/ dehydratase / 0.663
2qa2 FADPolyketide oxygenase CabE / 0.663
4pzd NAD3-Hydroxyacyl-CoA dehydrogenase / 0.663
3ehe NADUDP-glucose 4-epimerase (GalE-1) / 0.662
5ig2 NADShort-chain dehydrogenase/reductase SDR / 0.662
4j43 NADUncharacterized protein / 0.661
2vhw NAIAlanine dehydrogenase 1.4.1.1 0.660
3adp NAILambda-crystallin 1.1.1.45 0.660
4c4o NADSADH / 0.660
5lc1 NADL-threonine 3-dehydrogenase / 0.660
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.660
1up7 NAD6-phospho-beta-glucosidase BglT 3.2.1.86 0.659
1psd NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.658
2pa3 NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.658
1bws NDPGDP-L-fucose synthase / 0.657
1emd NADMalate dehydrogenase / 0.657
2ome NADC-terminal-binding protein 2 / 0.657
3s55 NADPutative short-chain dehydrogenase/reductase / 0.657
4k28 NADShikimate dehydrogenase family protein / 0.657
1e3s NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.656
2i9p NAD3-hydroxyisobutyrate dehydrogenase, mitochondrial 1.1.1.31 0.656
3abi NADUncharacterized protein / 0.656
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.656
1n2g APCPantothenate synthetase 6.3.2.1 0.655
2ldb NADL-lactate dehydrogenase 1.1.1.27 0.655
3pgx NADUncharacterized NAD-dependent oxidoreductase MAP_4146 / 0.655
4mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.654
4xq9 NADHomospermidine synthase 2.5.1.44 0.654
1cdo NADAlcohol dehydrogenase 1 1.1.1.1 0.653
1efk NADNAD-dependent malic enzyme, mitochondrial 1.1.1.38 0.653
2fzw NADAlcohol dehydrogenase class-3 1.1.1.1 0.653
3ko8 NADNAD-dependent epimerase/dehydratase / 0.653
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.653
2d1y NADOxidoreductase, short-chain dehydrogenase/reductase family / 0.652
1geg NADDiacetyl reductase [(S)-acetoin forming] 1.1.1.304 0.651
1u8x NADMaltose-6'-phosphate glucosidase 3.2.1.122 0.651
3qvw NADMyo-inositol-1-phosphate synthase (Ino1) / 0.651
4j33 FADKynurenine 3-monooxygenase / 0.651
1b8u NADMalate dehydrogenase / 0.650
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.650
2q1w NADPutative nucleotide sugar epimerase/ dehydratase / 0.650
3x2e NAIAdenosylhomocysteinase / 0.650