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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4jk3 NAD Uncharacterized protein

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4jk3 NADUncharacterized protein / 1.176
4j49 NADUncharacterized protein / 1.033
4j43 NADUncharacterized protein / 1.030
4j4b NAIUncharacterized protein / 0.993
4j49 NAIUncharacterized protein / 0.965
1lld NADL-lactate dehydrogenase 2 1.1.1.27 0.797
4c4o NADSADH / 0.790
3h3j NADL-lactate dehydrogenase 1 1.1.1.27 0.789
1u7h NADPutative ornithine cyclodeaminase / 0.786
2eer NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.773
1lde NADAlcohol dehydrogenase E chain 1.1.1.1 0.771
1sow NADL-lactate dehydrogenase 1.1.1.27 0.767
1r37 NADNAD-dependent alcohol dehydrogenase 1.1.1.1 0.754
5kcp NAJAlcohol dehydrogenase E chain 1.1.1.1 0.754
4gkv NADAlcohol dehydrogenase, propanol-preferring 1.1.1.1 0.753
1pzh NADLactate dehydrogenase / 0.752
5kjc NAJAlcohol dehydrogenase E chain 1.1.1.1 0.751
3m6i NADL-arabinitol 4-dehydrogenase 1.1.1.12 0.750
4jnk NAIL-lactate dehydrogenase A chain 1.1.1.27 0.749
5kjf NAJAlcohol dehydrogenase E chain 1.1.1.1 0.748
1pl8 NADSorbitol dehydrogenase 1.1.1.14 0.747
3d4p NADL-lactate dehydrogenase 1 1.1.1.27 0.747
5kj6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.745
1uxj NADMalate dehydrogenase / 0.744
5cdt NAJAlcohol dehydrogenase E chain 1.1.1.1 0.743
2fkn NADUrocanate hydratase 4.2.1.49 0.741
3cos NADAlcohol dehydrogenase 4 1.1.1.1 0.741
1u3v NADAlcohol dehydrogenase 1B 1.1.1.1 0.740
5cds NAJAlcohol dehydrogenase E chain 1.1.1.1 0.740
4dxh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.739
2o4c NADErythronate-4-phosphate dehydrogenase / 0.738
2x0r NADMalate dehydrogenase / 0.737
3jv7 NADSecondary alcohol dehydrogenase / 0.737
1adc PADAlcohol dehydrogenase E chain 1.1.1.1 0.736
2ohx NADAlcohol dehydrogenase E chain 1.1.1.1 0.736
4tvb NADHomospermidine synthase 2.5.1.44 0.732
3wle NAD(R)-specific carbonyl reductase / 0.731
1t2d NADL-lactate dehydrogenase 1.1.1.27 0.730
5cdg NAJAlcohol dehydrogenase E chain 1.1.1.1 0.730
5mdh NADMalate dehydrogenase, cytoplasmic 1.1.1.37 0.727
4k28 NADShikimate dehydrogenase family protein / 0.726
5kje NAJAlcohol dehydrogenase E chain 1.1.1.1 0.724
1hyh NADL-2-hydroxyisocaproate dehydrogenase / 0.723
4nu5 NADPhosphonate dehydrogenase 1.20.1.1 0.723
4w6z 8IDAlcohol dehydrogenase 1 1.1.1.1 0.720
4xqc NADHomospermidine synthase 2.5.1.44 0.719
5kcz NAJAlcohol dehydrogenase E chain 1.1.1.1 0.719
1axe NADAlcohol dehydrogenase E chain 1.1.1.1 0.718
2dfd NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.718
4hfm NAP2-alkenal reductase (NADP(+)-dependent) / 0.717
2xaa NADSecondary alcohol dehydrogenase / 0.716
4nd4 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.716
4wlu NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.715
1pjc NADAlanine dehydrogenase / 0.714
5env NADAlcohol dehydrogenase 1 1.1.1.1 0.713
4nfs NAJAlcohol dehydrogenase E chain 1.1.1.1 0.712
1hsz NADAlcohol dehydrogenase 1B 1.1.1.1 0.711
2fn7 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.711
4b7x NAPProbable oxidoreductase / 0.711
1ma0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.710
2nad NADFormate dehydrogenase / 0.710
3oet NADErythronate-4-phosphate dehydrogenase / 0.710
1pl6 NADSorbitol dehydrogenase 1.1.1.14 0.709
2j3k NAPNADPH-dependent oxidoreductase 2-alkenal reductase 1.3.1.74 0.709
1gv0 NADMalate dehydrogenase / 0.708
2dph NADFormaldehyde dismutase / 0.708
4xrg NADHomospermidine synthase 2.5.1.44 0.708
4e5n NADPhosphonate dehydrogenase 1.20.1.1 0.707
4nfh NAJAlcohol dehydrogenase E chain 1.1.1.1 0.707
4wlv NADMalate dehydrogenase, mitochondrial 1.1.1.37 0.707
4oaq NDPR-specific carbonyl reductase / 0.706
3tqh NDPQuinone oxidoreductase / 0.705
3wyc NAPMeso-diaminopimelate D-dehydrogenase 1.4.1.16 0.704
4okn NAIL-lactate dehydrogenase A chain 1.1.1.27 0.704
1a71 NADAlcohol dehydrogenase E chain 1.1.1.1 0.703
1kol NADGlutathione-independent formaldehyde dehydrogenase / 0.703
2voj NADAlanine dehydrogenase 1.4.1.1 0.703
1ie3 NADMalate dehydrogenase / 0.702
1hf3 NADAlcohol dehydrogenase E chain 1.1.1.1 0.701
2gsd NADFormate dehydrogenase / 0.700
3sx2 NADUncharacterized protein / 0.700
4nd3 NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.699
3d64 NADAdenosylhomocysteinase / 0.698
3two NDPMannitol dehydrogenase / 0.697
4plp NADHomospermidine synthase 2.5.1.44 0.697
2x0i NAIMalate dehydrogenase / 0.696
3n7u NADFormate dehydrogenase, chloroplastic/mitochondrial / 0.696
4nd2 A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase / 0.696
1mgo NADAlcohol dehydrogenase E chain 1.1.1.1 0.694
4cpd NADAlcohol dehydrogenase / 0.694
4weq NAPNAD-dependent dehydrogenase / 0.694
1h2b NAJNAD-dependent alcohol dehydrogenase / 0.693
3wsw NADL-lactate dehydrogenase / 0.693
4e5p NADPhosphonate dehydrogenase 1.20.1.1 0.692
4ng5 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.692
1mp0 NADAlcohol dehydrogenase class-3 1.1.1.1 0.691
3jyo NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.690
4z0p NDPNAD-dependent dehydrogenase / 0.690
1axg NADAlcohol dehydrogenase E chain 1.1.1.1 0.688
1wwk NAD307aa long hypothetical phosphoglycerate dehydrogenase / 0.687
4rls NAIL-lactate dehydrogenase A chain 1.1.1.27 0.687
1ht0 NADAlcohol dehydrogenase 1C 1.1.1.1 0.686
1uxk NADMalate dehydrogenase / 0.686
3wv7 ADPHmd co-occurring protein HcgE / 0.685
4dlb NADS-(hydroxymethyl)glutathione dehydrogenase / 0.685
4dwv NAJAlcohol dehydrogenase E chain 1.1.1.1 0.685
4i1i NADMalate dehydrogenase / 0.685
2dbr NAPGlyoxylate reductase 1.1.1.26 0.684
3m2t NADProbable dehydrogenase / 0.684
2v7g NADUrocanate hydratase 4.2.1.49 0.683
3oq6 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.683
3wv8 ATPHmd co-occurring protein HcgE / 0.683
5dt9 NADErythronate-4-phosphate dehydrogenase / 0.683
1omo NADAlanine dehydrogenase / 0.682
2ekl NADD-3-phosphoglycerate dehydrogenase / 0.681
2y05 NAPProstaglandin reductase 1 / 0.680
2oxi NADAlcohol dehydrogenase E chain 1.1.1.1 0.679
1ib6 NADMalate dehydrogenase / 0.678
1b3r NADAdenosylhomocysteinase 3.3.1.1 0.677
2g76 NADD-3-phosphoglycerate dehydrogenase 1.1.1.95 0.677
3nt4 NAIInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.677
4xyb NDPFormate dehydrogenase / 0.677
1nah NADUDP-glucose 4-epimerase 5.1.3.2 0.676
1y56 FAD382aa long hypothetical sarcosine oxidase / 0.676
4e5k NADPhosphonate dehydrogenase 1.20.1.1 0.676
2dbz NAPGlyoxylate reductase 1.1.1.26 0.675
2vhv NAIAlanine dehydrogenase 1.4.1.1 0.674
4ywj NAD4-hydroxy-tetrahydrodipicolinate reductase / 0.674
1teh NADAlcohol dehydrogenase class-3 1.1.1.1 0.673
3aw9 NADNAD-dependent epimerase/dehydratase / 0.672
4lcj NADC-terminal-binding protein 2 / 0.672
6adh NADAlcohol dehydrogenase E chain 1.1.1.1 0.672
1yb5 NAPQuinone oxidoreductase 1.6.5.5 0.671
5kj1 NAJAlcohol dehydrogenase E chain 1.1.1.1 0.671
3kbo NDPGlyoxylate/hydroxypyruvate reductase A / 0.670
3dmt NADGlyceraldehyde-3-phosphate dehydrogenase, glycosomal 1.2.1.12 0.669
4e5m NAPPhosphonate dehydrogenase 1.20.1.1 0.669
4l0q NADAlcohol dehydrogenase class-3 / 0.669
4l4s NAIL-lactate dehydrogenase A chain 1.1.1.27 0.669
1p1h NADInositol-3-phosphate synthase 5.5.1.4 0.668
3gvi ADPMalate dehydrogenase / 0.668
4xcv NDPProbable hydroxyacid dehydrogenase protein / 0.668
3jyp NADQuinate/shikimate dehydrogenase (NAD(+)) / 0.666
2dc1 NADProbable L-aspartate dehydrogenase / 0.665
4rvu NDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein) / 0.665
5bsf NADPyrroline-5-carboxylate reductase / 0.665
2dt5 NADRedox-sensing transcriptional repressor Rex / 0.664
3kb6 NADD-lactate dehydrogenase / 0.664
4nu6 NADPhosphonate dehydrogenase 1.20.1.1 0.664
4xq9 NADHomospermidine synthase 2.5.1.44 0.664
5bqf NAPProbable hydroxyacid dehydrogenase protein / 0.664
1f8f NADBenzyl alcohol dehydrogenase / 0.663
1hku NADC-terminal-binding protein 1 1.1.1 0.663
2vhx NADAlanine dehydrogenase 1.4.1.1 0.663
3nt2 NADInositol 2-dehydrogenase/D-chiro-inositol 3-dehydrogenase 1.1.1.18 0.663
3pym NADGlyceraldehyde-3-phosphate dehydrogenase 3 1.2.1.12 0.663
1b8v NADMalate dehydrogenase / 0.662
1jkf NADInositol-3-phosphate synthase 5.5.1.4 0.662
1o6z NADMalate dehydrogenase / 0.662
2a92 NAIL-lactate dehydrogenase / 0.662
4yag NAIC alpha-dehydrogenase / 0.662
1iy8 NADLevodione reductase / 0.661
1llu NADAlcohol dehydrogenase / 0.661
2vhz NAIAlanine dehydrogenase 1.4.1.1 0.661
4njo NADD-3-phosphoglycerate dehydrogenase, putative / 0.661
2e37 NADL-lactate dehydrogenase / 0.660
2ixa NADAlpha-N-acetylgalactosaminidase 3.2.1.49 0.660
3qwb NDPProbable quinone oxidoreductase 1.6.5.5 0.660
3tsc NADUncharacterized protein / 0.660
4gi2 NAPCrotonyl-CoA carboxylase/reductase / 0.660
1vjt NADAlpha-glucosidase, putative / 0.659
5c7o NADGlyceraldehyde-3-phosphate dehydrogenase, testis-specific 1.2.1.12 0.659
1j5p NADL-aspartate dehydrogenase 1.4.1.21 0.657
2q28 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.657
1e6w NAD3-hydroxyacyl-CoA dehydrogenase type-2 1.1.1.35 0.655
2ji7 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.655
4bv9 NDPKetimine reductase mu-crystallin 1.5.1.25 0.655
4xye NADFormate dehydrogenase / 0.655
5ig2 NADShort-chain dehydrogenase/reductase SDR / 0.655
1adb CNDAlcohol dehydrogenase E chain 1.1.1.1 0.654
1dc6 NADGlyceraldehyde-3-phosphate dehydrogenase A / 0.654
1npt NADGlyceraldehyde-3-phosphate dehydrogenase / 0.654
2c31 ADPOxalyl-CoA decarboxylase 4.1.1.8 0.654
4gl4 NAIAlcohol dehydrogenase class-3 / 0.654
1ky4 NADAdenosylhomocysteinase 3.3.1.1 0.653
1m75 NADHydroxyacyl-coenzyme A dehydrogenase, mitochondrial 1.1.1.35 0.653
2p9e NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.653
1guy NADMalate dehydrogenase / 0.652
1hld NADAlcohol dehydrogenase E chain 1.1.1.1 0.651
1wze NADMalate dehydrogenase / 0.651
2pa3 NAID-3-phosphoglycerate dehydrogenase 1.1.1.95 0.651
2zb3 NDPProstaglandin reductase 2 1.3.1.48 0.650
3pvz NADUDP-N-acetylglucosamine 4,6-dehydratase / 0.650