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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Interaction pattern similarity measured by Grim
You can zoom onto the graph by using the mouse to make a selection

Binding Modes are compared using Grim.
For more information, please see the following publication: Desaphy J. et al. Encoding Protein-Ligand Interaction Patterns in Fingerprints and Graphs J. Chem. Inf. Model., 2013, 53 (3), pp 623-637
Binding modes are considered as similar when the similarity value is greater than 0.65


Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
4i1w NAD 2-aminomuconate 6-semialdehyde dehydrogenase

Complex with similar interaction patterns:

PDB ID HET Uniprot Name EC Number Binding Mode
Similarity		 Align
4i1w NAD2-aminomuconate 6-semialdehyde dehydrogenase / 1.265
4oe2 NAD2-aminomuconate 6-semialdehyde dehydrogenase / 1.171
2j40 NAD1-pyrroline-5-carboxylate dehydrogenase / 1.056
2ehu NAD1-pyrroline-5-carboxylate dehydrogenase / 1.052
2bhp NAD1-pyrroline-5-carboxylate dehydrogenase / 1.051
2j5n NAD1-pyrroline-5-carboxylate dehydrogenase / 1.051
2eii NAD1-pyrroline-5-carboxylate dehydrogenase / 1.021
3b4w NADAldehyde dehydrogenase family protein / 0.970
3efv NADPutative succinate-semialdehyde dehydrogenase / 0.969
1o04 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.942
4i8p NADAminoaldehyde dehydrogenase 1 / 0.930
1o9j NADAldehyde dehydrogenase, cytosolic 1 1.2.1.3 0.929
2d4e NAD5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenaseiheyensis HTE831] / 0.926
2ehq NAP1-pyrroline-5-carboxylate dehydrogenase / 0.915
2eit NAD1-pyrroline-5-carboxylate dehydrogenase / 0.897
4pz2 NADAldehyde dehydrogenase 2-6 / 0.893
4i8q NADPutative betaine aldehyde dehyrogenase / 0.889
4v37 NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.847
3haz NADBifunctional protein PutA / 0.843
3rhq NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.842
4a0m NADBetaine aldehyde dehydrogenase, chloroplastic 1.2.1.8 0.835
2o2q NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.832
1t90 NADMalonate-semialdehyde dehydrogenase 1.2.1.27 0.830
4pxn NADAldehyde dehydrogenase family 7 member B4 / 0.819
1a4z NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.814
3rhr NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.811
1bpw NADBetaine aldehyde dehydrogenase 1.2.1.8 0.810
2euh NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.810
1uxt NADNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.803
4ihi NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.799
2jg7 NADAntiquitin / 0.796
3rhj NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.795
3v9l NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.789
4fr8 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.789
1o02 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.787
2id2 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.785
1o01 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.784
4fqf NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.784
4nmj NAPAldehyde dehydrogenase / 0.783
3n82 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.771
4wb9 NAIRetinal dehydrogenase 1 1.2.1.36 0.770
2j6l NAIAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.769
3lns NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.768
3rhl NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.768
4pt0 NADAldehyde dehydrogenase / 0.763
2onp NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.759
1nzx NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.758
4i3v NADAldehyde dehydrogenase (NAD+) / 0.755
4i3w NADAldehyde dehydrogenase (NAD+) / 0.755
4x4l NAIRetinal dehydrogenase 1 1.2.1.36 0.755
4i9b NADPutative betaine aldehyde dehyrogenase / 0.752
2bja NAD1-pyrroline-5-carboxylate dehydrogenase / 0.746
4go2 TAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.746
4gnz NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.745
4f3x NADPutative aldehyde dehydrogenase / 0.744
4fr8 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.737
3iwj NADAminoaldehyde dehydrogenase / 0.736
3lv1 NAPNAD(P)-dependent benzaldehyde dehydrogenase 1.2.1.28 0.731
2o2r NDPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.729
2qe0 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.728
1uxr NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.727
1cw3 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.724
3n83 ADPAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.722
4h73 NDPAldehyde dehydrogenase / 0.720
1bi9 NADRetinal dehydrogenase 2 / 0.719
4jdc NADProbable pyrroline-5-carboxylate dehydrogenase RocA / 0.717
1o00 NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.715
1uxn NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.710
1uxp NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.710
2w8r ADPSuccinate-semialdehyde dehydrogenase, mitochondrial 1.2.1.24 0.710
4nmk NAPAldehyde dehydrogenase / 0.710
2y5d NAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase / 0.705
4pxl NADAldehyde dehydrogenase3 / 0.705
5eyu NADBetaine-aldehyde dehydrogenase / 0.704
1uxv NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.703
3zqa NDPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.701
2onm NADAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.700
4x2q NADRetinal dehydrogenase 2 1.2.1.36 0.699
3rho NAPCytosolic 10-formyltetrahydrofolate dehydrogenase 1.5.1.6 0.698
2imp NAILactaldehyde dehydrogenase 1.2.1.22 0.696
4zuk NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.695
2wme NAPNAD/NADP-dependent betaine aldehyde dehydrogenase / 0.694
5dib NADBetaine-aldehyde dehydrogenase / 0.691
1qi1 NAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1.2.1.9 0.690
1ky8 NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.689
1bxs NADRetinal dehydrogenase 1 1.2.1.36 0.677
5ez4 NADBetaine-aldehyde dehydrogenase / 0.677
4itb NDPSuccinate-semialdehyde dehydrogenase / 0.675
1nzz NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.673
4zz7 NADMethylmalonate-semialdehyde dehydrogenase / 0.673
1nzw NAIAldehyde dehydrogenase, mitochondrial 1.2.1.3 0.670
1uxu NAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase / 0.670
4oe4 NADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial 1.2.1.88 0.665
4zvy NADAlpha-aminoadipic semialdehyde dehydrogenase 1.2.1.31 0.662
3ru7 NADUDP-N-acetylglucosamine 4-epimerase / 0.652